Current Signal Transduction Therapy最新文献

{"title":"Kinase Phosphorylation-based Mechanisms of PARP Inhibitor Resistance During Synthetic Lethal Oncotherapy","authors":"E. Osaki, S. Mizuno","doi":"10.2174/1574362413666180724134204","DOIUrl":"https://doi.org/10.2174/1574362413666180724134204","url":null,"abstract":"\u0000\u0000Poly-(ADP-Ribose) Polymerase (PARP) plays a central role in recovery\u0000from single-strand DNA (ssDNA) damage via base excision repair. When PARP activity is\u0000inhibited by a NAD+ mimetic analog, ssDNA is converted into a Double-Strand Break (DSB)\u0000during the S-phase in a cell cycle. However, the DSB site is repaired in a process of Homologous\u0000Recombination (HR) that is derived by genes such as BRCA1/2, PALB2, and RAD51. Under\u0000conditions of HR dysfunction, including mutations of BRCA1/2 (called BRCAness), PARP\u0000inhibitor (PARPi) induces “synthetic lethality” in BRCAness-specific cancer cells. Indeed, clinical\u0000trials using forms of PARPi that include olaparib, veliparib and rucaparib, have revealed that\u0000PARP inhibition produces a dramatic effect that actually arrests cancer progression. Its clinical\u0000efficiency is limited, however, due to the acquisition of PARPi resistance during long-term use of\u0000this inhibitor. Thus, it is important to elucidate the mechanisms of PARPi resistance.\u0000\u0000\u0000\u0000 We searched the scientific literature published in PubMed, with a special focus on\u0000kinase phosphorylation that is involved in acquiring PARPi resistance. We also summarized the\u0000possible molecular events for recovering HR system, a key event for acquiring PARPi resistance.\u0000\u0000\u0000\u0000CDK1 is a critical kinase for 5’-3’ DNA end resection, which is important for generating\u0000ssDNA for recruiting HR-priming factors. CDK12 is necessary for the transcription of HR-driver\u0000genes, such as BRCA1, BRCA2, RAD51 and ATR via the phosphorylation of RNA Pol-II. PLK-1\u0000participates in driving HR via the phosphorylation of RAD51. The PI3K-AKT-mTOR signaling\u0000cascade is involved in BRCA1 induction via an ETS1 transcriptional pathway. Even under ATMdeficient\u0000conditions, the ATR-CHK1 axis compensates for loss in the DNA damage response,\u0000which results in HR recovery. The HGF receptor Met tyrosine kinase is responsible for promoting\u0000DNA repair by activating the PARP catalytic domain.\u0000\u0000\u0000\u0000These kinase-based signaling pathways are biologically important for understanding\u0000the compensatory system of HR, whereas inactivation of these kinases has shown promise for the\u0000release of PARPi resistance. Several lines of preclinical studies have demonstrated the potential\u0000use of kinase inhibitors to enhance PARPi sensitivity. We emphasize the clinical importance of\u0000chemical inhibitors as adjuvant drugs to block critical kinase activities and prevent the possible\u0000PARPi resistance.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"12-23"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46990396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Signal Transduction via Over-expression of Pim-1 Regulated Senescence, Cell Cycle, Apoptosis and Metastatic Invasion: Novel Anticancer Targets and Their Potent Inhibitors from Marine Sources","authors":"Ankita Sharma, S. Nandi","doi":"10.2174/1574362413666180724105508","DOIUrl":"https://doi.org/10.2174/1574362413666180724105508","url":null,"abstract":"\u0000\u0000Existing cancer chemotherapeutics can kill normal as well as malignant\u0000cells. To solve these issues, scientists are now more concerned about the design and discovery of\u0000potential anticancer, least toxic leads, which can promote apoptosis process and inhibition of abnormal\u0000signal transduction via hyperactivation of protein kinases such as Pim-1 due to overexpression\u0000or mutation of proto-oncogenes and tumor suppressor genes related to molecular\u0000mechanisms of senescence, cell cycle, apoptosis and metastatic invasion, thus leading to anticancer\u0000activities. Natural scaffolds play a great role in this aspect.\u0000\u0000\u0000\u0000Sea is full of biodiverse natural resources of medicinal compounds derived from marine\u0000plants, sponges, actinomycetes, cynobacteria, fungi, corals and animals. Many anticancer\u0000compounds were successfully discovered. But there are few potent compounds developed against\u0000abnormal signal transduction mechanism.\u0000\u0000\u0000\u0000 Therefore, an attempt has been made in the present review to focus on\u0000molecular mechanisms of various targets in connection with the over-expression of Pim-1 mediated\u0000senescence, cell cycle, apoptosis and metastatic invasion and their potent inhibitors.\u0000\u0000\u0000\u0000Biochemical mechanisms of the potent marine sourced inhibitors keeping activities\u0000against abnormal signal transduction were discussed in this study. It gives great attention to expand\u0000the capabilities in these upcoming areas to remain globally relevant.\u0000\u0000\u0000\u0000Existed marine sourced anticancer compounds tabulated in this study could be used\u0000as a template for further design and synthesis of promising congeneric synthetic compounds\u0000against another disease by the application of in silico high throughput screening through drug repositioning.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42184394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Channel Scheduling Based on Orchestrator Live Node-Wavelength Reservation for Optical Burst Switching Networks","authors":"Sethu Selvi","doi":"10.2174/1574362413666181109111518","DOIUrl":"https://doi.org/10.2174/1574362413666181109111518","url":null,"abstract":"\u0000\u0000 Dedicated wavelength utilization and the isolation of control plane from\u0000the data plane are the important features in the design of Optical Burst Switching (OBS). The contention\u0000in bursts, link congestion and the reservation cause the burst dropping in optical networks.\u0000The slotted time and the burst assembly models incorporate the wavelength assignment and the\u0000channel reservation schemes to reduce the dropping probability. The reservation of resources prior\u0000to burst arrival and the additional delay due to the burst assembly and the offset time are the major\u0000issues in the reduction of probability. Besides, the traditional one-to-one packet transmission consumes\u0000more time due to a large number of packets handling.\u0000\u0000\u0000\u0000This paper proposes the novel OBS model that incorporates the three\u0000processes such as Open-Flow (OF)-based Orchestrator Live Node (OLN) modeling, fuzzy logic\u0000based ranking and the offset time-based reservation (without/with void filling) to overcome the issues\u0000in the traditional methods. Initially, the OLN modeling based on OF analysis includes the\u0000Flow Information Base (FIB) table for the periodical update of the link information. The fuzzy logic-\u0000based ranking of channels followed by OF-OLN predicts the status of the wavelength such as\u0000free, used and conversion. Based on the status, the channels are reserved without and with void\u0000filling to schedule the bursts effectively. The reservation scheme employs the Offset-Time Burst\u0000Assembly algorithm to allow the resource reservation prior to burst arrival. Through these processes,\u0000the reuse of wavelength and the reallocation of resources are possible in OBS.\u0000\u0000\u0000\u0000The controlling of maximum burst transfer delay by the OTBA efficiently\u0000reduces the end-to-end delay for data traffic. The comparative analysis between the proposed\u0000OLN-WR with the existing Hybrid Burst Assembly (HBA), Fuzzy-based Adaptive Threshold\u0000(FAT) and Fuzzy-based Adaptive Hybrid Burst Assembly (FAHBA) in terms of end-to-end delay\u0000and transmitted amount of bursts assures the applicability of OLN-WR in scheduling and communication\u0000activities in OBS networks.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"13 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41846841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single- and Multi-Step Image Enlargement for Medical Image Coding","authors":"M. Khosravi","doi":"10.2174/1574362414666190131105731","DOIUrl":"https://doi.org/10.2174/1574362414666190131105731","url":null,"abstract":"\u0000\u0000Some interpolators cannot be used in an image magnification problem in a freely scalable form.\u0000For instance, when we want to magnify an image to a 16-time bigger scale, some interpolators have to do this process in\u0000two steps including two 4-time magnification steps, however, some are able to do it directly.\u0000\u0000\u0000\u0000 For generating data of this study, MATLAB as a simulator has been used. Bi-; Linear (BL) and\u0000Cubic Convolution (CC) interpolators are the two applied re-samplers in the reconstruction of digital images.\u0000\u0000\u0000\u0000 Data shows that the performance of both free-size interpolators (BL and CC) is obviously different in both direct\u0000and indirect pixel reconstruction.\u0000\u0000\u0000\u0000The acquired data shows a less error in the condition of direct interpolation. The relative results of experiments\u0000are different from the type of core interpolators (BL and CC).\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"86-87"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574362414666190131105731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43101258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Kidney Disease and Urological Disorders: An Overview","authors":"S. Lai, A. Sciarra, Federico Pierella, S. Pastore, L. Piloni, S. Salciccia, A. Perrotta, P. Protopapa, G. Pintus, G. P. Ricciuti, Mauro Ciccariello, M. V. Heland","doi":"10.2174/1574362413666180412142930","DOIUrl":"https://doi.org/10.2174/1574362413666180412142930","url":null,"abstract":"\u0000\u0000Chronic Kidney Disease (CKD) is a highly prevalent condition and it is a\u0000major risk factor for End-Stage Renal Disease (ESRD), cardiovascular disease, and premature\u0000death. Some congenital and acquired anomalies of the kidneys and lower urinary tract (CAKUT\u0000and CALUT) are well-known causes of CKD and ESRD, but often remain undiagnosed and their\u0000prevalence is underestimated. This study aims to provide an overview that considered mainly\u0000some of the major congenital and acquired urological diseases that could lead to renal clinical\u0000manifestations common even to the most widespread renal pathologies, for which often underdiagnosed.\u0000\u0000\u0000\u0000 PubMed search was conducted for available English literature describing\u0000the actual knowledge on congenital and acquired urological disorders determining acute and\u0000chronic kidney disease. Prospective and retrospective studies as well as meta-analyses and latest\u0000systematic reviews were included.\u0000\u0000\u0000\u0000 Most of the studies examined and reviewed were discarded for wrong population or intervention\u0000or deemed unfit, and only 87 met the inclusion criteria for the review. The studies included\u0000in the review related to urological disorders that may determine chronic and acute kidney\u0000disease.\u0000\u0000\u0000\u0000Some urological diseases, as CAKUT and CALUT, especially in adults, show symptoms,\u0000as renal failure, proteinuria and hypertension, very common to other kidney diseases, for\u0000this reason may remain undiagnosed and their prevalence is not completely known. Therefore, in\u0000doubtful cases, non-invasive and inexpensive tests, as cystourethrogram, should be made, to rule\u0000out urological disorders and if necessary, ultrasonography, urography and scintigraphy, might allow\u0000a correct and early diagnosis of these defects and thus adequate therapy, preventing or at least\u0000slowing down an evolution toward CKD and ESRD.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"224-231"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47006961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S-Phase Kinase-Associated Protein-2 and Nuclear Factor-kappa Beta as Molecular Targets of Oral Burkitt’s Lymphoma Cell Induced by Quinolinone Derivate-Vesnarinone","authors":"Supriatno","doi":"10.2174/1574362413666180912113856","DOIUrl":"https://doi.org/10.2174/1574362413666180912113856","url":null,"abstract":"\u0000\u00003,4-Dihydro-6-[4-3,4-dimethoxybenzoyl-1-piperazinyl]-2(1H)-quinolinone\u0000(vesnarinone), a novel inotropic drug with unique and complex mechanisms of action, is\u0000known to show antitumor activity against several human malignancies. In the present study,\u0000vesnarinone-induced signal transduction of S-phase kinase-associated protein 2 (Skp2) and\u0000Nuclear Factor-kappa Beta (NF-κB) as molecular targets of oral malignant Burkitt’s lymphoma\u0000(Raji cells) was evaluated.\u0000\u0000\u0000\u0000Raji cells were incubated with vesnarinone at concentrations of 0,\u00001.25x10-2, 2.50x10-2, or 5.0x10-2 Molar. After 24 h, chemotactic cell migration was examined by\u0000a Boyden chamber kit. Apoptosis induction was observed by caspase-9 colorimetric assay. To\u0000evaluate levels of Skp2, NF-kB, and α-tubulin, Western blot analysis was performed.\u0000\u0000\u0000\u0000Vesnarinone markedly suppressed chemotactic cell migration and significantly induced\u0000apoptosis by increasing the caspase-9 activity of Raji cells through down regulation of Skp2\u0000and NF-κB.\u0000\u0000\u0000\u0000 Vesnarinone decreased the expression of Skp2 and NF-κB indicating these molecules\u0000may be targeted for the treatment of oral malignant Burkitt’s lymphoma (BL). The results\u0000of this work offer a promising therapeutic approach for BL tumors.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46600352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonic Hedgehog Signaling Activation Promotes Cardioprotective Strategies","authors":"Himanshi Khera, Anupam Awasthi, S. Mehan","doi":"10.2174/1574362413666181113124958","DOIUrl":"https://doi.org/10.2174/1574362413666181113124958","url":null,"abstract":"\u0000\u0000Hedgehog pathway plays a crucial role in the neovascularisation and angiogenesis\u0000during the embryonic stage in humans. Three genes of hedgehog protein isolated from\u0000humans are Sonic hedgehog, Desert hedgehog and Indian hedgehog gene. Two G-protein coupled\u0000receptors identified in the sonic hedgehog pathway served as patched receptor and smoothened receptor.\u0000\u0000\u0000\u0000 Particularly, sonic hedgehog gene plays a versatile role in cellular homeostasis\u0000and can be a novel therapeutic target in the prevention of cardiovascular disorders. Further\u0000various sonic hedgehog modulators have been reported working as futuristic drug molecules\u0000in the modulation of cardiovascular dysfunctions.\u0000\u0000\u0000\u0000 However, there was limited literature availability that has summarized the possible\u0000mechanism of targeting Sonic hedgehog signaling pathway.\u0000\u0000\u0000\u0000 Thus, the present review is aimed at exploring the role of targeting sonic hedgehog\u0000protein signaling and modulators as well as to enlighten that how targeting sonic hedgehog protein\u0000involves in the amelioration of atherosclerosis, ischemic heart diseases, vascular endothelial dysfunction,\u0000heart failure and congenital heart diseases.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"189-196"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48281598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmentation of Brain Magnetic Resonance Images using Deep Learning Classification and Multi-modal Composition","authors":"R. Kala, P. Deepa","doi":"10.2174/1574362414666181220105908","DOIUrl":"https://doi.org/10.2174/1574362414666181220105908","url":null,"abstract":"\u0000\u0000Accurate detection of brain tumor and its severity is a challenging task in\u0000the medical field. So there is a need for developing brain tumor detecting algorithms and it is an\u0000emerging one for diagnosis, planning the treatment and outcome evaluation.\u0000\u0000\u0000\u0000Brain tumor segmentation method using deep learning classification and\u0000multi-modal composition has been developed using the deep convolutional neural networks. The\u0000different modalities of MRI such as T1, flair, T1C and T2 are given as input for the proposed\u0000method. The MR images from the different modalities are used in proportion to the information\u0000contents in the particular modality. The weights for the different modalities are calculated blockwise\u0000and the standard deviation of the block is taken as a proxy for the information content of the\u0000block. Then the convolution is performed between the input image of the T1, flair, T1C and T2\u0000MR images and corresponding to the weight of the T1, flair, T1C, and T2 images. The convolution\u0000is summed between the different modalities of the MR images and its corresponding weight\u0000of the different modalities of the MR images to obtain a new composite image which is given as\u0000an input image to the deep convolutional neural network. The deep convolutional neural network\u0000performs segmentation through the different layers of CNN and different filter operations are performed\u0000in each layer to obtain the enhanced classification and segmented spatial consistency results.\u0000The analysis of the proposed method shows that the discriminatory information from the different\u0000modalities is effectively combined to increase the overall accuracy of segmentation.\u0000\u0000\u0000\u0000The proposed deep convolutional neural network for brain tumor segmentation method\u0000has been analysed by using the Brain Tumor Segmentation Challenge 2013 database (BRATS\u00002013). The complete, core and enhancing regions are validated with Dice Similarity Coefficient\u0000and Jaccard similarity index metric for the Challenge, Leaderboard, and Synthetic data set. To\u0000evaluate the classification rates, the metrics such as accuracy, precision, sensitivity, specificity,\u0000under-segmentation, incorrect segmentation and over segmentation also evaluated and compared\u0000with the existing methods. Experimental results exhibit a higher degree of precision in the segmentation\u0000compared to existing methods.\u0000\u0000\u0000\u0000 In this work, deep convolution neural network with different modalities of MR image\u0000are used to detect the brain tumor. The new input image was created by convoluting the input\u0000image of the different modalities and their weights. The weights are determined using the standard\u0000deviation of the block. Segmentation accuracy is high with efficient appearance and spatial consistency.\u0000The assessment of segmented images is completely evaluated by using well-established\u0000metrics. In future, the proposed method will be considered and evaluated with other databases and\u0000the segmentation accuracy results should be analysed with the presence of different ","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"94-108"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574362414666181220105908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44818955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances and Molecular Pathway in Salivary Adenoid Cystic Carcinoma (Review)","authors":"Laijun Xu, Lingzhi Li, Shouliang Zhao, Shangfeng Liu","doi":"10.2174/1574362414666190204124731","DOIUrl":"https://doi.org/10.2174/1574362414666190204124731","url":null,"abstract":"\u0000\u0000Salivary Adenoid Cystic Carcinoma (ACC) is a malignant tumor located\u0000at oral and maxillofacial regions, and its conventional treatments are surgery, chemotherapy and\u0000radiotherapy. However, its poor survival rates and prognosis resulting from the molecular mechanisms\u0000underlying the carcinogenesis remain obscure. To date, there are insufficient reviews to\u0000summarize the genes and molecular pathways for ACC. Therefore, it is required for us to highlight\u0000the main oncogenes, tumor suppressor genes and genetic signal transduction pathways associated\u0000with ACC in this review.\u0000\u0000\u0000\u0000A literature review based on PubMed for the genetic characteristics and\u0000molecular transduction pathways for ACC was conducted. Ninety articles were selected as references\u0000using the search terms or keywords such as “genes, molecular pathways, salivary adenoid\u0000cystic carcinoma or ACC”.\u0000\u0000\u0000\u0000We have briefly described histopathology, current treatments and main clinical features\u0000in ACC. Besides, we have also elaborated the associated genes and pathways in this review according\u0000to the searched articles in recent years.\u0000\u0000\u0000\u0000 We have summarized vital genes and proteins targeting or mechanism-based on proliferation,\u0000apoptosis, invasion and metastasis. Although there are few kinds of research on ACC\u0000currently exist, we expect that better detailed genetic studies would pave the way for promising\u0000advancement in our understanding of the molecular biology and pathogenesis mechanisms underlying\u0000tumors.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"197-207"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574362414666190204124731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41604994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tutorial and Performance Analysis on ENVI Tools for SAR Image Despeckling","authors":"M. Khosravi, Babak Bahri-Aliabadi, Seyed Reza Salari, S. Samadi, H. Rostami, Vahid Karimi","doi":"10.2174/1574362413666181005101315","DOIUrl":"https://doi.org/10.2174/1574362413666181005101315","url":null,"abstract":"\u0000\u0000The presence of speckle noise in synthetic aperture radar (SAR) images\u0000makes the images of low quality in terms of textural features and spatial resolution which are\u0000required for processing issues such as image classification and clustering. Already, there are many\u0000adaptive filters to remove noise in SAR images. ENVI software is a fully applicable tool for this\u0000purpose which has a good library including several filters in the classes of adaptive, orderstatistics\u0000and non-linear filters.\u0000\u0000\u0000\u0000In this study, the toolbox of ENVI is reviewed, analyzed and then\u0000numerically evaluated based on several single-band images along with multi-band polarimetric\u0000SAR (Pol-SAR) images achieved from SAR sensors such as TerraSAR-X. For evaluation, two\u0000metrics including Equivalent Number of Looks (ENL) and Edge Preservation Index (EPI) are used\u0000which show the ability of the filters in preserving jointly spatial/textural features based on general\u0000information and edges quality, respectively.\u0000\u0000\u0000\u0000 It is notable that both metrics illustrate that some classic filters are better in comparison\u0000to newer filters.\u0000\u0000\u0000\u0000The experiments can help us in selecting a better filter towards our aims. In this\u0000respect, attention to the results of commercial filters of ENVI software and their analysis can\u0000guide us to find the best case in order to process commercial data of SAR sensors in the\u0000applications of environmental monitoring, geo-science studies, industrial usages and so on.\u0000","PeriodicalId":10868,"journal":{"name":"Current Signal Transduction Therapy","volume":"15 1","pages":"215-222"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44473291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}