Current Hematologic Malignancy Reports最新文献_第4页

Novel Biomarkers and Molecular Targets in ALL. ALL的新生物标志物和分子靶点。

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2024-02-01 Epub Date: 2023-12-04 DOI: 10.1007/s11899-023-00718-3

Hong De Sa, Jessica Leonard

{"title":"Novel Biomarkers and Molecular Targets in ALL.","authors":"Hong De Sa, Jessica Leonard","doi":"10.1007/s11899-023-00718-3","DOIUrl":"10.1007/s11899-023-00718-3","url":null,"abstract":"Purpose of review: Acute lymphoblastic leukemia (ALL) is a widely heterogeneous disease in terms of genomic alterations, treatment options, and prognosis. While ALL is considered largely curable in children, adults tend to have higher risk disease subtypes and do not respond as favorably to conventional chemotherapy. Identifying genomic drivers of leukemogenesis and applying targeted therapies in an effort to improve disease outcomes is an exciting focus of current ALL research. Here, we review recent updates in ALL targeted therapy and present promising opportunities for future research.Recent findings: With the utilization of next-generation sequencing techniques, the genomic landscape of ALL has greatly expanded to encompass novel subtypes characterized by recurrent chromosomal rearrangements, gene fusions, sequence mutations, and distinct gene expression profiles. The evolution of small molecule inhibitors and immunotherapies, and the exploration of unique therapy combinations are some examples of recent advancements in the field. Targeted therapies are becoming increasingly important in the treatment landscape of ALL to improve outcomes and minimize toxicity. Significant recent advancements have been made in the detection of susceptible genomic drivers and the use of novel therapies to target them.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":" ","pages":"18-34"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138476962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the Potential of Artificial Intelligence in Acute Myeloid Leukemia and Myelodysplastic Syndromes. 释放人工智能在急性髓性白血病和骨髓增生异常综合征中的潜力。

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2024-02-01 Epub Date: 2023-11-24 DOI: 10.1007/s11899-023-00716-5

Abdulrahman Alhajahjeh, Aziz Nazha

{"title":"Unlocking the Potential of Artificial Intelligence in Acute Myeloid Leukemia and Myelodysplastic Syndromes.","authors":"Abdulrahman Alhajahjeh, Aziz Nazha","doi":"10.1007/s11899-023-00716-5","DOIUrl":"10.1007/s11899-023-00716-5","url":null,"abstract":"Purpose of the review: This review aims to elucidate the transformative impact and potential of machine learning (ML) in the diagnosis, prognosis, and clinical management of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It further aims to bridge the gap between current advances of ML and their practical application in these diseases.Recent findings: Recent advances in ML have revolutionized prognostication, diagnosis, and treatment of MDS and AML. ML algorithms have proven effective in predicting disease progression, optimizing treatment responses, and in the stratification of patient groups. Particularly, the use of ML in genomic and epigenomic data analysis has unveiled novel insights into the molecular heterogeneity of MDS and AML, leading to better-informed therapeutic strategies. Furthermore, deep learning techniques have shown promise in analyzing complex patterns in bone marrow biopsy images, providing a potential pathway towards early and accurate diagnosis. While still in the nascent stages, ML applications in MDS and AML signify a paradigm shift towards precision medicine. The integration of ML with traditional clinical practices could potentially enhance diagnostic accuracy, refine risk stratification, and improve therapeutic approaches. However, challenges related to data privacy, standardization, and algorithm interpretability must be addressed to realize the full potential of ML in this field. Future research should focus on the development of robust, transparent ML models and their ethical implementation in clinical settings.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":" ","pages":"9-17"},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138298611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Management of Pulmonary Manifestations of Telomere Biology Disorders 端粒生物学疾病肺部表现的诊断与管理

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-30 DOI: 10.1007/s11899-023-00720-9

Kathryn T. del Valle, Eva M. Carmona

{"title":"Diagnosis and Management of Pulmonary Manifestations of Telomere Biology Disorders","authors":"Kathryn T. del Valle, Eva M. Carmona","doi":"10.1007/s11899-023-00720-9","DOIUrl":"https://doi.org/10.1007/s11899-023-00720-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3>Telomere biology disorders (TBD) are a group of genetic disorders characterized by premature shortening of telomeres, resulting in accelerated aging of somatic cells. This often leads to major multisystem organ dysfunction, and TBDs have become increasingly recognized as a significant contributor to numerous disease processes within the past 10–15 years. Both research and clinical practice in this field are rapidly evolving.<h3 data-test=\"abstract-sub-heading\">Recent Findings</h3>A subset of patients with TBD suffers from interstitial lung disease, most commonly pulmonary fibrosis. Often, the clinical presentation is indistinguishable from other forms of lung fibrosis. There are no pathognomonic radiographic or histological features, and a high level of suspicion is therefore required. Telomere evaluation is thus crucial to establishing the diagnosis.<h3 data-test=\"abstract-sub-heading\">Summary</h3>This review details the clinical presentation, objective evaluation, indicated genetic testing, and recommended management strategies for patients affected by interstitial lung disease associated with TBDs. Our goal is to empower pulmonologists and other healthcare professionals who care for these patients to provide appropriate and personalized care for this population.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":"2 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139070758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders 端粒生物学疾病中的适应性和不适应性克隆造血

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-14 DOI: 10.1007/s11899-023-00719-2

Terra Lasho, Mrinal M. Patnaik

{"title":"Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders","authors":"Terra Lasho, Mrinal M. Patnaik","doi":"10.1007/s11899-023-00719-2","DOIUrl":"https://doi.org/10.1007/s11899-023-00719-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3>Telomere biology disorders (TBDs) are germline-inherited conditions characterized by reduction in telomerase function, accelerated shortening of telomeres, predisposition to organ-failure syndromes, and increased risk of neoplasms, especially myeloid malignancies. In normal cells, critically short telomeres trigger apoptosis and/or cellular senescence. However, the evolutionary mechanism by which TBD-related telomerase-deficient cells can overcome this fitness constraint remains elusive.<h3 data-test=\"abstract-sub-heading\">Recent Findings</h3>Preliminary data suggests the existence of adaptive somatic mosaic states characterized by variants in TBD-related genes and maladaptive somatic mosaic states that attempt to overcome hematopoietic fitness constraints by alternative methods leading to clonal hematopoiesis.<h3 data-test=\"abstract-sub-heading\">Summary</h3>TBDs are both rare and highly heterogeneous in presentation, and the association of TBD with malignant transformation is unclear. Understanding the clonal complexity and mechanisms behind TBD-associated molecular signatures that lead to somatic adaptation in the setting of defective hematopoiesis will help inform therapy and treatment for this set of diseases.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":"2 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138629780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NK Cell Therapeutics for Hematologic Malignancies: from Potential to Fruition. NK细胞治疗血液系统恶性肿瘤：从潜在到结果。

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-01 Epub Date: 2023-09-26 DOI: 10.1007/s11899-023-00711-w

Stephanie L Fetzko, Leander D Timothy, Robin Parihar

{"title":"NK Cell Therapeutics for Hematologic Malignancies: from Potential to Fruition.","authors":"Stephanie L Fetzko, Leander D Timothy, Robin Parihar","doi":"10.1007/s11899-023-00711-w","DOIUrl":"10.1007/s11899-023-00711-w","url":null,"abstract":"Purpose of review: The current review focuses on the preclinical development and clinical advances of natural killer (NK) cell therapeutics for hematologic malignancies and offers perspective on the unmet challenges that will direct future discovery in the field.Recent findings: Approaches to improve or re-direct NK cell anti-tumor functions against hematologic malignancies have included transgenic expression of chimeric antigen receptors (CARs), administration of NK cell engagers including BiKEs and TriKEs that enhance antibody-dependent cellular cytotoxicity (ADCC) by co-engaging NK cell CD16 and antigens on tumors, incorporation of a non-cleavable CD16 that results in enhanced ADCC, use of induced memory-like NK cells alone or in combination with CARs, and blockade of NK immune checkpoints to enhance NK cytotoxicity. Recently reported and ongoing clinical trials support the feasibility and safety of these approaches. NK cell-based therapeutic strategies hold great promise as cost-effective, off-the-shelf cell therapies for patients with relapsed and refractory hematologic diseases.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":" ","pages":"264-272"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41110633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates in the Classification of T-cell Lymphomas and Lymphoproliferative Disorders. T细胞淋巴瘤和淋巴增生性疾病分类的最新进展。

IF 2.7 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-01 Epub Date: 2023-10-23 DOI: 10.1007/s11899-023-00712-9

Naoki Oishi, Reham Ahmed, Andrew L Feldman

{"title":"Updates in the Classification of T-cell Lymphomas and Lymphoproliferative Disorders.","authors":"Naoki Oishi, Reham Ahmed, Andrew L Feldman","doi":"10.1007/s11899-023-00712-9","DOIUrl":"10.1007/s11899-023-00712-9","url":null,"abstract":"Purpose of review: Mature T/NK-cell neoplasms comprise a heterogeneous group of diseases with diverse clinical, histopathologic, immunophenotypic, and molecular features. A clinically relevant, comprehensive, and reproducible classification system for T/NK-cell neoplasms is essential for optimal management, risk stratification, and advancing understanding of these diseases. Two classification systems for lymphoid neoplasms were recently introduced: the 5th edition of World Health Organization classification (WHO-HAEM5) and the 2022 International Consensus Classification (ICC). In this review, we summarize the basic framework and updates in the classification of mature T/NK-cell neoplasms.Recent findings: WHO-HAEM5 and ICC share basic concepts in classification of T/NK-cell neoplasms, emphasizing integration of clinical presentation, pathology, immunophenotype, and genetics. Major updates in both classifications include unifying nodal T-follicular helper-cell lymphomas into a single entity and establishing EBV-positive nodal T/NK-cell lymphoma as a distinct entity. However, some differences exist in taxonomy, terminology, and disease definitions. The recent classifications of mature T/NK-cell neoplasms are largely similar and provide new insights into taxonomy based on integrated clinicopathologic features.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":" ","pages":"252-263"},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49689167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and Computational Approaches to Measure Telomere Length: Recent Advances and Future Directions. 测量端粒长度的实验和计算方法：最新进展和未来方向。

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-01 Epub Date: 2023-11-10 DOI: 10.1007/s11899-023-00717-4

Alejandro Ferrer, Zachary D Stephens, Jean-Pierre A Kocher

{"title":"Experimental and Computational Approaches to Measure Telomere Length: Recent Advances and Future Directions.","authors":"Alejandro Ferrer, Zachary D Stephens, Jean-Pierre A Kocher","doi":"10.1007/s11899-023-00717-4","DOIUrl":"10.1007/s11899-023-00717-4","url":null,"abstract":"Purpose of review: The length of telomeres, protective structures at the chromosome ends, is a well-established biomarker for pathological conditions including multisystemic syndromes called telomere biology disorders. Approaches to measure telomere length (TL) differ on whether they estimate average, distribution, or chromosome-specific TL, and each presents their own advantages and limitations.Recent findings: The development of long-read sequencing and publication of the telomere-to-telomere human genome reference has allowed for scalable and high-resolution TL estimation in pre-existing sequencing datasets but is still impractical as a dedicated TL test. As sequencing costs continue to fall and strategies for selectively enriching telomere regions prior to sequencing improve, these approaches may become a promising alternative to classic methods. Measurement methods rely on probe hybridization, qPCR or more recently, computational methods using sequencing data. Refinements of existing techniques and new approaches have been recently developed but a test that is accurate, simple, and scalable is still lacking.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":" ","pages":"284-291"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72013872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBV Reactivation and Lymphomagenesis: More Questions than Answers. EBV 再激活与淋巴致病：问题多于答案。

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-01 Epub Date: 2023-08-11 DOI: 10.1007/s11899-023-00708-5

Maegan Ford, Evelyn Orlando, Jennifer Effie Amengual

{"title":"EBV Reactivation and Lymphomagenesis: More Questions than Answers.","authors":"Maegan Ford, Evelyn Orlando, Jennifer Effie Amengual","doi":"10.1007/s11899-023-00708-5","DOIUrl":"10.1007/s11899-023-00708-5","url":null,"abstract":"Purpose of review: Epstein-Barr Virus (EBV) is a ubiquitous herpesvirus that affects almost all humans and establishes lifelong infections by infecting B-lymphocytes leading to their immortalization. EBV has a discrete life cycle with latency and lytic reactivation phases. EBV can reactivate and cause lymphoproliferation in both immunocompetent and immunocompromised individuals. There is sparse literature on monitoring protocols for EBV reactivation and no standardized treatment protocols to treat EBV-driven lymphoproliferation.Recent findings: While there are no FDA-approved therapies to treat EBV, there are several strategies to inhibit EBV replication. These include immunosuppression reduction, nucleoside analogs, HDAC inhibitors, EBV-specific cytotoxic T-lymphocytes (CTLs), and monoclonal antibodies, such as rituximab. There is currently an open clinic trial combining the use of a HDAC inhibitor, nanatinostat, and ganciclovir to treat refractory/relapsed EBV lymphomas. Another novel therapy includes tabelecleucel, which is an allogenic EBV-directed T-cell immunotherapy that was approved by the European Medicines Agency, but is currently only available in the US for limited use in relapsed or refractory EBV-positive PTLD. Further research is needed to establish EBV monitoring protocols in high-risk populations, such as those with autoimmune disease, cancer, HIV, or receiving immunosuppressive therapy. Additionally, standardized treatments for both the prevention of EBV reactivation in high-risk populations and treatment of EBV reactivation and lymphoproliferation need to be established.","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":" ","pages":"226-233"},"PeriodicalIF":2.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on the Management of Advanced Phase Chronic Myeloid Leukemia. 晚期慢性髓性白血病管理的最新进展。

IF 2.7 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-01 Epub Date: 2023-08-31 DOI: 10.1007/s11899-023-00709-4

Nicholas J Short, Jayastu Senapati, Elias Jabbour

引用次数: 0

Genetic Counseling and Family Screening Recommendations in Patients with Telomere Biology Disorders. 端粒生物学障碍患者的遗传咨询和家庭筛查建议。

IF 2.9 3区医学

Current Hematologic Malignancy Reports Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.1007/s11899-023-00713-8

Laura Ongie, Hannah A Raj, Katie Barrett Stevens

引用次数: 0