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Current Hematologic Malignancy Reports最新文献

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Maintenance Therapy Post-Stem Cell Transplantation for Patients with T-Cell Lymphomas. T 细胞淋巴瘤患者干细胞移植后的维持疗法。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-10-19 DOI: 10.1007/s11899-024-00743-w
Zachary Braunstein, Jonathan E Brammer
{"title":"Maintenance Therapy Post-Stem Cell Transplantation for Patients with T-Cell Lymphomas.","authors":"Zachary Braunstein, Jonathan E Brammer","doi":"10.1007/s11899-024-00743-w","DOIUrl":"https://doi.org/10.1007/s11899-024-00743-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Given the poor outcomes for peripheral T-cell lymphomas (PTCL), stem cell transplant (SCT) remains an important therapeutic approach. Post-SCT relapse is common and maintenance therapy post-SCT is increasingly being utilized. Here we review the use of post-SCT maintenance therapy for PTCL patients.</p><p><strong>Recent findings: </strong>Maintenance therapy is increasingly utilized to decrease post-SCT relapse and improve outcomes in PTCL. Ongoing and completed post-SCT maintenance trials utilizing agents such as romidepsin, brentuximab vedotin, duvelisib, and pembrolizumab have shown efficacy in decreasing relapse. Further, additional agents with efficacy in PTCL have emerged that may inform future maintenance approaches. Maintenance therapy is a promising approach to maintain response after SCT in PTCL. While several trials are ongoing to evaluate maintenance therapy in PTCL, current data suggests this may be an effective method to decrease post-SCT relapse.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAK Inhibitors for Myelofibrosis: Strengths and Limitations. 治疗骨髓纤维化的 JAK 抑制剂：优势与局限。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-10-14 DOI: 10.1007/s11899-024-00744-9
K Thaw, C N Harrison, P Sriskandarajah
{"title":"JAK Inhibitors for Myelofibrosis: Strengths and Limitations.","authors":"K Thaw, C N Harrison, P Sriskandarajah","doi":"10.1007/s11899-024-00744-9","DOIUrl":"https://doi.org/10.1007/s11899-024-00744-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>The landscape of myelofibrosis (MF) has changed since the discovery of the JAK2 V617F mutation and subsequent development of JAK inhibitors (JAKis). However, treatment with JAKis remain a challenge. In this review we critically analyze the strengths and limitations of currently available JAK inhibitors.</p><p><strong>Recent findings: </strong>In MF patients, JAK inhibitors have been associated with reduced symptom burden and spleen size, as well as improved survival. However, durability of response and development of treatment resistance remain an issue. Recently, there has been increased efforts to optimize treatment with the development of highly selective JAK inhibitors, as well as use of combination agents to counter disease resistance through targeting aberrant signaling pathways. Treatment of MF patients with JAKi therapy can be challenging but the development of more potent and selective JAK inhibitors, as well as combination therapies, represent exciting treatment advances in this field.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142460004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic Mastocytosis: State of the Art. 系统性肥大细胞增多症：艺术现状。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI: 10.1007/s11899-024-00737-8
Isabel Farmer, Deepti H Radia
{"title":"Systemic Mastocytosis: State of the Art.","authors":"Isabel Farmer, Deepti H Radia","doi":"10.1007/s11899-024-00737-8","DOIUrl":"10.1007/s11899-024-00737-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Since identification of Systemic mastocytosis (SM) as a distinct disease entity by the World Health Organisation (WHO), there has been a wealth of new research in therapeutic targeting of the pathogenic C-KIT D816V mutation.</p><p><strong>Recent findings: </strong>Avapritinib, the first licensed drug in SM capable of disease modification alongside the increasingly potent, oral and highly selective KIT tyrosine kinase inhibitors (TKIs) Bezuclastinib and now Elenestinib have enabled the prospect of long-term remissions. Studies have shown improved survival and symptomatic control in patients with SM. Of great triumph, this has been achieved in an outpatient setting with apparent tolerable and minimal toxicity. The importance of molecular profiling is being demonstrated in administering combination therapies for SM with an associated haematological neoplasm (AHN), allowing more personalised and streamlined treatment regimes. This review focuses on current management strategies of SM, focusing on state-of-the-art directed therapies, the evidence behind their use with presentation of two clinical cases to highlight key messages.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to the patient with eosinophilia in the era of tyrosine kinase inhibitors and biologicals. 在酪氨酸激酶抑制剂和生物制剂时代，如何治疗嗜酸性粒细胞增多症患者？
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-10-01 Epub Date: 2024-07-22 DOI: 10.1007/s11899-024-00738-7
Johannes Lübke, Georgia Metzgeroth, Andreas Reiter, Juliana Schwaab
{"title":"Approach to the patient with eosinophilia in the era of tyrosine kinase inhibitors and biologicals.","authors":"Johannes Lübke, Georgia Metzgeroth, Andreas Reiter, Juliana Schwaab","doi":"10.1007/s11899-024-00738-7","DOIUrl":"10.1007/s11899-024-00738-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>In this review, we aim to explore the optimal approach to patients presenting with eosinophilia, considering recent advances in diagnostic and therapeutic strategies. Specifically, we focus on the integration of novel therapies into clinical practice to improve patient outcomes.</p><p><strong>Recent findings: </strong>Advanced insights into the clinical and genetic features of eosinophilic disorders have prompted revisions in diagnostic criteria by the World Health Organization classification (WHO-HAEM5) and the International Consensus Classification (ICC). These changes reflect a growing understanding of disease pathogenesis and the development of targeted treatment options. The therapeutic landscape now encompasses a range of established and novel therapies. For reactive conditions, drugs targeting the eosinophilopoiesis, such as those aimed at interleukin-5 or its receptor, have demonstrated significant potential in decreasing blood eosinophil levels and minimizing disease flare-ups and relapse. These therapies have the potential to mitigate the side effects commonly associated with prolonged use of oral corticosteroids or immunosuppressants. Myeloid and lymphoid neoplasms with eosinophilia and tyrosine kinase (TK) gene fusions are managed by various TK inhibitors with variable efficacy. Diagnosis and treatment rely on a multidisciplinary approach. By incorporating novel treatment options into clinical practice, physicians across different disciplines involved in the management of eosinophilic disorders can offer more personalized and effective care to patients. However, challenges remain in accurately diagnosing and risk-stratifying patients, as well as in navigating the complexities of treatment selection.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic and Predictive Models in Myelofibrosis. 骨髓纤维化的预后和预测模型
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-10-01 Epub Date: 2024-08-24 DOI: 10.1007/s11899-024-00739-6
Barbara Mora, Cristina Bucelli, Daniele Cattaneo, Valentina Bellani, Francesco Versino, Kordelia Barbullushi, Nicola Fracchiolla, Alessandra Iurlo, Francesco Passamonti
{"title":"Prognostic and Predictive Models in Myelofibrosis.","authors":"Barbara Mora, Cristina Bucelli, Daniele Cattaneo, Valentina Bellani, Francesco Versino, Kordelia Barbullushi, Nicola Fracchiolla, Alessandra Iurlo, Francesco Passamonti","doi":"10.1007/s11899-024-00739-6","DOIUrl":"10.1007/s11899-024-00739-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Myelofibrosis (MF) includes prefibrotic primary MF (pre-PMF), overt-PMF and secondary MF (SMF). Median overall survival (OS) of pre-PMF, overt-PMF and SMF patients is around 14 years, seven and nine years, respectively. Main causes of mortality are non-clonal progression and transformation into blast phase.</p><p><strong>Recent findings: </strong>Discoveries on the impact of the biological architecture on OS have led to the design of integrated scores to predict survival in PMF. For SMF, OS estimates should be calculated by the specific MYSEC-PM (MYelofibrosis SECondary-prognostic model). Information on the prognostic role of the molecular landscape in SMF is accumulating. Crucial treatment decisions for MF patients could be now supported by multivariable predictive algorithms. OS should become a relevant endpoint of clinical trials. Prognostic models guide prediction of OS and treatment planning in MF, therefore, their timely application is critical in the personalized approach of MF patients.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Stem Cell Transplantation for Myelofibrosis. 干细胞移植治疗骨髓纤维化的进展。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-09-06 DOI: 10.1007/s11899-024-00742-x
Akhil Rajendra, Vikas Gupta
{"title":"Advances in Stem Cell Transplantation for Myelofibrosis.","authors":"Akhil Rajendra, Vikas Gupta","doi":"10.1007/s11899-024-00742-x","DOIUrl":"https://doi.org/10.1007/s11899-024-00742-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>Allogeneic hematopoietic cell transplantation is the only potentially curative treatment for myelofibrosis. This review discusses issues not well-covered by existing guidelines: timing of transplant, pre-transplant spleen management and alternative donors; providing our approach to these situations.</p><p><strong>Recent findings: </strong>Research continues to allow better identification, by better risk stratification and advances in understanding likelihood of durable JAKi response, which patients are likely to derive benefit from upfront transplant versus those for whom delayed transplant may be more appropriate. Several options of JAKi therapy provide a non-surgical option for pre-HCT splenomegaly management, allowing some patients to avoid risks associated with splenectomy. Recent years have also seen a sharp spike in haploidentical donor transplants, along with narrowing of the gap in outcomes between donor types. Continuous enrollment in prospective studies or well-designed registries is required to generate the high-quality data needed to develop better decision tools for these scenarios.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Toxicities Associated with BCMA, GPRC5D, and FcRH5-Targeting Bispecific Antibodies in Multiple Myeloma. 多发性骨髓瘤中与 BCMA、GPRC5D 和 FcRH5 靶向双特异性抗体相关的毒性管理。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-08-15 DOI: 10.1007/s11899-024-00740-z
Darren Pan, Joshua Richter
{"title":"Management of Toxicities Associated with BCMA, GPRC5D, and FcRH5-Targeting Bispecific Antibodies in Multiple Myeloma.","authors":"Darren Pan, Joshua Richter","doi":"10.1007/s11899-024-00740-z","DOIUrl":"https://doi.org/10.1007/s11899-024-00740-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>The introduction of bispecific antibodies is one of the most significant recent advances in the treatment of relapsed/refractory multiple myeloma. This review will summarize the management of the toxicities associated with newly approved T cell-engaging bispecific antibodies and those which may be approved in the near future.</p><p><strong>Recent findings: </strong>Numerous trials have shown that bispecific antibodies can be both effective and tolerable when adverse events are properly managed. Cytokine release syndrome and increased infections are observed across all bispecific antibodies. Additional adverse events are target-specific, such as the more severe hypogammaglobulinemia and infections of BCMA bispecific antibodies and the dysgeusia, nail dystrophy, and skin changes of GPRC5D bispecific antibodies. Bispecific antibodies will surely become a mainstay of multiple myeloma therapy given their efficacy and accessibility. Their unique toxicities must be carefully considered and managed to ensure they are utilized safely.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRD in Philadelphia Chromosome-Positive ALL: Methodologies and Clinical Implications. 费城染色体阳性 ALL 的 MRD：方法和临床意义。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-08-01 Epub Date: 2024-06-18 DOI: 10.1007/s11899-024-00736-9
Valerie Tran, Kiarash Salafian, Kenan Michaels, Caroline Jones, Daniel Reed, Michael Keng, Firas El Chaer
{"title":"MRD in Philadelphia Chromosome-Positive ALL: Methodologies and Clinical Implications.","authors":"Valerie Tran, Kiarash Salafian, Kenan Michaels, Caroline Jones, Daniel Reed, Michael Keng, Firas El Chaer","doi":"10.1007/s11899-024-00736-9","DOIUrl":"10.1007/s11899-024-00736-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Measurable residual disease (MRD) is integral in the management of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). This review discusses the current methods used to evaluate MRD as well as the interpretation, significance, and incorporation of MRD in current practice.</p><p><strong>Recent findings: </strong>New molecular technologies have allowed the detection of MRD to levels as low as 10<sup>- 6</sup>. The most used techniques to evaluate MRD are multiparametric flow cytometry (MFC), quantitative reverse transcription polymerase chain reaction (RT-qPCR), and high-throughput next-generation sequencing (NGS). Each method varies in terms of advantages, disadvantages, and MRD sensitivity. MRD negativity after induction treatment and after allogeneic hematopoietic cell transplantation (HCT) is an important prognostic marker that has consistently been shown to be associated with improved outcomes. Blinatumomab, a new targeted therapy for Ph + ALL, demonstrates high efficacy in eradicating MRD and improving patient outcomes. In the relapsed/refractory setting, the use of inotuzumab ozogamicin and tisagenlecleucel has shown promise in eradicating MRD. The presence of MRD has become an important predictive measure in Ph + ALL. Current studies evaluate the use of MRD in treatment decisions, especially in expanding therapeutic options for Ph + ALL, including tyrosine kinase inhibitors, targeted antibody therapies, chimeric antigen receptor cell therapy, and HCT.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Patient-Centered Technology and Digital Interventions in Pediatric and Adult Patients with Hematologic Malignancies. 在儿童和成人血液恶性肿瘤患者中使用以患者为中心的技术和数字干预。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-08-01 Epub Date: 2024-05-29 DOI: 10.1007/s11899-024-00732-z
Rachel S Werk, Mallorie B Heneghan, Sherif M Badawy
{"title":"Use of Patient-Centered Technology and Digital Interventions in Pediatric and Adult Patients with Hematologic Malignancies.","authors":"Rachel S Werk, Mallorie B Heneghan, Sherif M Badawy","doi":"10.1007/s11899-024-00732-z","DOIUrl":"10.1007/s11899-024-00732-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>As society continues to advance in technology, it is important to address how this advancement can impact and enhance patient care. The purpose of this review is to identify patient-centered technology currently available for adult and pediatric patients with and those having survived hematologic malignancies. Given that patients with hematologic malignancies often have to adhere to strenuous medication regimens, coordinate care with many different providers, manage symptoms associated with treatment, and manage late effects associated with survivorship, they would benefit greatly from patient-centered technology aimed at decreasing these burdens.</p><p><strong>Recent findings: </strong>This review found various available digital interventions for this patient population and focuses on an overview of commercially available smartphone applications, patient portals, and technology for remote monitoring. In summary, many digital interventions exist for use in the medical care of oncology patients. The incorporation of these interventions can allow for more personalized medical care, better organization of treatment plans by caregivers at home, and easy delivery of accurate medical information.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucocorticoid Therapy in Acute Lymphoblastic Leukemia: Navigating Short-Term and Long-Term Effects and Optimal Regimen Selection. 糖皮质激素治疗急性淋巴细胞白血病：驾驭短期和长期效应，选择最佳治疗方案。
IF 2.7 3区 医学
Current Hematologic Malignancy Reports Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI: 10.1007/s11899-024-00735-w
Hoda Pourhassan, Lindsey Murphy, Ibrahim Aldoss
{"title":"Glucocorticoid Therapy in Acute Lymphoblastic Leukemia: Navigating Short-Term and Long-Term Effects and Optimal Regimen Selection.","authors":"Hoda Pourhassan, Lindsey Murphy, Ibrahim Aldoss","doi":"10.1007/s11899-024-00735-w","DOIUrl":"10.1007/s11899-024-00735-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Glucocorticoids are a mainstay in acute lymphoblastic leukemia treatment and lack of early response is predictive for overall disease prognosis. Given the vital position of glucocorticoids and well known long and short-term side effects associated with differing glucocorticoids, we aim to highlight the wide breadth of historical and more contemporary data to describe the current landscape of glucocorticoid use in this arena.</p><p><strong>Recent findings: </strong>Emerging studies aim to overcome issues such as steroid resistance and to optimize the antileukemic effects of glucocorticoids while aiming to mitigate the risks and side effects associated with their exposure. Glucocorticoids have and likely always will be a fundamental component of acute lymphoblastic leukemia treatment and understanding how to navigate short- and long-term effects and how to optimize regimens is at the heart of continued treatment success.</p>","PeriodicalId":10852,"journal":{"name":"Current Hematologic Malignancy Reports","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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