Current Alzheimer research最新文献_第8页

Oculomotor abnormalities during reading in offspring of late-onset Alzheimer's disease. 迟发性阿尔茨海默病后代阅读时的动眼肌异常。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-04-13 DOI: 10.2174/1567205019666220413075840

G. Fernández, Ana Paula González, C. Abulafia, L. Fiorentini, Osvaldo Agamennoni, S. Guinjoan

{"title":"Oculomotor abnormalities during reading in offspring of late-onset Alzheimer's disease.","authors":"G. Fernández, Ana Paula González, C. Abulafia, L. Fiorentini, Osvaldo Agamennoni, S. Guinjoan","doi":"10.2174/1567205019666220413075840","DOIUrl":"https://doi.org/10.2174/1567205019666220413075840","url":null,"abstract":"INTRODUCTION\u0000Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and to program the following saccade. In this work, we investigated whether eye movement alterations during a reading task might be already present in middle-aged, cognitively normal offspring of late-onset Alzheimer's disease (O-LOAD).\u0000\u0000\u0000METHODS\u000018 O-LOAD and 18age-matched healthy individuals with no family history of LOAD participated in the study. Participants were seated in front of a 20-inch LCD monitor and single sentences were presented on it. Eye movements were recorded with an eye tracker, with a sampling rate of 1000 Hz.\u0000\u0000\u0000RESULTS\u0000Analysis of eye movements during reading revealed that O-LOAD displayed more fixations, shorter saccades and shorter fixation durations than controls.\u0000\u0000\u0000CONCLUSION\u0000The present study shows that O-LOAD evidenced alterations in their eye movements during reading. O-LOAD eye movement behavior could be considered an initial sign of oculomotor impairment. Hence, evaluation of eye movement during reading might provide a useful tool for monitoring well-defined cognitive resources.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43433937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the Alzheimer's Disease Assessment Scale-Cognitive Subscale useful in screening for mild cognitive impairment and Alzheimer's disease? A systematic review. 阿尔茨海默病评估量表-认知亚量表在轻度认知障碍和阿尔茨海默病筛查中有用吗?系统回顾。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-04-04 DOI: 10.2174/1567205019666220404104854

Seong-Hi Park, Kuem-Sun Han

{"title":"Is the Alzheimer's Disease Assessment Scale-Cognitive Subscale useful in screening for mild cognitive impairment and Alzheimer's disease? A systematic review.","authors":"Seong-Hi Park, Kuem-Sun Han","doi":"10.2174/1567205019666220404104854","DOIUrl":"https://doi.org/10.2174/1567205019666220404104854","url":null,"abstract":"BACKGROUND\u0000Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are screened to distinguish whether cognitive decline in older adults is attributed to pathological causes rather than normal aging.\u0000\u0000\u0000OBJECTIVE\u0000The purpose of this review was to analyze the diagnostic performance of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in screening for MCI and AD.\u0000\u0000\u0000METHODS\u0000Electronic searches were performed on MEDLINE, EMBASE, CINAHL, and PsycArticles databases using the following keywords: dementia and ADAS-Cog. The Quality Assessment of Diagnostic Accuracy Studies-2 was used to checked the risk of bias in the diagnostic studies.\u0000\u0000\u0000RESULTS\u0000We reviewed 14 studies, including 3,875 patients who met the selection criteria. In 2,624 MCI patients from nine studies, the pooled sensitivity of ADAS-Cog was 0.80 (95% confidence interval [CI], 0.68-0.88), the pooled specificity was 0.84 (95% CI, 0.75-0.90), and the area under the curve of summary receiver-operating characteristic curves (SROC AUC) was 0.89 (SE = 0.03). In 2,517 AD patients from 10 studies, the pooled sensitivity and pooled specificity were 0.91 (95% CI, 0.86-0.95) and 0.93 (95% CI, 0.88-0.95) respectively, and the sROC AUC was 0.97 (SE = 0.01). Although sub-analyzed according to age and years of education, there was no significant difference in the predictive validity of the ADAS-Cog.\u0000\u0000\u0000CONCLUSION\u0000The ADAS-Cog has high predictive validity as a screening tool in both MCI and AD, but has better diagnostic performance in patients with AD. When early screening for AD is desired, ADAS-Cog is a first-stage screener that can be initially employed.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":"1 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41956630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Blood Biomarkers Predict Future Cognitive Decline after Military-Related Traumatic Brain Injury. 血液生物标志物预测与军事有关的创伤性脑损伤后未来的认知能力下降。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-03-30 DOI: 10.2174/1567205019666220330144432

S. Lippa, J. Gill, T. Brickell, Vivian A. Guedes, L. French, R. Lange

{"title":"Blood Biomarkers Predict Future Cognitive Decline after Military-Related Traumatic Brain Injury.","authors":"S. Lippa, J. Gill, T. Brickell, Vivian A. Guedes, L. French, R. Lange","doi":"10.2174/1567205019666220330144432","DOIUrl":"https://doi.org/10.2174/1567205019666220330144432","url":null,"abstract":"BACKGROUND\u0000Traumatic brain injury (TBI) has been associated with increased likelihood of late-life dementia; however, the mechanisms driving this relationship are elusive. Blood-based biomarkers may provide insight into these mechanisms and serve as useful prognostic indicators of cognitive recovery or decline following a TBI.\u0000\u0000\u0000OBJECTIVE\u0000The aim of this study was to examine blood biomarkers within one year of TBI and explore their relationship with cognitive decline.\u0000\u0000\u0000METHODS\u0000Service members and veterans (n=224) without injury (n=77), or with history of bodily injury (n=37), uncomplicated mild TBI (n=55), or more severe TBI (n=55), underwent a blood draw and neuropsychological assessment within one year of their injury as part of a case-control study. A subsample (n=87) completed follow-up cognitive assessment.\u0000\u0000\u0000RESULTS\u0000In the more severe TBI group, baseline glial fibrillary acidic protein (p=.008) and ubiquitin C-terminal hydrolase-L1 (p=.026) were associated with processing speed at baseline, and baseline ubiquitin C-terminal hydrolase-L1 predicted change in immediate (R2Δ=.244, p=.005) and delayed memory (R2Δ=.390, p=.003) over time. In the mild TBI group, higher baseline tau predicted greater negative change in perceptual reasoning (R2Δ=.188, p=.033) and executive functioning (R2Δ=.298, p=.007); higher baseline neurofilament light predicted greater negative change in perceptual reasoning (R2Δ=.211, p=.012).\u0000\u0000\u0000CONCLUSION\u0000Baseline ubiquitin C-terminal hydrolase-L1 strongly predicted memory decline in the more severe TBI group, while tau and neurofilament light strongly predicted decline in the mild TBI group. A panel including these biomarkers could be particularly helpful in identifying those at risk for future cognitive decline following TBI.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44681215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of supplementation with probiotics in experimental models of Alzheimer's Disease: a systematic review of animal experiments. 补充益生菌对阿尔茨海默病实验模型的影响：动物实验的系统综述。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-03-18 DOI: 10.2174/1567205019666220318092003

F. Neta, Francisco Emílio Simplício de Souza, André Lima Batista, Francisco Irochima Pinheiro, R. Cobucci, F. Guzen

{"title":"Effects of supplementation with probiotics in experimental models of Alzheimer's Disease: a systematic review of animal experiments.","authors":"F. Neta, Francisco Emílio Simplício de Souza, André Lima Batista, Francisco Irochima Pinheiro, R. Cobucci, F. Guzen","doi":"10.2174/1567205019666220318092003","DOIUrl":"https://doi.org/10.2174/1567205019666220318092003","url":null,"abstract":"BACKGROUND\u0000Conditions along the brain-gut-microbiota (BGM) axis can significantly contribute to the pathogenesis of Alzheimer's disease (AD). Evidence from animal studies indicates a role for probiotics in regulating mood, cognition, and stress response via the BGM axis. However, the effect of probiotics on AD needs to be better clarified in preclinical and clinical studies.\u0000\u0000\u0000METHOD\u0000We prepared this systematic review according to PRISMA. PubMed, Web of Science, Embase, and Virtual Health Library (VHL) were searched for original articles concerning the effects of probiotics in experimental AD.\u0000\u0000\u0000RESULTS\u0000Results were presented as a narrative synthesis according to the Synthesis Without Meta-analysis (SWiM) Guideline.Seventeen studies met the inclusion criteria. The results showed significant effects in the experimental models of AD treated with probiotics alone or in mixture form due to expressive improvements in cognitive tests.\u0000\u0000\u0000CONCLUSION\u0000Furthermore, in most of the included studies, it was possible to observe a reduction in inflammatory processes, an increase in the concentration of peptide hormones, insulin homeostasis in the brain, increased antioxidant enzymes, and a decrease in beta-amyloid deposition and tau hyperphosphorylation. Supplementation of probiotics seems to improve performance in cognitive tests and increase the concentration of substances capable of delaying the neurodegenerative process of AD in experimental models.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46606531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

DEMENTIA COGNITIVE ASSESSMENT: NEED FOR AN INCLUSIVE TOOL DESIGN. 痴呆认知评估：需要一个包容性的工具设计。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-03-15 DOI: 10.2174/1567205019666220315092008

E. Mukaetova-Ladinska, C. De Lillo, Qadeer Arshad, H. Subramaniam, John J Maltby

引用次数: 2

Dysexecutive Alzheimer's Disease with Lewy Body Disease Co-Pathology. 性功能障碍阿尔茨海默病伴路易体病。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-03-08 DOI: 10.2174/1567205019666220308152219

Ryan P. Coburn, H. Botha, J. Graff‐Radford, R. Reichard, David T. Jones, V. Ramanan

{"title":"Dysexecutive Alzheimer's Disease with Lewy Body Disease Co-Pathology.","authors":"Ryan P. Coburn, H. Botha, J. Graff‐Radford, R. Reichard, David T. Jones, V. Ramanan","doi":"10.2174/1567205019666220308152219","DOIUrl":"https://doi.org/10.2174/1567205019666220308152219","url":null,"abstract":"BACKGROUND\u0000Alzheimer's disease can present atypically as a progressive dysexecutive syndrome (dAD), an entity which preferentially affects younger individuals and is frequently misdiagnosed, highlighting the imperative for additional research.\u0000\u0000\u0000OBJECTIVE\u0000To characterize the clinical, antemortem neuroimaging, and postmortem neuropathologic features of two cases of young-onset dAD who displayed evidence of Lewy body disease (LBD) co-pathology at autopsy.\u0000\u0000\u0000METHODS\u0000Clinical histories, antemortem MRI and PET imaging, and postmortem neuropathologic data were reviewed for each patient. Case Descriptions/Results: Canonical features of dAD were observed in both cases, including progressive and predominant impairment in tasks related to working memory and cognitive flexibility, a lack of major behavioral/personality changes, and evidence of abnormal amyloid and tau deposition by antemortem amyloid and tau PET and postmortem neuropathology. Relative sparing of hippocampal involvement was observed in both individuals, in keeping with many cases of clinically atypical AD. One of the patients developed subtle parkinsonian signs as well as paranoia and irritability in the years prior to passing. In both cases, transitional (brainstem and limbic) LBD co-pathology was observed at autopsy.\u0000\u0000\u0000DISCUSSION\u0000Although LBD co-pathology is not uncommon in AD overall, the presence of LBD pathology in these young-onset cases of dAD (including a case with apparent symptomatic correlate) warrants further investigation for broader frequency and underlying pathophysiology.\u0000\u0000\u0000CONCLUSION\u0000A better understanding of which specific young-onset AD phenotypes are associated with LBD co-pathology would have important implications for counseling, treatment, clinical trial enrollment, and knowledge on disease mechanisms.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44779385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sixteen weeks of aerobic exercise does not alter resting-state connectivity of the precuneus in patients with Alzheimer's disease. 16周的有氧运动不会改变阿尔茨海默病患者楔前叶的静息状态连接。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-03-04 DOI: 10.2174/1567205019666220304091241

C. Musaeus, L. B. Johansen, S. Hasselbalch, N. Beyer, P. Høgh, H. Siebner, K. Frederiksen

{"title":"Sixteen weeks of aerobic exercise does not alter resting-state connectivity of the precuneus in patients with Alzheimer's disease.","authors":"C. Musaeus, L. B. Johansen, S. Hasselbalch, N. Beyer, P. Høgh, H. Siebner, K. Frederiksen","doi":"10.2174/1567205019666220304091241","DOIUrl":"https://doi.org/10.2174/1567205019666220304091241","url":null,"abstract":"INTRODUCTION\u0000In healthy elderly persons and patients with mild cognitive impairment, physical exercise can increase functional brain connectivity in the default mode network (DMN) measured by restingstate functional magnetic resonance imaging (rs-fMRI). However, no studies have so far investigated the effect of physical exercise on functional resting-state connectivity in the DMN in patients with Alzheimer's disease (AD).\u0000\u0000\u0000OBJECTIVE\u0000In a single-blinded randomized controlled trial, we assessed the effects of an aerobic exercise intervention of 16 weeks of physical exercise on DMN connectivity using rs-fMRI in patients with AD.\u0000\u0000\u0000METHODS\u0000Forty-five patients were randomly assigned to either a control or exercise group. The exercise group performed 60-min of aerobic exercise three times per week for 16 weeks. All the patients underwent whole-brain rs-fMRI at 3 T, at baseline, and after 16 weeks. Since the posterior cingulate cortex (PCC) and adjacent precuneus constitute a central hub of the DMN, this parietal region was defined as region-ofinterest and used as the seed region for functional connectivity analysis of the rs-fMRI data treating age and gender as covariates.\u0000\u0000\u0000RESULTS\u0000Neither seed-based analysis, seeded in the PCC/precuneus region nor ICA-based analyses, focusing on components of the DMN network, showed any exercise-induced changes in functional resting-state connectivity from baseline to follow-up.\u0000\u0000\u0000CONCLUSION\u000016 weeks of aerobic exercise does not modify functional connectivity of the PCC/precuneus region in patients with AD. A longer intervention may be needed to show the effect of exercise on brain connectivity.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47139651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphism Rs2421943 of the insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease. 胰岛素降解酶基因Rs2421943多态性与晚发型阿尔茨海默病的风险

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-03-02 DOI: 10.2174/1567205019666220302120950

O. Šerý, T. Zeman, Alice Hálová, V. Janout, J. Janoutová, J. Lochman, V. Balcar

{"title":"Polymorphism Rs2421943 of the insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease.","authors":"O. Šerý, T. Zeman, Alice Hálová, V. Janout, J. Janoutová, J. Lochman, V. Balcar","doi":"10.2174/1567205019666220302120950","DOIUrl":"https://doi.org/10.2174/1567205019666220302120950","url":null,"abstract":"BACKGROUND\u0000Insulin-degrading enzyme (IDE) is a widely distributed Zn2+-binding metalloprotease that cleaves multiple short and medium-sized peptides prone to form β-structures. These include insulin and amyloid-β peptides. Accumulation and fibrillation of amyloid-β peptides leading to the formation of amyloid plaques is a characteristic sign of Alzheimer's disease (AD) pathology.\u0000\u0000\u0000OBJECTIVE\u0000The study investigated the rs2421943 single nucleotide polymorphism (SNP) of the IDE gene as a risk factor for MCI (Mild cognitive impairment) and AD.\u0000\u0000\u0000METHODS\u0000Two independent groups of 1670 patients and controls were included. The AD group consisted of 595 patients and 400 controls; the MCI group involved 135 patients and 540 matched controls. PCR and restriction fragment length analysis was used for analysis of the rs2421943 polymorphism. Using the miRBase and RNA22 prediction tools in silico indicated that the rs2421943 polymorphism is a potential target for a specific miRNA (hsa-miR-7110-5p).\u0000\u0000\u0000RESULTS\u0000AG and GG genotypes of rs2421943 significantly increased the risk of AD and the AG genotype increased the risk of MCI. It seems G allele both increases the risk of AD and accelerates the transition through the MCI phase. In silico study revealed that rs2421943 is inside the sequence binding miRNA hsa-miR-7110-5p. The polymorphism could affect the rate of IDE pre-RNA (heterogeneous nuclear RNA, hnRNA) processing, resulting in slower translation, lower levels of IDE, deficient removal of amyloid-β fragments and greater risk of and/or accelerated progression of AD.\u0000\u0000\u0000CONCLUSIONS\u0000GG and AG genotypes of the single nucleotide polymorphism rs2421943 of insulin degrading enzyme gene increase the risk of AD and MCI.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45103436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Discrepancy between cognitive test and brain imaging results in Alzheimer's disease associated with diabetes. 认知测试与脑成像结果在糖尿病相关的阿尔茨海默病中的差异

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-02-28 DOI: 10.2174/1567205019666220228152655

H. Hanyu, Yumi Koyama, Haruka Horita, Toshinori Aoki, Tomohiko Sato, H. Kanetaka, S. Shimizu, K. Hirao

{"title":"Discrepancy between cognitive test and brain imaging results in Alzheimer's disease associated with diabetes.","authors":"H. Hanyu, Yumi Koyama, Haruka Horita, Toshinori Aoki, Tomohiko Sato, H. Kanetaka, S. Shimizu, K. Hirao","doi":"10.2174/1567205019666220228152655","DOIUrl":"https://doi.org/10.2174/1567205019666220228152655","url":null,"abstract":"BACKGROUND/OBJECTIVE\u0000Although a large number of studies have been performed on the association between Alzheimer's disease (AD) and type 2 diabetes mellitus (DM), the underlying pathophysiology of AD associated with DM has not been fully elucidated to date. We compared cognitive functions and brain imaging findings between AD patients with and without DM to characterize the association between cognition and imaging findings in AD patients with DM.\u0000\u0000\u0000METHODS\u0000Cognitive functions and brain imaging findings, including medial temporal lobe atrophy analyzed by magnetic resonance imaging, and hypoperfusion in the parietal, posterior cingulate, and frontal regions analyzed by single-photon emission computed tomography were compared between 126 AD patients without DM ([AD-DM]) and 51 AD patients with DM ([AD+DM]). Factors associated with cognitive-imaging associations, including education, occupation, leisure activity, comorbidity, frailty, and other demographics, were analyzed.\u0000\u0000\u0000RESULTS\u0000The [AD+DM] group showed significantly more severe cognitive dysfunction than the [AD- DM] group, despite a similar degree of brain imaging abnormalities. Among the factors associated with cognitive-imaging associations, the level of leisure activity was significantly lower in the [AD+DM] group than in the [AD-DM] group, but no significant differences in other factors were observed between the 2 groups.\u0000\u0000\u0000CONCLUSION\u0000The cognitive-imaging discrepancy observed in AD patients with DM may be associated with their low cognitive reserve, possibly caused by their low amount of leisure activities. Our findings suggest that lifestyle interventions, including physical, cognitive, and social activities, may reduce cognitive decline in AD patients with DM.","PeriodicalId":10810,"journal":{"name":"Current Alzheimer research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46494825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Uremic Toxins on Alzheimer's Disease. 尿毒症毒素对阿尔茨海默病的影响。

IF 2.1 4区医学

Current Alzheimer research Pub Date : 2022-01-01 DOI: 10.2174/1567205019666220120113305

Yuqi Zheng, Bin Ji, Sijun Chen, Rong Zhou, Ruiqing Ni

引用次数: 0