F. Neta, Francisco Emílio Simplício de Souza, André Lima Batista, Francisco Irochima Pinheiro, R. Cobucci, F. Guzen
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引用次数: 3
摘要
背景脑肠微生物群(BGM)轴上的条件可显著促进阿尔茨海默病(AD)的发病机制。来自动物研究的证据表明,益生菌通过BGM轴在调节情绪、认知和应激反应中发挥作用。然而,益生菌对AD的影响需要在临床前和临床研究中更好地阐明。方法根据PRISMA编制本系统综述。检索PubMed、Web of Science、Embase和虚拟健康图书馆(VHL)中关于益生菌在实验性AD中的作用的原创文章。结果根据无荟萃分析综合(SWiM)指南作为叙述性综合呈现。17项研究符合纳入标准。结果显示,由于认知测试中的表达改善,单独或混合使用益生菌治疗的AD实验模型具有显著效果。结论此外,在大多数纳入的研究中,可以观察到炎症过程减少,肽激素浓度增加,大脑中胰岛素稳态,抗氧化酶增加,β淀粉样蛋白沉积和tau过度磷酸化减少。在实验模型中,补充益生菌似乎可以提高认知测试的表现,并增加能够延缓AD神经退行性过程的物质的浓度。
Effects of supplementation with probiotics in experimental models of Alzheimer's Disease: a systematic review of animal experiments.
BACKGROUND
Conditions along the brain-gut-microbiota (BGM) axis can significantly contribute to the pathogenesis of Alzheimer's disease (AD). Evidence from animal studies indicates a role for probiotics in regulating mood, cognition, and stress response via the BGM axis. However, the effect of probiotics on AD needs to be better clarified in preclinical and clinical studies.
METHOD
We prepared this systematic review according to PRISMA. PubMed, Web of Science, Embase, and Virtual Health Library (VHL) were searched for original articles concerning the effects of probiotics in experimental AD.
RESULTS
Results were presented as a narrative synthesis according to the Synthesis Without Meta-analysis (SWiM) Guideline.Seventeen studies met the inclusion criteria. The results showed significant effects in the experimental models of AD treated with probiotics alone or in mixture form due to expressive improvements in cognitive tests.
CONCLUSION
Furthermore, in most of the included studies, it was possible to observe a reduction in inflammatory processes, an increase in the concentration of peptide hormones, insulin homeostasis in the brain, increased antioxidant enzymes, and a decrease in beta-amyloid deposition and tau hyperphosphorylation. Supplementation of probiotics seems to improve performance in cognitive tests and increase the concentration of substances capable of delaying the neurodegenerative process of AD in experimental models.
期刊介绍:
Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.