Current drug targets最新文献

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Glutathione-responsive Nanoparticles for Optimized Cas9/sgRNA Gene Editing Delivery. 用于优化Cas9/sgRNA基因编辑递送的谷胱甘肽响应纳米颗粒
IF 3 4区 医学
Current drug targets Pub Date : 2025-04-11 DOI: 10.2174/0113894501370119250409074208
Md Sadique Hussain, Ajay Singh Bisht, Haider Ali, Gaurav Gupta
{"title":"Glutathione-responsive Nanoparticles for Optimized Cas9/sgRNA Gene Editing Delivery.","authors":"Md Sadique Hussain, Ajay Singh Bisht, Haider Ali, Gaurav Gupta","doi":"10.2174/0113894501370119250409074208","DOIUrl":"https://doi.org/10.2174/0113894501370119250409074208","url":null,"abstract":"","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Glycolipids and their Toxicity in the Context of Nanomaterials and Nanoparticles: A Review of the Literature. 纳米材料和纳米颗粒背景下的糖脂作用及其毒性:文献综述。
IF 3 4区 医学
Current drug targets Pub Date : 2025-03-10 DOI: 10.2174/0113894501347158250305074908
Moyu Li, Wenjin Peng, Siwei Zhu, Xianyu Chen, Li Li, Xiaolan Li, Chengfu Yuan
{"title":"The Role of Glycolipids and their Toxicity in the Context of Nanomaterials and Nanoparticles: A Review of the Literature.","authors":"Moyu Li, Wenjin Peng, Siwei Zhu, Xianyu Chen, Li Li, Xiaolan Li, Chengfu Yuan","doi":"10.2174/0113894501347158250305074908","DOIUrl":"https://doi.org/10.2174/0113894501347158250305074908","url":null,"abstract":"<p><strong>Background: </strong>Diseases triggered by glucose and lipid metabolic disorders, such as hyperglycemia and hyperlipidemia, have become a global health threat. According to statistics, diabetic patients have exceeded 463 million worldwide, and the prevalence of hyperlipidemia is also continuously rising. These glycolipid metabolic diseases not only significantly increase the risk of complications such as cardiovascular disease, stroke, and kidney disease but also impose a huge economic burden on the global healthcare system. Despite the continuous emergence of treatment methods for glucose and lipid metabolic diseases with the advancement of research technology, existing therapies still face many challenges. In recent years, the rapid development of nanotechnology has injected new vitality into the medical field. As an emerging research field, nanomedicine has attracted much attention for its application prospects in the treatment of glycolipid metabolic diseases. Nanotechnology is expected to provide more precise and efficient solutions for the treatment of these diseases, thereby reducing global health and economic pressures.</p><p><strong>Objective: </strong>The objective of this article is to comprehensively review the relationship between nanotechnology and glucose and lipid metabolism.</p><p><strong>Methods: </strong>We have carried out a series of literature searches, focusing on glycolipid effects and toxicity of nano-materials.</p><p><strong>Results: </strong>Nanoparticles as drug carriers or nanoparticles enhance bioavailability and activity. Nano-material-based optical reporters aid in detecting lysosome lipid content, facilitating treatment and drug development for glucose and lipid metabolism disorders. Additionally, nanomaterials find applications in glucose biofuel cells and microalgal lipid metabolism regulation. However, nanomaterials, such as polystyrene nanoplastics, may have toxic effects, inducing macrophage transformation and lipid accumulation in the liver.</p><p><strong>Conclusion: </strong>The development of nanotechnology is still in its infancy, and many disease-based studies are still in the stage of animal experiments and have not yet been applied in clinical practice. However, the universality and multilateralism of the use of nanotechnology give it excellent development prospects and also provide a research direction for medical research.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibroblast Growth Factors: Roles and Emerging Therapeutic Applications. 成纤维细胞生长因子:作用和新兴的治疗应用。
IF 3 4区 医学
Current drug targets Pub Date : 2025-03-06 DOI: 10.2174/0113894501351461250301072444
Gaëtane Ternier, Kaynat Shahzad, Oshadi Edirisinghe, Patience Okoto, Zeina Alraawi, Shivakumar Sonnaila, Phuc Phan, Paul D Adams, Suresh K Thallapuranam
{"title":"Fibroblast Growth Factors: Roles and Emerging Therapeutic Applications.","authors":"Gaëtane Ternier, Kaynat Shahzad, Oshadi Edirisinghe, Patience Okoto, Zeina Alraawi, Shivakumar Sonnaila, Phuc Phan, Paul D Adams, Suresh K Thallapuranam","doi":"10.2174/0113894501351461250301072444","DOIUrl":"https://doi.org/10.2174/0113894501351461250301072444","url":null,"abstract":"<p><p>Several fibroblast growth factors are expressed in the developmental stage, while others are present in adults. They are vital in maintaining cellular homeostasis and signaling important cellular functions, such as regeneration and growth. Over the years, a spike of interest has been observed in clinical applications of the different members of this family, especially for their implications in glucose and lipid homeostasis, cancer, and regeneration. Yet, the extent of this vast family's roles in different cellular activities and their mechanism of action remain unclear. Furthermore, they are structurally unstable molecules, making clinical applications more difficult. This work reviews the mechanism of action of FGFs and offers valuable insights into their therapeutic potential.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives. Bothrops蛇咬伤的药理学研究:现状与展望。
IF 3 4区 医学
Current drug targets Pub Date : 2025-02-27 DOI: 10.2174/0113894501352925250225045555
Álisson Emannuel Franco Alves, Allessya Lara Dantas Formiga, Ana Flávia Chaves Uchôa, Anny Leticia Marinho Ramos Cardoso, Eduardo Oliveira Aquino Leal Rodrigues, Graziela Maria de Araujo Pereira, Julia de Pádua Farias Bezerra Leite, Luís Fellipe Alves da Silva, Natália Ferreira de Sousa, Marcelo da Silva Sobral, Marcus Tullius Scotti, Luciana Scotti, Francisco Humberto Xavier Júnior
{"title":"Targets Involved in the Pharmacology of Bothrops Snakebite: Statu Quo and Future Perspectives.","authors":"Álisson Emannuel Franco Alves, Allessya Lara Dantas Formiga, Ana Flávia Chaves Uchôa, Anny Leticia Marinho Ramos Cardoso, Eduardo Oliveira Aquino Leal Rodrigues, Graziela Maria de Araujo Pereira, Julia de Pádua Farias Bezerra Leite, Luís Fellipe Alves da Silva, Natália Ferreira de Sousa, Marcelo da Silva Sobral, Marcus Tullius Scotti, Luciana Scotti, Francisco Humberto Xavier Júnior","doi":"10.2174/0113894501352925250225045555","DOIUrl":"https://doi.org/10.2174/0113894501352925250225045555","url":null,"abstract":"<p><strong>Introduction: </strong>Despite their hazardous nature, snake venoms hold immense potential for the development of novel therapies. This summary delves into the key aspects of snake venom research, focusing on their significance as targets for neutralization, their utility as novel drugs, the application of in silico studies, and future prospects with nanotechnology. Significance of Snake Venom: Snake venom harbors a rich diversity of toxic proteins with a wide range of biological activities. Its importance lies in the possibility of neutralizing its detrimental effects and exploring its therapeutic potential for diverse ailments. Venom Neutralization: The development of more effective and specific antivenoms is crucial for treating snakebites, particularly in regions with a high prevalence of accidents. Molecular-level venom studies are essential for identifying novel targets for the development of more efficacious antivenoms. Venom as a Source of Novel Drugs: Proteins present in snake venom exhibit diverse pharmacological activities, including antithrombotic, anti-inflammatory, analgesic, and antimicrobial properties. Investigating these proteins can lead to the development of novel medications for various diseases. In silico Studies: Bioinformatics tools and molecular modelling can aid in the discovery of novel molecular targets in snake venom, accelerating the process of developing new drugs and therapies. Nanotechnology for Drug Delivery: Nanotechnology offers new possibilities for developing more efficient and targeted drug delivery systems, enhancing the safety and effectiveness of snake venom-based treatments.</p><p><strong>Conclusion: </strong>Snake venom research represents a promising area of inquiry with immense potential for the development of novel drugs and therapies. The integration of traditional and innovative techniques, such as in silico studies and nanotechnology, can accelerate this process and contribute to the advancement of public health.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment. 揭示针对RNA病毒疾病的抗病毒药物的潜力。
IF 3 4区 医学
Current drug targets Pub Date : 2025-02-24 DOI: 10.2174/0113894501336800250220051811
Ritchu Babbar, Jasmeen Kaur, Kajalpreet Kaur, Swikriti, Vijay Dhondiram Vagh, Monika Sachdeva, Tapan Behl, Monica Gulati, Amin Gasmi
{"title":"Unfurling the Potential of Antiviral Agents Aimed for RNA Virus Ailment.","authors":"Ritchu Babbar, Jasmeen Kaur, Kajalpreet Kaur, Swikriti, Vijay Dhondiram Vagh, Monika Sachdeva, Tapan Behl, Monica Gulati, Amin Gasmi","doi":"10.2174/0113894501336800250220051811","DOIUrl":"10.2174/0113894501336800250220051811","url":null,"abstract":"<p><p>Globally, high mortality is brought on by RNA viruses, which are linked to chronic human disorders. Viruses dominate the WHO's current ranking of the top 10 global health hazards, especially RNA viruses. RNA viruses, like HIV, SARS-CoV-2, and influenza, which are among the most prevalent and frequently encountered RNA viruses, use RNA as their genetic material, making them prone to quick changes. They adapt rapidly, complicating the body's immune responses. HIV, a significant retrovirus, infiltrates the immune system, causing AIDS by compromising defenses against infections. SARS-CoV-2, which led to COVID-19, sparked a worldwide pandemic with respiratory symptoms, emphasizing the need for research and therapeutic innovations. The COVID-19 pandemic has demonstrated the insufficiency of available resources in effectively addressing emerging viral infections. Influenza, a seasonal RNA virus, triggers flu outbreaks, impacting public health. Research is crucial to understanding how these viruses interact with hosts, aiding the development of effective treatments and strengthening our ability to face new viral threats. The most effective defenses against viral illnesses are virus-specific vaccinations and antiviral drugs. The present review emphasizes the prevalence of the three most pathogenic and widespread RNA viruses, namely HIV, influenza, and SARS-CoV2, their pathophysiology, and the current treatment with FDA-approved drugs. It also incorporates novel analogs that are under clinical trials as there is an urgent need for innovative antiviral medications, and enormous global efforts are required to find secure and efficient cures for these viral infections.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health. 蛋白酶与骨质疏松症:它们在骨骼健康中的作用的综合综述。
IF 3 4区 医学
Current drug targets Pub Date : 2025-02-14 DOI: 10.2174/0113894501368814250212111828
Syed Sufian Ahmad, Faraha Ahmed, Sayeed Ahmad, Mohammad Ahmed Khan
{"title":"Proteases and Osteoporosis: A Comprehensive Review of Their Role in Bone Health.","authors":"Syed Sufian Ahmad, Faraha Ahmed, Sayeed Ahmad, Mohammad Ahmed Khan","doi":"10.2174/0113894501368814250212111828","DOIUrl":"https://doi.org/10.2174/0113894501368814250212111828","url":null,"abstract":"<p><p>Proteases, once thought to degrade proteins solely, are now recognized as key signaling molecules central to numerous physiological processes, including bone remodeling. Dysregulated protease contributes to various pathological diseases, including cardiovascular diseases, cancer, inflammation, osteoporosis, and neurological disorders. Protease targeting is now quite far along; some small molecules are already on the market, and others are in development. Despite drugs having been successfully developed to inhibit well-defined proteases, including angiotensin-converting enzyme and HIV protease, designing selective inhibitors for the newly identified protease targets is still difficult owing to problems like poor target selectivity. This review covers principles guiding the discovery of protease drugs with a focus on recent approaches, including the use of allosteric sites. In bone remodeling, proteases are involved in the regulation of cell surface properties and extracellular matrix in the degradation process that is fundamental to bone mineral density and quality. In particular, cathepsins, dipeptidyl peptidases, and caspases have become attractive targets for the therapy of osteoporosis. Selective inhibitors are different from other drugs in the way that they selectively inhibit bone resorption processes and do not bear on osteoblast survival factors or bone formation. However, some inhibitors proved to be effective in increasing bone density in osteoporotic patients, but due to side effects, they were withdrawn, highlighting the necessity of selective inhibitors. Newer generations of selective allosteric inhibitors aiming at protease activity would be safer and give an unexplored therapeutic angle to tackle osteoporosis without interfering with other physiological processes.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Carbon Dots Nanomaterials for Ovarian Cancer Diagnosis and Therapy. 新型碳点纳米材料用于卵巢癌的诊断和治疗。
IF 3 4区 医学
Current drug targets Pub Date : 2025-02-04 DOI: 10.2174/0113894501347816241223065618
Anoop Narayanan V, Rajesh B R D Yamajala, Jayachandran Venkatesan, Myung-Geol Pang, Gangaraju Gedda
{"title":"Emerging Carbon Dots Nanomaterials for Ovarian Cancer Diagnosis and Therapy.","authors":"Anoop Narayanan V, Rajesh B R D Yamajala, Jayachandran Venkatesan, Myung-Geol Pang, Gangaraju Gedda","doi":"10.2174/0113894501347816241223065618","DOIUrl":"https://doi.org/10.2174/0113894501347816241223065618","url":null,"abstract":"<p><p>Delayed diagnosis and limited treatment options make ovarian cancer difficult to treat. This paper examines the growing role of Carbon Dots (CDs) in ovarian cancer diagnosis and treatment. Photoluminescence and biocompatibility make CDs ideal for biomedical use. We emphasize their ability to improve fluorescence and molecular imaging in imaging and diagnostics. We also demonstrate the efficacy of carbon dots in targeted drug delivery systems in overcoming drug resistance and improving therapeutic outcomes. Photodynamic and photothermal therapies are used to show that CDs can treat hypoxic ovarian cancer tumours. We also discuss CD safety issues and constraints, emphasising the need for thorough assessments and fine-tuning. Future research focuses on personalised medicine and CD integration with other therapies. This text concludes by discussing CDs' clinical use and the challenges of production and regulatory approval. CDs can improve ovarian cancer diagnosis and treatment, improving patient outcomes and survival.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Anti-Acne Potentials Via in-vitro, Ex-vivo, and in-vivo Models: A Comprehensive Approach. 通过体外,离体和体内模型评估抗痤疮潜力:一种全面的方法。
IF 3 4区 医学
Current drug targets Pub Date : 2025-01-29 DOI: 10.2174/0113894501335548250123072644
Ravi Goyal, Gurpreet Kaur, Deepinder Singh Malik, Sachin Singh, Kamal Dua, Deependra Singh, Thakur Gurjeet Singh
{"title":"Assessing Anti-Acne Potentials Via in-vitro, Ex-vivo, and in-vivo Models: A Comprehensive Approach.","authors":"Ravi Goyal, Gurpreet Kaur, Deepinder Singh Malik, Sachin Singh, Kamal Dua, Deependra Singh, Thakur Gurjeet Singh","doi":"10.2174/0113894501335548250123072644","DOIUrl":"https://doi.org/10.2174/0113894501335548250123072644","url":null,"abstract":"<p><p>Acne vulgaris is the 8th most commonly prevailing skin disorder worldwide. Its pervasiveness has been predominant in juveniles, especially males, during adolescence and in females during adulthood. The lifestyle and nutrition adopted have been significantly reported to impact the occurrence and frequency of acne. It typically occurs over the regions of the forehead, upper chest, and back of the body, which are regions with high proportions of active sebaceous follicles. The market today is flooded with the pool of anti-acne medications (oral, topical/systemic) that contain either a single therapeutic agent or a blend targeting multiple pathological pathways. However, the clinical applicability of these preparations is limited due to formulation stability, drug penetrability, and targeting, the incidence of secondary effects, antibiotic resistance, etc. Moreover, the effectiveness of the former therapies varies as per the type and severity of acne. Therefore, it is necessary to extensively research skin physiology under normal and diseased conditions so that newer, safer, and more effective medications can be devised. Moreover, their safety and efficacy should be validated by employing various acne models, and their comparative profiling should be done with standard marketed anti-acne preparations. Acne models assist to uncover the complex disease pathogenesis and identify the potential targets for therapeutic interventions. This review is an attempt to highlight varied in-vitro, ex-vivo, and in-vivo testing procedures done to assess drug efficacy, track disease progression, and compare test substances with existing treatments. By presenting a unified approach to acne modeling, this review will assist researchers in selecting the most appropriate model for their specific research goals, helping them to generate valuable and reproducible data to support the development of effective acne therapies.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Structure to Function: Isatin Derivatives as a Promising Class of Antiviral Agents. 从结构到功能:Isatin衍生物作为一类有前途的抗病毒药物。
IF 3 4区 医学
Current drug targets Pub Date : 2025-01-28 DOI: 10.2174/0113894501352560250115054156
Anshul Jamwal, Shagun Sharma, V K Kapoor, Raveen Chauhan, Kamal Dua, Vikrant Dalwal, Akshay Kumar, Parteek Prasher, Poonam Negi
{"title":"From Structure to Function: Isatin Derivatives as a Promising Class of Antiviral Agents.","authors":"Anshul Jamwal, Shagun Sharma, V K Kapoor, Raveen Chauhan, Kamal Dua, Vikrant Dalwal, Akshay Kumar, Parteek Prasher, Poonam Negi","doi":"10.2174/0113894501352560250115054156","DOIUrl":"https://doi.org/10.2174/0113894501352560250115054156","url":null,"abstract":"<p><p>A range of heterocyclic compounds, including Isatin (oneH-indole-2, 3-dione) and its by-products, have been shown to represent potential unit blocks in the synthesis of potential medicinal agents. Numerous studies have been carried out on isatin, its synthesis, biological uses, and its chemical composition since when it was discovered. Functionally, these isatin-containing heterocycles have demonstrated antibacterial, antidiabetic, antiviral, antitubercular, and anticancer properties, among many others. In vitro and In vivo efficaciousness of several Isatin moieties has been assessed in recent years based on their antimicrobial qualities. Isatin has shown great promise as a flexible heterocycle in the realm of drug development in recent years. Many viruses have caused extensive epidemics during the last 50 years, which have had detrimental effects on social, economic, and health conditions. The current unprecedented SARS-CoV-2 epidemic necessitates intensive research into the development of potent antiviral medications. It has been shown that Isatin, a flexible heterocycle, has a great deal of potential for drug development. Appropriately functionalized Isatin compounds have shown noteworthy and extensive antiviral activities throughout the last fifty years. The goal of this study is to gather all known data on Isatin derivatives' antiviral activity, emphasizing their structure-activity correlations as well as research on mechanistic and molecular modelling. We think that the scientific community will find this review to be a useful tool in the development of more efficient and powerful antiviral treatments based on Isatin scaffolds.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling Neurological Drug Delivery: Polymeric Nanocarriers for Enhanced Blood-Brain Barrier Penetration. 揭开神经系统药物输送的神秘面纱:增强血脑屏障穿透性的聚合物纳米载体。
IF 3 4区 医学
Current drug targets Pub Date : 2025-01-01 DOI: 10.2174/0113894501339455241101065040
Aparna Inamdar, Bannimath Gurupadayya, Praveen Halagali, Vamshi Krishna Tippavajhala, Farhan Khan, Rashmi Pathak, Himanshu Sharma
{"title":"Unraveling Neurological Drug Delivery: Polymeric Nanocarriers for Enhanced Blood-Brain Barrier Penetration.","authors":"Aparna Inamdar, Bannimath Gurupadayya, Praveen Halagali, Vamshi Krishna Tippavajhala, Farhan Khan, Rashmi Pathak, Himanshu Sharma","doi":"10.2174/0113894501339455241101065040","DOIUrl":"10.2174/0113894501339455241101065040","url":null,"abstract":"<p><p>Treating neurological illnesses is challenging because the blood-brain barrier hinders therapeutic medications from reaching the brain. Recent advances in polymeric nanocarriers (PNCs), which improve medication permeability across the blood-brain barrier, may influence therapy strategies for neurological diseases. PNCs have several ways to deliver medications to the nervous system. This review article provides a summary of the parts and manufacturing methods involved in making PNCs. Additionally, it highlights the elements that result in PNCs having enhanced blood-brain barrier penetration. A combination of passive and active targeting strategies is used by PNCs intended to overcome the blood-brain barrier. Among these are micellar structures, nanogels, nanoparticles, cubosomes, and dendrimers. These nanocarriers, which are functionalized with certain ligands that target BBB transporters, enable the direct delivery of drugs to the brain. Mainly, the BBB prevents medications from entering the brain. Understanding the BBB's physiological and anatomical characteristics is necessary to get over this obstacle. Preclinical and clinical research demonstrates the safety and effectiveness of these PNCs, and their potential use in the treatment of neurological illnesses, including brain tumors, Parkinson's disease, and Alzheimer's disease, is discussed. Concerns that PNCs may have about their biocompatibility and possible toxicity are also covered in this review article. This study examines the revolutionary potential of PNCs in CNS drug delivery, potential roadblocks, ongoing research, and future opportunities for PNC design progress. PNCs open the door to more focused and efficient treatment for neurological illnesses by comprehending the subtleties of BBB penetration.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":"243-266"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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