Current Applied Polymer Science最新文献

{"title":"Revolutionizing Drug Delivery: The Potential of PLGA Nanoparticles in\u0000Nanomedicine","authors":"Akanksha R. Singh, R. Athawale","doi":"10.2174/0124522716282353240118114732","DOIUrl":"https://doi.org/10.2174/0124522716282353240118114732","url":null,"abstract":"\u0000\u0000Nanomedicine is an emerging field that utilizes nanoparticles to deliver drugs and\u0000other therapeutic agents to specific cells and tissues in the body. One of the most promising\u0000materials for creating these nanoparticles is Poly(Lactic-co-glycolic Acid) (PLGA), which has\u0000several unique properties that make it well-suited for biomedical applications. These\u0000nanomedicines, made from a combination of lactic acid and glycolic acid, can deliver drugs and\u0000other therapeutic agents directly to specific cells or tissues in the body. This allows for more\u0000precise and targeted treatment, reducing the potential for side effects and improving the\u0000effectiveness of the treatment. Additionally, PLGA nanomedicines are biocompatible and\u0000biodegradable, making them an attractive option for use in a wide range of biomedical\u0000applications to deliver a wide range of drugs, including proteins, peptides, nucleic acids, and\u0000small molecules for various biomedical applications such as neurodegenerative, cardiovascular\u0000diseases, inflammatory disorders, and cancer. In summary, research on PLGA nanoparticles for\u0000biomedical applications is ongoing and has the potential to lead a new and improved treatments\u0000for a wide range of diseases and conditions. Looking ahead, PLGA nanoparticles have the potential\u0000to revolutionize the way we treat diseases and improve human health. As research continues\u0000to advance, we can expect to see new and innovative uses for PLGA nanoparticles in the biomedical\u0000field, leading to the development of more effective and targeted therapeutics. The current\u0000review focuses on the synthesis, physicochemical properties, biodegradation properties of\u0000PLGA, method to prepare PLGA nanoparticles and biomedical application of PLGA. It\u0000examines the current progress and future directions for research on PLGA in drug delivery.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethylcellulose- An Amazing Polymer For Anticancer Formulations","authors":"Vishnu Mittal, P. Kriplani, Kumar Guarve","doi":"10.2174/0124522716273253231129104511","DOIUrl":"https://doi.org/10.2174/0124522716273253231129104511","url":null,"abstract":"A cellulose derivative known as ethyl cellulose has gained a lot of interest because of its special qualities and prospective uses in systems for the controlled administration of medications. This study concentrates on patents that examine the use of ethyl cellulose for anticancer preparations. Polymeric drug delivery methods are gaining significant research due to their potential to enhance therapeutic effectiveness, improve bioavailability, and reduce toxicity The primary objective of incorporating ethyl cellulose into anticancer preparations is to develop safe, effective, and targeted therapies for the treatment of cancer. This study aims to provide a comprehensive overview of recent patents that specifically explore the use of ethyl cellulose in the prevention and treatment of different cancers. The patent review methodology employed an extensive search across multiple patent databases to identify relevant patents on the utilization of ethyl cellulose in anticancer preparations. The formulations described in these patents demonstrated sustained and controlled drug release profiles, which resulted in improved therapeutic efficacy while minimizing potential adverse effects. Our comprehensive review revealed multiple patents that utilized ethyl cellulose as a polymer in the creation of anticancer preparations. The studies conducted in these patents showcased enhanced drug release kinetics, improved cellular uptake, and increased anticancer activity compared to conventional formulations. The analysis of these patents strongly indicates that ethyl cellulose exhibits substantial potential as a versatile polymer for anticancer preparations. The findings strongly suggest that incorporating ethyl cellulose into drug delivery systems can significantly enhance the effectiveness of anticancer drugs, thus benefiting patients.","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"11 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of physicochemical, flammability, and acoustic properties of Hookeri raphia natural from Cameroon","authors":"Jean de Dieu Briand Minsongui Mveh, R. Ligabue, Sandra Mara Oliveira Einloft, Jeane Estela Ayres de Lima","doi":"10.2174/2452271606666230801161335","DOIUrl":"https://doi.org/10.2174/2452271606666230801161335","url":null,"abstract":"\u0000\u0000The development of new materials is ultimately associated with requirements such as strength, lightness, low production cost, and raw materials from renewable sources, seeking to meet the needs, research, and development of new technologies, which value the qualification of materials from vegetable sources as natural fibers.\u0000\u0000\u0000\u0000In this context, this study aimed to characterize the main physicochemical properties of the natural raffia fiber and its flammability and thermo-acoustic characteristics. These characterizations were performed using several techniques, such as chemical composition analysis, density, moisture adsorption, SEM-EDS, FTIR, and TGA/DTG.\u0000\u0000\u0000\u0000The results showed that the morphology of the raffia fiber presents a similar shape to the beehive. The Elemental analysis of the natural fiber of raffia shows that carbon and oxygen contents are predominant, representing a proportion of more than 90%. Furthermore, the results suggest that the fiber is composed of lignin, hemicellulose, cellulose, tannin, and extractives, with cellulose in a proportion of 80%.\u0000\u0000\u0000\u0000TGA presents a profile similar to large parts of untreated vegetable fibers. The acoustic test showed excellent sound absorption coefficient (α) values at high frequencies, while the flammability test showed that natural raffia fiber is a good flame retardant.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82394768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini Review on Polymer-based Nano Enable System for Targeted Delivery of Chalcone Derivatives against Cancerous Tissues: An Effective Treatment Approach","authors":"S. Mukherjee, D. Karati","doi":"10.2174/2452271606666230731103057","DOIUrl":"https://doi.org/10.2174/2452271606666230731103057","url":null,"abstract":"\u0000\u0000Nanotechnology augmentation have enabled the creation of innovative colloidal preparations that can modify the pharmacological characteristics of medications. Numerous effective applications in the treatment of cancer have been made possible by the distinctive physicochemical and\u0000technological characteristics of therapies based on nanomaterials. To facilitate and maximize the\u0000interaction between cells and tissues, it is necessary to examine and modify the size, shape, charge,\u0000and patterning of nanoscale therapeutic molecules. The flavonoids chalcones and their natural scaffolds provide a variety of biological effects crucial for creating medicines. Plant-based anticancer\u0000medicines represent a promising scientific and business opportunity that should be investigated. By\u0000using traditional Chinese medicine (TCM) therapies, diseases can be avoided, and healthcare can be\u0000enhanced. Traditional Chinese medicine is safe, straightforward, and reasonably priced. There are\u0000numerous treatments for chronic, geriatric, and incurable diseases. Heterocyclic equivalents of chalcones have a variety of biological properties. One of them is its anti-cancer properties, and as a result Chalcones have drawn a huge interest in the study of malignancy. Licorice is an essential primary ingredient in many traditional folk medicines, including Chinese and Mongolian medicine. Research on chalcone scaffolds with strong growth-inhibitory activity in tumor cell lines was influenced by the rising interest in this medicinal molecule, and numerous papers on these scaffolds are\u0000now accessible. It is necessary to do a thorough examination before chalcone congeners can be developed as a prodrug or primary chemical to treat cancer. To create a focused and efficient drug delivery system for cancer treatment, we shall discuss chalcone derivatives and their nano-enabled\u0000drug delivery systems in this article. It has been discussed how polymeric nanoparticles might effectively localize in particular tumor tissues and act as drug delivery vehicles for anticancer drugs due\u0000to their physicochemical characteristics. A promising strategy to increase the effectiveness of various tumor treatments is the nanoencapsulation of anticancer active substances in polymeric systems.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80897839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Properties and Molecular Transport Behavior of NR/Clay and ENR/Clay Composites","authors":"S. C. George, Rakesh Reghunath, A. Mathew","doi":"10.2174/2452271606666230504110847","DOIUrl":"https://doi.org/10.2174/2452271606666230504110847","url":null,"abstract":"\u0000\u0000Natural rubber and epoxidized natural rubber composites reinforced with clay have been synthesized in this study using two roll mixing mill.\u0000\u0000\u0000\u0000The effect of clay concentration on basic mechanical properties and molecular transport phenomena of the elastomeric composites was analyzed. Tensile strength and tear strength variation as a function of clay concentration were studied.\u0000\u0000\u0000\u0000It was found that as clay concentration increased up to 4 phr, tensile strength improved up to 22.5MPa and tear strength up to 32 MPa, beyond which it went down. It was also found that corresponding to 4 phr clay concentrations, the crosslink density of the composite was at a maximum of 1.45gmol/cc.\u0000\u0000\u0000\u0000As the clay contents are added into the elastomeric matrix system, initially there is a decrease in the swelling coefficient, but later at higher loading, the swelling coefficient increases due to the agglomeration of clay particles in the matrix.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82851018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tıagabıne Incorporated Polymerıc Mıcroneedles: Formulatıon And Characterızatıon Studıes","authors":"Ebru Başaran, Kadir Aykaç","doi":"10.2174/2452271606666230427091330","DOIUrl":"https://doi.org/10.2174/2452271606666230427091330","url":null,"abstract":"The oral route is the primary route for both acute and chronic treatment of epilepsy. However, lack of oral access during the seizures and high drug resistance limit the anti-epileptogenic effects of most antiepileptic drugs. Therefore, alternative routes and novel drug delivery systems are required. In this study, polymeric microneedles were formulated and characterized for possible intranasal administration of Tiagabine (TIA) in order to overcome the blood-brain barrier (BBB).\u0000\u0000\u0000\u0000In our study, carboxymethyl cellulose (CMC) and Eudragit® S 100 (ES100) based polymeric microneedles were formulated by micro-molding SEM, DSC, XRD, FT-IR, 1H-NMR, in vitro release, and texture analyses were performed. For the stability analyses, formulations were kept at 25 °C ± 2 °C (60 ± 5% Relative Humidity; RH), 40 °C ± 2 °C (75 ± 5% RH) and 5 °C ± 3 °C for six months.\u0000\u0000\u0000\u0000Analysis results revealed that robust microneedles were formulated successfully by micromolding method with adjustable needle lengths. Depending on the polymer type, sustained TIA releases up to 72 hours were achieved. Structural integrities were maintained at all storage conditions during the storage period of six months.\u0000\u0000\u0000\u0000TIA-loaded microneedles have the potential with less invasive properties, even with small amounts of TIA, through the unconventional nasal route for effective treatment of epilepsy.","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75255566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Asparaginase For Treatment Of Cancer\u0000Historical appraisal and future perspectives","authors":"L. P. Icart, T. S. de Araújo, M. Almeida, L. M. T. Lima","doi":"10.2174/2452271606666230104143806","DOIUrl":"https://doi.org/10.2174/2452271606666230104143806","url":null,"abstract":"\u0000\u0000Asparaginase (ASNase) is widely used as an important component of first-line treatment for acute lymphoblastic leukemia (ALL). Although it is associated with a high rate of complete remission (~93%), challenges remain due to several side effects ranging from immune reactions to severe toxicity, largely associated with its higher immunogenicity and glutamine coactivity. Innovative products have therefore been devised to minimise these adverse reactions while increasing the enzymes’ pharmacokinetic properties, stability, and efficacy. This review focuses on commercially available formulations and others that remain in development, discussing the most recent strategies for preparing alternative formulations of the enzyme to be less immunogenic and have low glutaminase coactivity by using site-specific mutagenesis, PEGylation, and encapsulation techniques.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79210839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal Ion and Dye Adsorption Potential of Grafted Co-polymer of Polysaccharides for the Treatment of Wastewater","authors":"R. Malviya, Shilpa Singh, P. Sharma, A. Gupta","doi":"10.2174/2452271606666221206105936","DOIUrl":"https://doi.org/10.2174/2452271606666221206105936","url":null,"abstract":"\u0000\u0000This review explains the importance of polysaccharide derivatives in removing heavy metals and dyes from contaminated materials. With rising urbanization and industrialization, the availability of heavy metals and dyes in the environment is increasing. Heavy metals can cause a variety of health problems in individuals and offer major environmental dangers. This paper uses diverse techniques to discuss the most recent improvements in metal ion and dye adsorption from wastewater. Various derivatives of natural polymers can be used as good adsorbents for removing heavy metals and dyes from industrial wastewater and treated water released into the environment, lowering the risk of human disease and environmental problems. According to literature reviews, removing heavy metal ions from industrial effluent benefits both people and the environment. Graft copolymers are the most effective heavy metal ion and dye removal adsorbents, and the majority of them obey the pseudo-first and pseudo-second-order models. Also, an overview of each grafted co-polymers of polysaccharides for the adsorption of metal ions and dyes is mentioned in this review.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79950584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Jim Low","doi":"10.2174/245227160503221228103543","DOIUrl":"https://doi.org/10.2174/245227160503221228103543","url":null,"abstract":"","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76170135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on the Importance of Chitosan in Different Pharmaceutical Applications","authors":"Hourieh Alkadi, A. Allaf","doi":"10.2174/2452271606666221117163317","DOIUrl":"https://doi.org/10.2174/2452271606666221117163317","url":null,"abstract":"\u0000\u0000Chitosan is an amino-polysaccharide polymer that has a unique structure, multi properties, highly sophisti-cated functionality and a wide range of applications in biomedical and pharmaceutical research as well as other industrial applications in connection with both pharmaceutical and medical fields. Additionally, it appears that this unique material can be emphasized as a good candidate for drugs variety carrier, drug re-lease applications, and ocular and antimicrobial applications including treatment of diabetes. This review highlights the importance and pharmaceutical applications of chitosan in different fields of research and applications.\u0000","PeriodicalId":10768,"journal":{"name":"Current Applied Polymer Science","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73411243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}