Critical reviews in clinical laboratory sciences最新文献

{"title":"The dual roles of microorganisms in inflammatory diseases: initiators and regulators.","authors":"Yan Liao, Ruoyu Jiang, Haoling Zhang, Wangzheqi Zhang","doi":"10.1080/10408363.2026.2637106","DOIUrl":"https://doi.org/10.1080/10408363.2026.2637106","url":null,"abstract":"<p><p>Research on the microbiome is reshaping the conceptual foundations of inflammatory diseases. As a dynamic component of the host ecosystem, microbial communities collectively influence inflammatory responses and homeostatic balance through their metabolites, structural signals, and interactions with immune pathways. Dysbiosis can amplify immune activation and metabolic disturbances, leading to persistent inflammation, whereas specific commensal taxa and their metabolites possess the capacity to suppress excessive immune responses and restore homeostasis. This bidirectional regulatory capacity positions the microbiome as a central node that both drives and modulates inflammatory networks. Multi-omics investigations have delineated the systemic architecture of microbe-host interactions, revealing cross-system axes such as the gut-brain, gut-liver, and skin-gut pathways that constitute a signaling framework integrating inflammation and immunity, thereby reshaping our understanding of disease pathogenesis. Within this framework, inflammation is redefined as an adaptive strategy for maintaining systemic stability rather than merely a singular pathological reaction. Therapeutic approaches including fecal microbiota transplantation (FMT), engineered microbial strains, and interventions targeting metabolic signaling are propelling microecological medicine into an era of precision modulation. As systems biology converges with spatial omics, research on the microbiome is shifting from descriptive pathology toward mechanistic control, establishing it as a critical nexus linking immunity, metabolism, and disease evolution. This transformation heralds a paradigm shift in medicine from merely \"suppressing inflammation\" to actively \"reconstructing ecological order.\"</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"1-33"},"PeriodicalIF":5.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The sex difference in plasma cystatin C is age-dependent: a systematic review and meta-analysis.","authors":"Filip Landgren, Bertil Kågedal, Eva Landberg","doi":"10.1080/10408363.2026.2640949","DOIUrl":"https://doi.org/10.1080/10408363.2026.2640949","url":null,"abstract":"<p><p>Cystatin C-based GFR equations (eGFR_cys) are inconsistent; some include a sex-adjustment factor while others do not. This reflects ongoing uncertainty about whether cystatin C concentrations differ between sexes in healthy individuals without kidney disease and how any such difference varies with age. We performed a systematic review and meta-analysis to address this discrepancy. We conducted a PRISMA-compliant systematic review (PubMed, Scopus, Embase) of studies reporting sex-specific cystatin C data in healthy adults. From 21 studies comprising more than 46,000 healthy adults, 52 unique subgroups (<i>k</i> = 52) were extracted. Analyses comprised: (1) a meta-regression of all subgroups by mean age; (2) a random-effects model for younger and middle-aged adults (<i>k</i> = 32, age ≤ 60 years); and (3) a separate model for older adults (<i>k</i> = 13, age ≥ 60 years). A qualitative review of pediatric data provided life-course context. The qualitative pediatric review confirmed a consistent 12-15% sex difference (men > women) emerging during adolescence. In younger and middle-aged adults, men had 8.6% higher cystatin C concentrations than women (pooled M/F ratio 1.0860, 95% CI 1.0587-1.1133; <i>p</i> < .0001). In older adults, this difference was markedly attenuated (M/F ratio 1.0338, 95% CI 1.0132-1.0544). Across all adult subgroups, meta-regression indicated an age-related attenuation of the sex difference (β = -0.0011 per year). Between-study heterogeneity was substantial (I² = 98% in younger adults, 76% in older adults), likely reflecting true variability in population characteristics and analytical methods; however, the direction of the sex difference was highly consistent across studies. Sensitivity analyses using robust variance estimation, leave-one-out analysis, and trim-and-fill methods confirmed the robustness of pooled estimates and found no evidence of substantial publication bias. Plasma cystatin C exhibits a consistent, biologically plausible sex difference that varies across the life course, with a pronounced difference in adolescence and early to mid-adulthood that attenuates after 60 years of age. This pattern coincides with age-related changes in sex hormone exposure and, together with experimental and clinical evidence, supports a hormonal contribution to cystatin C regulation. These findings challenge the validity of both sex-neutral eGFR_cys equations, which may underestimate kidney function in younger men, and uniform sex-adjustment equations, which may overcorrect in older adults. Our results support the development of age-dependent, sex-specific approaches to cystatin C-based kidney function assessment.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"1-21"},"PeriodicalIF":5.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for diagnosing and differentiating infection with antifungal-resistant <i>Trichophyton indotineae</i> from other dermatophytoses.","authors":"Ali Abdul Hussein S Al-Janabi","doi":"10.1080/10408363.2025.2551649","DOIUrl":"10.1080/10408363.2025.2551649","url":null,"abstract":"<p><p>This review attempts to find a crucial set of criteria that can be applied to diagnose infections caused by <i>Trichophyton indotineae</i>, based on laboratory and clinical characteristics derived from other studies. <i>T. indotineae</i> has emerged as a new species from the anthropophilic <i>Trichophyton mentagrophytes</i> and <i>Trichophyton interdigitale</i>. The close relationship between <i>T. indotineae</i> and these two species makes it difficult to distinguish them based on morphological and physiological features. Resistance to terbinafine was first observed in <i>T. indotineae</i>, and later to other antifungals, which increased the treatment failure rate in several dermatophytoses. In conclusion; identifying criteria specific to infections with <i>T. indotineae</i> can provide a framework for physicians to readily diagnose such infections and distinguish them from other dermatophytoses. Categorization guidelines for all diagnostic characteristics of <i>T. indotineae</i> and its infection can make a forward step in prescribing effective therapies.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"135-146"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large scale implementation of DP for clinical diagnoses: experience, challenges, and lessons learned.","authors":"Blaise Clarke, Charlotte Carment-Baker, Christine Bruce, Kattreen Hanna, George M Yousef","doi":"10.1080/10408363.2025.2549309","DOIUrl":"10.1080/10408363.2025.2549309","url":null,"abstract":"<p><p>Implementing DP on a large scale is a complex, multi-dimensional process that requires strategic planning, technological adaptation, and change management. We provide a detailed account of the full-scale implementation of DP at the University Health Network (UHN), a multi-site tertiary clinical center in Canada, highlighting practical lessons learned, ongoing challenges, and mitigation strategies.</p><p><p>A phased implementation approach was adopted, involving pre-implementation planning, procurement, infrastructure development, and optimized validation protocols. Significant focus was placed on technical considerations, including system interoperability, storage capacity, and image quality. Procurement was structured to ensure vendor neutrality and long-term sustainability.A critical component of the implementation was \"change management\", addressing resistance to change through extensive training, real-time troubleshooting, utilizing \"super users\" as change champions. Attention was paid to pathologist office configuration.</p><p><p>A dual workflow model, with simultaneous access to both glass and digital slides, facilitated smoother transition. As of this writing all histopathology H&E cases and tissue hematopathology are being scanned. Efforts to implement digital liquid hematopathology and cytopathology are ongoing.</p><p><p>The financial implications of DP implementation were evaluated, including direct and indirect costs. While initial investments in scanners, storage, and software infrastructure were substantial, long-term savings are anticipated through increased efficiency, reduced physical slide storage, enhanced workload distribution and the integration of AI-based tools.</p><p><p>Continuous monitoring and feedback were established to assess system performance and address emerging challenges. Scalability and future applications of DP remain a priority. The adoption of AI-driven pathology tools, remote diagnostics, and cross-institutional data sharing are anticipated to further enhance the value of DP. UHN's experience underscores the importance of a structured, multidisciplinary approach to DP implementation.</p><p><p>Our experience offers a realistic and evolving roadmap for institutions considering DP adoption. We provide practical guidance, highlight persistent challenges and emphasize the importance of continuous evaluation and adaptation.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"109-123"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory mechanisms and emerging diagnostic and therapeutic opportunities of non-coding RNAs in tumorigenesis: a pan-cancer perspective.","authors":"Doblin Sandai, Zengkan Du, Haoling Zhang, Qi Sun","doi":"10.1080/10408363.2025.2555278","DOIUrl":"10.1080/10408363.2025.2555278","url":null,"abstract":"<p><p>Non-coding RNAs (ncRNAs) are a class of functional transcripts that are not translated into proteins and primarily include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). In recent years, as therapeutic challenges such as tumor heterogeneity and drug resistance have become increasingly prominent, ncRNAs have emerged as pivotal targets in cancer mechanistic research and precision intervention strategies due to their central roles in tumor initiation, progression, metastasis, and therapeutic resistance. Given the limitations of conventional treatments, inadequate early detection methods, and significant inter-individual variability, elucidating the regulatory functions of ncRNA networks have become an urgent imperative for advancing cancer diagnosis and treatment. This review systematically integrates the regulatory mechanisms of miRNAs, lncRNAs, and circRNAs in key oncogenic processes from a pan-cancer perspective, including cell proliferation, cell cycle control, apoptosis evasion, metastatic activation, and resistance reprogramming, while highlighting their hub-like roles in multi-pathway crosstalk,the application of ncRNA in cancer diagnosis and its role in treatment and prognosis. Furthermore, future research must strive for breakthroughs in areas such as the optimization of nanodelivery systems, AI-driven target identification, and dynamic multi-omics integration, with the ultimate goal of achieving the systematic translation of ncRNAs into actionable strategies for personalized precision medicine-transforming \"functional transcriptional regulation\" into \"targetable therapeutic intervention.\"</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"147-203"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical considerations and clinical utility of plasma phosphorylated Tau217.","authors":"Hans Frykman","doi":"10.1080/10408363.2025.2551648","DOIUrl":"10.1080/10408363.2025.2551648","url":null,"abstract":"<p><p>Blood-based biomarkers are an easily available and practical tool for Alzheimer's disease (AD) screening and diagnosis. Plasma phosphorylated Tau217 (p-tau217) is the front-runner candidate for AD diagnosis due to its strong correlation with core AD pathology determined either by cerebrospinal fluid biomarker (CSF) and positron emission tomography (PET) or postmortem examination. While plasma p-tau217 is firmly associated with AD pathology, it is crucial to evaluate its performance in distinguishing AD from mixed pathologies, as brain autopsies have shown the coexisting of AD pathology with other related types of dementia. Moreover, the measurement of AD biomarkers will be a crucial element in defining eligibility for disease-modifying treatment in clinical practice. Moreover, plasma p-tau217 is a highly efficacious biomarker in the early detection of Aβ pathology, making it a feasible test for AD screening in clinical practice. Several assays, including the ALZpath p-tau217 assay and the Fujirebio plasma p-tau217 assay, have been made commercially available for research use. A few studies analytically and clinically have validated these immunoassays as laboratory diagnostic tests for AD diagnosis and differentiating from non-AD neurodegenerative disorders in clinical practice.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"124-134"},"PeriodicalIF":5.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota and tumor epigenetics: deep interconnections and emerging therapeutic perspectives.","authors":"Lei Duan, Dan Hu, Haoling Zhang, Yan Liao","doi":"10.1080/10408363.2025.2602551","DOIUrl":"https://doi.org/10.1080/10408363.2025.2602551","url":null,"abstract":"<p><p>Cancer is a major global public health problem. Epigenetic regulation, such as DNA methylation, histone modifications, and non-coding RNA (ncRNA) dysregulation, is a main driver of tumorigenesis and progression. Recent studies are suggesting that the human microbiota, commonly referred to as a \"super-organ,\" are not only associated with tumors but play an active role in regulating the epigenetic state of the host. The aim of this review is to systematically explain the main regulatory mechanisms of the \"microbiota-epigenetic-cancer regulatory axis\", their heterogeneous manifestations across various tumors, and the exploration of novel diagnostic biomarkers and therapeutic strategies of this regulatory axis. Microbiota mainly drive tumor epigenetic remodeling through three levels. First, microbial metabolites (e.g., butyrate) can act as natural histone deacetylase inhibitors (HDACis), or tryptophan metabolites can directly regulate the host chromatin state by activating the aryl hydrocarbon receptor (AhR) pathway. Second, bacterial structures such as lipopolysaccharide (LPS) can induce inflammation and disease by activating inflammatory signaling pathways. Third, specific pathogens like HBV and <i>Helicobacter pylori</i> can hijack the host's epigenetic machinery or induce epigenetic reprogramming via virulence factors. The tumor-resident microbiota (TRM) is an emerging and important field. TRM that actively partake in the tumor microenvironment (TME) may promote immune evasion through <i>in situ</i> mechanisms (e.g., lactylation), thereby confirming a direct and causal role for microbes within tumors. The epigenetic therapeutic strategies based on these mechanisms are being rapidly developed, including, for example, the regulation of microbial community structure (e.g., FMT), the targeting of microbial metabolic pathways, and TRM-specific approaches and key pathways (e.g., engineered bacteria). These strategies also have great potential as biomarkers for tumor prognosis prediction and therapy response evaluation. Overall, microbes and tumor epigenetics are part of a network that brings together their metabolism, inflammation, immunity, and gene regulation. Future research will shift from exploring the correlation of the gut microbiota at the macro level to exploring TRM's causality within the TME. By using gnotobiotic mouse models, organoid co-cultures, and multiomics, we will deeply analyze the microenvironment specificity of this network and develop precision interventions targeting TRM that could transform cancer therapy.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"1-41"},"PeriodicalIF":5.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern techniques used in the diagnosis of autoimmune rheumatic diseases.","authors":"Yana Kaliberda, Anna Wajda, Magdalena Węglarska, Agnieszka Paradowska-Gorycka","doi":"10.1080/10408363.2025.2528869","DOIUrl":"10.1080/10408363.2025.2528869","url":null,"abstract":"<p><p>Laboratory diagnostics of diseases have improved significantly with modern laboratory techniques offering greater accuracy, earlier detection, and opportunities for personalized diagnosis. This review highlights the key techniques used in the diagnostics of autoimmune rheumatic diseases. Detection of autoantibodies is the basis for modern laboratory diagnostics of autoimmune rheumatic diseases. Immunofluorescent analysis, enzyme-linked immunosorbent assay, chemiluminescent immunoassay, and immunoblotting are nowadays common methods for differential diagnostics, screening, and monitoring the progression of autoimmune diseases. Polymerase chain reaction methods allow the identification of genetic markers associated with autoimmune disorders, which facilitates early diagnosis. Next Generation Sequencing allows for comprehensive analysis of genetic variants, identifying novel biomarkers, and furthering our understanding of disease mechanisms. Diagnostics and treatment are now approaching personalized medicine based mainly on modern molecular discoveries. Such an approach aims to determine disease risk, tailor treatment to individual patient needs, improve safety and efficacy, and reduce treatment costs. This review covers essential laboratory techniques for diagnosing autoimmune rheumatic diseases and aims to serve as a reliable resource for clinicians, including rheumatologists, and researchers.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"12-27"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loop-mediated isothermal amplification (LAMP)-based microbial detection: a review of FDA-authorized tests and future perspectives.","authors":"Austin Jin, Maggie Deng, He S Yang, Zejuan Li","doi":"10.1080/10408363.2025.2542808","DOIUrl":"10.1080/10408363.2025.2542808","url":null,"abstract":"<p><p>Loop-mediated isothermal amplification (LAMP) has emerged as a rapid and accessible alternative to traditional polymerase chain reactions (PCR) for nucleic acid amplification in research, significantly enhancing pathogen detection in infectious disease diagnostics. This review aims to bridge the gap in the literature regarding the real-world applications of LAMP assays and their potential to improve infectious disease diagnostics across various healthcare settings. We evaluated the current landscape of United States Food and Drug Administration (FDA)-authorized LAMP-based microbial tests, categorizing 30 such tests and detailing their regulatory pathways, such as 510(k) clearance and Emergency Use Authorization (EUA), particularly in response to the COVID-19 pandemic. We comprehensively examine the technical characteristics of LAMP assays, including sample collection, nucleic acid extraction, amplification processes, signal detection, device automation, and their analytical and clinical performance. We highlight the versatility of LAMP assays in diagnostic applications and their growing role in rapid infectious disease. We discuss the advantages and limitations of LAMP technology and identify future directions for its development in infectious disease diagnostics. By analyzing FDA-authorized LAMP-based microbial tests, this review aims to guide healthcare professionals and support future research and product development, ultimately improving patient care.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"57-79"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guardians on call: neutrophils, macrophages and dendritic cells in arthritis pathogenesis.","authors":"Navita Sharma, Jasika Bashal, Basma Bouchefra, Vinod Chandran, Ali Abdul-Sater, Katerina Oikonomopoulou","doi":"10.1080/10408363.2025.2539133","DOIUrl":"10.1080/10408363.2025.2539133","url":null,"abstract":"<p><p>Several immune/inflammatory components have been associated with arthritis. The role of monocytes/macrophages in inflammatory arthritis has been explored over the last years; however, the role of other myeloid cells, such as neutrophils and dendritic cells, in driving the pathophysiology of arthritis is largely overlooked. In this article, we aim to discuss literature pointing to the role of these immune cells in inflammatory arthritis and emphasize the multiple and dynamic phenotypic roles these cells can hold either in the persistence or in the resolution of inflammation. We also highlight the interactions between neutrophils, macrophages, and/or dendritic cells in the arthritic joint space. We further discuss pathways and features that may be of importance for characterizing neutrophils and dendritic cells, the phenotype of which can be \"reprogrammed\" to direct the resolution of inflammation efficiently in the arthritic joint. Identifying novel and patient-tailored approaches for addressing persistent or recurrent inflammation through these cellular pathways, might address unmet needs in arthritis management. Types of arthritides discussed in this review include osteoarthritis, spondyloarthritis and rheumatoid arthritis. Brief reference to the role of these immune cells in the acute gouty inflammation is also included.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"28-56"},"PeriodicalIF":5.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}