Clinical otolaryngology and allied sciences最新文献_第2页

Risk-adjusted comparative audit. Is Possum applicable to head and neck surgery? 风险调整比较审计。负鼠是否适用于头颈部手术?

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00626.x

H Griffiths, P Cuddihy, S Davis, S Parikh, A Tomkinson

引用次数: 23

Middle ear instillation of gentamicin and streptomycin in chinchillas: electrophysiological appraisal of selective ototoxicity. 龙猫中耳滴注庆大霉素和链霉素:选择性耳毒性的电生理评价。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00614.x

M Hilton, J Chen, A Kakigi, H Hirakawa, R J Mount, R V Harrison

{"title":"Middle ear instillation of gentamicin and streptomycin in chinchillas: electrophysiological appraisal of selective ototoxicity.","authors":"M Hilton, J Chen, A Kakigi, H Hirakawa, R J Mount, R V Harrison","doi":"10.1046/j.1365-2273.2002.00614.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00614.x","url":null,"abstract":"The purpose of this study was to investigate selective vestibular ototoxicity of gentamicin and streptomycin in the chinchilla model. In total, 10 chinchillas underwent left middle ear instillation of one of three agents: gentamicin, streptomycin and saline. Electrophysiological data (otoacoustic emissions (OAEs), auditory brainstem evoked response (ABRs), and ice-water electronystagmography were recorded before and after instillation. Animals were sacrificed for temporal bone studies using scanning electron microscopy. Morphological changes in the cochlear and vestibular neuroepithelia were correlated with electrophysiological changes. Widespread ipsilateral cochlear and vestibular neuroepithelial injuries were observed and correlated with loss of OAEs, ABRs and ice-water caloric response. This study provides no evidence of selective vestibular ototoxicity of gentamicin or streptomycin. Morphological damage correlates with, but precedes loss of electrophysiological parameters. Chinchillas, like other small mammals, may not be an ideal model for the study of human ototoxicity.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"529-35"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00614.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Analysis of intra-operative bleeding and recurrence of juvenile nasopharyngeal angiofibromas. 青少年鼻咽血管纤维瘤术中出血及复发分析。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00611.x

L Liu, R Wang, D Huang, D Han, E J Ferguson, H Shi, W Yang

引用次数: 40

Benefit from endoscopic sinus surgery. 受益于内窥镜鼻窦手术。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00610.x

H Mehanna, J Mills, B Kelly, G W McGarry

引用次数: 41

The use of topical nasal anaesthesia before flexible nasendoscopy: a double-blind, randomized controlled trial comparing cophenylcaine with placebo. 柔性鼻内窥镜检查前使用局部鼻麻醉:一项双盲、随机对照试验，比较酚卡因和安慰剂。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00608.x

A J Cain, D P Murray, L G McClymont

{"title":"The use of topical nasal anaesthesia before flexible nasendoscopy: a double-blind, randomized controlled trial comparing cophenylcaine with placebo.","authors":"A J Cain, D P Murray, L G McClymont","doi":"10.1046/j.1365-2273.2002.00608.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00608.x","url":null,"abstract":"The objective was to evaluate the necessity to use topical nasal anaesthesia before flexible nasendoscopy and to compare its use with placebo. The study was carried out using a double-blind randomized controlled trial, with three treatment arms, at the out-patient department at Raigmore Hospital, Inverness. The participants were 90 patients attending the otolaryngology out-patient department who required flexible nasendoscopy as part of their assessment. Each participant was randomized to one of three groups. Group 1 received cophenylcaine spray, group 2 received a placebo spray, and group 3 received no nasal preparation. Flexible nasendoscopy was carried out via a stated protocol and the patient's diagnosis and findings were discussed in the usual way. After the consultation, the patient filled in a questionnaire marking answers on a visual analogue scale. The main outcome measures were pain and overall unpleasantness of procedure. Patient anxiety and willingness to be examined again in the same way if necessary were also assessed. Ease of examination and quality of view were asked from the operator's perspective. The mean scores on a visual analogue scale showed the main outcome measures to be as follows. Pain score measured 1.7 for cophenylcaine, 2.1 for no spray and 2.2 for placebo. Overall unpleasantness scores were 2.0 for cophenylcaine, 1.9 for no spray and 2.4 for placebo. On a visual analogue scale of 0-10, none of these mean main outcome measures reached levels of significance. It was concluded that the use of cophenylcaine spray before flexible nasendoscopy does not give significant advantages over the use of no nasal preparation.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"485-8"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00608.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Has the internet overtaken other traditional sources of health information? Questionnaire survey of patients attending ENT outpatient clinics. 互联网是否已经取代了其他传统的健康信息来源?耳鼻喉科门诊患者问卷调查。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00621.x

A Rokade, P K D Kapoor, S Rao, V Rokade, K T V Reddy, B N Kumar

引用次数: 41

Prognosis is predicted by early hearing improvement in patients with idiopathic sudden sensorineural hearing loss. 特发性突发性感音神经性听力损失患者的早期听力改善预测预后。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00620.x

S Ito, T Fuse, M Yokota, T Watanabe, K Inamura, S Gon, M Aoyagi

{"title":"Prognosis is predicted by early hearing improvement in patients with idiopathic sudden sensorineural hearing loss.","authors":"S Ito, T Fuse, M Yokota, T Watanabe, K Inamura, S Gon, M Aoyagi","doi":"10.1046/j.1365-2273.2002.00620.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00620.x","url":null,"abstract":"The time-course of the recovery of the hearing level after treatment in 90 patients with idiopathic sudden sensorineural hearing loss was examined. The improvement rate calculated relative to the hearing level of the opposite ear was investigated to estimate the hearing recovery. Follow-up audiograms were performed once per week for 1 month after treatment and once per month thereafter. There were two groups that differed with respect to the characteristics of hearing recovery. One group showed an improvement rate of over 50% at 1-2 weeks and a good improvement rate at 3 months after treatment. In the other group, the improvement rate did not reach 50% at 1-2 weeks, and the improvement rate was poor at 3 months after treatment. The patients with improvement rates of over 50% at 1-2 weeks had earlier initial visits and had mild hearing loss, whereas the patients with profound hearing loss had improvement rates under 50% and poor long-term prognosis. We conclude that the improvement rate at 1-2 weeks after treatment predicts the long-term prognosis for recovery of hearing level in patients with sudden sensorineural hearing loss.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"501-4"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00620.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Sudden deafness: long-term follow-up and recurrence. 突发性耳聋:长期随访及复发。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00612.x

A Furuhashi, K Matsuda, K Asahi, T Nakashima

引用次数: 80

The Epley manoeuvre for benign paroxysmal positional vertigo--a systematic review. Epley手法治疗良性阵发性位置性眩晕——系统回顾。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00613.x

M Hilton, D Pinder

引用次数: 52

11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck. -羟基类固醇脱氢酶1在头颈部鳞状细胞癌中的表达。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00609.x

S Gronau, D Koenig Greger, M Jerg, H Riechelmann

{"title":"11Beta-hydroxysteroid dehydrogenase 1 expression in squamous cell carcinomas of the head and neck.","authors":"S Gronau, D Koenig Greger, M Jerg, H Riechelmann","doi":"10.1046/j.1365-2273.2002.00609.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00609.x","url":null,"abstract":"11Beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) has been identified as a major detoxification enzyme of one of the most potent tobacco smoke-derived carcinogens, NNK. If not metabolized by 11beta-HSD1, activation of NNK by cytochrome p450 mono-oxidase 2D6 (CYP2D6) results in an electrophile intermediate responsible for DNA damage. Interindividual variability in the expression of 11beta-HSD1 and CYP2D6 has been found to influence the susceptibility to lung cancer. The aim of this study was to compare 11beta-HSD1 mRNA expression and CYP2D6 metabolizer status in pharyngeal tissues of patients with oropharyngeal carcinoma and controls. In 20 patients with oropharyngeal cancer and 15 non-smoking controls, the 11beta-HSD1 mRNA expression was assessed with RT-PCR. The frequency of genetic polymorphisms of the CYP2D6 gene was assessed using RFLP. It was found that 11beta-HSD1 mRNA is expressed in human pharyngeal mucosa. It is upregulated in mucosa exposed to tobacco smoke. In tumour tissues, 11beta-HSD1 expression was significantly lower than in non-affected mucosa. The frequency distribution of CYP2D6 gene polymorphisms was similar in patients and controls. Chronic tobacco abuse results in 11beta-HSD1 enzyme induction. A reduction of 11beta-HSD1 expression in tumour tissues could be a consequence of malignantly transformed cells. It remains unclear if the lower 11beta-HSD1 expression gives rise to an increased rate of additional mutations.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"453-7"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00609.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22145927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11