Clinical otolaryngology and allied sciences最新文献

Prognostic indicators for malignant tumours of the parotid gland. 腮腺恶性肿瘤的预后指标。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00625.x

G Harbo, T Bundgaard, D Pedersen, H Søgaard, J Overgaard

{"title":"Prognostic indicators for malignant tumours of the parotid gland.","authors":"G Harbo, T Bundgaard, D Pedersen, H Søgaard, J Overgaard","doi":"10.1046/j.1365-2273.2002.00625.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00625.x","url":null,"abstract":"The best treatment of malignant parotid tumours still remains to be defined, and a better knowledge about the tumour features that predict the treatment result is needed. The histological classification of parotid tumours may present difficulties on account of their great morphological diversity. In a series of 152 patients with a malignant tumour of the parotid gland, the prognostic factors and treatment results were investigated over a 25-year period. Treatment consisted of surgery, radiation therapy or a combination (49%, 13% and 38% respectively). Crude 5-year survival was 50% with significant differences related to stage (stage I, 65%; stage II, 50%; stage III, 21%; and stage IV, 9%). With respect to histopathology, the adenoid cystic carcinomas and the acinic cell carcinomas had the best prognosis (76% and 67% 5-year crude survival and 53% and 67% 10-year crude survival respectively). There was a significant difference in crude survival between well/intermediate and poorly differentiated tumours (P = 0.007). In a Cox hazard regression analysis including 136 patients and using death from cancer as the end-point, the following parameters were independent prognostic predictors: T-classification (P = 0.002), M-classification (P < 0.0001), N-classification (N+versus N0) (P = 0.005), local invasion (P = 0.003) and histological differentiation of the tumour (P = 0.03). The TNM system is a good predictor of treatment outcome for malignant parotid tumours. The use of a combination of clinical and histological factors will assist the design of treatment strategies for parotid gland tumours.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"512-6"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00625.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Integrity in medical research and publication. 医学研究和出版的诚信。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00623.x

J E Fenton, A S Jones

引用次数: 5

Are hearing and middle ear statuses at risk in Chinese patients undergoing orthognathic surgery? 中国正颌手术患者的听力和中耳状况有危险吗?

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00616.x

L L N Wong, N Samman, T L Whitehill

引用次数: 11

Sequelae of otitis media with effusion among children with cleft lip and/or cleft palate. 唇裂和/或腭裂儿童中耳炎伴积液的后遗症。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00607.x

P Sheahan, A W Blayney, J N Sheahan, M J Earley

引用次数: 119

Changes in external ear resonance after mastoidectomy: open cavity mastoid versus obliterated mastoid cavity. 乳突切除术后外耳共振的变化:开放腔乳突与封闭乳突腔。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00617.x

C H Jang

{"title":"Changes in external ear resonance after mastoidectomy: open cavity mastoid versus obliterated mastoid cavity.","authors":"C H Jang","doi":"10.1046/j.1365-2273.2002.00617.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00617.x","url":null,"abstract":"The creation of an open mastoid cavity changes the acoustic characteristics of the external ear. The aim of this study was to ascertain the acoustic change in the external auditory canal caused by an open mastoid cavity and to compare it with mastoid obliteration. The external ear resonance characteristics were measured in 40 normal adult ears, 20 ears with an open mastoid cavity and 40 ears with an obliterated mastoid. The measurement of resonance characteristics was performed using a real ear analyser. An open mastoid cavity changed the mean peak resonant frequency of the external ear from 2.1 kHz to 2.3 kHz (P < 0.02), with a mean attenuation of 8 dB SPL at 4 kHz. An obliterated mastoid produced higher resonance frequencies from 2.5 kHz to 2.8 kHz. The sound pressure gain of the external auditory canal with an open mastoid cavity was higher than with an obliterated mastoid. The author concludes that an open mastoid cavity can affect the resonance frequency, and that this effect is reduced by mastoid obliteration. Therefore, mastoid obliteration results in a more normal ear canal both anatomically and functionally.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"509-11"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00617.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Conservation surgery in the management of T1 and T2 oropharyngeal squamous cell carcinoma: the Birmingham UK experience. 保守手术治疗T1和T2口咽鳞状细胞癌:英国伯明翰的经验。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00618.x

J C Watkinson, C Owen, S Thompson, A R Das Gupta, J Glaholm

{"title":"Conservation surgery in the management of T1 and T2 oropharyngeal squamous cell carcinoma: the Birmingham UK experience.","authors":"J C Watkinson, C Owen, S Thompson, A R Das Gupta, J Glaholm","doi":"10.1046/j.1365-2273.2002.00618.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00618.x","url":null,"abstract":"The aim of this paper was to evaluate our experience using conservation surgery in the management of T1 and T2 oropharyngeal squamous cell carcinoma. Eighteen patients underwent conservation surgery between 1993 and 2000 and were analysed retrospectively. The mean age was 54 years and the male to female ratio was 8:1. There were 14 tonsil and 4 tongue base tumours and 83% of cases presented with neck nodes, thereby classifying them as having advanced disease (stages 2-4). All patients received postoperative radiotherapy. All patients were followed up to December 2001. The median follow-up time was 3.8 years (minimum was 1.5 years). The 2-year and 5-year survival rates were 100% and 92% respectively. Approximately 66% of patients returned the EORTC and GHQ/12 quality-of-life questionnaires. Of these, seventy-five percent had a high healthy level of general functioning in accordance with the EORTC general health section. These results show that conservation surgery techniques are effective in the treatment of T1 and T2 oropharyngeal squamous carcinoma associated with significant metastatic neck disease. The techniques are well tolerated, produce minimal functional deficit and do not have a negative impact on the patients quality of life in either the immediate postoperative period or up to 4 years post-treatment.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"541-8"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00618.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

A randomized double-blind study to compare the effects of nasal fluticasone and betamethasone on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis. 一项比较鼻氟替卡松和倍他米松对鼻息肉患者下丘脑-垂体-肾上腺轴和骨转换影响的随机双盲研究。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00627.x

P D Fowler, A G Gazis, S R Page, N S Jones

{"title":"A randomized double-blind study to compare the effects of nasal fluticasone and betamethasone on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis.","authors":"P D Fowler, A G Gazis, S R Page, N S Jones","doi":"10.1046/j.1365-2273.2002.00627.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00627.x","url":null,"abstract":"Treatment of nasal polyposis with topical betamethasone is associated with suppression of the hypothalamo-pituitary-adrenal (HPA) axis and, potentially, has adverse effects on bone turnover. Fluticasone propionate is a potent corticosteroid with negligible absorption across the nasal mucosa and extensive first-pass hepatic metabolism. We performed a randomized double-blind study, in patients with nasal polyposis, comparing the effects of 8 weeks' treatment with betamethasone drops or fluticasone nasules on the HPA axis using the 1 micro g tetracosactide test, and on bone turnover using two serum markers. Nine patients were allocated to each treatment. Betamethasone resulted in significant suppression in the tetracosactide test (P = 0.006), but fluticasone did not (P = 0.113). There were no differences in bone turnover or treatment efficacy between treatments. Treatment of nasal polyposis with topical betamethasone drops, but not with fluticasone nasules, suppresses the HPA axis and, given comparable efficacy, fluticasone administered via nasule should be the preferred agent.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"489-93"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00627.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

p53 Expression and keratinocyte hyperproliferation in middle ear cholesteatoma. 中耳胆脂瘤组织中p53表达与角化细胞增生。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00622.x

M Motamed, D Powe, C Kendall, J P Birchall, A R Banerjee

引用次数: 8

Facial migraine in a rhinological setting. 鼻内科的面部偏头痛。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00628.x

A T Daudia, N S Jones

{"title":"Facial migraine in a rhinological setting.","authors":"A T Daudia, N S Jones","doi":"10.1046/j.1365-2273.2002.00628.x","DOIUrl":"https://doi.org/10.1046/j.1365-2273.2002.00628.x","url":null,"abstract":"This study aims to investigate the incidence of migraine involving the face in a rhinology clinic and to describe its characteristics. It is a study of a cohort of 973 patients consecutively presenting to the outpatient clinic with symptoms of facial pain and/or rhinosinusitis. The study subgroup consisted of patients with facial pain and migraine excluding cluster headache and paroxysmal hemicrania. We studied the features of 51 patients who had facial pain with migraine. The diagnosis was based on the criteria used by the International Headache Society and was also supported by the outcome and response to treatment after a mean of 2 years and 2 months. Of the 973 consecutive patients, 409 (42%) had symptoms of facial pain and/or head pain or pressure. Fifty-one (12%) had migraine. Of these, 39 (76%) had unilateral pain and, in 12 (24%), it was bilateral. The distribution affected the forehead and/or eye or cheek in 32 (63%) patients. Twenty-four (47%) had migraine isolated to the second division of the trigeminal nerve. Twelve per cent of patients attending a rhinology clinic with facial pain had migraine. Of particular interest were the 6% of patients with facial pain who had migraine confined to the second division of the trigeminal nerve. This entity is not widely recognized and has rarely been described in the literature.","PeriodicalId":10694,"journal":{"name":"Clinical otolaryngology and allied sciences","volume":"27 6","pages":"521-5"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1365-2273.2002.00628.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22146918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 62

Combating bacterial resistance in otorhinolaryngology. 对抗耳鼻喉科的细菌耐药性。

Clinical otolaryngology and allied sciences Pub Date : 2002-12-01 DOI: 10.1046/j.1365-2273.2002.00624.x

U Raghavan, N S Jones

引用次数: 5