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Biology of Coronaviruses and Predicted Origin of SARS-CoV-2 冠状病毒生物学与SARS-CoV-2的预测起源
Coronavirus Disease 2019 (COVID-19) Pub Date : 2022-02-07 DOI: 10.1201/9781003190394-2
G. Palù, A. Reale, N. Bazan, P. Panda, V. Uversky, M. Seyran, A. Aljabali, S. Sherchan, G. Azad, W. Baetas-da-Cruz, P. Adadi, M. Tambuwala, B. Uhal, Kazuo Takayama, Ã. Serrano-Aroca, T. El-Aziz, A. Brufsky, K. Lundstrom
{"title":"Biology of Coronaviruses and Predicted Origin of SARS-CoV-2","authors":"G. Palù, A. Reale, N. Bazan, P. Panda, V. Uversky, M. Seyran, A. Aljabali, S. Sherchan, G. Azad, W. Baetas-da-Cruz, P. Adadi, M. Tambuwala, B. Uhal, Kazuo Takayama, Ã. Serrano-Aroca, T. El-Aziz, A. Brufsky, K. Lundstrom","doi":"10.1201/9781003190394-2","DOIUrl":"https://doi.org/10.1201/9781003190394-2","url":null,"abstract":"","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75322530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Vaccine Development Strategies and the Current Status of COVID-19 Vaccines 疫苗开发策略及COVID-19疫苗现状
Coronavirus Disease 2019 (COVID-19) Pub Date : 2022-02-07 DOI: 10.1201/9781003190394-13
Mohsen Akbarian, K. Lundstrom, E. Redwan, V. Uversky
{"title":"Vaccine Development Strategies and the Current Status of COVID-19 Vaccines","authors":"Mohsen Akbarian, K. Lundstrom, E. Redwan, V. Uversky","doi":"10.1201/9781003190394-13","DOIUrl":"https://doi.org/10.1201/9781003190394-13","url":null,"abstract":"","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75378928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Computational Biology and Bioinformatics in Anti-SARS-CoV-2 Drug Development 抗sars - cov -2药物开发中的计算生物学和生物信息学
Coronavirus Disease 2019 (COVID-19) Pub Date : 2022-02-07 DOI: 10.1201/9781003190394-11
V. Uversky
{"title":"Computational Biology and Bioinformatics in Anti-SARS-CoV-2 Drug Development","authors":"V. Uversky","doi":"10.1201/9781003190394-11","DOIUrl":"https://doi.org/10.1201/9781003190394-11","url":null,"abstract":"","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78917318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Focus and Interdisciplinary Approaches in COVID-19 Research and Their Outcomes COVID-19研究的全球焦点和跨学科方法及其成果
Coronavirus Disease 2019 (COVID-19) Pub Date : 2022-02-07 DOI: 10.1201/9781003190394-5
H. Senol, S. Tüzmen
{"title":"Global Focus and Interdisciplinary Approaches in COVID-19 Research and Their Outcomes","authors":"H. Senol, S. Tüzmen","doi":"10.1201/9781003190394-5","DOIUrl":"https://doi.org/10.1201/9781003190394-5","url":null,"abstract":"","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89324278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evolution of COVID-19 Diagnostics COVID-19诊断方法的演变
Coronavirus Disease 2019 (COVID-19) Pub Date : 2022-02-07 DOI: 10.1201/9781003190394-6
Praveen Rai, B. Kumar, D. V. Kumar, Prashant Kumar, Anoop Kumar, Shashi Kumar Shetty, B. Maiti
{"title":"The Evolution of COVID-19 Diagnostics","authors":"Praveen Rai, B. Kumar, D. V. Kumar, Prashant Kumar, Anoop Kumar, Shashi Kumar Shetty, B. Maiti","doi":"10.1201/9781003190394-6","DOIUrl":"https://doi.org/10.1201/9781003190394-6","url":null,"abstract":"","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"320 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87660986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Therapeutic Challenges in COVID-19 COVID-19的治疗挑战
Coronavirus Disease 2019 (COVID-19) Pub Date : 2022-02-07 DOI: 10.1201/9781003190394-3
A. Aljabali, M. Tambuwala, D. Barh, K. Lundstrom
{"title":"Therapeutic Challenges in COVID-19","authors":"A. Aljabali, M. Tambuwala, D. Barh, K. Lundstrom","doi":"10.1201/9781003190394-3","DOIUrl":"https://doi.org/10.1201/9781003190394-3","url":null,"abstract":"","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80796743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical trials during the COVID-19 pandemic: research design and lessons COVID-19大流行期间的临床试验:研究设计和经验教训
Coronavirus Disease 2019 (COVID-19) Pub Date : 2021-12-01 DOI: 10.1183/2312508x.10005521
H. Abo-Leyah, J. Chalmers
{"title":"Clinical trials during the COVID-19 pandemic: research design and lessons","authors":"H. Abo-Leyah, J. Chalmers","doi":"10.1183/2312508x.10005521","DOIUrl":"https://doi.org/10.1183/2312508x.10005521","url":null,"abstract":"The COVID-19 pandemic has required a substantial coordinated international effort to develop effective treatments and vaccines, which has led to an acceleration in innovation in clinical research with the rapid adoption of pragmatic, open, adaptive platform trials for new therapeutics. Large platform trials such as RECOVERY, SOLIDARITY and REMAP-CAP have demonstrated the ability to recruit thousands of patients across multiple sites in a short period of time, resulting in therapies that have now been adopted into clinical practice. Therapies tested for COVID-19 include repurposed antivirals, immunomodulatory drugs, convalescent plasma and, more recently, novel therapeutics developed specifically to target SARS-CoV-2. Challenges have included ethical and practical issues of delivering clinical research during a pandemic, some duplication of effort and the testing of some therapies with a low likelihood of success. COVID-19 has required acceleration of the process of clinical trial conduct, from grant funding to approvals and simplification of trial processes. Many of the innovations and simplifications to clinical trial conduct that have featured so prominently during the COVID-19 pandemic are likely to be just as valuable in a post-pandemic world. An important legacy of the pandemic may be a more efficient and effective way of delivering clinical research in the future.Copyright © ERS 2021.","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81417035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Historical perspective: other human coronavirus infectious diseases, SARS and MERS 历史视角:其他人类冠状病毒传染病，SARS和MERS
Coronavirus Disease 2019 (COVID-19) Pub Date : 2021-12-01 DOI: 10.1183/2312508x.10025620
D. Hui, Alimuddin Zumla
{"title":"Historical perspective: other human coronavirus infectious diseases, SARS and MERS","authors":"D. Hui, Alimuddin Zumla","doi":"10.1183/2312508x.10025620","DOIUrl":"https://doi.org/10.1183/2312508x.10025620","url":null,"abstract":"Alphacoronaviruses (HCoV-229E and HCoV-NL63) and betacoronaviruses (HCoV-OC43 and HCoV-HKU1) are common causes of upper respiratory tract infection in humans. SARS-CoV-1 and MERS-CoV emerged in 2002 and 2012, respectively, with the potential of causing severe and lethal disease in humans, termed SARS and MERS, respectively. Bats appear to be the common natural source of SARS-like coronaviruses including SARS-CoV-1, but their role in MERS-CoV is less clear. Civet cats and dromedary camels are the intermediary animal sources for SARS-CoV-1 and MERS-CoV, respectively. Nosocomial outbreaks are hallmarks of SARS and MERS. MERS patients with comorbidities or immunosuppression tend to progress more rapidly to respiratory failure and have a higher case fatality rate than SARS patients. SARS has disappeared since 2004, while there are still sporadic cases of MERS in the Middle East. Continued global surveillance is essential for SARS-like coronaviruses and MERS-CoV to monitor changing epidemiology due to viral variants.Copyright © ERS 2021.","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"366 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83024041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Post-COVID-19 sequelae Post-COVID-19后遗症
Coronavirus Disease 2019 (COVID-19) Pub Date : 2021-12-01 DOI: 10.1183/2312508x.10024420
A. Gramegna, M. Mantero, F. Amati, S. Aliberti, F. Blasi
{"title":"Post-COVID-19 sequelae","authors":"A. Gramegna, M. Mantero, F. Amati, S. Aliberti, F. Blasi","doi":"10.1183/2312508x.10024420","DOIUrl":"https://doi.org/10.1183/2312508x.10024420","url":null,"abstract":"This chapter explores the currently available knowledge (as at October 2021) about the long-term clinical consequences of COVID-19. Distinction between cardiorespiratory and extra-cardiorespiratory sequelae can facilitate understanding of the post-COVID sequelae problem and may aid the clinical management of patients. The strength of the recommendations is highlighted at the end of each paragraph.Copyright © ERS 2021.","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83072693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory failure in COVID-19: a patient's perspective and clinical cases COVID-19呼吸衰竭:患者视角和临床病例
Coronavirus Disease 2019 (COVID-19) Pub Date : 2021-12-01 DOI: 10.1183/2312508x.10025320
F. Amati, A. Vigni, Sofia Misuraca, Francesco Bindo, A. Gramegna, A. Voza, F. Blasi, S. Aliberti
{"title":"Respiratory failure in COVID-19: a patient's perspective and clinical cases","authors":"F. Amati, A. Vigni, Sofia Misuraca, Francesco Bindo, A. Gramegna, A. Voza, F. Blasi, S. Aliberti","doi":"10.1183/2312508x.10025320","DOIUrl":"https://doi.org/10.1183/2312508x.10025320","url":null,"abstract":"The major morbidity and mortality from COVID-19 is due to acute viral pneumonitis that evolves to ARDS. Furthermore, COVID-19 patients may be affected by extrarespiratory involvement, including cardiac, renal, neurological and vascular complications. Different hospitals reorganised their logistical structures to optimise the care of COVID-19 patients and ensure infection control, and the public health scenario worldwide was characterised by the rapid spread of multidisciplinary units specifically dedicated to COVID-19 patients. This chapter describes the personal experience and clinical case of a previously healthy and active patient who suffered from severe COVID-19. Two other cases of patients hospitalised because of severe acute respiratory failure due to COVID-19 are also discussed.Copyright © ERS 2021.","PeriodicalId":10691,"journal":{"name":"Coronavirus Disease 2019 (COVID-19)","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75257817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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