Clinical chemistry最新文献_第7页

Glomerular Filtration Rate (GFR) Estimation with Cystatin C—Past, Present, and Future 用胱抑素c估计肾小球滤过率（GFR）——过去、现在和将来

IF 9.3 2区医学

Clinical chemistry Pub Date : 2025-02-04 DOI: 10.1093/clinchem/hvae226

Amy B Karger, Michael G Shlipak

{"title":"Glomerular Filtration Rate (GFR) Estimation with Cystatin C—Past, Present, and Future","authors":"Amy B Karger, Michael G Shlipak","doi":"10.1093/clinchem/hvae226","DOIUrl":"https://doi.org/10.1093/clinchem/hvae226","url":null,"abstract":"Background Cystatin C is a long-established filtration marker which can be used to assess kidney function, but it has been sparingly used for clinical care due to creatinine’s role as the primary biomarker for kidney function assessment based on estimated glomerular filtration rate (eGFR). Content This review summarizes the evolution of cystatin C’s role in kidney disease assessment and highlights new guidelines promoting more widespread use. Specifically, the 2021 National Kidney Foundation and American Society of Nephrology Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease report, and the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD), recommend increased use of cystatin C as an alternative and complementary biomarker for kidney function assessment, since it does not differ by race like creatinine, correlates better with adverse outcomes compared to creatinine, and provides a more accurate eGFR when used in combination with creatinine. Summary While robust literature demonstrates improved accuracy with cystatin C-based eGFR (eGFRcys) in certain clinical subpopulations, future research is needed to better understand its performance relative to creatinine-based eGFR (eGFRcr) and measured glomerular filtration rate (mGFR) in additional diverse cohorts, and to achieve assay standardization to match the performance of creatinine assays. Additionally, cystatin C testing availability will need to be broadened from primarily reference laboratories to local laboratories, and partnerships will need to be developed between clinical stakeholders and the laboratory to promote cystatin C’s clinical use, to achieve widespread adoption of guideline-recommended eGFR equations.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":"39 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143125104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on An Unexpectedly High IgE Level during Allergic Exploration. 对过敏探查中异常高的IgE水平的评论。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae175

Louis Nevejan, Xavier Bossuyt

引用次数: 0

An Unexpectedly High IgE Level during Allergic Exploration. 过敏探查时异常高的IgE水平。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae151

Guillaume Feugray, Jennifer Guillerme, Stéphanie Pramil, Marion Carrette, Muriel Quillard Muraine

引用次数: 0

Commentary on Hiding in Plain Sight: Protein Electrophoresis Profile Inconsistent with Patient's Diagnosis. 评论隐藏在普通视线：蛋白质电泳谱与患者诊断不一致。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae162

Melissa R Snyder

引用次数: 0

Commentary on Hiding in Plain Sight: Protein Electrophoresis Profile Inconsistent with Patient's Diagnosis. 评论隐藏在普通视线：蛋白质电泳谱与患者诊断不一致。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae161

Jing Cao

引用次数: 0

New Insights into Xylazine Pharmacokinetics in Humans. 人体内噻嗪药代动力学的新认识。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae201

Kara L Lynch

引用次数: 0

Commentary on An Unexpectedly High IgE Level during Allergic Exploration. 对过敏探查中异常高的IgE水平的评论。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae176

Rebecca S Treger

引用次数: 0

Rethinking Albuminuria in Low-Risk Patients and a Call for Urine Albumin Standardization. 反思低风险患者的白蛋白尿，呼吁尿白蛋白标准化。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae157

Jesse C Seegmiller, Joachim H Ix

引用次数: 0

Estimating Reference Change Values Using Routine Patient Data: A Novel Pathology Database Approach. 利用常规患者数据估算参考变化值：一种新颖的病理数据库方法。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae166

Eirik Åsen Røys, Kristin Viste, Ralf Kellmann, Nora Alicia Guldhaug, Bashir Alaour, Marit Sverresdotter Sylte, Janniche Torsvik, Heidi Strand, Michael Marber, Torbjørn Omland, Elvar Theodorsson, Graham Ross Dallas Jones, Kristin Moberg Aakre

{"title":"Estimating Reference Change Values Using Routine Patient Data: A Novel Pathology Database Approach.","authors":"Eirik Åsen Røys, Kristin Viste, Ralf Kellmann, Nora Alicia Guldhaug, Bashir Alaour, Marit Sverresdotter Sylte, Janniche Torsvik, Heidi Strand, Michael Marber, Torbjørn Omland, Elvar Theodorsson, Graham Ross Dallas Jones, Kristin Moberg Aakre","doi":"10.1093/clinchem/hvae166","DOIUrl":"10.1093/clinchem/hvae166","url":null,"abstract":"Background: The reference change value (RCV) is calculated by combining the within-subject biological variation (CVI) and local analytical variation (CVA). These calculations do not account for the variation seen in preanalytical conditions in routine practice or CVI in patients presenting for treatment. As a result, the RCVs may not reflect routine practice or align with clinicians' experiences. We propose a novel RCV approach based on routine patient data that is potentially more clinically relevant.Methods: This study used the refineR algorithm to determine RCVs using serial patient data extracted from a local Laboratory Information System (LIS). The model was applied to biomarkers with a range of result ratio distributions varying from normal to log-normal. Results were compared against conventional formula-based RCVs using CVI estimates from a state-of-the-art biological variation study. Monte Carlo simulations were also used to validate the LIS data approach.Results: The RCVs estimated from LIS data were: 11-deoxycortisol (men): -70%/+196%, 17-hydroxyprogesterone (men): -49%/+100%, albumin: -10%/+11%, androstenedione (men): -47%/+96%, cortisol (men): -54%/+51%, cortisone (men): -32%/+51%, creatinine: -16%/+14%, phosphate (women): -23%/+29%, phosphate (men): -27%/+29%, testosterone (men): -38%/+60%. The formula-based RCV estimates showed similar but slightly lower results, and the Monte Carlo simulations confirmed the applicability of the new approach.Conclusions: RCVs may be estimated from patient results without prior assumptions about the shape of the ratios between serial results. Laboratories can determine RCVs based on local practice and population.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":"307-318"},"PeriodicalIF":7.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin and Risk of Psoriasis: Observational and Mendelian Randomization Studies in up to 900 000 Individuals. 脂联素与牛皮癣风险：对多达 900 000 人进行的观察性和孟德尔随机研究。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae160

Maria B Nielsen, Marianne Benn, Børge G Nordestgaard, Lone Skov, Yunus Çolak

{"title":"Adiponectin and Risk of Psoriasis: Observational and Mendelian Randomization Studies in up to 900 000 Individuals.","authors":"Maria B Nielsen, Marianne Benn, Børge G Nordestgaard, Lone Skov, Yunus Çolak","doi":"10.1093/clinchem/hvae160","DOIUrl":"10.1093/clinchem/hvae160","url":null,"abstract":"Background: Psoriasis is a chronic inflammatory skin disorder often associated with obesity. Adiponectin, an anti-inflammatory protein-hormone secreted by adipose tissue, may be a link between obesity and psoriasis. We hypothesized that low plasma adiponectin is associated with an increased risk of psoriasis in observational and causal genetic studies.Methods: In observational analyses, we used information on plasma adiponectin and psoriasis in 30 045 individuals from the Copenhagen General Population Study (CGPS). In one-sample Mendelian randomization analyses, we used genetic information on adiponectin and psoriasis in 107 308 individuals from the CGPS. In two-sample Mendelian randomization analyses, we used genetic information on adiponectin from the ADIPOGen consortium and genetic information on psoriasis in 373 338 and 462 933 individuals from the FinnGen study and UK Biobank (UKB).Results: In observational analyses, a 1-unit log-transformed higher plasma adiponectin was associated with a hazard ratio (HR) for psoriasis of 0.67 (95% confidence interval: 0.48-0.94) in an age- and sex-adjusted model but not in a multivariable adjusted model including obesity measures with a HR of 0.95 (0.66-1.35). In genetic one-sample Mendelian randomization analysis, a 1-unit log-transformed higher plasma adiponectin was not associated with a causal risk ratio for psoriasis of 1.33 (0.77-2.32) in the CGPS. In two-sample Mendelian randomization analyses, a 1-unit log-transformed higher plasma adiponectin was not associated with causal risk ratios for psoriasis of 0.96 (0.81-1.14) in FinnGen and 1.00 (1.00-1.01) in UKB.Conclusions: Low plasma adiponectin is associated with increased risk of psoriasis in age- and sex-adjusted observational analyses; however, this was not the case after adjustment for obesity measures or in causal genetic analyses.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":"286-295"},"PeriodicalIF":7.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0