Clinical Pediatric Endocrinology最新文献_第5页

Effects of a diabetes-themed cartoon-based education on disease knowledge and physical activity among Japanese children: a preliminary randomized controlled trial. 糖尿病主题卡通教育对日本儿童疾病知识和身体活动的影响：一项初步随机对照试验

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2026-01-01 Epub Date: 2025-10-16 DOI: 10.1297/cpe.2025-0058

Yasuhiro Suzuki, Daichi Sugawara, Mika Oki, Hirofumi Takahashi, Takaaki Matsuda, Hiroaki Suzuki, Hitoshi Shimano, Yasushi Hada, Kenji Suzuki

{"title":"Effects of a diabetes-themed cartoon-based education on disease knowledge and physical activity among Japanese children: a preliminary randomized controlled trial.","authors":"Yasuhiro Suzuki, Daichi Sugawara, Mika Oki, Hirofumi Takahashi, Takaaki Matsuda, Hiroaki Suzuki, Hitoshi Shimano, Yasushi Hada, Kenji Suzuki","doi":"10.1297/cpe.2025-0058","DOIUrl":"10.1297/cpe.2025-0058","url":null,"abstract":"We examined whether cartoon-based diabetes education could enhance diabetes knowledge and physical activity among children. During the first visit, participants completed a diabetes knowledge test; accelerometers, which were worn, were distributed. During the second visit, participants were randomly assigned to the cartoon distribution or lecture attendance group. At 6 mo post-intervention, the children received the diabetes knowledge test and accelerometers via mail, completed them at home, and returned them. Thirty children participated, with a 100% follow-up rate. Changes in diabetes knowledge test scores or physical activity levels showed no significant between-group differences; however, both groups exhibited significant within-group improvements. In the diabetes knowledge test, the cartoon distribution and lecture attendance groups improved by 11 (19 [17, 22] to 30 [23, 35], p = 0.003) and 10 (17 [14, 23] to 28 [26, 32], p = 0.007) points, respectively. Physical activity significantly increased, with the cartoon distribution and lecture attendance groups gaining 1,427 ± 2,980 (6190 ± 2529 to 7617 ± 3315, p = 0.047) and 1,371 ± 2,659 (6640 ± 3056 to 8011 ± 3046, p = 0.037) steps/d, respectively. This pilot intervention revealed that diabetes-themed cartoons and lecture attendance were similarly effectiveness in improving diabetes knowledge and physical activity.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"35 1","pages":"74-84"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe headache as the initial manifestation of painless thyroiditis: a pediatric case report. 严重头痛为无痛性甲状腺炎的初始表现：一个儿科病例报告。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2026-01-01 Epub Date: 2025-08-31 DOI: 10.1297/cpe.2025-0036

Risa Nagase, Yuki Kawashima, Mari Asakura, Masashi Ogasawara, Kunihiro Oba, Masahiro Noda

{"title":"Severe headache as the initial manifestation of painless thyroiditis: a pediatric case report.","authors":"Risa Nagase, Yuki Kawashima, Mari Asakura, Masashi Ogasawara, Kunihiro Oba, Masahiro Noda","doi":"10.1297/cpe.2025-0036","DOIUrl":"10.1297/cpe.2025-0036","url":null,"abstract":"Painless thyroiditis is a potential cause of thyrotoxicosis, typically presenting with weakness, fatigue, irritability, palpitations, and tremors; however, headache is an uncommon manifestation. Herein, we report two pediatric cases of painless thyroiditis in which headache was the initial presenting symptom. Two 14-yr-old boys presented to our emergency department with chief complaints of severe migraine-like headaches. They did not exhibit typical symptoms of thyrotoxicosis. Head imaging findings revealed no abnormalities, and blood test results indicated elevated thyroid hormone and suppressed thyroid-stimulating hormone levels. Both patients were diagnosed with painless thyroiditis based on the absence of thyroid pain and increased blood flow on thyroid ultrasonography, and were monitored on an outpatient basis with only symptomatic treatment. One patient experienced palpitations and required treatment with propranolol. Within a few months, thyroid hormone levels normalized spontaneously in both patients, and their headaches improved accordingly. Although the mechanism by which thyroid hormones cause headaches remains unclear, these two cases suggest that thyrotoxicosis may be associated with headaches. Thus, it is important to measure thyroid hormone levels in patients with severe headaches without an obvious cause. Furthermore, early detection of thyrotoxicosis may be possible, leading to appropriate treatment, prediction of the future course of the patient's headache, and relief of the patients' and parents' anxiety levels.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"35 1","pages":"85-91"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Necrotizing enterocolitis following a single very low dose of octreotide in a patient with congenital hyperinsulinism: a case successfully managed with 18F-DOPA PET/CT-guided surgery. 先天性高胰岛素血症患者单次极低剂量奥曲肽后的坏死性小肠结肠炎：一例在18F-DOPA PET/ ct引导下成功治疗的病例

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2026-01-01 Epub Date: 2025-08-20 DOI: 10.1297/cpe.2025-0023

Takeshi Uehara, Haruki Mizutani, Naomi Hatabu, Toshinaru Fukae, Nao Takizaki, Masako Izawa, Junko Hanakawa, Hidehito Usui, Norihiko Kitagawa, Michiya Masue, Koji Muroya

{"title":"Necrotizing enterocolitis following a single very low dose of octreotide in a patient with congenital hyperinsulinism: a case successfully managed with 18F-DOPA PET/CT-guided surgery.","authors":"Takeshi Uehara, Haruki Mizutani, Naomi Hatabu, Toshinaru Fukae, Nao Takizaki, Masako Izawa, Junko Hanakawa, Hidehito Usui, Norihiko Kitagawa, Michiya Masue, Koji Muroya","doi":"10.1297/cpe.2025-0023","DOIUrl":"10.1297/cpe.2025-0023","url":null,"abstract":"Octreotide is considered a second-line treatment for congenital hyperinsulinism unresponsive to diazoxide. Necrotizing enterocolitis (NEC) is a serious adverse effect of octreotide, typically occurring in a dose-dependent manner. Here, we report a case of necrotizing enterocolitis following a single administration of a very low dose of octreotide. A female infant was admitted on day 3 of life with severe hypoglycemia. Laboratory findings revealed hyperinsulinemia and hypoketotic hypoglycemia, confirming a diagnosis of congenital hyperinsulinism. Despite diazoxide therapy, adequate glycemic control was not achieved. As a second-line intervention, a single subcutaneous injection of octreotide (1.6 μg/kg) was administered. Two days post-administration, the patient developed abdominal distension and significant vomiting. NEC was diagnosed, necessitating bowel decompression surgery. Subsequent 18F-DOPA positron emission tomography/computed tomography revealed a focal lesion extending from the pancreatic head to the body. The lesion was successfully resected with preservation of nearly the entire normal pancreas. This case highlights that even a very low dose of octreotide may precipitate necrotizing enterocolitis, warranting close monitoring. Lesion localization using 18F-DOPA positron emission tomography/computed tomography is critical in guiding surgical management of congenital hyperinsulinism.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"35 1","pages":"92-97"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents. 日本青少年血清催产素与血清瘦素和体重指数相关。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2026-01-01 Epub Date: 2025-10-09 DOI: 10.1297/cpe.2025-0051

Junji Takaya, Yuko Tanabe, Naohiro Nomura, Miki Minami, Yoko Nakai, Mitsuru Yamagishi, Kazunari Kaneko

{"title":"The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents.","authors":"Junji Takaya, Yuko Tanabe, Naohiro Nomura, Miki Minami, Yoko Nakai, Mitsuru Yamagishi, Kazunari Kaneko","doi":"10.1297/cpe.2025-0051","DOIUrl":"10.1297/cpe.2025-0051","url":null,"abstract":"Oxytocin (OXT), a hypothalamic neuropeptide traditionally associated with reproduction and social bonding, has recently garnered attention for its role in regulating appetite and energy metabolism. To evaluate serum OXT levels and their association with adipokines in obese adolescents and those with type 2 diabetes mellitus (T2DM) compared to healthy controls. In this cross-sectional study, we included 27 participants-9 obese (median age [interquartile range] 10.0 [8.7-13.0] yr; men/women 3/6), 7 T2DM (16.0 [13.0-17.0] yr; 6/1), and 11 controls (10.8 [7.5-15.9] yr; 9/2). Serum OXT and adipokine levels were measured via the enzyme-linked immunosorbent assay. OXT levels were higher in patients with T2DM (130 [110-380] pg/mL) than in controls (85 [60-95] pg/mL; p = 0.002) and the obese group (125 [90-250] pg/mL) was intermediate between the two groups. Across all participants, OXT correlated positively with body mass index-standard deviation score (r = 0.51, p < 0.01) and leptin (r = 0.62, p < 0.001), and inversely with adiponectin (r = -0.39, p = 0.04). Leptin emerged as the strongest predictor of OXT variability (β = 0.53, p < 0.01). In adolescents with T2DM, serum OXT levels may reflect compensatory mechanisms in response to leptin resistance or metabolic stress.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"35 1","pages":"67-73"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seizures in pediatric thyroid storm: Two cases and a literature review. 小儿甲状腺风暴的癫痫发作：2例及文献回顾。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2026-01-01 Epub Date: 2025-11-14 DOI: 10.1297/cpe.2025-0005

Sayaka Kawashima, Chisumi Sogi, Dai Suzuki, Miki Kamimura, Atsuo Kikuchi, Junko Kanno

{"title":"Seizures in pediatric thyroid storm: Two cases and a literature review.","authors":"Sayaka Kawashima, Chisumi Sogi, Dai Suzuki, Miki Kamimura, Atsuo Kikuchi, Junko Kanno","doi":"10.1297/cpe.2025-0005","DOIUrl":"10.1297/cpe.2025-0005","url":null,"abstract":"Thyroid storm is a life-threatening disorder caused by thyrotoxicosis. Diagnostic criteria in adults emphasize central nervous system (CNS) symptoms, including seizures, as CNS symptoms are associated with irreversible damage. However, children have a lower seizure threshold than adults, which may lead to overestimation of severity in pediatric cases with seizures. This study reports two pediatric cases of thyroid storm with seizures, fever, and tachycardia. The more severe case remained unconscious and restless, necessitating intubation and intensive care. The other case regained consciousness spontaneously following the initiation of treatment for thyroid storm. A literature review of 84 children and adolescents with thyroid storm revealed 16 cases (19%) that exhibited seizures. The prevalence of seizures was higher in infants (30.0%) and children (30.4%) than in adolescents (7.3%). Almost all 16 cases with seizures had favorable outcomes, suggesting that seizures in pediatric thyroid storm cases may not be associated with poor prognosis. Although seizures appear to be more common in pediatric thyroid storm and may not necessarily predict poor outcomes, the presence of seizures warrants careful evaluation because of the life-threatening nature of the condition.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"35 1","pages":"117-122"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical practice guidelines for the management of differences of sex development in Japan. 日本性别发育差异管理的临床实践指南。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2026-01-01 Epub Date: 2025-12-03 DOI: 10.1297/cpe.2025-0073

Tomohiro Ishii, Kenichi Kashimada, Masanobu Kawai, Tomoyo Itonaga, Takeshi Iwasa, Akari Utsunomiya, Kayo Ozaki, Kazuhiro Kawamura, Junko Kanno, Jun Koh, Yoshiyuki Kojima, Shoko Sasaki, Hiroyuki Sato, Koji Shiraishi, Yasuhiro Naiki, Mitsuru Nishiyama, Takashi Hamajima, Yasuko Fujisawa, Noriko Makita, Katsuyuki Matsui, Toshihiro Yanai, Reiko Horikawa, Tsutomu Ogata

{"title":"Clinical practice guidelines for the management of differences of sex development in Japan.","authors":"Tomohiro Ishii, Kenichi Kashimada, Masanobu Kawai, Tomoyo Itonaga, Takeshi Iwasa, Akari Utsunomiya, Kayo Ozaki, Kazuhiro Kawamura, Junko Kanno, Jun Koh, Yoshiyuki Kojima, Shoko Sasaki, Hiroyuki Sato, Koji Shiraishi, Yasuhiro Naiki, Mitsuru Nishiyama, Takashi Hamajima, Yasuko Fujisawa, Noriko Makita, Katsuyuki Matsui, Toshihiro Yanai, Reiko Horikawa, Tsutomu Ogata","doi":"10.1297/cpe.2025-0073","DOIUrl":"10.1297/cpe.2025-0073","url":null,"abstract":"Differences of sex development (DSD) are congenital conditions in which chromosomal, gonadal, and anatomical sex characteristics are discordant with typical male or female development. These clinical practice guidelines provide evidence-based recommendations for the diagnosis and management of individuals with DSD across the lifespan. The guidelines were developed by a multidisciplinary committee of specialists representing pediatric endocrinology, adult endocrinology, urology, gynecology, psychiatry, and psychology. The committee employed a systematic review of the literature and used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to assess the strength of recommendations and the quality of evidence. Key areas addressed include the initial management of infants with atypical genitalia, diagnostic approaches, hormonal treatment, surgical interventions, gonadal tumor risk assessment, fertility preservation, and the transition from pediatric to adult care. The guidelines integrate international best practices with Japan's unique sociocultural, healthcare, and legal contexts for optimal DSD management and aim to improve clinical care for individuals with DSD while acknowledging the limited high-quality evidence in many aspects of DSD management.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"35 1","pages":"1-49"},"PeriodicalIF":1.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipocytokine profiles in maternal obesity: The impact of lipoinflammation on serum, breastmilk, and infant metabolic development. 脂肪细胞因子在母体肥胖中的分布：脂肪炎症对血清、母乳和婴儿代谢发育的影响。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI: 10.1297/cpe.2025-0038

Mario Daniel Caba-Flores, Cesar Huerta-Canseco, Carmen Martínez-Valenzuela, Aurora de Jesús Garza-Juárez, Ana María Rivas-Estilla, Alberto Camacho-Morales

{"title":"Adipocytokine profiles in maternal obesity: The impact of lipoinflammation on serum, breastmilk, and infant metabolic development.","authors":"Mario Daniel Caba-Flores, Cesar Huerta-Canseco, Carmen Martínez-Valenzuela, Aurora de Jesús Garza-Juárez, Ana María Rivas-Estilla, Alberto Camacho-Morales","doi":"10.1297/cpe.2025-0038","DOIUrl":"10.1297/cpe.2025-0038","url":null,"abstract":"Adipocytokines are proteins with systemic metabolic effects, and additional adipocytokines have been identified. Adipocytokines are present in the serum, and obesity-mediated inflammation can alter their expression. Breast milk also contains adipocytokines that may influence infant metabolism and growth. Nonetheless, the relationship between circulating and milk adipocytokines during maternal inflammation and their effects on infant development remain unclear. We conducted a comprehensive literature review of studies published between 2000 and 2024 in PubMed to analyze the associations between obesity-mediated inflammation and adipocytokines in maternal serum and breast milk and to explore their potential effects on infant growth and metabolic health. We focused on updated evidence for the legacy adipocytokines leptin, adiponectin, TNF-α, and IL-6 and the emerging adipocytokines chemerin, neuregulin-4, and betatrophin. The results indicated that although obesity-mediated inflammation affected circulating adipocytokines, their levels were not consistently reflected in breast milk. Leptin, chemerin, and betatrophin were more influenced by lipoinflammation than adiponectin, IL-6, and TNF-α. Neuregulin-4 was present in milk, and its serum levels decreased during gestational diabetes. Some adipocytokines were correlated with infant growth; however, the evidence remains inconclusive. Importantly, no adverse metabolic or growth outcomes were linked to changes in milk adipocytokine profiles. These findings support the promotion of breastfeeding as part of infant health strategies, even in the context of maternal lipoinflammation.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"34 4","pages":"204-212"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Japanese infant with fulminant type 1 diabetes with disease-sensitive CSAD polymorphism and HLA haplotype. 1例伴有疾病敏感CSAD多态性和HLA单倍型的日本暴发性1型糖尿病婴儿

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2025-10-01 Epub Date: 2025-06-28 DOI: 10.1297/cpe.2025-0031

Junko Kanno, Hirohito Shima, Miki Kamimura, Akiko Saito-Hakoda, Atsuo Kikuchi

{"title":"A Japanese infant with fulminant type 1 diabetes with disease-sensitive CSAD polymorphism and HLA haplotype.","authors":"Junko Kanno, Hirohito Shima, Miki Kamimura, Akiko Saito-Hakoda, Atsuo Kikuchi","doi":"10.1297/cpe.2025-0031","DOIUrl":"10.1297/cpe.2025-0031","url":null,"abstract":"Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes (T1DM) with an acute onset. There are limited reports on FT1DM in pediatric patients. Here, we report the case of a Japanese female infant with FT1DM, representing the youngest female with FT1DM documented to date. The patient was referred to our hospital at 10 mo of age. Although her laboratory findings met the diagnostic criteria for severe diabetic ketoacidosis, her HbA1c level was not excessively high. Anti-glutamic acid decarboxylase and anti-insulinoma-associated protein-2 antibodies were not detected. Test results for insulin autoantibodies were positive. The glucagon stimulation-loading test revealed a C-peptide level of < 0.6 ng/mL. At 8 yr of age, the patient was diagnosed with Graves' disease. Human leukocyte antigen typing and analysis of a single-nucleotide polymorphism (rs3782151) in CSAD/lnc-ITGB7-1 revealed that the patient was predisposed to FT1DM owing to these two factors. Her findings at the disease onset fulfilled the diagnostic criteria for FT1DM. Although rare in FT1DM, the patient developed Graves' disease, a complication commonly associated with autoimmune T1DM. Moreover, although her condition at onset and genetic predisposition were consistent with those of FT1DM, her clinical course resembled that of autoimmune T1DM.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"34 4","pages":"249-253"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal hyperthyroidism in an extremely low birth weight infant born to a mother with Graves' disease. 新生儿甲状腺功能亢进在极低出生体重婴儿出生的母亲与格雷夫斯病。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1297/cpe.2025-0001

Daly Pen, Kimyi Phou, Sokuntheavy Ly, Rathmony Heng, Sakviseth Bin, Sethikar Im

{"title":"Neonatal hyperthyroidism in an extremely low birth weight infant born to a mother with Graves' disease.","authors":"Daly Pen, Kimyi Phou, Sokuntheavy Ly, Rathmony Heng, Sakviseth Bin, Sethikar Im","doi":"10.1297/cpe.2025-0001","DOIUrl":"10.1297/cpe.2025-0001","url":null,"abstract":"Neonatal hyperthyroidism (NH) mostly commonly occurs in infants born to mothers with Graves' disease. NH in extremely low birth weight (ELBW) infants has been rarely described. Here, we report a case of NH in an infant born at 29 wk 6 d of gestation with a birth weight of 825 g. The mother had untreated Graves' disease during pregnancy. During the 2nd wk of life, the infant developed persistent tachycardia (heart rate > 160 beats per min). Diagnosis of NH was made according to the results of her thyroid function: thyroid-stimulating hormone,< 0.005 mU/L (Reference range: 0.8-12.0 mU/L); free triiodothyronine, 5.1 pg/mL (Reference range: 2.3-4.2 pg/mL); free thyroxine, 38.5 pmol/L (Reference range: 10-33 pmol/L); and thyroid-stimulating hormone receptor antibody, 7.6 IU/L (Reference range: ≤ 1.22 IU/L). Carbimazole was administered. After 1 wk of treatment, levothyroxine was added due to a rapid decline in thyroid function. The treatment regimen was adjusted to achieve normal thyroid function. Her heart rate normalized with no significant hemodynamic instability or long-term complications during her hospitalization or follow-up visits. NH should be considered in ELBW infants with a maternal history of Graves' disease who present with persistent tachycardia. Monitoring thyroid function may be required more closely in ELBW infants when NH management is administered.","PeriodicalId":10678,"journal":{"name":"Clinical Pediatric Endocrinology","volume":"34 4","pages":"264-267"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of autosomal dominant hypophosphatemic rickets. 常染色体显性低磷血症佝偻病1例。

IF 1.2

Clinical Pediatric Endocrinology Pub Date : 2025-10-01 Epub Date: 2025-06-14 DOI: 10.1297/cpe.2024-0054

Shigeru Takishima, Kei Takasawa, Nozomi Matsuda, Hisae Nakatani, Kenichi Kashimada

引用次数: 0