Congenital Heart Disease最新文献

{"title":"A Tense Race: Correlation of Liver Stiffness with Ultrasound Elastography and Hemodynamics in Fontan Patients.","authors":"Yuen Lo Yau, Matthew S Purlee, Lindsey M Brinkley, Dipankar Gupta, David M Saulino, Dalia Lopez-Colon, John-Anthony Coppola, Dhanashree Rajderkar, Himesh Vyas","doi":"10.32604/chd.2025.065661","DOIUrl":"10.32604/chd.2025.065661","url":null,"abstract":"<p><strong>Background: </strong>Patients with Fontan physiology are predisposed to congestive hepatopathy, progressive liver fibrosis, and end-stage liver disease. Ultrasound-based shear wave elastography (SWE) is a non-invasive tool to diagnose and monitor liver fibrosis. We sought to determine whether the degree of hemodynamic derangement prior to and after the Fontan operation is associated with increased liver stiffness measured by SWE.</p><p><strong>Methods: </strong>A single-center retrospective study of patients with Fontan circulation who underwent ultrasound elastography between 2008 and 2024 was conducted. Liver stiffness was measured by SWE and reported as velocity in m/s. Hemodynamic assessment with cardiac catheterization and echocardiograms were collected before and after the Fontan operation. Data was analyzed as a continuous (linear regression model) and a dichotomous variable (<i>t</i>-test).</p><p><strong>Results: </strong>78 post-Fontan ultrasound elastography studies performed in 56 patients were analyzed. Pre-Fontan hemodynamics included median effective pulmonary flow of 2.45 L/min/m² [2.21, 3.16] (<i>p</i> = 0.46), ventricular end-diastolic pressure of 10 mmHg [8, 10.5] (<i>p</i> = 0.77), and median Glenn pressure of 12 mmHg [13, 15] (<i>p</i> = 0.83). Post-Fontan median systemic cardiac index was 2.80 L/min/m² [2.4, 3.34] (<i>p</i> = 0.93), median ventricular end-diastolic pressure of 12 mmHg [13.5, 14] (<i>p</i> = 0.99), median systemic saturation of 93% [87, 96] (<i>p</i> = 0.77), median indexed pulmonary vascular resistance of 1.80 WU·m² [1.49, 2.37] (<i>p</i> = 0.93), and median Fontan pressure of 18 mmHg [16, 21] (<i>p</i> = 0.86). No correlation was found between SWE and hemodynamics. On echocardiography, no correlation was found between SWE and systemic ventricular systolic function (<i>p</i> = 0.35) or degree of systemic atrioventricular valve regurgitation (<i>p</i> = 0.35).</p><p><strong>Conclusions: </strong>The degree of liver stiffness by SWE in this cohort did not correlate with pre- and post-Fontan hemodynamics on cardiac catheterization, degree of ventricular dysfunction, or severity of atrioventricular valve regurgitation by echocardiography.</p>","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"20 2","pages":"265-272"},"PeriodicalIF":0.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaborating to Improve Outcomes in Congenital Heart Disease: The Pediatric Heart Network Experience.","authors":"Bryanna N Schwartz, Victoria L Pemberton, D'Andrea Freemon, Kristin M Burns, Gail D Pearson","doi":"10.32604/chd.2025.073995","DOIUrl":"10.32604/chd.2025.073995","url":null,"abstract":"<p><strong>Background: </strong>In the 1990s, there were few multicenter research collaborations and pediatric cardiovascular clinical trials. The National Heart, Lung, and Blood Institute at the National Institutes of Health established the Pediatric Heart Network (PHN) in 2001 to stimulate multi-center collaboration and clinical studies in children and adults with congenital heart disease (CHD) and pediatric acquired heart disease.</p><p><strong>Methods: </strong>The PHN developed a flexible infrastructure for multi-center collaborative clinical research in children and adults with CHD and pediatric acquired heart disease. The objectives of the PHN are to improve health outcomes in individuals of all ages with CHD and pediatric acquired heart disease, to disseminate findings to improve treatment options and standards of care, to train and educate new investigators, and to support families during the conduct of clinical research.</p><p><strong>Results: </strong>To date, the PHN has conducted 30 studies, including 13 clinical trials, across over 60 sites and has enrolled over 10,000 participants. PHN studies have impacted clinical practice and guidelines in CHD and have supported the career development of young investigators, research nurses, and study coordinators. None of this would have been possible without the many partnerships with patient advocacy organizations, the U.S. Food and Drug Administration, a variety of industry collaborators and clinical registries. PHN studies have leveraged registry data to improve efficiency, minimize burden and reduce errors in data collection.</p><p><strong>Conclusion: </strong>The PHN's success is due to fostering collaboration across pediatric cardiology centers, creating a clinical research infrastructure that can adapt to different types of studies, and emphasizing career development of young investigators and research coordinators. This paper will summarize the PHN's history, partnerships, use of clinical registries, future directions, and ways to get involved.</p>","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"20 6","pages":"637-646"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13322310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of congenital heart defects (CHD) with factors related to maternal health and pregnancy in newborns in Puerto Rico.","authors":"Yamixa Delgado, Caliani Gaytan, Naydi Perez, Eric Miranda, Bryan Colón Morales, Mónica Santos","doi":"10.32604/chd.2024.046339","DOIUrl":"10.32604/chd.2024.046339","url":null,"abstract":"<p><strong>Background: </strong>Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among BMI, pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development.</p><p><strong>Methods: </strong>Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI, pregestational diabetes, gestational diabetes, hypertension, history of abortion, and presence of preeclampsia.</p><p><strong>Results: </strong>A cohort of 673 patients was included in our study. The average maternal age was 26 years, within a range of 22 to 32 years. The mean gestational age measured 39 weeks, with a median span of 38 to 39 weeks. Of the 673 patients, 274 (41%) mothers gave birth to neonates diagnosed with CHD. Within this group, 22 cases were linked to pre-gestational diabetes, while 202 were not; 20 instances were associated with gestational diabetes, compared to 200 without; and 148 cases exhibited an overweight or obese BMI, whereas 126 displayed a normal BMI.</p><p><strong>Conclusion: </strong>We identified a statistically significant correlation between pre-gestational diabetes mellitus and the occurrence of CHD. However, our analysis did not show a statistically significant association between maternal BMI and the likelihood of CHD. These results may aid in developing effective strategies to prevent and manage CHD in neonates.</p>","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"19 1","pages":"19-31"},"PeriodicalIF":0.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11192526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation","authors":"Yuki Kawasaki, Takeshi Sasaki, Daisuke Kobayashi","doi":"10.32604/chd.2023.030910","DOIUrl":"https://doi.org/10.32604/chd.2023.030910","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135400718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classifying Cardiac Anomalies in Right and Left Isomerism: Concordant and Discordant Patterns","authors":"L. Oreto, G. Mandraffino, P. Ciliberti, Teresa P. Santangelo, P. Romeo, A. Celona, P. Gitto, L. Galletti, Fiore S. Iorio, Alfredo di Pino, A. Secinaro, P. Guccione, Robert H. Anderson, S. Agati","doi":"10.32604/chd.2022.023619","DOIUrl":"https://doi.org/10.32604/chd.2022.023619","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69719629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pentalogy of Cantrell with Pentalogy of Fallot and Left Ventricular Diverticulum","authors":"Weimin Zhang, Zheng Liu, Tao Zhu, Q. Huo","doi":"10.32604/chd.2023.026404","DOIUrl":"https://doi.org/10.32604/chd.2023.026404","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69719992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventricular Septal Crypts: Remnants of Spontaneous Interventricular Defect Closure?","authors":"A. Cresti, S. Sparla, S. Stefanelli, A. Picchi, U. Limbruno","doi":"10.32604/chd.2023.025639","DOIUrl":"https://doi.org/10.32604/chd.2023.025639","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69720271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life in Congenital Heart Disease Patients According to Their Anatomical and Physiological Classification","authors":"Efr閚 Mart韓ez-Quintana, Hiurma Estupi襻n-Le髇, Ana Beatriz Rojas-Brito, Liuva D閚iz-D閚iz, Alejandro Barreto-Mart韓, Fayna Rodr韌uez-Gonz醠ez","doi":"10.32604/chd.2021.013308","DOIUrl":"https://doi.org/10.32604/chd.2021.013308","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69713592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Surgery with Cardiopulmonary Bypass in Low-Weight or Preterm Neonates: A Retrospective Study Analyzing Early Outcome","authors":"Alain J. Poncelet, Maureen Peers de Nieuwburgh, St閜hane Moniotte, G. de Beco, K. Carbonez, Jean E. Rubay, T. Detaille, L. Houtekie, M. Momeni","doi":"10.32604/chd.2023.022636","DOIUrl":"https://doi.org/10.32604/chd.2023.022636","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69719903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency Hybrid Correction in a Newborn with Critical Aortic Valve Stenosis with Acute Pulmonary Edema in the First Hour after Birth","authors":"V. Suvorov, V. Zaitsev, N. Pilyugov, O. Tereshenko, M. Komissarov","doi":"10.32604/chd.2023.025522","DOIUrl":"https://doi.org/10.32604/chd.2023.025522","url":null,"abstract":"","PeriodicalId":10666,"journal":{"name":"Congenital Heart Disease","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69720173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}