Contemporary Clinical Dentistry最新文献

{"title":"The Esthetics of the Nasolabial Fold and Age in the Elderly Via Eye-Tracking.","authors":"Orlando Motohiro Tanaka,&nbsp;Lorenzo Daroit Cavassin,&nbsp;Gil Guilherme Gasparello,&nbsp;Thiago Martins Meira,&nbsp;Caio Seiti Miyoshi,&nbsp;Giovani Ceron Hartmann","doi":"10.4103/ccd.ccd_539_21","DOIUrl":"10.4103/ccd.ccd_539_21","url":null,"abstract":"<p><strong>Background: </strong>Facial aging is associated with the loss of soft tissue fullness. Perioral signs of facial aging can add years to individuals' appearances and even affect their facial expressions in smiling and nonsmiling images.</p><p><strong>Aims: </strong>To evaluate the influence of the nasolabial fold on the visual perception of esthetics and age in the elderly, eye-tracking and a visual analog scale were used.</p><p><strong>Material and methods: </strong>This study applied a cross-sectional study using 40 laypeople. Facial images of an elderly woman were modified to include facial expression lines such as nasolabial folds and marionette lines with no folds, intermediate, and accentuated depths folds. Eye tracking was implemented to measure the average number of fixations. Heat maps and dot maps were generated using eye-tracking software. A visual analog scale of attractiveness and age perception questionnaire were also incorporated into the study. Statistical analysis was performed using a significance of (<i>P</i><0.05).</p><p><strong>Results: </strong>The majority of visual attention was paid to the eye and mouth areas. In the images with no folds, the right eye attracted a greater degree of fixation. In the images in which nasolabial folds were accentuated, the mouth area served as an area of high fixation. No statistical difference was observed between the groups in which smiling images were viewed. Nonsmiling images demonstrated significant differences between groups for variables including time until first fixation, complete fixation time, and number of fixations on the eyes and hemifaces. Old age and diminished attractiveness were associated with attenuated nasolabial folds, especially in nonsmiling images.</p><p><strong>Conclusion: </strong>The facial lines and expressions of elderly female individuals were assessed by laypeople using eye-tracking, showing that the deeper one's nasolabial folds, the more aged and less attractive one appears, especially in nonsmiling images. Smiling pictures were perceived to be more attractive and youthful; these perceptions should be considered in the search for improved esthetic results, whether in dental or facial esthetic treatments.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/6e/CCD-14-18.PMC10209770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Dentin Remineralization with Zinc Oxide and Calcium Fluoride Nanoparticles - An <i>In vitro</i> Study.","authors":"P Ahalya,&nbsp;K S Uloopi,&nbsp;C Vinay,&nbsp;Kakarla Sri RojaRamya,&nbsp;RamaKrishna Alla,&nbsp;P RangaRaju","doi":"10.4103/ccd.ccd_701_21","DOIUrl":"10.4103/ccd.ccd_701_21","url":null,"abstract":"<p><strong>Background: </strong>Partially demineralized dentin is remineralizable when mineral ions are made available in the near vicinity. Nanoparticles (NPs) have wide applications in remineralization process. Zinc promotes remineralization and has a synergistic effect when combined with fluoride. Hence, zinc oxide and calcium fluoride NPs were considered for dentin remineralization.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the remineralizing ability of zinc oxide and calcium fluoride NPs on demineralized dentin individually and in combined form.</p><p><strong>Settings and design: </strong>This was an <i>in vitro</i> study.</p><p><strong>Materials and methods: </strong>Forty-eight dentin disks were prepared from the crowns of 12 extracted human molars and were allocated into four groups of 12 each, i.e., Group I - nano zinc oxide (nZnO), Group II - nano calcium fluoride (nCaF₂), Group III - combined group (nZnO + nCaF₂), and Group IV - artificial saliva (AS, control group). The specimens were demineralized with 37% phosphoric acid and placed in the respective remineralizing solutions for 24 h and 1 month. Calcium (Ca) and phosphorous (P) uptake was measured using energy-dispersive X-ray spectrometry, and structural changes were analyzed using scanning electron microscopy (SEM).</p><p><strong>Statistical analysis: </strong>One-way analysis of variance, Student's <i>t</i>-test, and <i>post hoc</i> Tukey's test were used for statistical analysis.</p><p><strong>Results: </strong>At 1-month interval, all the groups showed an increase in Ca/P ratio, with highest being the combined group (4.24), followed by nCaF₂ (3.30), nZnO (1.71), and AS (1.31) groups, and these differences were statistically significant (<i>P</i> = 0.000). On SEM analysis of dentinal samples at 1 month, depositions were evident in intertubular regions, wherein the highest deposits were observed in the nZnO group, followed by nZnO + nCaF₂ and nCaF₂ groups.</p><p><strong>Conclusion: </strong>Dentin samples subjected to remineralization with aqueous solutions of nZnO and nCaF₂ showed an increase in calcium and phosphorous uptake and also dense granular depositions were evident in intertubular regions of dentin.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/a3/CCD-14-57.PMC10209774.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandibular Teeth as Predictors in Forensic Age Estimation: A Cone-Beam Computed Tomography-Based Pulp Volume Regression Study.","authors":"Akshay Rathore,&nbsp;Nidhi Puri,&nbsp;Balwinder Singh,&nbsp;Kirandeep Kaur,&nbsp;Bikramjeet Singh,&nbsp;Shivangi Singh","doi":"10.4103/ccd.ccd_508_21","DOIUrl":"10.4103/ccd.ccd_508_21","url":null,"abstract":"<p><strong>Background: </strong>Age estimation is integral to science of forensic odontology and plays an important role in human identification. Pulp volume estimation using cone-beam computed tomography (CBCT) to derive age can be very useful as it is noninvasive and can be applied on individuals of all ages.</p><p><strong>Aims and objectives: </strong>The study aimed to estimate the chronological age-based pulp and tooth volume (PTV) ratios in adults from Uttar Pradesh, India, using CBCT and voxel counting dental software.</p><p><strong>Materials and methods: </strong>Thirty-six CBCT scans were allocated into three Groups, I, II, and III (12 in each group) randomly to study the pulp volume of lateral incisor, canine, and first premolar, respectively. PTV was calculated by image segmentation method using Xelis Dental software. A correlation between chronological age with PTV was established using derived regression equations.</p><p><strong>Statistical analysis: </strong>All the data were subjected to statistical analysis using Statistical Package for Social Sciences version 16.0.</p><p><strong>Results: </strong>Estimated age and standard error were determined. Standard errors of estimates were 11.24 years (LI), 7.78 years (C), 9.89 years (PM) group, lowest being for canines. The estimated age was compared with the chronological age. The difference between the chronological age and the estimated age by the derived equation for the present study was statistically nonsignificant (<i>P</i> = 1.00).</p><p><strong>Conclusions: </strong>The results of the study show the feasibility of calculation of PTV ratios on CBCT to estimate the age for the set population with canine as the best predictor of age for the present study population.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/f2/CCD-14-11.PMC10209780.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraradicular Dentinal Changes Following Fiber Postremoval: Micro-computed Tomography Analysis","authors":"Nathalia Elissa M. Almeida, Fabiola Ormiga, Carolina O. Lima, Thais M. P. Santos, Ricardo T. Lopes, Patrícia de Andrade Risso","doi":"10.4103/ccd.ccd_484_22","DOIUrl":"https://doi.org/10.4103/ccd.ccd_484_22","url":null,"abstract":"Abstract Context: Excessive dentine wear during postremoval can occur due to the adhesion between the cement and the post. Aim: The aim is to evaluate dentine wear and microcrack occurrence following the removal of intraradicular fiberglass posts that were previously cemented with two types of resin cement. Methods: Distal roots ( n = 38) of lower molars were instrumented, filled, prepared for intraradicular postinstallation, and divided into two groups according to the cement used for the posts: RelyX ARC or RelyX U200. The posts were removed through abrasion using ultrasonic diamond tips, after which the degrees of dentine wear (volume/mm 3 ) and microcrack formation were assessed using microcomputed tomographic imaging. Statistical Analysis Used: The Mann–Whitney U ( P ≤ 0.05) and Chi-squared tests ( P ≤ 0.05) were used. Results: After the removal of the posts, no statistically significant difference in root canal volume or microcrack occurrence was observed between the groups ( P > 0.05). The procedure produced significant dentine wear regardless of the type of cement used ( P < 0.05). Conclusions: The removal of fiberglass posts caused extensive dentine wear but did not influence microcrack occurrence. The type of resin cement used did not affect the dentine loss or microcrack appearance that resulted from fiberglass postremoval.","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134981166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Eggshell Powder and Nano-Hydroxyapatite on the Surface Roughness and Microhardness of Bleached Enamel.","authors":"Shahinaz Nabil Hassan,&nbsp;Lamiaa Mahmoud Moharam","doi":"10.4103/ccd.ccd_590_21","DOIUrl":"10.4103/ccd.ccd_590_21","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to evaluate the remineralizing potential of prepared solutions of eggshell powder (ESP) and nano-hydroxyapatite (nHA) on the surface roughness and microhardness of bleached enamel.</p><p><strong>Materials and methods: </strong>Fifty bovine anterior teeth were selected and cleaned then bleached using a chemically activated in-office bleaching agent then the teeth were randomly allocated into five groups (<i>n</i> = 10) according to the tested remineralizing agents (10% ESP solution, 10% nHA solution, and MI Paste Plus) into; control, bleached, bleached + ESP solution, bleached + nHA solution, and bleached + MI Paste Plus groups. Then, the teeth were tested for surface roughness and microhardness of the bleached enamel, respectively.</p><p><strong>Results: </strong>There was a statistically significant difference in the surface roughness and microhardness values of the tested groups. The highest surface roughness mean value was found in bleached enamel group, while the least mean value was found in the control group. The highest mean microhardness value was found in the bleached enamel + ESP solution group, while the least mean value was found in the bleached enamel group.</p><p><strong>Conclusions: </strong>The application of the tested remineralizing agents following the bleaching procedure had improved the surface roughness and microhardness of the bleached enamel. ESP and nHA present promising and potent remineralizing agents.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/ee/CCD-14-62.PMC10209778.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometrics - Need to Look Beyond Numbers?","authors":"Girish Malleshappa Sogi","doi":"10.4103/ccd.ccd_99_23","DOIUrl":"10.4103/ccd.ccd_99_23","url":null,"abstract":"","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/d0/CCD-14-1.PMC10209777.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Evaluate and Compare the Effect of Various Surface Treatment Modalities on Shear Bond Strength of Composite to Polyetherketoneketone and SEM Analysis: An In vitro Study","authors":"Arushi Chopra, Roma Goswami, Deepesh Saxena, Anshul Trivedi","doi":"10.4103/ccd.ccd_420_22","DOIUrl":"https://doi.org/10.4103/ccd.ccd_420_22","url":null,"abstract":"Abstract Context: It is a challenge to bond resin materials with polyetherketoneketone (PEKK). To increase the bond strength, surface treatments using chemical adhesion, mechanical adhesion, or a combination of both can be used. Aims: The objective of the present study was to evaluate and compare the shear bond strength of PEKK to the composite resin after various surface treatments and to evaluate the fracture mode analyses. Materials and Methods: One hundred and twenty PEKK specimens were randomly divided into four groups ( n = 30) after three different surface treatments (95% sulfuric acid etching, airborne abrasion with 110 μm aluminum-oxide, and 99% acetone). With the help of polytetrafluorethylene tube, resin composite (3M ESPE) was bonded on all the specimens, thermocycled, and subjected to shear bond strength testing. Thereafter, 15 samples from each group were assessed for fracture mode analyses using a scanning electron microscope. Statistical Analysis Used: Mean, Standard deviation, one-way analysis of variance (ANOVA) f -test, post hoc Tukey’s test. Results: Statistical analysis using one-way ANOVA f -test revealed that the results were significant with a P < 0.05 with the maximum value obtained in the case of air abraded group and the minimum value obtained in the case of the untreated group. Adhesive failure mode was the most common among the air-abraded group. Conclusions: The mechanical surface treatment group (air abrasion) showed higher shear bond strength than the chemical surface treatment groups (sulfuric acid and acetone). The mixed-type fracture mode was most commonly noted in the air-abraded group.","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134981020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Strain and Insertion Torque of Mini-implants at 90° and 45° Angulations on a Bone Model using Three-Dimensional Finite Element Analysis.","authors":"Jes Xavier,&nbsp;K Sarika,&nbsp;V V Ajith,&nbsp;N K Sapna Varma","doi":"10.4103/ccd.ccd_725_21","DOIUrl":"10.4103/ccd.ccd_725_21","url":null,"abstract":"<p><strong>Background: </strong>Temporary anchorage devices or mini-implants have gained great attraction due to its capability to provide absolute anchorage, low cost, versatility, and can be loaded immediately after placement.</p><p><strong>Aims and objectives: </strong>The aim of this study is to use FEA analysis to assess the strain and insertion torque of mini-implants on a bone model at two distinct angulations of 45° and 90°.</p><p><strong>Materials and methods: </strong>A computer-aided three-dimensional (3-D) model representing alveolar bone and mini-implants were developed using ANSYS software. Computed tomography scan images of the implant and the alveolar bone were taken and exported in DICOM format for 3-D image processing. The thickness of the bone model is 1 mm. Ti6Al4V orthodontic single and double threaded mini-implants (L = 7 mm, D = 1.5 mm) were inclined at 45° and 90° on to the bone surface to measure the insertion torque and strain produced.</p><p><strong>Results: </strong>Maximum insertion torque (MIT) for single-threaded mini implant at 45° and 90° angulations are 20.001 Nmm and 19.977 Nmm, respectively. MIT for double-threaded mini-implants obtained is 19.977 Nmm at 90° and 19.991 Nmm at 45° angulation. The strain of the bone at 90° angulation for single-threaded mini-implant is 0.00893 mm and for single-threaded mini implant at 45° angulation is 0.01257 mm. The strain in double-threaded mini-implant at 90° angulation is 0.0125 mm and that of 45° angulation is 0.01773 mm.</p><p><strong>Conclusion: </strong>For maximum stability single-threaded mini-implant with perpendicular insertion, angle is preferred.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/62/CCD-14-25.PMC10209767.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Fibrin Network Formation after Root Conditioning using Erbium, Chromium-Doped Yttrium Scandium Gallium and Garnet Laser, Ethylene-Diamine-Tetra-Acetic Acid, and Tetracycline on Dentin: A Scanning Electron Microscopic Study.","authors":"Riya Liza Satish,&nbsp;Maya Rajan Peter,&nbsp;Anuradha Bhaskar,&nbsp;Rajesh Vylopillil,&nbsp;Biju Balakrishnan,&nbsp;Reshma Suresh","doi":"10.4103/ccd.ccd_626_21","DOIUrl":"10.4103/ccd.ccd_626_21","url":null,"abstract":"<p><strong>Context: </strong>Regeneration of periodontal tissues depend on the adhesion and development of fibrin clots to the root surface. Demineralization of the root surface ensures removal of smear layer uncovering dentin tubules and collagen matrix. Root conditioning agents were introduced to remove the smear layer and enhance the adhesion of blood components.</p><p><strong>Aims: </strong>The aim of the study was to determine the effect of erbium, chromium-doped yttrium, scandium, gallium and garnet (Er, Cr: YSGG) laser on smear layer removal (SLR) and fibrin network formation when compared to tetracycline, and ethylene-diamine-tetra-acetic acid (EDTA) for periodontal regeneration.</p><p><strong>Settings and design: </strong>The study was conducted at Amrita school of dentistry and the study design involves <i>in vitro</i> comparative study.</p><p><strong>Subjects and methods: </strong>Forty dentinal sections were prepared from freshly extracted teeth that were periodontally affected. The samples were divided into four groups: Scaling and root planing (SRP), tetracycline, EDTA, and Er, Cr: YSGG laser. The samples were assessed using a scanning electron microscope and photomicrographs were taken and analyzed for removal of smear layer, blood component adhesion (BCA), and fibrin network formation.</p><p><strong>Statistical analysis used: </strong>Analysis of variance test and Kruskal-Wallis test with <i>P</i> < 0.05 considered to be statistically significant.</p><p><strong>Results: </strong>There was a significant difference between Er, Cr: YSGG laser, tetracycline hydrochloride, and EDTA categories when compared with SRP categories. There was no significant difference between Er, Cr: YSGG laser, tetracycline, and EDTA according to SLR scoring and BCA scoring.</p><p><strong>Conclusions: </strong>It can be concluded that Er, Cr: YSGG laser-treated samples presented complete elimination of smear layer, formation of fibrin network, and BCA along with desensitizing effect for a better reduction in dentin hypersensitivity.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/f1/CCD-14-72.PMC10209766.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9900215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of α-Mangostin on Interleukin-11 and Runt-related Transcription Factor-2 Gene Expression on Cell Line Osteoblast Cultures Induced with Lipopolysaccharide.","authors":"Ivan Tantra,&nbsp;Andra Rizqiawan,&nbsp;Ni Putu Mira Sumarta,&nbsp;David Buntoro Kamadjaja,&nbsp;Pratiwi Soesilowati,&nbsp;Mohammad Zeshaan Rahman,&nbsp;Coen Pramono","doi":"10.4103/ccd.ccd_723_21","DOIUrl":"10.4103/ccd.ccd_723_21","url":null,"abstract":"<p><strong>Background: </strong>Loss of permanent teeth after tooth extraction without replacement of missing teeth can result in impaired masticatory, esthetic, phonetic functions, and impaired balance of the masticatory organ in the mouth. Therefore, a method is needed to inhibit the alveolar bone resorption process so that the dimensions of the tooth socket can be maintained vertically or horizontally until the time of implant placement, which is called the socket preservation procedure. α-mangostin is known to have a potential anti-inflammatory effect and most likely can be used as a potential therapeutic agent to inhibit bone resorption caused by posttooth extraction inflammatory processes.</p><p><strong>Aims: </strong>The aim of the study was to determine the effect on the inflammatory process and osteogenesis on osteoblast cell line culture by induction with lipopolysaccharide (LPS) and α-mangostin.</p><p><strong>Materials and methods: </strong>This was an <i>in vitro</i> laboratory experimental study on mouse osteoblast cell line culture. The treatment was given with LPS, α-mangostin, and combination on osteogenic medium, using the same concentration for all concentrates. The sample will then be processed and analyzed using the real-time polymerase chain reaction.</p><p><strong>Results: </strong>The highest interleukin-11 (IL-11) gene expression was found in α-mangostin treatment, but there was no significant difference in IL-11 expression between the study groups. The highest runt-related transcription factor-2 (RUNX-2) gene expression was found in a group that received induction with LPS and α-mangostin, and from these results, it was found that there was a significant difference in RUNX-2 expression between the study groups.</p><p><strong>Conclusions: </strong>LPS and α-mangostin can increase osteogenesis in osteoblast cell culture in the osteogenic medium.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/37/CCD-14-68.PMC10209769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9545663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}