Contemporary Clinical Dentistry最新文献

{"title":"Quantitative Assessment of Receptors of Advanced Glycation End Products Expression in Tissue Samples from Patients with oral Submucous Fibrosis, Leukoplakia, and Oral Squamous Cell Carcinoma.","authors":"Palati Sinduja, Pratibha Ramani, Saravanan Sekaran","doi":"10.4103/ccd.ccd_427_23","DOIUrl":"10.4103/ccd.ccd_427_23","url":null,"abstract":"<p><strong>Background and aim: </strong>Oxidative stress markers have been firmly established as elevated in oral squamous cell carcinomas (OSCCs). These markers play a crucial role in the pathogenic mechanism underlying the accumulation of advanced glycation end products (AGEs) and their respective receptors. The primary objective of this study is to discern and compare the levels of receptors of AGEs (RAGEs) within tissue samples from patients diagnosed with oral submucous fibrosis (OSMF) at varying stages, oral leukoplakia at various stages, and OSCC.</p><p><strong>Materials and methods: </strong>A cross-sectional investigation was conducted, enrolling a total of 49 patients, distributed across three distinct groups. Tissue samples were meticulously collected from the aforementioned patient groups. Subsequently, these samples underwent a process of homogenization and centrifugation. The supernatant obtained was subjected to enzyme-linked immunosorbent assay analysis to precisely determine the concentration of RAGE.</p><p><strong>Results: </strong>The concentration of RAGEs was found to be significantly higher at various stages of OSMF when compared to the reference group of OSCC (<i>P</i> < 0.05). This difference was statistically significant, indicating a substantial association. In contrast, the levels of RAGE in patients with hyperkeratosis accompanied by epithelial dysplasia at various stages were observed to be lower than those in the OSCC group, with the difference in concentration being statistically insignificant (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>This comprehensive study has provided compelling evidence demonstrating the heightened levels of RAGE in OSMF when compared to OSCC. These findings collectively suggest the potential utility of anti-RAGE interventions as a promising avenue for novel therapeutic strategies in potentially malignant disorders such as OSMF.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"71-76"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of an Extraoral Suction Apparatus on Reduction of Splatter Contamination during Impacted Lower Third Molar Surgical Procedure: An Observational Study.","authors":"Surya Karthikeyan, Ravi Veeraraghavan, Jaeson Mohanan Painatt, Girisankar Manimangalath, Krishnaa Vijayan","doi":"10.4103/ccd.ccd_305_23","DOIUrl":"10.4103/ccd.ccd_305_23","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has affected the delivery of dental care globally. Air contamination during aerosol and splatter-generating procedures is of great concern to dental healthcare provider during these times. Extra oral suction (EOS) apparatus has been shown to be effective in preventing infection by control of aerosol. But very limited data is available regarding the efficacy of the apparatus in preventing splatter contamination.</p><p><strong>Objectives of the study: </strong>To assess the efficacy of EOS apparatus in reducing frequency and mean intensity of splatter contamination at clinician, assistant, patient sites during lower third molar surgical procedures.</p><p><strong>Materials and methods: </strong>Patients who required surgical removal of an impacted lower third molar were divided into two groups (EOS and non-EOS) with 20 patients each. Universal indicating paper (UIP) was placed in specific locations on the surgeon, patient, and assistant. Colour changes after the settling of splatter on the UIP were analyzed to calculate the percentage intensity of splatter contamination.</p><p><strong>Results: </strong>The use of an EOS device has shown an overall reduction in the total number of contaminated sites, with a difference of 6.36%. Surgeon, patient, and assistant sites showed reductions of 6.25, 10%, and 1.66%, respectively. The apparatus has showed statistically significant reduction of splatter frequency and intensity at the patient's chest and left shoulder regions respectively, during surgical removal of the impacted 48.</p><p><strong>Conclusion: </strong>The magnitude of splatter contamination during minor dentoalveolar surgical procedures is inevitable. Therefore, to achieve a better working environment, usage of an EOS apparatus is advocated.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"113-117"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome Assessment of Three Different Methods of Root-end Preparation and Filling Materials in Endodontic Surgery: A Comparative Clinical Prospective Study.","authors":"Ibadat P Kaur, Renu B Sroa, Monalisa Debbarma, Sinha Pallawi, Ashok Kumar","doi":"10.4103/ccd.ccd_570_23","DOIUrl":"10.4103/ccd.ccd_570_23","url":null,"abstract":"<p><strong>Introduction: </strong>The technique of endodontic surgery had evolved tremendously in the recent years with introduction of new instruments and materials.</p><p><strong>Aim: </strong>This study aims to compare the clinical outcome of endodontic microsurgery using three different techniques with three different root-end filling materials for 16 months.</p><p><strong>Materials and methods: </strong>A total of 45 maxillary incisors indicated for root-end surgery were selected for the study. They were enrolled into three groups, i.e. Group A (traditional [TRS]/heat burnished gutta-percha), Group B (concave [CON]/Retroplast), and Group C (cavity/DiaRoot BioAggregate), of 15 teeth each. The clinical and radiographic outcome was recorded at 1, 6, 12, and 16 months using various criteria.</p><p><strong>Statistical analysis: </strong>The data were analyzed by one-way analysis of variance and Tukey's <i>post</i> <i>hoc</i> test using SPSS V. 21 software (IBM Corp., Somers, NY, USA).</p><p><strong>Results: </strong>All patients had uneventful healing at the final follow-up. Radiological intratime analysis concluded a highly high significant (<i>P</i> < 0.0001) decrease in the size of radiolucency between the three groups at the third recall visit. Intertime analysis recorded no significant decrease in radiolucency between Groups A and B, a significant decrease in B and C, and a highly significant decrease between Groups A and C at 12 months.</p><p><strong>Conclusions: </strong>There was no significant difference in the clinical outcome after endodontic surgery when comparing TRS/heat burnished gutta-percha, CON/Retroplast, and cavity/DiaRoot BioAggregate techniques at 16 months. However, cavity/DiaRoot BioAggregate resulted in significantly rapid and predictable healing at 12 months.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 2","pages":"77-83"},"PeriodicalIF":0.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Urinary Metabolomics as Biomarkers in Tobacco Users: A Systematic Review.","authors":"Somya Sharma, Shalu Rai, Deepankar Misra, Akansha Misra, Shalini Sharma, Anusuya Sharma, Manish Singh Prayasi","doi":"10.4103/ccd.ccd_23_21","DOIUrl":"https://doi.org/10.4103/ccd.ccd_23_21","url":null,"abstract":"<p><strong>Aim: </strong>Urine as a biofluid has been rarely used as a diagnostic fluid in oral diseases. The article aims to systematically review the utility of human urinary carcinogen metabolites as an approach for obtaining important information about tobacco and cancer.</p><p><strong>Materials and methods: </strong>The following article reviews the use of urine and its metabolites as biomarkers in various lesions of the oral cavity including oral squamous cell carcinoma and as a screening method in evaluating tobacco and its components. A bibliographic comprehensive search was carried out in the main databases: PUBMED, SciELO, Google Scholar, VHL, and LILACS for articles that were published from 1985 to 2020. The inclusion criteria were \"urinary metabolites,\" \"oral cancer/HNSCC,\" \"body fluids,\" \"tobacco,\" and \"metabolomics.\" A total of 55 articles were collected which included laboratory studies, systematic reviews, and literature of urinary metabolites in tobacco users.</p><p><strong>Results: </strong>Most of the studies carried out show accurate results with high sensitivity of urinary metabolite biomarkers in individuals with tobacco-based habits and lesions caused by them.</p><p><strong>Conclusion: </strong>The review indicates that urinary metabolite analysis demonstrates its applicability for the diagnosis and prognosis of disease. Urine is a remarkable and useful biofluid for routine testing and provides an excellent resource for the discovery of novel biomarkers, with an advantage over tissue biopsy samples due to the ease and less invasive nature of collection.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"3-9"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Mini Implant Assisted Rapid Palatal Expansion (MARPE) Designs on Maxillary Protraction in Skeletal Class III malocclusion: An FEM Study.","authors":"Ashik Suresh, Ajith Vallikat Velath, K Sarika, Rahul Damodaran Prabha, N K Sapna Varma","doi":"10.4103/ccd.ccd_428_23","DOIUrl":"https://doi.org/10.4103/ccd.ccd_428_23","url":null,"abstract":"<p><strong>Background: </strong>Four different designs of mini-implant-assisted rapid palatal expansion (MARPE) and protraction in nasomaxillary complex and mid-palatal sutures in late adolescent skeletal Class III malocclusion were compared using a three-dimensional finite element analysis.</p><p><strong>Methods: </strong>A finite element model of skull and related sutures was constructed using the computed tomography scan of a 16-year-old female patient with skeletal Class III and ANB of -2°. Four appliance designs: Type I: MARPE with palatal force, Type II: MARPE with buccal force, Type III: Hybrid hyrax with palatal force, and Type IV: Hybrid hyrax with buccal force. Protraction vectors were and analyzed using Ansys software (ANSYS 2021 R2). The displacement pattern of the nasomaxillary structures and the stress distribution in the sutures were examined in all four appliance designs.</p><p><strong>Results: </strong>All the appliance designs resulted in a forward movement of the maxilla, while Type I and III, which used palatal protraction force, caused the greatest forward displacement. In Type I, II, and III, along with forward movement, a clockwise rotation of maxilla was observed, while in Type IV, an anticlockwise rotation of maxilla was observed. Type I, II, and III resulted in higher stress distribution around the superior structures, while Type IV resulted in less stress distribution around the superior structures of maxilla.</p><p><strong>Conclusion: </strong>The forward displacement was enhanced when palatal plates were used to protract the maxilla. The effective appliance design for skeletal class III with open bite case was Type I, II, and III and Type IV for deep bite cases.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"27-34"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap between Endodontic Failure and Success: A Case Report on Intentional Replantation.","authors":"Gaurav Kumar, Krishna Prasad Biswas, Navin Mishra","doi":"10.4103/ccd.ccd_134_23","DOIUrl":"https://doi.org/10.4103/ccd.ccd_134_23","url":null,"abstract":"<p><p>This case report describes a case of intention replantation in a 15-year-old patient with a mandibular permanent right second molar that had undergone root canal treatment previously. The tooth was tender on percussion. Radiographic evaluation showed the presence of a separated instrument and periapical radiolucency. The surgical procedure was performed under local anesthesia, and the tooth was extracted. After cleaning and disinfecting the root canal system, the tooth was reimplanted, and the socket was filled with a mixture of bone graft material and a growth factor. A stainless steel crown was then placed to protect the tooth. A follow-up examination was performed after 12 months. The clinical and radiographic examinations revealed a well-healing periapical lesion with no signs of infection. The patient was asymptomatic, and the tooth was functional. The results of this case indicate that intentional replantation can lead to a favorable outcome.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"67-70"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Pediatric Buccal Fat Pad Herniation: A Report of Two Cases.","authors":"Divya Sharma, Jaspreet Kaur Deo, Akanshya Loshali, Pravesh Nath Mehra","doi":"10.4103/ccd.ccd_392_23","DOIUrl":"https://doi.org/10.4103/ccd.ccd_392_23","url":null,"abstract":"<p><p>The buccal fat pad (BFP) is a specialized encapsulated adipose tissue, located intimately between the buccinator muscle and oral mucous membrane. A small perforation of buccinator muscle can lead to herniation of BFP into the oral cavity, which can be readily mistaken with a pathological entity. In general, the size of herniated BFP is larger than the perforation. The treatment options for BFP are excision or repositioning in its anatomical position if noticed early. This article reports two such cases presenting with herniation of the BFP, following trauma to buccal mucosa and its surgical management.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"58-60"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Nano-hydroxyapatite Toothpaste on Enamel Erosive Lesions of Third Molars Induced by Exposure to Orange Juice.","authors":"Marzieh Mehrjoo, Roza Haghgoo, Motahare Ahmadvand","doi":"10.4103/ccd.ccd_104_23","DOIUrl":"https://doi.org/10.4103/ccd.ccd_104_23","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the effect of a nano-hydroxyapatite (nano-HA) toothpaste on erosive enamel lesions of third molars induced by exposure to orange juice.</p><p><strong>Materials and methods: </strong>In this <i>in vitro</i>, experimental study, the microhardness of 24 sound-extracted third molars was measured by a Vickers tester. The teeth were then randomly assigned to three groups (<i>n</i> = 8) of nano-HA toothpaste (Pharmed), 1.23% sodium fluoride gel, and artificial saliva. The teeth were exposed to orange juice for 5 min daily for 7 days and were then exposed to nano-HA toothpaste, fluoride gel, or artificial saliva (depending on their group allocation) for 10 min a day. The microhardness of the teeth was measured again after 7 days. Data were analyzed using paired <i>t</i>-test, analysis of variance, and Bonferroni test (alpha = 0.05).</p><p><strong>Results: </strong>Within-group comparisons showed a significant reduction in microhardness of the teeth after the intervention in artificial saliva (<i>P</i> = 0.000), and fluoride gel (<i>P</i> = 0.002) groups. However, no significant reduction occurred in the microhardness of the nano-HA group, compared with the baseline (<i>P</i> = 0.132). Between-group comparisons revealed no significant difference in the microhardness of the three groups at baseline (<i>P</i> > 0.05). However, after the intervention, the microhardness of the nano-HA group was significantly higher than that of other groups (<i>P</i> < 0.05). However, the difference in secondary microhardness between fluoride gel and artificial saliva groups was not significant (<i>P</i> = 1.00).</p><p><strong>Conclusion: </strong>Pharmed toothpaste containing nano-HA has optimal efficacy for remineralization of enamel erosive lesions induced by exposure to orange juice.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"17-21"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Color Stability of Three Resin-Ceramic Materials Using a Spectrophotometer and a Digital Photography Software.","authors":"Nicolas Naffah, Hani Ounsi, Mutlu Ozcan, Ziad Salameh","doi":"10.4103/ccd.ccd_656_18","DOIUrl":"https://doi.org/10.4103/ccd.ccd_656_18","url":null,"abstract":"<p><strong>Background: </strong>Computer-aided design/computer-aided manufacturing (CAD/CAM) resin ceramics allow easier milling than glass ceramics but are suspected to be more stainable. Although Photoshop^® is widely used for picture analysis, its potential for shade selection has not been properly assessed.</p><p><strong>Aim: </strong>Purpose primary: To evaluate the color stability of three CAD/CAM resin ceramics and Lithium Disilicate. Secondary: to compare the color evaluation between a spectrophotometer (Vita Easyshade compact) and Photoshop software.</p><p><strong>Materials and methods: </strong>Three CAD/CAM resin ceramic materials (<i>n</i> = 10) and a fourth group of lithium disilicate were used. Half of each group were thermocycled (5°C and 55°C; 3000 cycles). All samples were immersed in colored beverages (coffee, tea and red wine) for 30 days. Values were obtained by spectrophotometry and photographs analyzed using Photoshop software. The parameters measured were CIEL*a*b, and the color difference (ΔE) was analyzed. A mixed model test was used to compare the results through time and materials (α = 0.05). The comparison between the spectrophotometer and Photoshop results was performed using the bivariate Pearson's correlation test.</p><p><strong>Results: </strong>Lithium disilicate glass ceramic exhibited less color change (ΔE = 14) than resin ceramics (15.7 < ΔE < 18.7). The least change was noted with GC Cerasmart (ΔE = 15.7) followed by Vita Enamic (ΔE = 17*) and Brilliant Crios (ΔE = 18.7*). Spectrophotometer and Photoshop values showed low correlations.</p><p><strong>Conclusions: </strong>Resin ceramics may suffer from color change in clinical use. Photoshop is technique sensitive; pictures are easily affected by the light conditions and camera settings.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"44-50"},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Probiotics for Dental Caries in Preschool Children: A Systematic Review and Meta-analysis.","authors":"Aarati S Panchbhai, Mahalaqua Nazli Khatib, Rajiv M Borle, Shravani S Deolia, Vijay M Babar, Anjali H Vasistha, Ritika P Parida","doi":"10.4103/ccd.ccd_40_23","DOIUrl":"10.4103/ccd.ccd_40_23","url":null,"abstract":"<p><strong>Background: </strong>Early childhood caries is one of the most serious and high-priced oral health conditions among young children. With advancing dental sciences, the focus of dental caries treatment is shifted from restorative procedures to preventive measures, and a modality grabbing attention is probiotics. Probiotics exert their effects in many ways as chemical inhibition of pathogenic bacteria and stimulation of the immune response through the production of immunoglobulin A and many more.</p><p><strong>Objective: </strong>This systematic review aims to explore the efficacy and safety of probiotics in dental caries in preschool children.</p><p><strong>Methodology: </strong>The study was registered in the PROSPERO International Prospective Register of Systematic Reviews (registration number: CRD42020159058). The search was done for randomized control trials in electronic databases such as Cochrane, PubMed, ClinicalTrials.gov, Medline, and Embase. It has further included manual searches of journals, conference abstracts, and books. Three reviewers done the selection of the study as per the criteria and also did the risk of bias assessment independently and wherever required, a fourth reviewer resolved the discrepancy in case of disagreement.</p><p><strong>Results: </strong>The nine randomized control trials were included in the study, and the pooled analysis revealed probiotics as an effective intervention in preschool children with dental caries.</p><p><strong>Conclusion: </strong>The results about the efficacy of probiotics in the prevention of dental caries are very encouraging, though the level of evidence is still inadequate.</p>","PeriodicalId":10632,"journal":{"name":"Contemporary Clinical Dentistry","volume":"15 1","pages":"10-16"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11068249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}