Comptes Rendus Chimie最新文献

{"title":"Essential oils and molecular chirality","authors":"","doi":"10.5802/crchim.130-en","DOIUrl":"https://doi.org/10.5802/crchim.130-en","url":null,"abstract":"La chiralité moléculaire est une propriété de la nature et de la vie, elle est présente à toutes les échelles de grandeur. Un aspect fondamental des molécules qui est généralement négligé de l’aromathérapie scientifique pourtant basée sur l’utilisation de la chimie des groupes fonctionnels. Cette mise au point tente d’apporter de l’information sur la stéréochimie moléculaire dans la composition des huiles essentielles (HE) et son impact sur leurs activités biologiques. Des notions de stéréochimie sont introduites et un nouvel éclairage est apporté avec de nombreux exemples sur les principales molécules composant les HE. L’importance du profil énantiomérique des HE est démontrée avec une évaluation plus précise des conséquences sur leurs propriétés biologiques. Molecular chirality is a property of the nature and life, it is present everywhere and at all scales of magnitude. A fundamental aspect of molecules that is generally overlooked in scientific aromatherapy yet based on the use of the chemistry of functional groups. This update attempts to provide information on molecular stereochemistry in the composition of essential oils and its impact on their biological activities. Notions of stereochemistry are introduced and new light is shed with numerous examples on the main molecules making up EO. The importance of the enantiomeric profile of EOs is shown with a more precise evaluation of the consequences on their biological properties.","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"110 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135136509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Louis Pasteur, from physical chemistry to biology","authors":"","doi":"10.5802/crchim.179-en","DOIUrl":"https://doi.org/10.5802/crchim.179-en","url":null,"abstract":"Louis Pasteur commença ses travaux de recherche scientifique par des études de cristallographie, qui le conduisirent à distinguer différentes formes d’acides tartriques et de tartrates. Sa nomination à l’université de Lille, dans un environnement industriel qui lui fit étudier les alcools amyliques, contribua à réorienter son activité scientifique, mais il restait surtout mu par son hypothèse selon laquelle la « dissymétrie optique » était l’apanage du vivant. Butant sur l’inactivité optique de certains composés organiques, il abandonna progressivement une recherche pour laquelle manquaient des concepts chimiques qui ne furent élaborés que plus tard, par d’autres, pour étudier des fermentations, avant d’aller explorer les micro-organismes qui causaient ces dernières. Louis Pasteur began his scientific research with crystallographic studies, which led him to distinguish different forms of tartaric acids and tartarates. His appointment to the University of Lille, in an industrial environment that led him to study amyl alcohols, helped to reorient his scientific activity, but he remained mainly driven by his hypothesis that “molecular dissymmetry” was the prerogative of the living. Stumbling on the optical inactivity of certain organic compounds, he progressively abandoned a research for which chemical concepts were missing and which were only elaborated later, by others, to study fermentation, before going to explore the micro-organisms which caused them.","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"5 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135680042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How the element names reveal their history","authors":"","doi":"10.5802/crchim.21-en","DOIUrl":"https://doi.org/10.5802/crchim.21-en","url":null,"abstract":"","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"98 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135584433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Aβ) species: a structure–activity relationship","authors":"Margot Lefèvre, Lielou Lantigner, Laura Andolfo, Corinne Vanucci-Bacqué, Eric Benoist, Charlène Esmieu, Florence Bedos-Belval, Christelle Hureau","doi":"10.5802/crchim.255","DOIUrl":"https://doi.org/10.5802/crchim.255","url":null,"abstract":"","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"19 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135871022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermediate pyrolysis of Ficus nitida wood in a fixed-bed reactor: effect of pyrolysis parameters on bio-oil and bio-char yields and properties","authors":"Amine Tabal, Oumayma Belyazid, Hicham Dahman, Emna Berrich, Mejdi Jeguirim, Mounir El Achaby, Khalifa El Harfi, Adil Aboulkas","doi":"10.5802/crchim.253","DOIUrl":"https://doi.org/10.5802/crchim.253","url":null,"abstract":"","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"179 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane","authors":"Emilie Lesur, Paulin Rollando, Dominique Guianvarc’h, Yann Bourdreux","doi":"10.5802/crchim.246","DOIUrl":"https://doi.org/10.5802/crchim.246","url":null,"abstract":"Corynebacteriales including the causative agent of many diseases such as tuberculosis are known to be extremely resistant against external stress as well as to antibiotic treatments which is believed to be related to the singular architecture of their mycomembrane. Over the last decades, both bioorthogonal chemical reporters and fluorescent probes for the metabolic labeling of bacterial cell glycans were developed including several trehalose-based probes to study the dynamics of mycomembrane components. This review presents an exhaustive view on the reported syntheses of trehalose-based probes enabling the study of the mycomembrane biogenesis. Les Corynebacteriales sont des bactéries, dont certaines sont responsables de maladies infectieuses telle que la tuberculose, connues pour être extrêmement résistantes aux stress externes et aux traitements antibiotiques. Cette résistance est due à l’architecture particulière de leur membrane externe, la mycomembrane. Depuis plusieurs années des sondes fluorescentes et des rapporteurs chimiques ont été développés pour la marquage métabolique de biomolécules dans leur environnement cellulaire. Ces outils incluent des dérivés à base de tréhalose pour l’étude de la mycomembrane. Cette revue présente les syntèses d’outils chimiques à base de tréhalose décrits pour étudier la biogenèse de la mycomembrane.","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135779052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1.4 nm gold nanoparticle-antibody conjugates for in situ gold immunolabelling after transduction into living human cells","authors":"Nadja Groysbeck, Anne Marie Haeberlé, Stéphane Ory, Victor Hanss, Mikhael Eltsov, Patrick Schultz, Guy Zuber","doi":"10.5802/crchim.251","DOIUrl":"https://doi.org/10.5802/crchim.251","url":null,"abstract":"Despite advances in Electron Microscopy (EM) that enable to image protein assemblies within vitreous sections of cells at nearly atomic resolution, labelling is still necessary to locate small proteins or rare complexes. Gold immunolabelling has been used for decades to localise specific proteins within cellular sections. However, current gold particle-antibody conjugates are not built with enough chemical precision to match the current resolution offered by cryo-EM methodology. Furthermore, as a close to native specimen state can only be achieved by strict preservation of a frozen hydrated state, it is required to deliver gold labelling agents into living cells prior to their vitrification. Several 1.4 nm gold nanoparticle-antibody conjugates were synthesised. Their abilities to bind to and label their corresponding epitopes within living cells after cytosolic delivery by electroporation are documented here. Supplementary Materials: Supplementary material for this article is supplied as a separate file: crchim-251-suppl.pdf Les progrès de la microscopie électronique (ME) en conditions cryogéniques permettent d’imager les assemblages de protéines à une résolution quasi atomique. L’immunomarquage à l’or est utilisé depuis des décennies pour localiser des protéines spécifiques dans des sections cellulaires, mais les sondes actuelles à base d’or et d’anticorps ne sont plus adaptées aux exigences de la cryo-EM. Le maintien de l’état hydraté congelé de l’échantillon et la stricte exclusion de la réticulation chimique ou des réactifs de contraste exigent que les agents de marquage à l’or soient délivrés dans les cellules vivantes avant leur vitrification. Plusieurs conjugués nanoparticules d’or-anticorps de 1,4 nm ont été synthétisés. Leur capacité à se lier à leurs épitopes correspondants et à les marquer dans des cellules vivantes après livraison cytosolique est documentée ici. Compléments : Des compléments sont fournis pour cet article dans le fichier séparé : crchim-251-suppl.pdf","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135883268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA","authors":"Jérôme Dejeu, Eric Defrancq","doi":"10.5802/crchim.256","DOIUrl":"https://doi.org/10.5802/crchim.256","url":null,"abstract":"Tetrameric DNA structures such as G-quadruplex (G4) and i-motif (i-DNA) have attracted increasing interest in the last decades. They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. This review reports on our works over the past decade. Les structures d’ADN tétramériques telles que le G-quadruplex (G4) et le i-motif (i-DNA) ont suscité un intérêt croissant au cours des dernières décennies. Elles sont en effet impliquées dans de nombreux processus biologiques dont la régulation de la traduction, le traitement des pré-ARNm, le ciblage des ARNm, la maintenance des télomères, etc. Nous avons développé des outils chimiques nommés TASQ (Template-Assembled Synthetic Quadruplex) pour répondre aux objectifs scientifiques suivants : (i) identifier des ligands interagissant sans ambiguïté (c’est-à-dire affins et spécifiques) avec l’ADN G-quadruplex ou l’ADN i-motif, (ii) identifier les protéines interagissant avec ces structures et déterminer leur pertinence cellulaire et (iii) sélectionner des anticorps spécifiques pour le G4 et l’i-ADN. Cette revue rend compte de nos travaux au cours de la dernière décennie.","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135591880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean island endemic Arum pictum emits isomyocorene as a major component of floral scent","authors":"Marc Gibernau, Arianna Amadori, Adrienne Godschalx, Jérôme Albre, Félix Tomi, Paolo Marcia, Emmanuele Farris","doi":"10.5802/crchim.236","DOIUrl":"https://doi.org/10.5802/crchim.236","url":null,"abstract":"","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135013968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of the effect of microtubule-targeting drugs on the microtubule cytoskeleton of breast cancer cells with different invasive properties","authors":"Sophie Michallet, Lauriane Bosc, Laurence Lafanechère","doi":"10.5802/crchim.247","DOIUrl":"https://doi.org/10.5802/crchim.247","url":null,"abstract":"The characterization of microtubule-targeting drugs at the cellular level is an essential step in the development of drugs targeting the microtubule network. To that aim, we have previously developed a quantitative cell-based assay easy to perform in microplates that requires only a luminescence reader and no microscopic analysis. Here, we show that this assay can be easily adapted to different breast cancer cell lines. An ideal application of this test could be the comparative analysis of the response of human tumor samples to different microtubule targeting drugs, to optimize therapeutic treatment. La caractérisation au niveau cellulaire des agents pharmacologiques ciblant les microtubules est une étape essentielle dans le développement de médicaments. Dans ce but, nous avons développé un test quantitatif cellulaire facile à réaliser en microplaques qui ne nécessite qu’un lecteur de luminescence et aucune analyse microscopique. Nous montrons ici que ce test peut être facilement adapté à différentes lignées cellulaires de cancer du sein. Une application idéale de ce test pourrait être l’analyse comparative de la réponse d’échantillons de tumeurs humaines à différents médicaments ciblant les microtubules, afin d’optimiser le traitement thérapeutique.","PeriodicalId":10577,"journal":{"name":"Comptes Rendus Chimie","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135060622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}