Clinical pharmacy最新文献

{"title":"Analysis of the main directions of therapeutic regimens for the treatment of helminthiases of the digestive system given in the new clinical treatment protocols","authors":"K. Semchenko, L. Vyshnevska","doi":"10.24959/cphj.20.1523","DOIUrl":"https://doi.org/10.24959/cphj.20.1523","url":null,"abstract":"The treatment of helminthiases of the digestive system is a socially significant problem that is urgent for many countries in the world, including Ukraine. Over the last 5 years, cases of enterobiosis, ascariasis and trichocephalosis have been reported most frequently in Ukraine. Therefore, it is advisable to update and implement the latest treatment protocols for the specified pathology.Aim. To analyze recommendations for the treatment of helminthiasis of the digestive system, which are given in the new clinical protocols, and identify the promising directions for saturation of the domestic pharmaceutical market with drugs that meet the needs of patients with this pathology.Materials and methods. The objects of the study were guidelines for the treatment of helminthiases of the digestive system in the open access on the website of the Ministry of Health of Ukraine, scientific publications of domestic and foreign authors and our own research. The methods of generalization, systematization of theoretical and practical material, bibliosemantic and systematic analysis were used in the work.Results. The study of recommendations for the treatment of enterobiosis, ascariasis, intestinal cestodes, strongyloidosis, nematodosis and trichocephalosis has shown that the drug of choice for the treatment of this group of diseases is albendazole, which is included in each treatment protocol. Mebendazole is recommended for use in all regimens, except for the treatment of strongyloidosis. Drugs of other pharmaceutical ingredients are recommended for administration in rare cases. The main types of the pharmacological activity and side effects of albendazole are given.Conclusions. The treatment regimens recommended for helminthiasis of the digestive system have been analyzed, and the substances, based on which the development of domestic anthelmintic drugs is rational, have been determined.","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"20 1","pages":"4-8"},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78053472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pharmacological substantiation of hyaluronic acid application in combined soft medicines in dentistry","authors":"D. Orlenko, D. Lytkin, A. Zagayko, V. Yakovenko","doi":"10.24959/cphj.20.1529","DOIUrl":"https://doi.org/10.24959/cphj.20.1529","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75996350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the range of antifungal drugs for systemic use and evidence-based clinical efficacy and safety of fluconazole","authors":"O. V. Tkachоva, T. Sheptak","doi":"10.24959/cphj.20.1524","DOIUrl":"https://doi.org/10.24959/cphj.20.1524","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88264848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative therapy of chronic heart failure: glyflosins destroy the worldview","authors":"I. Kravchenko, Y. Rudyk, O. Medentseva, M. E. Chernenok","doi":"10.24959/cphj.20.1525","DOIUrl":"https://doi.org/10.24959/cphj.20.1525","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"19 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89612889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pharmacoeconomic analysis of olaparib (Linparza®) application for the supporting therapy of patients with BRCA-mutated platinum-sensitive recurrent ovarian cancer","authors":"N. Bezdetko, O. Muzhychuk","doi":"10.24959/cphj.20.1522","DOIUrl":"https://doi.org/10.24959/cphj.20.1522","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"496 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80018501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of the acute toxicity and the laxative effect of pectins from Pimpinella anisum herb","authors":"С. В. Колісник, У. А. Умаров, К. В. Динник, М. Фатхуллаєва, А. А. Шабілалов, А. С. Газієва, S. Kolisnyk, U. Umarov, K. Dynnyk, M. Fathullaeva, А. А. Shabilalov, A. Gazieva, Светлана Валерьевна Колесник, Е. В. Дынник, М. Фатхуллаева, А. А. Шабилалов, А. С. Газиева","doi":"10.24959/cphj.20.1528","DOIUrl":"https://doi.org/10.24959/cphj.20.1528","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72927815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoneering medicines in the treatment of acute rhinosinusitis: an emphasis on effectiveness and safety of application","authors":"T. Zhulai, S. Shebeko, T. Sakharova, N. Bezugla, I. Otrishko","doi":"10.24959/cphj.20.1526","DOIUrl":"https://doi.org/10.24959/cphj.20.1526","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85603929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinolones (ATC-group J01M): the state of the pharmaceutical market, analysis of consumption in Ukraine and in some European countries in 2013-2018","authors":"Т. О. Баглай, T. Bahlai, Т. А. Баглай","doi":"10.24959/cphj.20.1519","DOIUrl":"https://doi.org/10.24959/cphj.20.1519","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"86 1","pages":"43-50"},"PeriodicalIF":0.0,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82735969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antidiabetic activity of the new composition “Thigliben” on the experimental dexamethasone diabetes mellitus model in rats","authors":"N. Tsubanova, O. H. Berdnyk, Н. А. Цубанова, О. Г. Бердник","doi":"10.24959/cphj.20.1520","DOIUrl":"https://doi.org/10.24959/cphj.20.1520","url":null,"abstract":"Being a metabolic disease with long-term hyperglycemia, diabetes mellitus significantly increases the risk of microvascular and macrovascular diseases and organ pathologies, respectively. The creation of the new composition “Thigliben”, which allows not only qualitatively controlling diabetic hyperglycemia, but also providing a preventive and/or therapeutic effect on the development of diabetic polyneuropathy was pathogenetically reasonable. Aim. To study the antidiabetic activity of “Thigliben” on the experimental dexamethasone diabetes mellitus in rats. Materials and methods. The pharmacological study of the antidiabetic activity of the new composition “Thigliben” in the dose of 4 mg/kg was performed. The experimental studies were conducted on a standard model of the experimental dexamethasone type 2 diabetes mellitus in rats. Glibenclamide in the dose of 0.6 mg/kg (corresponds to an average human daily dose of 10 mg) was selected as the reference drug. Results. It was found that by its effects on the carbohydrate and lipid metabolism the new composition “Thigliben” was similar to the reference drug glibenclamide administered in a higher dose. By the antioxidant activity this composition exceeded the effect of the reference drug, provided that normalization of the TBA-RS level in the liver homogenate was significant. The new composition “Thigliben” normalized all the parameters of the cerebral energy metabolism studied relative to the control pathology group and its efficiency was significantly higher than that of the reference drug glibenclamide. The new composition “Thigliben” increased the content of ATP by 109 % compared to the control pathology group, in contrast to 68 % on the background of glibenclamide; restored the activity of citrate synthase by 65 %, succinate dehydrogenase by 134 %, and pyruvate dehydrogenase by 61 % relative to the control pathology group. For glibenclamide the change in these indicators was 28 %, 50 %, and 22 %, respectively. The results obtained suggest that the metabolic effect of “Thigliben” composition is significantly more effective than that of the reference drug glibenclamide. Conclusions. The new composition “Thigliben” is a promising antidiabetic drug with a pronounced hypolipidemic, antioxidant effect and the ability to restore energy deficiency; it is its significant advantage over the standard treatment regimens, including the average therapeutic doses of glibenclamide.","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"30 1","pages":"06-13"},"PeriodicalIF":0.0,"publicationDate":"2020-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76193282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The photoprotective action of “Salizink” cream on the model of photodynamic injury in rats","authors":"L. Maloshtan, V. Pidhaina, Ye. V. Gladukh, Yuriy Taranenko, O. Shatalova","doi":"10.24959/cphj.20.1513","DOIUrl":"https://doi.org/10.24959/cphj.20.1513","url":null,"abstract":"","PeriodicalId":10498,"journal":{"name":"Clinical pharmacy","volume":"1 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2020-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82372729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}