Analysis of the main directions of therapeutic regimens for the treatment of helminthiases of the digestive system given in the new clinical treatment protocols

Clinical pharmacy Pub Date : 2020-06-03 DOI:10.24959/cphj.20.1523

K. Semchenko, L. Vyshnevska

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Abstract

The treatment of helminthiases of the digestive system is a socially significant problem that is urgent for many countries in the world, including Ukraine. Over the last 5 years, cases of enterobiosis, ascariasis and trichocephalosis have been reported most frequently in Ukraine. Therefore, it is advisable to update and implement the latest treatment protocols for the specified pathology.Aim. To analyze recommendations for the treatment of helminthiasis of the digestive system, which are given in the new clinical protocols, and identify the promising directions for saturation of the domestic pharmaceutical market with drugs that meet the needs of patients with this pathology.Materials and methods. The objects of the study were guidelines for the treatment of helminthiases of the digestive system in the open access on the website of the Ministry of Health of Ukraine, scientific publications of domestic and foreign authors and our own research. The methods of generalization, systematization of theoretical and practical material, bibliosemantic and systematic analysis were used in the work.Results. The study of recommendations for the treatment of enterobiosis, ascariasis, intestinal cestodes, strongyloidosis, nematodosis and trichocephalosis has shown that the drug of choice for the treatment of this group of diseases is albendazole, which is included in each treatment protocol. Mebendazole is recommended for use in all regimens, except for the treatment of strongyloidosis. Drugs of other pharmaceutical ingredients are recommended for administration in rare cases. The main types of the pharmacological activity and side effects of albendazole are given.Conclusions. The treatment regimens recommended for helminthiasis of the digestive system have been analyzed, and the substances, based on which the development of domestic anthelmintic drugs is rational, have been determined.

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分析了新临床治疗方案中消化系统蠕虫病治疗方案的主要方向

消化系统蠕虫病的治疗是世界上许多国家迫切需要解决的重大社会问题，包括乌克兰。在过去5年中，乌克兰最常报告肠菌病、蛔虫病和头毛症病例。因此，建议针对特定病理更新和实施最新的治疗方案。分析新临床方案中对消化系统蛔虫病的治疗建议，并确定国内药品市场饱和的有希望的方向，以满足这种病理患者的需求。材料和方法。研究对象是乌克兰卫生部网站上开放获取的消化系统蠕虫病治疗指南、国内外作者的科学出版物和我们自己的研究。在工作中采用了归纳、整理理论和实践资料、文献语义学和系统分析的方法。对肠菌病、蛔虫病、肠线虫病、类圆线虫病和头毛蚴病的治疗建议进行的研究表明，治疗这类疾病的首选药物是阿苯达唑，每个治疗方案中都包括阿苯达唑。除治疗类圆线虫病外，建议在所有方案中使用甲苯达唑。在极少数情况下，建议使用其他药物成分的药物。介绍了阿苯达唑的主要药理作用类型和毒副作用。分析了消化系统寄生虫病的推荐治疗方案，确定了国内驱虫药合理开发的物质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical pharmacy

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