Clinical Rheumatology最新文献

{"title":"Association between systemic lupus erythematosus and cardiovascular health based on genetic data.","authors":"Rui Wang, Xiao-Wei Cui, Miao Zhang, Jian Xu, Chan-Yuan Bu, Xiang-Yang Zhao","doi":"10.1007/s10067-025-07396-x","DOIUrl":"10.1007/s10067-025-07396-x","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the genetic causal relationship between systemic lupus erythematosus (SLE) and cardiovascular diseases through Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>This study employed a two-sample bidirectional MR design. Data were sourced from publicly available genome-wide association study (GWAS) databases. A total of 482,911 European individuals diagnosed with SLE were selected, covering 24,198,877 single-nucleotide polymorphisms (SNPs), along with relevant GWAS summary data for cardiovascular diseases. Genetic variants were used as instrumental variables. The MR analysis was conducted using the TwoSampleMR R package, employing methods including inverse-variance weighting (IVW), weighted median, and MR-Egger to assess the causal relationships. Sensitivity analyses were also performed to verify result robustness.</p><p><strong>Results: </strong>MR analysis indicated potential causal risk relationships between genetic predisposition to SLE and increased risk of pericarditis and peripheral artery disease (PAD). Conversely, reverse MR analyses did not demonstrate significant causal associations, with IVW estimates indicating no causal relationships between coronary artery disease (OR = 1.038, 95%CI 0.829-1.3, P = 0.745), dilated cardiomyopathy (OR = 1.044, 95%CI 0.907-1.203, P = 0.548), heart failure (OR = 0.991, 95%CI 0.729-1.348, P = 0.956), hypertrophic cardiomyopathy (OR = 0.958, 95%CI 0.896-1.024, P = 0.207), pericarditis (OR = 0.958, 95%CI 0.821-1.118, P = 0.589), or PAD (OR = 1.157, 95%CI 0.625-2.143, P = 0.642) and the risk of SLE.</p><p><strong>Conclusions: </strong>This study utilizes MR analysis to reveal genetic causal relationships between SLE and cardiovascular complications, specifically pericarditis and PAD. These findings suggest that inflammation control in SLE patients may help prevent pericarditis while managing dyslipidemia could mitigate PAD risk. Key Points • This study utilizes MR analysis to reveal the causal relationships between SLE and conditions such as pericarditis and PAD from a genetic perspective. • It suggests that controlling inflammation in the treatment of SLE can prevent pericarditis, and managing abnormal lipid levels can reduce the risk of PAD.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2277-2285"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal lupus erythematosus presenting with congenital heart block: clinical characteristics and follow-up.","authors":"Murad Gezer, Halise Hande Gezer","doi":"10.1007/s10067-025-07453-5","DOIUrl":"10.1007/s10067-025-07453-5","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2591-2592"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLAM receptors regulate immune checkpoints via SAP and EAT- 2 in rheumatoid arthritis: association with disease activity.","authors":"Mohammad Malekan, Armin Dozandeh-Jouybari, Najmeh Sadeghian, Mohsen Soltanshahi, Hossein Azadeh, Abolghasem Ajami, Hossein Asgarian-Omran, Saeid Taghiloo","doi":"10.1007/s10067-025-07461-5","DOIUrl":"10.1007/s10067-025-07461-5","url":null,"abstract":"<p><strong>Objective: </strong>Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and immune dysregulation. This study aimed to investigate the role of SLAM family receptors (SLAMF1 and SLAMF7), immune checkpoint molecules (PD- 1 and TIGIT), and SH2-containing adaptor proteins (SAP and EAT- 2) in rheumatoid arthritis (RA) and their association with disease activity.</p><p><strong>Methods: </strong>A total of 50 RA patients (30 inactive, 20 active) and 20 healthy controls were enrolled. Real-time ​polymerase chain reaction (PCR) was used to assess the expression of target genes in peripheral blood mononuclear cells (PBMCs). Gene expression profiling datasets (GSE77298, GSE206848, GSE236924, GSE15573) were analyzed to identify differentially expressed genes (DEGs). Correlation of gene expression with Disease Activity Score 28-joint count (DAS28) was evaluated.</p><p><strong>Results: </strong>SLAMF1, SLAMF7, SAP, and EAT- 2 expression levels were significantly elevated in RA patients compared to controls. SLAMF1 and SAP expression correlated positively with DAS28 (r = 0.319, p = 0.02; r = 0.460, p = 0.0008, respectively). PD- 1 expression was higher in RA patients but showed no correlation with DAS28, while TIGIT expression was not significantly different. Bioinformatics analysis revealed significant upregulation of SLAMF7 and TIGIT in synovial tissues from RA patients.</p><p><strong>Conclusion: </strong>SLAMF1 and SLAMF7 appear to contribute to RA pathogenesis by modulating immune cell activity and cytokine production. Elevated PD- 1 levels suggest a role in immune dysregulation. The interplay between SLAM receptors, immune checkpoints, and adaptor proteins may exacerbate T cell overactivity and chronic inflammation, offering potential therapeutic targets. Key Points •RA patients showed significantly higher expression of SLAMF1, SLAMF7, PD- 1, SAP, and EAT- 2 compared to healthy controls. •SLAMF1 and SAP expression correlated with disease activity, with SLAMF1 levels higher in active RA cases. •PD- 1 overexpression suggested immune dysregulation, while TIGIT showed no significant difference in RA patients. •The interplay between SLAM receptors, immune checkpoints, and adaptor proteins may contribute to RA pathogenesis and serve as potential therapeutic targets.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2201-2212"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose IL-2 restores Tfh/Tfr imbalance and modulates B cell subset distribution in the pre-arthritis phase of the collagen-induced arthritis model.","authors":"Rui Su, Hui Wang, Baochen Li, Ruihe Wu, Yuhuan Xie, Xiaoyu Zi, Chunxue Fan, Chong Gao, Xiaofeng Li, Caihong Wang","doi":"10.1007/s10067-025-07455-3","DOIUrl":"10.1007/s10067-025-07455-3","url":null,"abstract":"<p><strong>Objective: </strong>This study is aimed at investigating the characteristics of RA patients at different stages and at evaluating the potential application of low-dose interleukin-2 (ld-IL-2) during the preclinical stage.</p><p><strong>Methods: </strong>Patients with undifferentiated arthritis (UA), early RA (Ea-RA), new-onset RA (New-RA), and recurrent RA (Re-RA) were included. Clinical data and laboratory parameters were collected from all participants. A comparative analysis of arthritis-related clinical features and serum levels of IL-2 and soluble IL-2 receptor (sIL-2R) was conducted. Collagen-induced arthritis (CIA) mice received ld-IL-2 on days 0, 7, 14, and 28 after primary immunisation for 4 weeks. The percentages of Treg, Tfr, Tfh, and PD-1⁺Tfh cells were analysed. Additionally, naive CD4⁺ T cells were cultured in vitro to assess the effects of IL-2 on Tfh and Tfr differentiation.</p><p><strong>Results: </strong>UA patients primarily exhibited early involvement of large joints. The sIL-2R level in UA patients was significantly lower than in those with Ea-RA, New-RA, and Re-RA and was comparable to levels in healthy controls. ld-IL-2 administration at different time points in the CIA model exerted varying effects on arthritis severity. Prophylactic ld-IL-2 administration reduced arthritis severity and incidence in CIA; it decreased the percentage of PD-1⁺Tfh cells while increasing Tfr cells, thereby restoring immune balance. All IL-2 intervention groups effectively reduced the Tfh/Tfr ratio and altered the distribution of B cell subsets. Mechanistically, ld-IL-2 primarily suppressed the differentiation of PD-1⁺Tfh cells and promoted Treg cell differentiation via STAT3 and STAT5 signalling, contributing to the restoration of immune tolerance.</p><p><strong>Conclusion: </strong>These findings indicate that elevated sIL-2R levels in UA patients may predict progression to Ea-RA. Furthermore, ld-IL-2 restores immune tolerance by rebalancing Tfh/Tfr populations, highlighting its potential as a novel immunoregulatory strategy during the preclinical phase of RA. Key Points • Prophylactic low-dose IL-2 intervention reduces the severity and incidence of arthritis in the CIA model. • Low-dose IL-2 decreases the percentage of PD-1⁺Tfh cells while increasing Tfr cells, contributing to the restoration of immune balance.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2487-2500"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Other musculoskeletal disorders in China, 1990-2021, and projections to 2050: findings from the Global Burden of Disease Study 2021.","authors":"Suying Liu, Yingying Chen, Liuting Zeng, Siyu Cao, Juan Meng, Fengchun Zhang","doi":"10.1007/s10067-025-07459-z","DOIUrl":"10.1007/s10067-025-07459-z","url":null,"abstract":"<p><strong>Objectives: </strong>Other musculoskeletal disorders showed a growing burden globally, but data specific to China remain sparse. This study aims to analyze the burden of other musculoskeletal disorders in China from 1990 to 2021 using data from the Global Burden of Disease (GBD) 2021.</p><p><strong>Methods: </strong>Decomposition analysis, Bayesian Age-Period-Cohort, and Age-Period-Cohort models were utilized to investigate the key influencing factors and project future burden.</p><p><strong>Results: </strong>In China, the prevalence of other musculoskeletal disorders was 85.0 (72.4-99.4) million in 2021, with a 20% increase from 1990. The number of Disability-Adjusted Life Years (DALYs) was 7.6 (5.2-10.6) million in 2021, indicating a 18.1% rise. Although age-standardized mortality rate remained stable, deaths number increased from 5,279.4 (4,289.9-6,724.3) to 9,166.9 (7,000.8-11,693.4). Females consistently showed higher rates than males, while China remained below the global average in prevalence, DALYs, and mortality. Population growth was the predominant contributor to the burden's increase in China, showing a different pattern from other BRICS countries. Prevalence is projected to triple by 2050, while DALYs and mortality may decline. For Age-Period-Cohort analysis of mortality, net drift was below zero. Age effects exhibited a significant increase after age group 70-75. Period effects played a negative role after 2004-2005. Cohort effects revealed a notable decrease among more recent generation.</p><p><strong>Conclusions: </strong>The burden of other musculoskeletal disorders in China is increasing with sex, age, and regional differences. Future growth in prevalence is predicted for this category of disorders, highlighting the need for effective public health policies and tailored interventions. Key Points • The burden of other musculoskeletal disorders in China is substantial and has been growing from 1990 to 2021, with significant sex, age, and regional differences. • Population growth is the predominant contributor to the increased burden of other musculoskeletal disorders in China, showing a distinct pattern compared to other BRICS countries.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2119-2130"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of intra-articular ozone and steroid injection in patients with adhesive capsulitis.","authors":"Ali Sahillioğlu, Aylin Ayyıldız, Tülay Şahin","doi":"10.1007/s10067-025-07471-3","DOIUrl":"10.1007/s10067-025-07471-3","url":null,"abstract":"<p><strong>Objective: </strong>Adhesive capsulitis is a disease characterized by a significant decrease in the active and passive range of motion(ROM) of the glenohumeral joint along with pain. Ozone therapy has demonstrated promising results in treating various diseases. This study aims to compare the efficacy of intraarticular ozone administration with steroid injection in treating adhesive capsulitis.</p><p><strong>Methods: </strong>Our study is a single-blind, prospective and comparative clinical trial. The study included 40 patients who were randomly assigned to one of two groups. The study group received 8 sessions of intra-articular ozone injection under ultrasound guidance, while the control group received a single intra-articular steroid injection. Patient evaluations were conducted before treatment, as well as 4 and 12 weeks after treatment. The study utilized three evaluation scales: the visual analog scale(VAS) for pain, the Shoulder Pain and Disability Index (SPADI), and ROM measurements.</p><p><strong>Results: </strong>Both treatment groups demonstrated a statistically significant improvement in range of motion, SPADI, and VAS scores compared to their values at baseline and weeks 4 and 12. However, no statistically significant difference was found between the two groups in the magnitude of improvement across these outcomes.</p><p><strong>Conclusion: </strong>The study results demonstrate that ozone injection repeated eight times led to improvements in pain, function, and range of motion that were not statistically different from those observed with a single corticosteroid injection in treating adhesive capsulitis. Although the study was not designed as a non-inferiority trial, the findings suggest that intra-articular ozone administration may be a potentially beneficial alternative treatment option. Key Points • This study demonstrates that intra-articular ozone (O₂-O₃) injection resulted in significant clinical improvements in pain, function, and range of motion in patients with primary adhesive capsulitis. • Despite differences in injection frequency, both ozone and corticosteroid injections led to improvements, with no statistically significant difference between groups. • This study contributes to the limited literature on ozone therapy for adhesive capsulitis and suggests its potential as an alternative to corticosteroid injection, particularly for patients who may not tolerate steroids. • Further research with longer follow-up periods is warranted to confirm the long-term efficacy and safety of ozone therapy in adhesive capsulitis management.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2517-2525"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of regional adiposity distribution with risk of autoimmune diseases.","authors":"Rui Fan, Zhihan Zhang, Qinlian Huang, Linqi Liu, Wenjun Que, Dan Lu, Sisi Jing, Yaoqi Gan, Shiyi Liu, Fei Xiao","doi":"10.1007/s10067-025-07426-8","DOIUrl":"10.1007/s10067-025-07426-8","url":null,"abstract":"<p><strong>Objective: </strong>To detect the association between regional adiposity distribution and the incidence of seven autoimmune diseases (ADs) in UK Biobank cohort and Mendelian randomization (MR) analyses.</p><p><strong>Methods: </strong>We used Cox models to evaluate the associations between seven adiposity distribution measures and seven ADs (systemic lupus erythematosus [SLE], seropositive rheumatoid arthritis [PRA], psoriasis [PSO], multiple sclerosis [MS], myasthenia gravis [MG], Crohn's disease [CD] and ulcerative colitis [UC]) in cohort studies. In the MR analyses, we used the inverse variance-weighted MR method to estimate causal effects between adiposity distribution and obesity-related ADs in the cohort.</p><p><strong>Results: </strong>In the cohort study, PSO, MG, CD, and female UC were associated with almost all types of adiposity distribution; PRA and male UC were associated with central adiposity distribution; SLE and MS were found to be not associated with any types of obesity. Almost all adiposity distribution were certified in MR as an exposure to PSO, MG and PRA.</p><p><strong>Conclusions: </strong>Adiposity, despite its distribution, are associated with an increased risk of PSO and MG, and central adiposity distribution is robustly associated with the increased risk of PRA, indicating that lifestyle interventions aimed at obesity contribute to preventing ADs. Key Points • Body mass index (BMI) was a risk factor for several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis (PSO), multiple sclerosis (MS) and inflammatory bowel disease (IBD). However, obesity as a heterogeneous and complex condition and that regional fat mass has obviously differential contributions to the development of obesity-related diseases. • We revealed that all types of adiposity distribution, whether general, central or peripheral, were associated with an increased risk of psoriasis and myasthenia gravis, and central adiposity distribution was robustly associated with the increased risk of seropositive rheumatoid arthritis. • Our findings indicated that lifestyle interventions aimed at individuals with obesity might contribute to preventing autoimmune diseases.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2541-2552"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MTX-induced gastrointestinal reactions in RA: Prevotella enrichment, gut dysbiosis, and PI3K/Akt/Ras/AMPK pathways.","authors":"Ruixue Duo, Yining Wang, Quanzhi Ma, Xiaoyuan Wang, Yan Zhang, Haili Shen","doi":"10.1007/s10067-025-07406-y","DOIUrl":"10.1007/s10067-025-07406-y","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the role of gut microbiota in methotrexate (MTX)-induced gastrointestinal reactions (MRGR) in patients with rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>As a prospective, single-center, convenience sampling study, stool samples were obtained from 28 RA patients (male: female = 10:18) at Lanzhou University Second Hospital who were undergoing MTX treatment for analysis of their gut microbiota using 16S rRNA gene sequencing. Clinical disease activity (CDAI) and MRGR were assessed after two months of MTX therapy. All data collection periods exceeded one year. Intestinal germ-free mice, generated through antibiotic treatment, received fecal microbiota transplantation (FMT) from the patients, followed by varying doses of MTX to observe MRGR. Intestinal transcriptomics and markers related to intestinal barrier function were subsequently examined.</p><p><strong>Results: </strong>Females (84.6%) and high disease activity (CDAI scores, 39.6 ± 11.2 vs 26.3 ± 9.2) were prone to have MRGR in RA patients. Patients with MRGR (PT-GR) showed lower gut microbial diversity versus non-MRGR (PT-noGR). Prevotella abundance, positively correlated with CDAI and MRGR (p < 0.05), was elevated in PT-GR. Administering 10 mg/kg MTX to mice caused intestinal damage. FMT-GR-MTX mice exhibited weight loss (95.2%), morphological deterioration (86.4%), and reduced tight junction proteins (Claudin-1:72.4%; ZO-1:81.2%). Transcriptomics linked upregulated Gβγ/CREB/Atp4b to PI3K/Akt/Ras pathways and downregulated PFK2/PP2 to AMPK signaling in MRGR.</p><p><strong>Conclusion: </strong>Our study identified notable gut microbiota alterations in RA patients prone to MRGR, with changes in intestinal gene expression and reduced intestinal barrier function potentially contributing to MRGR. These findings suggest potential strategies to mitigate MRGR in RA patients undergoing MTX treatment. Key Points • The RA-related MRGR is correlated with the intestinal microbiota. • Females, low gut diversity, and Prevotella enrichment are MRGR risks in RA. • Upregulated DEGs in MRGR linked to PI3K/Akt, Ras pathways. • Downregulated DEGs in MRGR focus on the AMPK pathway.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2163-2177"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characterization of malignant lymphoma mimicking IgG4-related disease.","authors":"Man Luo, Dongdong Fu, Huaqun Zhu, Yuan Li, Hua Ye","doi":"10.1007/s10067-025-07466-0","DOIUrl":"10.1007/s10067-025-07466-0","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical characteristics of malignant lymphoma that closely resembles IgG4-related disease (IgG4-RD).</p><p><strong>Methods: </strong>This study retrospectively analysis involving 31 patients who were lymphoma mimicking, IgG4-RD and 50 contemporaneous IgG4-RD patients serving as controls. Lymphoma mimicking IgG4-RD was defined as presenting with masses in the typical sites of IgG4-RD, with or without elevated serum IgG4 levels, and ultimately confirmed to be lymphoma. The clinical data, including the extent of lymph node involvement, maximum diameter of lymph nodes, systemic symptoms, and laboratory parameters were assessed. Student's t-test, the Mann-Whitney test, and the chi-squared test were used to compare the two groups.</p><p><strong>Results: </strong>Fever emerged as a distinctive feature in lymphoma patients. Compared to IgG4-RD, lymphoma patients exhibited a greater extent of lymph node involvement (p < 0.001), larger maximum diameters of lymph nodes (p = 0.007), and higher frequency of enlargement in supraclavicular (41.9% vs 10.0%; p = 0.001), armpit (45.2% vs 16.0%; p = 0.004), retroperitoneal (70.9% vs 10.0%; p < 0.001), and groin lymph nodes (41.9% vs 8.0%; p < 0.001). In contrast, IgG4-RD patients were more likely to show involvement of submandibular gland (58.0% vs 29.0%; p = 0.015) and pancreatic (44.0% vs 9.7%; p = 0.001). Additionally, lymphoma patients presented with higher levels of erythrocyte sedimentation rate (ESR) (p = 0.010), C-reactive protein (CRP) (p < 0.001), and lactate dehydrogenase (LDH) (p = 0.002), along with a higher prevalence of anemia (35.5% vs 4.0%; p < 0.001) and lower albumin levels (p = 0.039), while IgG4-RD patients had higher IgG4/IgG ratio (p < 0.001) and lower complement 3 (C3) (p = 0.009) levels than lymphoma patients.</p><p><strong>Conclusion: </strong>Although patients with malignant lymphoma and IgG4-RD share some overlapping presentations, they differ significantly in some distinct features, including fever, pattern of lymph node and organ involvement distribution, and some laboratory parameters. Key Points • IgG4-related disease (IgG4-RD) is an immune-mediated disorder characterized by elevated serum IgG4 levels, presenting lymphadenopathy and tumor-like sclerosing lesions in extranodal sites. • Lymphoma, a malignancy that originates from lymphocytes, can present with a variety of clinical manifestations, including painless swelling of lymph nodes and enlargement of different organs. • While patients with malignant lymphoma and IgG4-RD share certain overlapping clinical presentations, they exhibit significant differences in distinct features, including fever, patterns of lymph node and organ involvement, and various laboratory parameters.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2413-2419"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Living with osteoarthritis pain during COVID-19: perspectives of Black and White Canadians.","authors":"Rachel D Almaw, Natasha K Ivanochko, Sheereen Harris, Monica R Maly","doi":"10.1007/s10067-025-07450-8","DOIUrl":"10.1007/s10067-025-07450-8","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the lived experience and daily impact of hip and knee osteoarthritis pain in Black and White Canadians in the context of the COVID-19 pandemic.</p><p><strong>Methods: </strong>An interpretative description approach was used. Recruitment was tailored to engage a diverse sample. During semi-structured, one-on-one interviews, participants reflected on their pain, its impact, and strategies for its management. A constant comparative approach was used. Standardized questionnaires collected gender, race, and OA severity to describe the sample.</p><p><strong>Results: </strong>Thirty participants (15 Black, 15 White) with moderate knee and hip symptoms participated. OA pain was experienced on two continua. A continuum of control ranged from OA pain versus the participant controlling decisions to participate in daily activities. A continuum of certainty ranged from doubting versus feeling confident in the ability to manage OA pain. These continua intersected, creating quadrants. Pain controlling decisions and uncertainty led to a quadrant of feeling worn out. Pain controlling decisions and certainty resulted in a quadrant of unmet expectations. The participant controlling decisions combined with uncertainty was experienced as coping. The participant controlling decisions combined with certainty in managing OA pain created overcoming. Contextual factors that influenced these continua included COVID-19 restrictions, housing, employment, interactions with healthcare providers, and health literacy.</p><p><strong>Conclusion: </strong>Participants' experiences of OA pain were linked to the sense of control in daily decisions and certainty in managing OA pain, reflecting concepts of locus of control and self-efficacy. Sociocultural factors, life experiences, and issues such as employment, housing, COVID-19 restrictions, and health literacy shaped these experiences.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2477-2486"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}