Clinical Rheumatology最新文献

{"title":"Serological distribution of anti-endothelial cell antibodies and their association with laboratory indicators in autoimmune and immune-mediated diseases.","authors":"Renren Ouyang, Xu Yuan, Rujia Chen, Wei Wei, Yun Wang, Ting Wang, Lin Zhu, Shiji Wu, Feng Wang, Hongyan Hou","doi":"10.1007/s10067-025-07692-6","DOIUrl":"https://doi.org/10.1007/s10067-025-07692-6","url":null,"abstract":"<p><strong>Background: </strong>Anti-endothelial cell antibodies (AECA) are implicated in vascular injury associated with autoimmune and inflammatory diseases. However, their distribution and clinical significance across diverse conditions remain inadequately characterized.</p><p><strong>Methods: </strong>We analyzed 1,334 serum samples from patients with vasculitis, systemic autoimmune diseases, kidney diseases, arthritis, and other immune-mediated disorders. AECA titers were measured using indirect immunofluorescence assays and categorized as low (1:100), moderate (1:320) or high (1:1000). Laboratory parameters, including hematological, renal, hepatic, and coagulation indicators, were compared among different AECA titer groups within each disease category.</p><p><strong>Results: </strong>AECA positivity was most frequently observed in vasculitis (40.6%), arthritis (44.4%), and autoimmune kidney diseases (25.5%). Higher titers were especially common in Behet's disease, ANCA-associated vasculitis, and ankylosing spondylitis. In autoimmune nephropathy, patients with moderate to high AECA titers (≥ 1:320) exhibited significantly elevated serum creatinine and urea levels compared to both AECA-negative and low-titer groups, suggesting impaired renal function. In the kidney disease subgroup, higher AECA titers indicated lower red blood cell counts and decreased estimated glomerular filtration rate (eGFR). Among systemic autoimmune diseases, moderate to high AECA titers were linked to significantly reduced white blood cell counts.</p><p><strong>Conclusion: </strong>AECAs show heterogeneous distribution across immune-mediated diseases and are linked to laboratory abnormalities inidicative of endothelial injury and organ dysfunction. These findings support the potential role of AECA titier as biomarkers for systemic involvement, warranting validation in prospective studies. Key Points • Anti-endothelial cell antibodies (AECAs) are heterogeneously distributed across a broad spectrum of immune-mediated diseases. • AECA positivity is associated with disease-specific patterns, particularly in Behçet's disease and ANCA-associated vasculitis. • AECA may serve as potential serological biomarkers for disease severity and immune-mediated endothelial injury.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between tooth loss and clinical complications in rheumatoid arthritis: a pilot study.","authors":"Laura Silva Siano Rodrigues, Victoria Boëchat Feyo, Lydia Silva Provinciali, José Jonas Pereira, Cristhiane Almeida Leite da Silva, Viviane Angelina de Souza, Cynthia Savioli, Gisele Maria Campos Fabri","doi":"10.1007/s10067-025-07647-x","DOIUrl":"https://doi.org/10.1007/s10067-025-07647-x","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid Arthritis (RA) is a chronic autoimmune disease that affects the oral cavity, contributing to the development of periodontal disease (PD), an inflammatory condition that has a bidirectional relationship with various systemic conditions and can lead to tooth loss (TL).This study aimed to evaluate whether the number of missing teeth could serve as an additional indicator for the medical team in assessing the association with systemic disease exacerbations.</p><p><strong>Methods: </strong>This pilot study assessed patients with rheumatoid arthritis (RA) using specific protocols, including medical record analysis and a systematic orofacial examination to calculate the Decayed, Missing, and Filled Teeth (DMFT) index. Validated questionnaires were applied, and the disease activity (DAS-28) and functional capacity (HAQ) indices were collected.</p><p><strong>Results: </strong>The study included 21 patients with a mean DAS28 of 3.12 and a mean HAQ of 1.077. Of these, 7 (33.4%) were in remission, while 14 (66.6%) had some level of disease activity. 10 (47%) had moderate to severe disability due to RA. Statistical analysis identified polypharmacy as a clinically relevant factor associated with tooth loss (p = 0.029; r = 0.48). Additionally, patients with disease activity had higher DMF-T scores. Correspondence analysis indicated that polypharmacy was associated with a higher prevalence of moderate to severe disability (HAQ) and higher DMF-T scores.</p><p><strong>Conclusion: </strong>It is concluded that there is a relationship between the DMF-T index, RA activity, the number of missing teeth, and the need for polypharmacy, making these data important to be assessed in the clinical routine of RA patients. Additional studies are necessary to explore this association in greater depth and strengthen the evidence base.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the causal role of the gut microbiome in Kawasaki disease: mediating effects of immune cells.","authors":"Youfei Fan, Shuo Zhang, Feng Guo","doi":"10.1007/s10067-025-07687-3","DOIUrl":"https://doi.org/10.1007/s10067-025-07687-3","url":null,"abstract":"<p><strong>Introduction: </strong>The etiology of Kawasaki disease (KD), a leading cause of acquired heart disease in children, is unknown, though a link to the gut microbiome is suspected. This study aimed to move beyond association by establishing a causal relationship between gut microbiota and KD, and to explore the immune pathways involved.</p><p><strong>Method: </strong>We conducted a two-step, two-sample MR study using GWAS summary data from European-ancestry cohorts. Genetic variants for 471 gut microbiota were used as instruments. The primary causal estimate was derived using the inverse-variance weighted (IVW) method, validated with nine sensitivity analyses. A subsequent two-step MR analysis assessed mediation by 731 immune cell phenotypes.</p><p><strong>Results: </strong>We identified 17 gut microbiota taxa causally associated with KD. Robust analyses consistently supported a protective association for Ensifer (beta = -3.33, P = 0.01) and a risk-increasing association for Lawsonibacter sp900066645 (beta = 3.05, P = 0.02). The protective effect of Ensifer was partially mediated by its influence on CD8dim Natural Killer T %lymphocyte (10.71% mediation). The risk-increasing effect of Coprobacter secundus was mediated through CD27 on CD20- B cells (9.41% mediation).</p><p><strong>Conclusion: </strong>This study provides the first genetic evidence for a causal link between specific gut microbiota and KD, with effects partially mediated by the immune system. These findings highlight the gut-immune axis in KD pathogenesis and offer genetically validated targets for novel therapeutic strategies. Key Points • This study is the first to use Mendelian Randomization to establish a causal link between specific gut microbiota and Kawasaki disease. • It identifies 17 specific microbial taxa that causally increase or decrease the risk of developing the disease. • The research elucidates the mechanistic pathway, showing that the effects of the gut microbiota on Kawasaki disease are partially mediated by specific immune cell populations. • The findings provide genetically validated targets (specific microbes and immune cells) for developing novel therapies and preventative strategies for Kawasaki disease.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation influences fibromyalgia severity in terms of widespread pain among female patients: data from a large national registry.","authors":"Marco Di Carlo, Sonia Farah, Manuela Di Franco, Cristina Iannuccelli, Annunziata Capacci, Serena Guiducci, Giovanni Biasi, Roberto Giacomelli, Laura Bazzichi, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Fausto Salaffi","doi":"10.1007/s10067-025-07697-1","DOIUrl":"https://doi.org/10.1007/s10067-025-07697-1","url":null,"abstract":"<p><strong>Introduction/objectives: </strong>Seasonal variation may influence musculoskeletal pain, and fibromyalgia is primarily characterized by widespread chronic pain. This study aimed to assess whether symptom severity in fibromyalgia varies by season.</p><p><strong>Methods: </strong>A retrospective, cross-sectional analysis was conducted on patients from the Italian Fibromyalgia Registry. Patients were grouped based on the season of their clinical evaluation. Disease severity was measured using disease-specific clinimetric tools: the Polysymptomatic Distress Scale (PSD), including the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS), as well as the revised Fibromyalgia Impact Questionnaire (FIQR) and the modified Fibromyalgia Assessment Status (FASmod). Statistical analyses included the Kruskal-Wallis test and pairwise comparisons using the Dwass-Steel-Critchlow-Fligner test.</p><p><strong>Results: </strong>A total of 2614 patients were evaluated. Significant seasonal differences were found for both WPI (p = 0.042) and FASmod (p = 0.037). In female patients, these differences were more pronounced (WPI, p = 0.016; FASmod, p = 0.018), while no significant variation was observed in males. Pairwise analysis showed higher symptom severity in autumn compared to summer for both WPI (W = -4.009; p = 0.024) and FASmod (W = -3.800; p = 0.037).</p><p><strong>Conclusion: </strong>In fibromyalgia, widespread pain appears more severe in autumn than in summer, particularly among female patients. These findings highlight the potential role of seasonality in symptom modulation and underscore the importance of incorporating seasonal factors into patient management and education.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"The association between serum 25-hydroxyvitamin D levels and clinical outcomes in Chinese adult inpatients: A retrospective cohort stud\".","authors":"Kun Zhang, Fan Yang","doi":"10.1007/s10067-025-07704-5","DOIUrl":"10.1007/s10067-025-07704-5","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burdens of psoriasis in adolescents and young adults: a trend analysis based on the global burden of disease.","authors":"Suli Wang, Xia Lyu, Jia Li, Qiong Fu, Liangjing Lu","doi":"10.1007/s10067-025-07672-w","DOIUrl":"https://doi.org/10.1007/s10067-025-07672-w","url":null,"abstract":"<p><strong>Background: </strong>This study assessed the global, regional, and national burdens of psoriasis in adolescents and young adults (aged 10-24 years) from 1990 to 2021.</p><p><strong>Methods: </strong>Using Global Burden of Disease 2021 data, this study analyzed 1990-2021 global, regional, and national psoriasis burden trends through multidimensional methods, assessed cross-country disparities via WHO health equity frameworks, and projected disease burden projections through 2035.</p><p><strong>Results: </strong>Psoriasis incidence and disability-adjusted life years (DALYs) among adolescents and young adults globally increased from 38.73 and 25.62 per 100,000 in 1990 to 41.57 and 27.74 per 100,000 in 2021, respectively. The average annual percentage change (AAPC) from 1990 to 2021 was 0.23 for incidence and 0.26 for DALYs. Joinpoint regression revealed significant changes in incidence in 1994, 2001, 2005, 2015, and 2019, while notable shifts in DALYs occurred in 1993, 2002, 2009, 2015, and 2019. Disparities in psoriasis burden varied significantly across regions and countries. High Socio-demographic Index (SDI) countries had a consistently high burden, while middle and low SDI regions saw significant increases, especially in females, driven by population growth. A nuanced change in SDI-related inequalities was detected. Disease burden for psoriasis in this population is projected to continue increasing from 2022 to 2035, with females continuing to bear a greater burden than males.</p><p><strong>Conclusion: </strong>Psoriasis burden among adolescents and young adults has risen sharply over three decades, with projections indicating accelerating trends, highlighting the urgent need for targeted interventions in high-SDI regions where prevalence peaks. Key Points • Pronounced regional disparities reveal unequal psoriasis burdens across global populations, underscoring persistent health inequities. • Steadily rising global trends signal an accelerating increase in psoriasis prevalence among youth (10-24 years), demanding urgent attention. • Unexpectedly acute impacts disproportionately affect adolescents in high-SDI regions, highlighting unique demographic vulnerabilities. • Projected escalation through 2035 necessitates proactive, evidence-based public health interventions to mitigate future impacts.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPARG-centered regulatory network of ferroptosis in lupus nephritis: insights by integrated comprehensive bioinformatics analysis and machine learning.","authors":"Xiaolong Li, Qingmiao Zhu, Jinge Huang, Kai Zhao, Ting Zhao","doi":"10.1007/s10067-025-07703-6","DOIUrl":"https://doi.org/10.1007/s10067-025-07703-6","url":null,"abstract":"<p><strong>Introduction: </strong>Ferroptosis has garnered attention as a mechanism of cell death contributing to lupus and lupus nephritis pathogenesis. However, the precise locations of occurrence, mechanisms triggering disease progression, and critical targets remain unclear.</p><p><strong>Materials and methods: </strong>Differentially expressed genes were identified using the \"limma\" package in R. Weighted gene co-expression network analysis was applied to explore gene modules associated with LN. Ferroptosis-related genes were obtained from FerrDb V2 and intersected with DEGs and WGCNA modules to identify candidate genes. Hub genes were selected using LASSO and Random Forest algorithms, followed by ROC curve validation. Immune cell infiltration was analyzed using the CIBERSORT algorithm, and correlations with hub gene expression were assessed. A protein-protein interaction network was constructed via STRING. Finally, RT-qPCR was performed to validate the expression of selected genes in kidney tissues from MRL/lpr and C57BL/6 mice.</p><p><strong>Results: </strong>Differential expression gene analysis and weighted gene co-expression network analysis identified 688 LN-related genes in PBMC, 625 in the renal tubulointerstitium, and 1428 in renal glomeruli. The LASSO and Random Forest algorithms selected hub genes associated with ferroptosis and were validated through ROC analysis. Immunocyte infiltration analysis revealed differential patterns in different tissues, with most hub genes highly correlated with immune cell infiltrations. PPI analysis and RT-qPCR validation identified a PPARG-centered regulatory network (including PPARG, CDKN1A, NR4A1, ATF3, DUSP1 and PDK4) that may be crucial for the regulation of ferroptosis in lupus nephritis.</p><p><strong>Conclusion: </strong>This study reveals, for the first time, the mechanisms and regulatory hub genes of ferroptosis in different LN tissues. The regulatory network centered around PPARG may play a crucial role in ferroptosis in LN, providing a new perspective for in-depth investigation into LN pathogenesis and targeted therapy development. Key Points • Identified tissue-specific ferroptosis biomarkers in lupus nephritis using multiple machine learning methods. • The diagnostic efficacy of the PPARG regulatory network was validated through both internal and external validation. • Discovered the regulatory network of ferroptosis in lupus nephritis by constructing the PPARG regulatory network.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and prevalence of sacroiliac joint bone marrow edema during pregnancy: A retrospective analysis.","authors":"Frank Verhoeven, Pierre Verdot, Daniel Wendling, Clément Prati","doi":"10.1007/s10067-025-07688-2","DOIUrl":"https://doi.org/10.1007/s10067-025-07688-2","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnancy is associated with the presence of bone marrow edema (BME) in the sacroiliac joints during the postpartum period. The aim of this study is to evaluate the frequency and localization of sacroiliac joint edema during pregnancy.</p><p><strong>Methods: </strong>This retrospective, monocentric study included pregnant women who underwent pelvic MRI for any reason during their pregnancy. Women with a history of chronic inflammatory rheumatic diseases and minors were excluded. Two experienced readers independently evaluated the presence of bone marrow edema (BME) using a two-plane assessment method: axial and semi-coronal oblique views. Each sacroiliac joint was divided into four quadrants per slice and the presence of deep lesion was also scored.</p><p><strong>Results: </strong>We included 28 women with a median age of 30.0 [27.0-33.0] years and a median gestational age of 27.5 [25.5-32.0] weeks of amenorrhea. Ten women (36%) presented with at least one BME in a sacroiliac joint, and 3 of these women had bilateral sacroiliac joint BME. BME was observed in 12 of 13 cases (92%) in the lower part of the sacroiliac joint. In 8 cases (66%), the edema was present on both the iliac and sacral sides, in 1 case (8%) only on the iliac side, and in 4 cases (33%) only on the sacral side. There were no correlation between gestational age and the presence of BME.</p><p><strong>Conclusion: </strong>BME in the sacroiliac joint is common during pregnancy and is typically located in the anterior and inferior parts of the joint, similar to the postpartum period.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome of undifferentiated recurrent fever (SURF): a multicenter real-world experience from Türkiye.","authors":"Vildan Güngörer, Dilara Ünal, Mustafa Çakan, Semra Ayduran, Ümit Gül, Hatice Kübra Zora, Nimet Öner, Oya Köker, Kübra Uçak, Nihal Şahin, Selcan Demir, Bahar Demirbaş, Semanur Özdel, Selçuk Yüksel, Sara Sebnem Kilic, Yelda Bilginer, Özgür Kasapçopur, Seza Özen, Banu Çelikel Acar","doi":"10.1007/s10067-025-07682-8","DOIUrl":"https://doi.org/10.1007/s10067-025-07682-8","url":null,"abstract":"<p><strong>Introduction/objectives: </strong>Syndrome of undifferentiated recurrent fever (SURF) is an autoinflammatory disorder that is recognised in an increasing number of patients. In this study, we aimed to assess the data of SURF patients from the main reference centres in our country.</p><p><strong>Methods: </strong>Data for this retrospective multicentre observational cohort study were obtained from the records of SURF patients aged 0-18 years who were followed up in 10 pediatric rheumatology clinics in Türkiye between 2010 and June 2023. Patients with recurrent fever that could not be explained by periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) and hereditary recurrent fevers and had no other cause were included in the study.</p><p><strong>Results: </strong>Of the 134 patients included in the study, 74 (55.2%) were male. The median age at diagnosis was 67 months. The most common symptom was abdominal pain in 98 (73.1%), arthralgia in 82 (61.2%), malaise in 77 (57.5%). The age at symptom onset was ≤ 5 years in 109 patients (81.3%). Pharyngitis was more common symptom in children aged ≤ 5 years (p = 0.008), headache, arthralgia, chest pain were more common findings in children > 5 years (p = 0.008, p = 0.032, p = 0.045). There were 113 patients receiving colchicine alone or in combination therapy and 74.3% of them achieved complete or partial remission. The presence of abdominal pain (p = 0.021, OR = 0.254) increased the remission rate with colchicine.</p><p><strong>Conclusion: </strong>SURF patients present with a wide range of clinical manifestations. Distinguishing between SURF and PFAPA is not concrete. Further omics studies will enlighten whether there is a true group of SURF. Key Points • SURF is an autoinflammatory disease that is becoming increasingly recognised. • The clinical manifestations of SURF are quite heterogeneous. • Colchicine and anti-IL-1 treatment is effective in most SURF patients. • It is controversial whether it should be called SURF or PFAPA-like syndrome, especially in children aged ≤ 5 years.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward precision maternal care in systemic lupus erythematosus: bridging data limitations and research gaps.","authors":"Talha Ali, Mateen Khan, Mazhar Ali Jarwar","doi":"10.1007/s10067-025-07705-4","DOIUrl":"https://doi.org/10.1007/s10067-025-07705-4","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}