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Clinical reproduction and fertility最新文献

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LHRH analogue therapy in infertile women with luteal phase defects. LHRH模拟治疗黄体期缺陷不孕妇女。
Clinical reproduction and fertility Pub Date : 1987-06-01
R N Heasley, D D Boyle, W Thompson
{"title":"LHRH analogue therapy in infertile women with luteal phase defects.","authors":"R N Heasley,&nbsp;D D Boyle,&nbsp;W Thompson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Management of patients with unexplained (ovulatory) infertility is a difficult clinical problem. Some of these women exhibit repetitive luteal phase defects which may or may not respond to conventional treatment with anti-oestrogens or progesterone supplementation. Ablation of the defective cycles, by rendering the patients hypogonadotrophic, and then substituting induced cycles using exogenous gonadotrophins, was employed in 10 women who had been inexplicably infertile for up to 14 years. Over a trial period of six cycles good luteal phase progesterone profiles were achieved in all instances, but only two term pregnancies occurred. A further two patients conceived but one aborted and one had a tubal pregnancy. The results are discussed critically, regarding the importance of luteal phase defects in the aetiology of infertility and the conception rates which may occur even if no specific therapy is prescribed.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 3","pages":"133-9"},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14254054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of human seminal plasma proteins on polyacrylamide gel electrophoresis. 人精浆蛋白的聚丙烯酰胺凝胶电泳图谱。
Clinical reproduction and fertility Pub Date : 1987-02-01
M G Jennings, M P McGowan, P L Nayudu, H W Baker
{"title":"Patterns of human seminal plasma proteins on polyacrylamide gel electrophoresis.","authors":"M G Jennings,&nbsp;M P McGowan,&nbsp;P L Nayudu,&nbsp;H W Baker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seminal plasma proteins were separated by sodium dodecylsulphate polyacrylamide gel electrophoresis and the patterns for different conditions compared by densitometry. The changes in pattern with time after ejaculation because of proteolysis could be largely prevented by addition of bacitracin. Patterns were similar within the one man and little influenced by duration of abstinence from ejaculation. There were marked variations in pattern between individuals and no specific differences could be detected between samples from men with normal semen analyses, vasectomy, or azoospermia from seminiferous tubule failure. However, there were distinct patterns with congenital absence of the vasa and seminal vesicles and with androgen deficiency. Methods for identification of testicular and epididymal proteins in semen would expand the clinical usefulness of examination of seminal plasma proteins.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Verapamil, a Ca2+ channel antagonist, accelerates the in vitro penetration of zona-free hamster eggs by human spermatozoa. 维拉帕米是一种Ca2+通道拮抗剂，可加速人类精子在体外对无带仓鼠卵的渗透。
Clinical reproduction and fertility Pub Date : 1987-02-01
E R Roldan, H Wramsby, R Yanagimachi
{"title":"Verapamil, a Ca2+ channel antagonist, accelerates the in vitro penetration of zona-free hamster eggs by human spermatozoa.","authors":"E R Roldan,&nbsp;H Wramsby,&nbsp;R Yanagimachi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human spermatozoa were preincubated for 3.5 h with various concentrations (0-100 mumol/l) of verapamil, a Ca2+ channel antagonist, before they were mixed with zona-free hamster eggs. Control spermatozoa penetrated only 3% of the eggs, whereas the highest penetration (40.3%) was reached after preincubation with 100 mumol/l verapamil. Thus, verapamil increases the ability of human spermatozoa to penetrate zona-free hamster eggs, possibly by an acceleration of the acrosome reaction. Although it has been established that the acrosome reaction requires the entry of extracellular Ca2+ into the spermatozoa, the Ca2+ ions do not seem to enter by means of Ca2+ channels.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-medical selection criteria for artificial insemination and adoption. 人工授精和收养的非医学选择标准。
Clinical reproduction and fertility Pub Date : 1987-02-01
B Freedman, P J Taylor, T Wonnacott, S Brown
{"title":"Non-medical selection criteria for artificial insemination and adoption.","authors":"B Freedman,&nbsp;P J Taylor,&nbsp;T Wonnacott,&nbsp;S Brown","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A survey of Canadian providers of AID was conducted, along with a parallel survey of adoption workers. The questionnaire focused upon non-medical criteria for patient acceptance (for AID and adoption), including acceptance/rejection of single, lesbian, and common-law women, those economically or mentally unable to support children, and those who themselves have or whose partners have criminal records. Further questions concerned decision-making in patient selection, referral of unacceptable patients elsewhere, and the influence if any of legal advice. Most characteristics reflect great disagreement and lack of consensus within the profession. Attitudes towards characteristics may be influenced by the size and form (university vs private) of the practice, as well as by experience with patients with those characteristics. Systematic differences between AID and adoption providers are detailed and explored, as are implications of the study for the development of bioethical thinking and policy making.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"55-66"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Failure of daily measurements of hCG in urine to demonstrate a high rate of early embryonic mortality. 尿中绒毛膜促性腺激素的每日测量失败，以证明早期胚胎死亡率高。
Clinical reproduction and fertility Pub Date : 1987-02-01
H W Baker, G T Kovacs, H G Burger
{"title":"Failure of daily measurements of hCG in urine to demonstrate a high rate of early embryonic mortality.","authors":"H W Baker,&nbsp;G T Kovacs,&nbsp;H G Burger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A radioimmunoassay employing beta hCG antiserum and tracer and hCG standard was used in an attempt to detect transient luteal phase rises in hCG in urine as evidence of occult pregnancy loss. It was found that the assay lacked specificity and detected 'hCG' surges at midcycle which were not confirmed using a more specific monoclonal antibody based immunoradiometric assay. Measurements on first morning urine samples across midcycle and throughout the luteal phase in 65 cycles from 36 women attempting to conceive revealed no evidence of transient hCG production in the 56 cycles which did not go on to a clinical pregnancy.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Problem with AIDS in Philadelphia. 费城的艾滋病问题。
Clinical reproduction and fertility Pub Date : 1987-02-01
S L Corson
{"title":"Problem with AIDS in Philadelphia.","authors":"S L Corson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mild endometriosis and infertility--to treat or not to treat? 轻度子宫内膜异位症和不孕症——治疗还是不治疗?
Clinical reproduction and fertility Pub Date : 1987-02-01
R T O'Shea
{"title":"Mild endometriosis and infertility--to treat or not to treat?","authors":"R T O'Shea","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"87-8"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress in IVF workers. 体外受精工作人员的压力。
Clinical reproduction and fertility Pub Date : 1987-02-01
R D Harris, M J Bond
{"title":"Stress in IVF workers.","authors":"R D Harris,&nbsp;M J Bond","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Workers in new and personally exacting health services face particular challenges which are not evident in more traditional areas. IVF workers are involved in such an innovative service. Their perception of workplace stressors has not previously been addressed in the literature. Fifty-nine IVF workers and 32 non-IVF workers (in routine obstetrics and gynaecology) completed a battery of standardized psychological questionnaires on the symptomatology of stress and in addition answered questions on workplace problems and work satisfaction. Reported stress was highest among scientific/technical workers who varied significantly from the control group scores. IVF medical staff showed elevated stress scores, but were not significantly separated from controls, except on state anxiety. Work satisfaction scores were generally high for all IVF professions, except for pay and promotion satisfaction scores which were depressed among nurses and scientific/technical staff. It was concluded that this initial survey had revealed important information about the impact of a new scientific and clinical enterprise upon staff and should promote closer examination of the reasons for such reported stress.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"27-35"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the time of day of onset of menstruation. 分析一天中月经开始的时间。
Clinical reproduction and fertility Pub Date : 1987-02-01
J L Donald, I S Fraser, L Duncan, G McCarron
{"title":"Analysis of the time of day of onset of menstruation.","authors":"J L Donald,&nbsp;I S Fraser,&nbsp;L Duncan,&nbsp;G McCarron","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The exact time of day of onset of menstruation was studied in 86 women over 4-6 cycles. Detailed information on the time of retiring the previous night, time of rising in the morning, time of onset of premenstrual spotting and time of onset of any menstrual cramps was obtained from 48 of these women. A significantly greater number of cycles (70.4%) commenced during the night or in the first 4 h after rising, compared with later in the day. In a large proportion of these (29 out of 76), blood was noted to be present on waking, menstruation thus having begun at some time during the hours of sleep. Premenstrual spotting of greater than 3 h duration was more common than expected and was noted by 67% of women. Onset of menstrual cramps was fairly evenly distributed closely either side of commencement of menstruation proper in the 50% of women who experienced them. In only 13% of women studied did bleeding commence within the same 3-hour time interval in each of four cycles, and almost 50% demonstrated a very wide variation with onset at almost any time of day.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14810836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increase in seminal transferrin following antiandrogen treatment. 抗雄激素治疗后精液转铁蛋白升高。
Clinical reproduction and fertility Pub Date : 1987-02-01
G Schleicher, U A Knuth, T G Cooper, E Nieschlag
{"title":"Increase in seminal transferrin following antiandrogen treatment.","authors":"G Schleicher,&nbsp;U A Knuth,&nbsp;T G Cooper,&nbsp;E Nieschlag","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seminal plasma transferrin was determined by radioimmunoassay in normal and infertile men under basal conditions and after manipulations of FSH and testosterone known to stimulate Sertoli cell activity and transferrin secretion in vitro. Normal volunteers were given the antiandrogens cyproterone acetate or flutamide, or a combination of 19-nortestosterone together with medroxyprogesterone. Severely oligozoospermic patients were treated with pulsatile GnRH to decrease elevated FSH levels. No close correlation between seminal transferrin and any of the serum hormones could be detected under basal conditions. However, antiandrogen treatment increased transferrin in seminal plasma, although from the in vitro studies a decrease or no effect would have been expected. No effect on seminal transferrin was detected in the patients receiving GnRH treatment. Since seminal transferring after hormonal treatment did not parallel transferrin secretion by Sertoli cells under hormonal stimulation in vitro, its role as a diagnostic marker for Sertoli cell function remains questionable.</p>","PeriodicalId":10478,"journal":{"name":"Clinical reproduction and fertility","volume":"5 1-2","pages":"67-75"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14252412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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