Clinical Phytoscience最新文献

{"title":"Delayed prescription of antibiotics and the capabilities of herbal medicine when used in respiratory infections","authors":"V. I. Popovych, I. V. Koshel","doi":"10.1186/s40816-023-00364-5","DOIUrl":"https://doi.org/10.1186/s40816-023-00364-5","url":null,"abstract":"Excessive and improper use of antibiotics in respiratory infections is still an urgent issue. In most cases of ARS and AT, antibiotics can be considered excessive treatment, since they are a completely inappropriate solution for viral infections. An important issue is negative changes to the microbiome in the patient’s body, which cause a negative impact on health, and abnormal changes can last longer and be more severe than the disease itself. Misuse of antibiotics can be harmful, especially in children, because the long-term effects of antibiotics on the macroorganism and microbiome can cause the disease to recur in adulthood. Sinupret® in the strategy of delayed prescription of antibiotics in ARS patients as part of a controlled study helps reduce prescription of antibacterials by 1.81 times and by 15.5 times (53% to 3.4%) versus statistics. Imupret® in patients with severe acute tonsillitis when employing the approach of delayed antibiotics prescription reduces the need for antibacterial therapy by 43.7% or 2.3 times, and by 11 times (72% to 10.1%) versus the average statistical level of prescription. Unlike antibiotics, herbal medicines positively affect the patient’s microbiome and have a favourable safety profile. It is imperative to increase knowledge and awareness, as well as provide appropriate training and communication strategies among physicians to prevent overuse and misuse of antibiotics. Herbal medicinal products BNO1016 (Sinupret®) and BNO1030 (Imupret®) can be considered as an alternative to antibiotics for the treatment of uncomplicated forms of acute rhinosinusitis and acute tonsillitis. Evidence shows that herbal medicines are effective and have a favourable safety profile. However, herbal medicinal products cannot replace antibiotics in all the cases, so delayed prescription of antibiotics with pre-treatment using herbal products can help reduce excessive and unjustified use of antibiotics.","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139500615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective effects of Rhododendron arboreum leaf extract against Doxorubicin-induced cardiotoxicity in Wistar rats by modulating electrocardiographic and cardiac biomarkers","authors":"Adersikha Pradhan, Manodeep Chakraborty, Oonglim Lepcha, Ananya Bhattacharjee, Devid Chutia, Nihar Ranjan Bhuyan","doi":"10.1186/s40816-023-00361-8","DOIUrl":"https://doi.org/10.1186/s40816-023-00361-8","url":null,"abstract":"Cardiotoxicity and related complications are well-known adverse effects of anticancer drugs like doxorubicin (DOX). A medicinal plant called Rhododendron arboreum is used by traditional healers of Sikkim in the treatment of heart ailments and has also been reported for widespread therapeutic effects in many clinical studies. Thus the present study has been designed to evaluate the protective effects of Rhododendron arboreum leaf extract (RALE) against DOX-induced cardiotoxicities. Commencement of research with the collection of the Rhododendron arboreum leaves and drying it in the shade, the extraction was performed using the Soxhlet method with an ethanolic solvent. The phytoconstituents of the RALE were then quantified and qualitatively evaluated. Doxorubicin-induced cardiotoxicity was carried out using four groups consisting of six animals each. Doxorubicin was administered with a dose of 3 mg/kg injected intraperitoneally (i.p.) on the 1st,7th,14th,21st and 28th day of cumulative dose of 15 mg/kg throughout the experimental period with RALE treatment (250 mg/kg and 100 mg/kg) orally for 28 days. The influence of the treatment was analyzed by quantification of cardiac biomarkers and electrocardiographic method. The serum levels of cardiac biomarkers such as Lactate Dehydrogenase (LDH), Creatine kinase-N-acetyltransferase (CK-NAC), Creatine kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT), which were elevated due to DOX-induced cardiotoxicity were significantly reduced in all RALE (250 mg/kg and 100 mg/kg) treated groups. Similarly, the electrocardiographic changes like prolonged QT interval, widening of QRS complex amplitude, undefined ST segment, arrhythmias and increased heart rate were also restored close to normal in all treated groups compared to the DOX control group. Following the data observed during the study, results reported that R. arboreum possesses the free radical scavenging property, improved cardiotoxic laboratory parameters and restored reversible cellular injury due to existing of the principle constituent’s impact on proinflammatory mediators.","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138536859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemistry, efficacy, and safety of medicinal plants used traditionally for the management of peptic ulcer diseases in Ethiopia: a systematic review","authors":"Abdulkerim Mustefa, Aschalew Nardos, Dejene Hailu, Serawit Deyno","doi":"10.1186/s40816-023-00362-7","DOIUrl":"https://doi.org/10.1186/s40816-023-00362-7","url":null,"abstract":"Despite significant advances in synthetic medicine, medicinal plants are still widely utilized to treat peptic ulcer disease. This study synthesized evidence on commonly used medicinal plants to manage peptic ulcer disease in Ethiopia. The evidence was synthesized using electronic databases such as PubMed/Medline, Web of Science, Science Direct, Hinari, and Google Scholar. This review considers all controlled in vivo and ex vivo anti-ulcer studies evaluating Ethiopian medicinal plants with regards to phytochemistry, efficacy, and safety. The search technique covered all published papers using descriptors like Ethiopia, medicinal plants, and anti-ulcer until January 30, 2022. The percentage of ulcer reduction was used to measure the success of the treatment. Anti-ulcer properties were investigated in 13 papers. Twelve in vivo and one ex vivo study were retrieved. Osyris quadripartita, Plantago lanceolata, Ensete ventricosum, Taverniera abyssinicia, Crotonmacrostachyus Persea Americana and Moringa stenopetala showed effect close to a standard control in difference ulcer induced model. Osyris quadripartite in the dose of 200 mg/kg, Ficus thonningii in dose of 200 and 400 mg/kg, Plantago lanceolata in dose of 400 mg/kg, Trigonella feonum-gracum in dose of 500 and 1000 mg/kg, Linum ussitatissimum in dose of 1000 and 1500 mg/kg, Urtica simensis 400 mg/kg have higher activity compared with standard control in difference different models. Phytochemistry studies revealed presence of numerous components, including flavonoids, phenols, tannins, and saponins, which may be responsible for the anti-ulcer activity. This study revealed that there are some promising medicinal plant extracts that have been used in Ethiopia for centuries that could be used as anti-ulcer agents. The most effective anti-ulcer agents in animal models are Indigofera spicata Forssk, Thymus schimperi, and Urtica simensis. Identification of most active pharmacological agents and clinical evaluation of Ethiopian medicinal plants used to treat peptic ulcers are worthy of further investigation.","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"1999 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138536855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Mucuna milk (Mucuna pruriens L.) on body weight and serum biochemistry in rats fed hyperlipidaemic diet","authors":"Mang Yannick Dimitry, Bidja Abena Marie Thérèse, Djiogue Manejo Josiane Edith, Abdou Bouba Armand, Njintang Yanou Nicolas","doi":"10.1186/s40816-023-00360-9","DOIUrl":"https://doi.org/10.1186/s40816-023-00360-9","url":null,"abstract":"Abstract Background Hyperlipidemia and oxidative stress is recognized as risk factor for several diseases such as COVID-19. The aim of this study was to evaluate the effect of oral administration of Mucuna milks on body weight gain, blood lipid levels and redox status in rat model fed high fat diet. Methods Mucuna milks were produced from two varieties of Mucuna seeds. Three controls (I, II, III) made of normal rats fed with standard diet, rats fed with high fat diet and rats fed with high fat diet submitted to oral administration of atorvastatin (10 mg/kg/day). In addition, four test groups (IV, V, VI, VII) made with rats fed high fat diet and received oral administration of 20 mL of vegetable milk per day (10 mL at morning and 10 mL at afternoon). Results Results confirmed that rats on the high fat diet only showed an increasing of about 224% of their initial body weight, abdominal fat and a significant (p < 0.05) increases of lipid peroxidation (MDA) in liver and heart after five weeks. However, oral administration of Mucuna milk inhibit weight gain by about 66% and abdominal fat (54.53–55.60%). The reduction of LDL, VLDL, Triglycerides and Total cholesterol was remarkable in groups of rat treated with vegetable milk, about 67% reduction for dehulled Mucuna milks (DCM, DVM) and 69% reduction for whole Mucuna milks (WCM, WVM). Hyperlipidemic group rats had higher ASAT (134.17 UI/L) and ALAT (101.72 UI/L) levels, but Mucuna milks improved the ASAT and ALAT levels in rats. The reduction of MDA (70 − 50%) was related to phenolic content of Mucuna milks. significant and negative correlations was observed between catalase and MDA (r= -0.86; p = 0.05); MDA and SOD (r = − 0.60; p = 0.05). Conclusion This study suggests that treatment with Mucuna milks have anti-hyperlipidemia properties and increased the activity of antioxidant enzymes.","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"214 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135853947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the anti-urolithiasis potential of Ficus religiosa seed GC MS evaluated phytoconstituents based on their in-vitro antioxidant properties and in-silico ADMET and molecular docking studies","authors":"Felicity Pinipay, Rajesh Rokkam, Satyanarayana Botcha, Raghava Rao Tamanam","doi":"10.1186/s40816-023-00359-2","DOIUrl":"https://doi.org/10.1186/s40816-023-00359-2","url":null,"abstract":"Abstract Background Urolithiasis, the deposit of stones in the urinary tract is a pertinent clinical issue in daily practice that imposes a burden on the human health system. Ficus religiosa plant has historically been useful in preventing urolithiasis. There is currently no information on phytochemical profiling that specifies the precise phytochemicals in the seed that are active against urolithiasis. Methods F. religiosa seeds were extracted with different solvents in increasing order of their polarity by Soxhlet extraction. All the extracts were evaluated for their antioxidant potential. GC–MS profiling of the most potent antioxidant F. religiosa seed extract was done to evaluate the phytoconstituents. To evaluate the pharmacokinetics and drug-likeness properties of these compounds in silico ADMET analysis was done. To comprehend the binding potential of the best ADMET evaluated phytochemicals contained in the F. religiosa seed extract against the several protein targets (matrix metalloproteinases (MMP-2, MMP-9), and Human calcium-sensing receptor (CaSR)) and antioxidant enzymes (Glutathione S-transferase (GST), glutathione-disulfide reductase (GR), glutathione peroxidase (GPX), and superoxide dismutase (SOD)) involved in urolithiasis, multi targets based virtual screening tests were done using Autodock Vina tool. Results GC–MS profiling revealed the presence of 53 different compounds. Of all these compounds, based on ADMET analysis 2-Methoxy-4-vinylphenol; 3,5-Di-tert-butylphenol; diethyl benzene-1,2-dicarboxylate; 4-hydroxy-3,5-dimethoxybenzaldehyde; 2-methoxy-4-prop-2-enylphenol; and bis (2-methyl propyl) benzene-1,2-dicarboxylate were found to have best pharmacokinetics and drug-likeness properties. In the autodocking studies, 3,5-Di-tert-butyl phenol is proved to be the best of all in terms of binding energies with the selected targets. Conclusion The findings of this study suggest a framework for employing F. religiosa seed ethyl acetate extract as a potent herbal treatment for urolithiasis.","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134975343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A comparative study on the antihyperlipidemic and antibacterial potency of the shoot and flower extracts of Melastoma malabathricum Linn’s","authors":"Md. Abdul Kader, Md. Masuder Rahman, Shahin Mahmud, Md. Sharif Khan, Shamsunnahar Mukta, Fatama Tous Zohora","doi":"10.1186/s40816-023-00358-3","DOIUrl":"https://doi.org/10.1186/s40816-023-00358-3","url":null,"abstract":"","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135836186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the Antihyperlipidemic and antibacterial potency of the shoot and flower extracts of Melastoma malabathricum Linn's","authors":"Md. Abdul Kader, Md. Masuder Rahman, S. Mahmud, Md. Sharif Khan, S. Mukta, F. T. Zohora","doi":"10.1186/s40816-023-00355-6","DOIUrl":"https://doi.org/10.1186/s40816-023-00355-6","url":null,"abstract":"","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42231854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of anticancer potential of Kingiodendron pinnatum (DC.) Harms","authors":"C. Pareeth, N. Meera, P. Silpa, Kannoor M. Thara, A. Raghavamenon, T. Babu","doi":"10.1186/s40816-023-00356-5","DOIUrl":"https://doi.org/10.1186/s40816-023-00356-5","url":null,"abstract":"","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48662682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of the herbal cream formulation from methanolic leaf extracts of Tephrosia vogelii Hook.f for topical application","authors":"S. H. Mlozi, Juma A. Mmongoyo, M. Chacha","doi":"10.1186/s40816-023-00357-4","DOIUrl":"https://doi.org/10.1186/s40816-023-00357-4","url":null,"abstract":"","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46189698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiolytic, analgesic and anti-inflammatory effects of Citrus maxima (Burm.) Merr. Seed extract in Swiss albino mice model","authors":"Md. Tanveer Ahsan, Nazratun Noor Maria, Umme Tahmida, Ayesha Akter Jasmin, D. Chowdhury","doi":"10.1186/s40816-023-00354-7","DOIUrl":"https://doi.org/10.1186/s40816-023-00354-7","url":null,"abstract":"","PeriodicalId":10462,"journal":{"name":"Clinical Phytoscience","volume":"9 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46302727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}