CNS & neurological disorders drug targets最新文献_第6页

Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism. 酪蛋白激酶 2 通过调节离子通道影响癫痫：潜在机制

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230622124618

Yan Liu, Di Xia, Lianmei Zhong, Ling Chen, Linming Zhang, Mingda Ai, Rong Mei, Ruijing Pang

{"title":"Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential Mechanism.","authors":"Yan Liu, Di Xia, Lianmei Zhong, Ling Chen, Linming Zhang, Mingda Ai, Rong Mei, Ruijing Pang","doi":"10.2174/1871527322666230622124618","DOIUrl":"10.2174/1871527322666230622124618","url":null,"abstract":"Epilepsy, characterized by recurrent seizures and abnormal brain discharges, is the third most common chronic disorder of the Central Nervous System (CNS). Although significant progress has been made in the research on antiepileptic drugs (AEDs), approximately one-third of patients with epilepsy are refractory to these drugs. Thus, research on the pathogenesis of epilepsy is ongoing to find more effective treatments. Many pathological mechanisms are involved in epilepsy, including neuronal apoptosis, mossy fiber sprouting, neuroinflammation, and dysfunction of neuronal ion channels, leading to abnormal neuronal excitatory networks in the brain. CK2 (Casein kinase 2), which plays a critical role in modulating neuronal excitability and synaptic transmission, has been shown to be associated with epilepsy. However, there is limited research on the mechanisms involved. Recent studies have suggested that CK2 is involved in regulating the function of neuronal ion channels by directly phosphorylating them or their binding partners. Therefore, in this review, we will summarize recent research advances regarding the potential role of CK2 regulating ion channels in epilepsy, aiming to provide more evidence for future studies.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"894-905"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10033209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Number of Antiseizure Medications Taken and not the Lipid Profile was Associated with Seizure Control in Adult Patients with Epilepsy. 服用抗癫痫药物的数量与成人癫痫患者的发作控制有关，而非血脂状况。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527323666230816090102

Vania Aparecida Leandro-Merhi, Glória Maria de Almeida Souza Tedrus, Giovanna Gigolotti Jacober de Moraes, Michele Novaes Ravelli

{"title":"The Number of Antiseizure Medications Taken and not the Lipid Profile was Associated with Seizure Control in Adult Patients with Epilepsy.","authors":"Vania Aparecida Leandro-Merhi, Glória Maria de Almeida Souza Tedrus, Giovanna Gigolotti Jacober de Moraes, Michele Novaes Ravelli","doi":"10.2174/1871527323666230816090102","DOIUrl":"10.2174/1871527323666230816090102","url":null,"abstract":"Previous studies show changes in lipid metabolism in epilepsy. The aim of this study was to investigate the association between lipid profile and clinical variables in adult patients with epilepsy (APE). Seventy-two APE participated in this pilot study at an outpatient neurology service. The lipid profile (total cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoproteins (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides), age at disease onset, disease duration, seizures frequency, and the number of antiseizure medications (ASM) used were investigated. Data were analyzed using the Chi-square, Fisher, Mann-Whitney, Spearman coefficient, and logistic regression tests. There were significant differences in HDL (p = 0.0023) and total cholesterol (p = 0.0452) levels in connection with the number of ASM used. There was a significant difference in seizure control among the different numbers of ASM used (p = 0.0382). Higher HDL values were found in females (p = 0.0170). The logistic regression showed that only the number of ASM used was associated with seizure control (p = 0.0408; OR = 2.800; 95% CI = 1.044; 7.509). The number of ASM taken and not the lipid profile was associated with seizure control in APE.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"927-930"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10367853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signalling Pathways Involved in Microglial Activation in Alzheimer's Disease and Potential Neuroprotective Role of Phytoconstituents. 参与阿尔茨海默病小胶质细胞活化的信号通路及植物成分的潜在神经保护作用

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666221223091529

Mohd Uzair Ali, Laiba Anwar, Mohd Humair Ali, Mohammad Kashif Iqubal, Ashif Iqubal, Sanjula Baboota, Javed Ali

{"title":"Signalling Pathways Involved in Microglial Activation in Alzheimer's Disease and Potential Neuroprotective Role of Phytoconstituents.","authors":"Mohd Uzair Ali, Laiba Anwar, Mohd Humair Ali, Mohammad Kashif Iqubal, Ashif Iqubal, Sanjula Baboota, Javed Ali","doi":"10.2174/1871527322666221223091529","DOIUrl":"10.2174/1871527322666221223091529","url":null,"abstract":"Alzheimer's disease (AD) is a commonly reported neurodegenerative disorder associated with dementia and cognitive impairment. The pathophysiology of AD comprises Aβ, hyperphosphorylated tau protein formation, abrupt cholinergic cascade, oxidative stress, neuronal apoptosis, and neuroinflammation. Recent findings have established the profound role of immunological dysfunction and microglial activation in the pathogenesis of AD. Microglial activation is a multifactorial cascade encompassing various signalling molecules and pathways such as Nrf2/NLRP3/NF-kB/p38 MAPKs/ GSK-3β. Additionally, deposited Aβ or tau protein triggers microglial activation and accelerates its pathogenesis. Currently, the FDA-approved therapeutic regimens are based on the modulation of the cholinergic system, and recently, one more drug, aducanumab, has been approved by the FDA. On the one hand, these drugs only offer symptomatic relief and not a cure for AD. Additionally, no targetedbased microglial medicines are available for treating and managing AD. On the other hand, various natural products have been explored for the possible anti-Alzheimer effect via targeting microglial activation or different targets of microglial activation. Therefore, the present review focuses on exploring the mechanism and associated signalling related to microglial activation and a detailed description of various natural products that have previously been reported with anti-Alzheimer's effect via mitigation of microglial activation. Additionally, we have discussed the various patents and clinical trials related to managing and treating AD.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"819-840"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10431820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia. 尼古丁滥用和神经退行性变:帮助戒烟和降低痴呆风险的新药理学靶点。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230220121655

Fatimah Almahasneh, Romany H Gerges, Ejlal Abu-El-Rub, Ramada R Khasawneh

{"title":"Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia.","authors":"Fatimah Almahasneh, Romany H Gerges, Ejlal Abu-El-Rub, Ramada R Khasawneh","doi":"10.2174/1871527322666230220121655","DOIUrl":"10.2174/1871527322666230220121655","url":null,"abstract":"Nicotine dependence has deleterious neurological impacts. Previous studies found an association between cigarette smoking and accelerating age-related thinning of the brain's cortex and subsequent cognitive decline. Smoking is considered the third most common risk factor for dementia, which prompted the inclusion of smoking cessation in dementia prevention strategies. Traditional pharmacologic options for smoking cessation include nicotine transdermal patches, bupropion and varenicline. However, based on smokers' genetic makeup, pharmacogenetics can be used to develop novel therapies to replace these traditional approaches. Genetic variability of cytochrome P450 2A6 has a major impact on smokers' behavior and their response to quitting therapies. Gene polymorphism in nicotinic acetylcholine receptor subunits also has a great influence on the ability to quit smoking. In addition, polymorphism of certain nicotinic acetylcholine receptors was found to affect the risk of dementia and the impact of tobacco smoking on the development of Alzheimer's disease. Nicotine dependence involves the activation of pleasure response through the stimulation of dopamine release. Central dopamine receptors, catechol-o-methyltransferase and the dopamine transporter protein, regulate synaptic dopamine levels. The genes of these molecules are potential targets for novel smoking cessation drugs. Pharmacogenetic studies of smoking cessation also investigated other molecules, such as ANKK1 and dopamine-beta-hydroxylase (DBH). In this perspective article, we aim to highlight the promising role of pharmacogenetics in the development of effective drugs for smoking cessation, which can increase the success rate of smoking quitting plans and ultimately reduce the incidence of neurodegeneration and dementia.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"2-8"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Apigenin on Neurodegenerative Diseases. 芹菜素对神经退行性疾病的影响

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230406082625

Kajal Gaur, Yasir Hasan Siddique

引用次数: 0

Neuropsychiatric Manifestations in Alzheimer's Disease Patients: Genetics and Treatment Options. 阿尔茨海默病患者的神经精神表现：遗传学和治疗选择。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230301111216

Arun Kumar Singh, Rishabha Malviya, Anuj Prakash, Swati Verma

{"title":"Neuropsychiatric Manifestations in Alzheimer's Disease Patients: Genetics and Treatment Options.","authors":"Arun Kumar Singh, Rishabha Malviya, Anuj Prakash, Swati Verma","doi":"10.2174/1871527322666230301111216","DOIUrl":"10.2174/1871527322666230301111216","url":null,"abstract":"Background: Alzheimer's disease (AD) is characterized by neuropsychiatric symptoms (NPS), which cause great misery to those with dementia and those who care for them and may lead to early institutionalization.Objective: The present systematic review aims to discuss the various aspects of Alzheimer's, including treatment options.Methods: The databases Embase, PubMed, and Web of Science were searched to collect data.Results: Incipient cognitive deterioration is commonly accompanied by these early warning signals of neurocognitive diseases. The neurobiology of NPSs in Alzheimer's disease, as well as particular symptoms, including psychosis, agitation, apathy, sadness, and sleep disorders, will be examined in this review. For NPSs in Alzheimer's disease, clinical trial designs, as well as regulatory issues, were also addressed. A fresh wave of research, however, is helping to push the discipline ahead. For medication development and repurposing, we highlight the most recent results in genetics, neuroimaging, and neurobiology. Even though identifying and treating psychosis in adults with dementia is still a challenging endeavor, new options are coming up that give the field fresh focus and hope. Conclsuion: It can be concluded from the complete literature survey that Alzheimer's-related psychosis as well as other symptoms that are not psychotic, have made significant progress in the last decade. These milestones in the development of safer, more effective treatments have been achieved as a consequence of great focus on non-pharmacological interventions like DICE or WHELD; the investigation into ways to improve existing drugs like aripiprazole, risperidone, amisulpride, and Escitalopram for safer precision-based treatment; and the development of a clinical trial program for pimavanserin.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"39-54"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10794284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Perspective Towards the Management of Proteinopathies by Elucidating Protein Misfolding and Aggregation. 阐明蛋白质错误折叠和聚集对蛋白质疾病管理的综合展望。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230306085937

Ishfaq Ahmad Ahanger, Ghulam Md Ashraf, Anurag Sharma, Asimul Islam

{"title":"Comprehensive Perspective Towards the Management of Proteinopathies by Elucidating Protein Misfolding and Aggregation.","authors":"Ishfaq Ahmad Ahanger, Ghulam Md Ashraf, Anurag Sharma, Asimul Islam","doi":"10.2174/1871527322666230306085937","DOIUrl":"10.2174/1871527322666230306085937","url":null,"abstract":"Protein misfolding and aggregation is the phenomenon of the generic propensity of proteins, considered as a dark side of the protein world, and its exact mechanism is still not deciphered. Understanding the complexity of protein aggregation is currently the primary apprehension and challenge in biology and medicine due to their association with various debilitating human proteinopathies and neurodegenerative diseases. The mechanism of protein aggregation, associated diseases, and the development of efficient therapeutic strategies against these diseases are very challenging. These diseases are caused by different proteins, each protein with different mechanisms and consisting of various microscopic phases or events. These microscopic steps are functioning on different timescales during aggregation. Here, we highlighted the different features and current trends in protein aggregation. The study thoroughly recapitulates the various factors influencing, possible causes, types of aggregates and aggregation, their different proposed mechanisms, and the methods used to study the aggregation. Additionally, the formation and elimination of misfolded or aggregated proteins in the cell, the role of the ruggedness of the protein folding landscape in protein aggregation, proteinopathies, and the challenges for their prevention are comprehensively elucidated. A holistic understanding of different aspects of aggregation, molecular steps governing the various features of protein quality control, and crucial queries about the modulation of these processes and their interactions with other systems in cellular protein quality control can be considered conducive to comprehending the mechanism, designing effective approaches towards prevention of protein aggregation, rationalizing the etiology and development of novel strategies against therapy and management of the proteinopathies.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"153-180"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10832489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choice and Timing of Antithrombotic after Ischemic Stroke, Intracerebral Hemorrhage or Cerebral Venous Thrombosis. 缺血性脑卒中、脑出血或脑静脉血栓形成后抗血栓治疗的选择和时机。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230309100626

Dylan Ryan, Tarun Girotra, Wuwei Feng

引用次数: 0

Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies. 揭示 Neuroligin3 在自闭症谱系障碍中的作用：病理生理学见解和靶向治疗。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527323666230727102244

Fatima Azzahrae El Yacoubi, Mohamed Oukabli, Azeddine Ibrahimi, Hassan Kisra, Mounia Bensaid

{"title":"Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies.","authors":"Fatima Azzahrae El Yacoubi, Mohamed Oukabli, Azeddine Ibrahimi, Hassan Kisra, Mounia Bensaid","doi":"10.2174/1871527323666230727102244","DOIUrl":"10.2174/1871527323666230727102244","url":null,"abstract":"Autism Spectrum Disorder is a neurodevelopmental disorder characterized by impaired social and communication skills, repetitive behaviors, and/or restricted interests with a prevalence of as high as 1% of children. Autism spectrum has strongly associated with genetic factors and exhibits wide clinical and heterogeneous genetic architecture. Most genes associated with Autism are involved in neuronal and synaptic development. The neuroligin3, the sex-linked gene on the X chromosome, was the first gene to be associated with a monogenic form of Autism. Neuroligin3 is a postsynaptic cell adhesion protein involved in synapse transmission, brain formation, and neuronal development. In this review, we provide recent findings on different mutations in the Neuroligin3 gene linked to Autism spectrum disorder and their molecular pathway effect. We also give the behavioral, and synaptic alterations reported in the Neuroligin3 animal model of Autism and the potential therapeutic strategies targeting the biological processes and the main symptoms of autism spectrum disorder. In addition, we discuss the use of novel technologies like induced pluripotent stem cells from Autistic patients that have the potential to differentiate in human neurons and therefore have a variety of applications in therapy and biomedical studies to search specific biomarkers, and develop systems for screening chemical molecules in human cells to discover target therapies.","PeriodicalId":10456,"journal":{"name":"CNS & neurological disorders drug targets","volume":" ","pages":"801-811"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of Parkinson's Disease: From Risk Factors to Early Interventions. 帕金森病的预防：从风险因素到早期干预。

IF 3 4区医学

CNS & neurological disorders drug targets Pub Date : 2024-01-01 DOI: 10.2174/1871527322666230616092054

Ming Guan Ng, Brendan Jun Lam Chan, Rhun Yian Koh, Khuen Yen Ng, Soi Moi Chye

引用次数: 0