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Susac Syndrome: Collaboration is Required for a Diagnosis Susac综合征:诊断需要合作
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.23937/2378-3656/1410396
Candale Claudia, Akindotun Akintomide Femi, H. Reza, T. Sibi, Ljostad Unn, Mygland Åse
{"title":"Susac Syndrome: Collaboration is Required for a Diagnosis","authors":"Candale Claudia, Akindotun Akintomide Femi, H. Reza, T. Sibi, Ljostad Unn, Mygland Åse","doi":"10.23937/2378-3656/1410396","DOIUrl":"https://doi.org/10.23937/2378-3656/1410396","url":null,"abstract":"Background: Susac Syndrome is a rare auto-immune endotheliopathy that rarely presents with the full triad of branched retinal artery occlusion, encephalopathy and sensorineural hearing loss. The diagnosis of Susac can be a challenge due to the variability in presentation, course and severity of disease. Objective: Diagnosis of Susac requires a careful history, diagnostic procedures such as fluorescein angiography, audiometry and MRI, and most importantly interdisciplinary teamwork, all of which aid in the diagnosis of this rare disorder. Case report: A 38-year-old female with no cardiovascular risk factors developed sudden vision loss in the left eye. Extensive evaluations were negative thus prompting the diagnosis of amaurosis fugax. A few days later, she began experiencing flickers in the left eye with new onset blurring of vision in the right eye that progressed to loss of vision after 3 months, with associated headaches, paresthesias of the lips and extremities, and increasing fatigue. There was no loss of hearing. Retina fluorescein angiography revealed multiple occlusions, hyper fluorescence and leakage from the retinal branches. MRI FLAIR sequence demonstrated several hyperintense lesions in the corpus callosum, corona radiata and centrum semiovale. After collaborative efforts, Susac Syndrome was entertained, and our patient received immunoglobulin and rituximab after relapse on pulsed methylprednisolone, with marked resolution of symptoms. Conclusion: Only a small percentage of patients will present with the triad, however, it is most common to see only 2 out of the 3 as exemplified in our case. Collaborative efforts are required to come to a quick diagnosis. Excellent recovery is expected once diagnosis is made, and patients are commenced on immunosuppressants.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80074920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gestational Pemphigus : A Case Report 妊娠期天疱疮1例报告
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.33425/2768-6647.1021
S. Sabir, Z. Sami, N. Youssouf, Safia Gmih, M. Jalal, A. Lamrissi, S. Bouhya
{"title":"Gestational Pemphigus : A Case Report","authors":"S. Sabir, Z. Sami, N. Youssouf, Safia Gmih, M. Jalal, A. Lamrissi, S. Bouhya","doi":"10.33425/2768-6647.1021","DOIUrl":"https://doi.org/10.33425/2768-6647.1021","url":null,"abstract":"Pregnancy-associated dermatoses represent a heterogeneous group with variable expression, ranging from pathologies with simple aesthetic impact to those with a pejorative prognosis. The occurrence of pemphigus during pregnancy is exceptional. The diagnosis is generally easy and is based on the clinic, histology and direct and indirect immunofluorescence. No clinico-biological particularity is observed during this association, but the occurrence of maternal-fetal complications makes it all the more serious. The treatment is mainly based on corticosteroid therapy, plasmapheresis as well as intravenous immunoglobulins. We report the case of a patient37 years old, married and mother of 3 living vaginally who consults for spots erythemato-papular lesions, vesicular in places associated with lesions in rosette and pseudo-rosette occupying the abdomen without respecting the periumbilical region, the limbs generalized lower arms and forearms occurring in the third trimester in a presumed unmonitored pregnancy at 36 weeks of amenorrhea and 3 days and whose skin biopsy wasin favor of a pemphigoid.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87009845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual site of yellow ligament ossification- cervical spine 不寻常的黄色韧带骨化部位-颈椎
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.23937/2378-3656/1410397
Mahmoodkhani Mehdi, Askariardehjani Navid
{"title":"Unusual site of yellow ligament ossification- cervical spine","authors":"Mahmoodkhani Mehdi, Askariardehjani Navid","doi":"10.23937/2378-3656/1410397","DOIUrl":"https://doi.org/10.23937/2378-3656/1410397","url":null,"abstract":"The patient is an 80-year-old man who presented with pain and paresis in all four limbs about a year ago. The patient’s symptoms have worsened over the past month. The force of the patient’s upper limbs was about three-fifths and the lower limbs were about four-fifths. The patient complained of numbness and tingling in all four limbs, especially the upper limbs. Sphincter disorder has been characterized by urinary incontinence, which began a year ago and has now worsened over the past few months. Hoffman’s sign was positive on both sides. Introduction","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76368787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spindle Cells Oncocytoma and Rathke’s Cyst; A Collision Sellar Tumor– Brief Communication & Case Report 梭形细胞、嗜瘤细胞瘤和拉克囊肿;1例碰撞性鞍区肿瘤的简短交流与病例报告
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.33425/2768-6647.1022
M. Tena-Suck, Axel Adair Hernández-Pacheco, Daniel Rocandio-Hernández, C. Salinas-Lara, C. Sánchez-Garibay
{"title":"Spindle Cells Oncocytoma and Rathke’s Cyst; A Collision Sellar Tumor– Brief Communication & Case Report","authors":"M. Tena-Suck, Axel Adair Hernández-Pacheco, Daniel Rocandio-Hernández, C. Salinas-Lara, C. Sánchez-Garibay","doi":"10.33425/2768-6647.1022","DOIUrl":"https://doi.org/10.33425/2768-6647.1022","url":null,"abstract":"Collision tumors comprising of pituitary adenomas with other sellar neoplasms are rare. Histological examination is necessary since preoperative studies cannot guarantee an accurate diagnosis. A 66-year-old man with headache and progressive visual alterations, MRI showed a sellar tumor that was diagnosed as pituitary adenoma and graduated as HV IIIc. He underwent surgery and two lesions were resected, one on the cavernous sinus and the other one in sellar region. The lesion of the venous sinus corresponds to a cyst covered by a ciliated pseudostratified epithelium that was diagnosed as Rathke's cyst, and the second one was formed by a neoplastic lesion of elongated cells with focal cellular atypia in a sarcomatous pattern, forming fascicles alternating with a pattern formed by medium eosinophilic cells predominantly in elongated cells in a stroma with abundant sinusoids. For immunohistochemistry, the epithelium of the cyst was PTTG-1, cytokeratin 6/8, and chromogranin positive, while the other lesion was positive chromogranin, FSH, LH PTTG-1, TTF-1, while the spindle cells area was positive immunoreaction for PTTG-1, GFAP, S-100, and VIM and weak expression for TTF-1. These histologic and immunohistochemical findings are suggestive of spindle cells oncocytoma and Rathke cyst, is a rare sellar collision tumor. The expression of TTF-1 in the spindle cell oncocytoma with the idea of common histogenesis for pituicytoma and SCOs and raise the possibility of more aggressive growth in SCOs as compared to pituicytoma.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83176554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Hydrocephalus Secondary To Parvovirus Infection (About One Case) 细小病毒感染继发先天性脑积水(附1例)
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.33425/2768-6647.1018
Youssouf N, W. O, S. ..-S., Benhaddouga K, J. M, L. A, F. K, B. S
{"title":"Congenital Hydrocephalus Secondary To Parvovirus Infection (About One Case)","authors":"Youssouf N, W. O, S. ..-S., Benhaddouga K, J. M, L. A, F. K, B. S","doi":"10.33425/2768-6647.1018","DOIUrl":"https://doi.org/10.33425/2768-6647.1018","url":null,"abstract":"In pregnancy, even if the risk of fetal complications is extremely low in case of parvovirus infection, a preventive or therapeutic attitude must be implemented as quickly as possible in the event of contagion because the risk of foetoplacental hydrops exists as well as the risk of death fetal in utero and malformative. We report the case of parvovirus seroconversion during pregnancy discovered in the etiological assessment of hydrocephalus associated with hydramnios.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81771371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontal Right Plasma Cell Granuloma; Case Report 额右浆细胞肉芽肿;病例报告
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.33425/2768-6647.1020
Daniel Rocandio-Hernández, Daniel Ballesteros-Herrera, M. Tena-Suck, Carlos Peñafiel-Salgado, Laura G. Chávez Macías, Erick Gmez Apo
{"title":"Frontal Right Plasma Cell Granuloma; Case Report","authors":"Daniel Rocandio-Hernández, Daniel Ballesteros-Herrera, M. Tena-Suck, Carlos Peñafiel-Salgado, Laura G. Chávez Macías, Erick Gmez Apo","doi":"10.33425/2768-6647.1020","DOIUrl":"https://doi.org/10.33425/2768-6647.1020","url":null,"abstract":"The Plasma Cells Granuloma is a relatively rare lesion, that forms a nodule or a mass, it is conformed of polyclonal plasmatic cells in storiform background fibrosis and spread of fusiform cells. We present the case of a 62-year-old woman, with a history of oophorectomy and increased volume in the right frontal area of the head, then presenting neurologic signs of frontal lobe syndrome. Radiologic images showed a wide right frontal lobe neoplasia that spreads diffusely. Histologically the tumor was formed by plasma cells, B lymphocytes infiltrate, and numerous blood vessels. It was positive for CD20, kappa, lambda, CD3, and CD4. Even though it is uncommon, it can develop at any place and must be included in the differential diagnoses list for plasma cells neoplasia. The positivity of light chains kappa and lambda make evident the polyclonality that confirms the diagnosis.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87130304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Most Difficult Disease to Diagnose Even With Biopsy 即使用活组织检查也最难诊断的疾病
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.33425/2768-6647.1019
A. Ekladious
{"title":"The Most Difficult Disease to Diagnose Even With Biopsy","authors":"A. Ekladious","doi":"10.33425/2768-6647.1019","DOIUrl":"https://doi.org/10.33425/2768-6647.1019","url":null,"abstract":"Sarcoidosis is granulomatous autoinflammatory autoimmune remitting relapsing disease affecting every organ in the body, it is the most difficult disease to diagnose in the absence of serum or imaging biomarker, Differential diagnosis is broad which included inflammatory, infective, neurodegenerative and neoplastic, histological biopsy is the only confirmative marker, and even histological confirmation is not robust as infection, malignancy and some drugs can induce granuloma, the most common organs affected are lung, lymph nodes, skin, eyes, liver, and less commonly pituitary gland, bones, brain, peripheral nerves, and heart, causing bilateral hilar lymphadenopathy, granulomatous lymphadenitis.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85941522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methotrexate Induced Stevens-Johnson Syndrome: Two Cases Reports 甲氨蝶呤诱发Stevens-Johnson综合征2例报告
Clinical Medical Reviews and Case Reports Pub Date : 2022-06-30 DOI: 10.23937/2378-3656/1410395
M. I., Baklouti F., Siala N., Yaye YO., M. A, K. A.
{"title":"Methotrexate Induced Stevens-Johnson Syndrome: Two Cases Reports","authors":"M. I., Baklouti F., Siala N., Yaye YO., M. A, K. A.","doi":"10.23937/2378-3656/1410395","DOIUrl":"https://doi.org/10.23937/2378-3656/1410395","url":null,"abstract":"Methotrexate induced Stevens-Johnson syndrome (SJS) is rare but life-threatening cutaneous reaction. This is a case report of two 14-year-old girls with methotrexate (MTX)-induced Stevens-Johnson syndrome (SJS). Both girls received chemotherapy with MTX in the treatment of osteosarcoma and then developed SJS. They showed cutaneous and mucosal erosions, macular and purplish rash, and ulceration in the cutaneous and mucosal areas. The full spectrum of all mucous membranesinvolved is less than 10% of the body surface area in the two patients. The diagnosis of SJS is based on clinical features and there are no universally accepted diagnostic criteria. Prompt withdrawal of causative drugs should be a priority and the re-exposure of culprit drug is not recommended. Corticosteroid at a dose of 1 mg / kg / day was administered to them and they both recovered from SJS. MTX is known as a drug that can induce SJS. So, it is rare but is not extremely rare.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77987889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-Onset Atypical Coeliac Disease Presenting with Severe Anaemia and Hidradenitis Suppurativa: A Case Report 成人发病的不典型乳糜泻伴严重贫血和化脓性汗腺炎1例报告
Clinical Medical Reviews and Case Reports Pub Date : 2022-05-31 DOI: 10.23937/2378-3656/1410394
Dassanayake Udani, Jayasinghe Saroj
{"title":"Adult-Onset Atypical Coeliac Disease Presenting with Severe Anaemia and Hidradenitis Suppurativa: A Case Report","authors":"Dassanayake Udani, Jayasinghe Saroj","doi":"10.23937/2378-3656/1410394","DOIUrl":"https://doi.org/10.23937/2378-3656/1410394","url":null,"abstract":"Background: Coeliac disease is an autoimmune disease causing intestinal mucosal damage in response to dietary gluten resulting in malabsorption. It is a rarity in Sri Lanka and southern Asia possibly due to the low gluten consumption. This report is of a young female who presented with severe anaemia and hidradenitis suppurativa and was found to have coeliac disease. It is the first serologically confirmed adult case of the disease reported from Sri Lanka. Case presentation: A 23-year-old female presented with a history of an acute febrile illness associated with cough for about 24 hours. She gave a background history of altered bowel habits for 2 years. A mixed deficiency anaemia was detected, and endoscopy, serology and histological tests confirmed a diagnosis of coeliac disease. She was successfully treated with a gluten free diet. She also had hidradenitis suppurativa which subsided with a gluten-free diet. Conclusion: This case highlights an atypical presentation of anemia in coeliac disease in a population with low disease expression. Association of hidradenitis suppurativa with gluten hypersensitivity is an area of recent interest and complete resolution of the skin eruption occurred with a gluten free diet.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77636924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleomorphic Adenoma of External Auditory Canal: First Case Report from Ethiopia with Relevant Literature Review 外耳道多形性腺瘤:埃塞俄比亚首例报告并相关文献复习
Clinical Medical Reviews and Case Reports Pub Date : 2022-05-31 DOI: 10.23937/2378-3656/1410392
Shumiye Yonas Girma, Bushra Fatuma Yassin, Alemayehu Ruth Abera, Wondimagegnehu Muluken Bekele
{"title":"Pleomorphic Adenoma of External Auditory Canal: First Case Report from Ethiopia with Relevant Literature Review","authors":"Shumiye Yonas Girma, Bushra Fatuma Yassin, Alemayehu Ruth Abera, Wondimagegnehu Muluken Bekele","doi":"10.23937/2378-3656/1410392","DOIUrl":"https://doi.org/10.23937/2378-3656/1410392","url":null,"abstract":"Ceruminous Pleomorphic Adenoma is a very rare, benign neoplasm originating from the ceruminal glands in the external auditory canal. Clinical manifestations are nonspecific. Meticulous preoperative clinical, pathologic, and radiologic evaluations are crucial in effective management of patients. Its diagnosis depends on identification of proliferation of regular epithelial and myoepithelial cells embedded in a chondromyxoid stroma. We present a case of pleomorphic adenoma of external auditory canal diagnosed in a 25-yearold female Ethiopian patient hoping to help clinicians and pathologists in recognizing this rare benign neoplasm.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73458218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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