Clinical Medicine Insights: Psychiatry最新文献_第4页

Neurobiological Pathways between Chronic Stress and Depression: Dysregulated Adaptive Mechanisms? 慢性应激和抑郁之间的神经生物学通路:失调的适应机制?

Clinical Medicine Insights: Psychiatry Pub Date : 2009-01-01 DOI: 10.4137/CMPsy.S3658

C. Sharpley

引用次数: 21

Database Analysis of Adults with Bipolar Disorder Consuming a Micronutrient Formula 双相情感障碍成人食用微量营养素配方的数据库分析

Clinical Medicine Insights: Psychiatry Pub Date : 2009-01-01 DOI: 10.4137/CMPsy.S2278

D. Gately, B. Kaplan

{"title":"Database Analysis of Adults with Bipolar Disorder Consuming a Micronutrient Formula","authors":"D. Gately, B. Kaplan","doi":"10.4137/CMPsy.S2278","DOIUrl":"https://doi.org/10.4137/CMPsy.S2278","url":null,"abstract":"Background Bipolar disorder is a lifelong problem with imperfect available treatments. Recent research has shown potential benefit of nutritional treatment for mood symptoms. The goal of the current study was to determine whether adults with bipolar disorder reported treatment benefit from consuming a micronutrient formula. Methods Self-report data were available from 682 adults who reported a diagnosis of bipolar disorder; 81% were taking psychiatric medications. Those reporting additional diagnoses were excluded, as well as those who provided data <60 times during 180 days of using the micronutrients, leaving 358 for analysis. Results Mean symptom severity was 41% lower than baseline after 3 months (effect size = 0.78), and 45% lower after 6 months (effect size = 0.76) (both paired t-tests significant, p < 0.001). In terms of responder status, 53% experienced ≥50% improvement at 6 months. Half the sample were taking medications approved for bipolar disorder (lithium, anticonvulsants, atypical antipsychotics), and half were either medication-free or taking other medications: the magnitude of treatment benefit did not differ between these two groups. Regression analyses indicated that decreased symptom severity over the 6 months was associated with increasing micronutrient dosage and with reducing medication. Symptom improvements were significant and sustained at 6 months, suggesting that benefits were not attributable to placebo/expectancy effects. Conclusions Further research on this micronutrient formula is warranted.","PeriodicalId":10437,"journal":{"name":"Clinical Medicine Insights: Psychiatry","volume":"28 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89310192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Introductory Editorial 入门篇社论

Clinical Medicine Insights: Psychiatry Pub Date : 2009-01-01 DOI: 10.4137/117955730900200001

J. Ghuman

引用次数: 0

Anthroposophic Therapy for Anxiety Disorders: A Two-year Prospective Cohort Study in Routine Outpatient Settings 焦虑障碍的人智疗法:常规门诊设置的两年前瞻性队列研究

Clinical Medicine Insights: Psychiatry Pub Date : 2009-01-01 DOI: 10.4137/CMPsy.S2791

H. Hamre, C. Witt, G. Kienle, A. Glockmann, R. Ziegler, S. Willich, H. Kiene

{"title":"Anthroposophic Therapy for Anxiety Disorders: A Two-year Prospective Cohort Study in Routine Outpatient Settings","authors":"H. Hamre, C. Witt, G. Kienle, A. Glockmann, R. Ziegler, S. Willich, H. Kiene","doi":"10.4137/CMPsy.S2791","DOIUrl":"https://doi.org/10.4137/CMPsy.S2791","url":null,"abstract":"Background and Methods Anthroposophic treatment for anxiety disorders includes special artistic and physical therapies and special medications. We conducted a prospective cohort study of 64 consecutive adult outpatients starting anthroposophic treatment for anxiety disorders under routine conditions. Main outcomes were Anxiety Severity (physician and patient ratings 0–10), Self-rating Anxiety Scale (0–100), Center for Epidemiological Studies Depression Scale, German version (CES-D, 0–60), and SF-36 Mental Component Summary. Results Mean age was 42.3 years. Most frequent diagnoses were generalized anxiety disorder (44% of patients, n = 28/64) and panic disorder (39%). Median disease duration was 4.5 years. The anthroposophic treatment modalities used were medications (56% of patients), eurythmy therapy (41%), art therapy (30%), and rhythmical massage therapy (3%). Median number of eurythmy/art/massage sessions was 12, median therapy duration was 120 days. From baseline to six-month follow-up, all outcomes improved significantly; average improvements were: Physician-rated Anxiety Severity 3.60 points (95% confidence interval 2.97–4.22, p < 0.001), patient-rated Anxiety Severity 3.50 (2.88–4.12, p < 0.001), Self-rating Anxiety Scale 11.88 (7.70–16.05, p < 0.001), CES-D 8.79 (5.61–11.98, p < 0.001), and SF-36 Mental Component 9.53 (5.98–13.08, p < 0.001). All improvements were maintained until last follow-up after 24 months. Conclusions Patients with anxiety disorders under anthroposophic treatment had long-term improvements of symptoms and quality of life.","PeriodicalId":10437,"journal":{"name":"Clinical Medicine Insights: Psychiatry","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80068480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Hopelessness and Low Social and Occupational Functioning are Associated with Non-Recovery from Depression—Results of a 6-Year Follow-Up Study 绝望、低社会和职业功能与抑郁症无法康复相关——一项6年随访研究的结果

Clinical Medicine Insights: Psychiatry Pub Date : 2008-01-01 DOI: 10.4137/CMPsy.S768

H. Viinamäki, H. Koivumaa-Honkanen, K. Honkalampi, K. Haatainen, T. Tolmunen, R. Antikainen, J. Hintikka

{"title":"Hopelessness and Low Social and Occupational Functioning are Associated with Non-Recovery from Depression—Results of a 6-Year Follow-Up Study","authors":"H. Viinamäki, H. Koivumaa-Honkanen, K. Honkalampi, K. Haatainen, T. Tolmunen, R. Antikainen, J. Hintikka","doi":"10.4137/CMPsy.S768","DOIUrl":"https://doi.org/10.4137/CMPsy.S768","url":null,"abstract":"Objective The aim of this study was to explore variables associated with poor recovery from depression. Method A sample of depressive patients (n = 121) referred to treatment was followed prospectively for 6 years. Clinical evaluations were done at baseline and at 6 month, 1, 2 and 6 years study visits. A diagnosis of major depression based on SCID interview at 6 year and high BDI score along follow-up indicated poor recovery. A diagnosis of full remission at 6 year and low BDI score during follow-up indicated good recovery. Results Chronic depression was found in 15% of patients. A repeated measures analysis of variance of HDRS-, SCL-90, hopelessness (HS) and Social and Occupational Functioning Assessment Scale (SOFAS) scores showed that those with poor recovery had recovered poorly also according these scales during the whole follow-up. Treatment factors did not associate with recovery. Logistic regression analyses revealed an independent association between poor recovery at 6 year and both high HS- and low SOFAS scores at 12 months, 24 months and 6 year assessments. Conclusions Assessment of hopelessness and social and occupational functioning help to early identify high-risk patients who would be in need for more individually tailored treatments.","PeriodicalId":10437,"journal":{"name":"Clinical Medicine Insights: Psychiatry","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84495463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Parental Psychiatric Morbidity with their Altruistic Behaviors and Sense of Obligation to Children in the United States 美国父母精神疾病与他们的利他行为和对孩子的责任感的关系

Clinical Medicine Insights: Psychiatry Pub Date : 2008-01-01 DOI: 10.4137/CMPsy.S883

T. Fujiwara, Cynthia Lee

引用次数: 3

Relationship between Perceived Sleep Problems and Thalamic Size in Patients with Chronic Fatigue Syndrome Compared to Non-Fatigued Controls: A Preliminary Study 与非疲劳对照相比，慢性疲劳综合征患者感知睡眠问题与丘脑大小的关系:一项初步研究

Clinical Medicine Insights: Psychiatry Pub Date : 2008-01-01 DOI: 10.4137/CMPsy.S704

S. Begré, Tobias Lütgert, L. Remonda, R. Wiest, C. Kiefer, R. von Känel

{"title":"Relationship between Perceived Sleep Problems and Thalamic Size in Patients with Chronic Fatigue Syndrome Compared to Non-Fatigued Controls: A Preliminary Study","authors":"S. Begré, Tobias Lütgert, L. Remonda, R. Wiest, C. Kiefer, R. von Känel","doi":"10.4137/CMPsy.S704","DOIUrl":"https://doi.org/10.4137/CMPsy.S704","url":null,"abstract":"Chronic fatigue syndrome (CFS) is characterized by disabling fatigue of unknown etiology. The thalamus is a key subcortical structure in sleep disorders and certain cognitive functions previously shown to be impaired in CFS patients. We investigated the association between subjective sleep quality and thalamic size in CFS. Twelve right-handed CFS patients and 12 age-, gender-, and handedness-matched healthy controls completed the Jenkins Sleep Questionnaire in order to assess subjective sleep problems. Thalamic size was determined by MR-based volumetry. More sleep problems correlated with greater total thalamic volume in patients (rP = 0.62, 95% CI 0.07–0.88, p = 0.032) but not in controls (rP = −0.034, p = 0.30). In post hoc analysis, more sleep problems correlated with right thalamic size in patients (rP = 0.70, 95% CI 0.21–0.91, p = 0.012) but not in controls (rP = −0.080, p = 0.81). Our preliminary results provide a basis for further studies on a possible role of the thalamus in sleep complaints and fatigue of patients with CFS.","PeriodicalId":10437,"journal":{"name":"Clinical Medicine Insights: Psychiatry","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81635558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Implications of Psychotropic Medications in a Publicly-Funded State Psychiatric Hospital 精神药物在公立精神病院的代谢影响

Clinical Medicine Insights: Psychiatry Pub Date : 2008-01-01 DOI: 10.4137/CMPsy.S844

R. Bota, Timothy Dellenbaugh, A. Giorgadze, Chadd K Eaglin, C. Dávila

引用次数: 0