Clinical Nephrology. Case Studies最新文献_第4页

Minimal change disease after multiple wasp stings. 多次黄蜂蜇伤后的微小变化疾病。

Clinical Nephrology. Case Studies Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI: 10.5414/CNCS110369

Yasmine S Humeda, William L Clapp, Humam Humeda

引用次数: 1

Acute respiratory distress syndrome driven by severe hypercalcemia and acute kidney injury: A case report and literature review of a rare, life-threatening complication. 由严重高钙血症和急性肾损伤引起的急性呼吸窘迫综合征:一个罕见的危及生命的并发症的病例报告和文献回顾。

Clinical Nephrology. Case Studies Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI: 10.5414/CNCS110464

Haresh Selvaskandan, Katherine Hull, Rachel Gregory, Daniel Pan, Thrasos Macriyiannis, Jenny Briggs, Catherine Richards, Catherine Mason, Jorge Jesus-Silva, Ricky Bell

{"title":"Acute respiratory distress syndrome driven by severe hypercalcemia and acute kidney injury: A case report and literature review of a rare, life-threatening complication.","authors":"Haresh Selvaskandan, Katherine Hull, Rachel Gregory, Daniel Pan, Thrasos Macriyiannis, Jenny Briggs, Catherine Richards, Catherine Mason, Jorge Jesus-Silva, Ricky Bell","doi":"10.5414/CNCS110464","DOIUrl":"https://doi.org/10.5414/CNCS110464","url":null,"abstract":"Acute respiratory distress syndrome (ARDS) is a rare and under-reported complication of hypercalcemia, which often presents in conjunction with acute kidney injury (AKI). Unfamiliarity with the condition inevitably leads to management uncertainty, resulting in fatal outcomes. Early identification, however, confers a good prognosis. We report a case of a 40-year-old male who presented with severe hypercalcemia and AKI and rapidly deteriorated due to ARDS, with no evidence of cardiogenic pulmonary edema or fluid overload. Infection screens were negative. He died despite invasive ventilation and continuous venous-venous hemofiltration. His autopsy revealed extensive metastatic pulmonary calcifications and alveolar edema. We found only 10 other cases of hypercalcemia-induced ARDS in the literature, with only 2 patients surviving. We provide the first literature review on the subject to guide the management of this rare but fatal complication, which can be managed with good outcomes if considered early.","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":" ","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8802067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39879865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An atypical case of hemodialysis access stent migration. 血液透析通路支架移位的非典型病例。

Clinical Nephrology. Case Studies Pub Date : 2022-01-24 eCollection Date: 2022-01-01 DOI: 10.5414/CNCS110737

Juan C Duque, Marwan Tabbara, Laisel Martinez, Karen Manzur-Pineda, Roberto I Vazquez-Padron, Adriana Dejman

引用次数: 0

The "new normal" osmotic threshold: Osmostat reset. “新常态”渗透阈值:渗透复位。

Clinical Nephrology. Case Studies Pub Date : 2022-01-10 eCollection Date: 2022-01-01 DOI: 10.5414/CNCS110740

Larissa G Rigueto, Henrique M Santiago, David J Hadad, Antonio Carlos Seguro, Adriana Castello C Girardi, Weverton M Luchi

引用次数: 2

Recurrence or reactivation of SARS-CoV-2 infection after immunosuppressive therapy in patients with ANCA-associated vasculitis and COVID-19. anca相关性血管炎和COVID-19患者免疫抑制治疗后SARS-CoV-2感染复发或再激活

Clinical Nephrology. Case Studies Pub Date : 2022-01-05 eCollection Date: 2022-01-01 DOI: 10.5414/CNCS110567

Mansour Mbengue, Bede Bigirimana, Lolly Romeo Irankunda, Mohamed Cherif Dial, Abdou Niang

引用次数: 0

Kidney autotransplantation as a treatment for resistant hypertension due to renal artery stenosis: A case report and review of the literature. 自体肾移植治疗肾动脉狭窄引起的顽固性高血压:1例报告及文献复习。

Clinical Nephrology. Case Studies Pub Date : 2022-01-05 eCollection Date: 2022-01-01 DOI: 10.5414/CNCS110565

Tahira Scott, Sree Krishna Venuthurupalli

引用次数: 1

Lymphomatous infiltration of the kidney in a patient with Waldenstrom's macroglobulinemia. 瓦尔登斯特罗姆大球蛋白血症患者肾脏的淋巴瘤浸润。

Clinical Nephrology. Case Studies Pub Date : 2022-01-01 DOI: 10.5414/CNCS110756

Prasanth Ravipati, Lihong Bu, Zohar Sachs, Patrick H Nachman

{"title":"Lymphomatous infiltration of the kidney in a patient with Waldenstrom's macroglobulinemia.","authors":"Prasanth Ravipati, Lihong Bu, Zohar Sachs, Patrick H Nachman","doi":"10.5414/CNCS110756","DOIUrl":"https://doi.org/10.5414/CNCS110756","url":null,"abstract":"Kidney disease can be an initial presentation or a chronic manifestation of plasma cell dyscrasias. Here, we describe a rare presentation of kidney disease driven by lymphomatous infiltration of the kidney in a patient with Waldenstrom's macroglobulinemia (WM). A 70-year-old female with an 8-year history of WM (IgM, κ) was referred for declining renal function. Prior to presentation, she had stable WM disease without evidence of worsening disease burden. She had been previously hospitalized with SARS-CoV-2 infection and acute kidney injury (AKI). Her serum creatinine (sCr) peaked at 3.7 mg/dL (baseline 0.9 mg/dL) but recovered to 1.1 mg/dL by the time of discharge. Two months after discharge, her sCr increased to 1.9 mg/dL, and she had new proteinuria of 1.5 g/day. Kidney biopsy showed lymphomatous infiltration of the interstitium without glomerular involvement. Treatment with rituximab and bendamustine resulted in an improvement in renal function (sCr 1.4 mg/dL). WM is an uncommon hematologic malignancy, and extramedullary involvement, including renal involvement, is rare. This case emphasizes the importance of surveillance for kidney dysfunction in patients with plasma cell dyscrasias, even if patients appear to have stable lymphoproliferative disease.","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"10 ","pages":"87-90"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9795319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10512464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-induced CYP induction as therapy for tacrolimus intoxication. 药物诱导CYP治疗他克莫司中毒。

Clinical Nephrology. Case Studies Pub Date : 2022-01-01 DOI: 10.5414/CNCS110744

John M Hoppe, Alexander Holderied, Ulf Schönermarck, Volker Vielhauer, Hans-Joachim Anders, Michael Fischereder

{"title":"Drug-induced CYP induction as therapy for tacrolimus intoxication.","authors":"John M Hoppe, Alexander Holderied, Ulf Schönermarck, Volker Vielhauer, Hans-Joachim Anders, Michael Fischereder","doi":"10.5414/CNCS110744","DOIUrl":"https://doi.org/10.5414/CNCS110744","url":null,"abstract":"Management of calcineurin inhibitor (CNI) therapy in kidney transplant recipients may be complicated due to polypharmacy. As CNI undergo extensive metabolism by cytochrome-P450 enzymes (CYP), drug-mediated CYP inhibition poses a risk for elevated CNI blood concentrations. Here, we report on 2 kidney transplant recipients treated with tacrolimus who presented with signs of tacrolimus intoxication at admission. Patient A was started on antiviral medication ombitasvir, paritaprevir, ritonavir, and dasabuvir for hepatitis C virus treatment 3 days prior to hospitalization. Patient B was treated with clarithromycin for pneumonia. Both therapies cause drug-mediated CYP inhibition, and both patients displayed highly elevated tacrolimus serum concentrations and acute kidney injury (Table 1). After application of the CYP-inducing agents rifampicin and phenytoin, respectively, tacrolimus levels were rapidly reduced, and renal function recovered. Treating severe CNI intoxication is an infrequent yet emergent condition. These results add to the knowledge of therapeutic drug-induced CYP induction as rescue therapy.","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"10 ","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9153279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Concordant nephrotic syndrome in twins with PAX2 and MYO1E mutations. PAX2和MYO1E突变双胞胎的一致性肾病综合征。

Clinical Nephrology. Case Studies Pub Date : 2022-01-01 DOI: 10.5414/CNCS110799

Oulimata K Grossman, Claire F Schretlen, Linda S Nield

{"title":"Concordant nephrotic syndrome in twins with PAX2 and MYO1E mutations.","authors":"Oulimata K Grossman, Claire F Schretlen, Linda S Nield","doi":"10.5414/CNCS110799","DOIUrl":"https://doi.org/10.5414/CNCS110799","url":null,"abstract":"Introduction: The medical literature is scant with reports of twins diagnosed with nephrotic syndrome associated with genetic mutations. Mutations in the protein coding paired box gene 2 (PAX2) and in the non-muscle class I myosin, myosin 1E, (MYO1E) have been implicated in the development of steroid-resistant nephrotic syndrome. We describe the first case, to our knowledge, of the concordant presentation of nephrotic syndrome in twins with simultaneous mutations in PAX2 and MYO1E.Case report: At 32 months and 33 months of age, monochorionic, diamniotic twin girls presented with nephrotic syndrome. Each twin experienced three relapses during or after completion of corticosteroid treatment. Sustained remission was achieved with tacrolimus. Genetic testing of each twin revealed two heterozygous mutations of MYO1E and one homozygous mutation of PAX2. Renal biopsy results of one twin revealed pathologic findings consistent with minimal change nephropathy. The twins' phenotypes have been essentially identical.Conclusion: Our cases add to the scant medical literature addressing nephrotic syndrome in twins with genetic mutations. Close monitoring of our unique patients will provide novel information about the clinical significance of combined mutations in PAX2 and MYO1E.","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"10 ","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Non-diabetic metabolic nodular glomerulosclerosis. 非糖尿病代谢性结节性肾小球硬化。

Clinical Nephrology. Case Studies Pub Date : 2022-01-01 DOI: 10.5414/CNCS110943

Catarina Mateus, Eunice Cacheira, Ivo Laranjinha, Jorge Dickson, Augusta Gaspar

引用次数: 0