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A case of nephrotic syndrome showing contemporary presence of apolipoprotein E2 homozygote glomerulopathy and membranous nephropathy-like findings modified by apolipoprotein E Toyonaka. 肾病综合征1例，显示当代存在载脂蛋白E2纯合子肾小球病和膜性肾病样表现，由载脂蛋白E Toyonaka修饰。
Clinical Nephrology. Case Studies Pub Date : 2018-11-30 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109509
Hisako Hirashima, Toshiyuki Komiya, Naoya Toriu, Shigeo Hara, Akira Matsunaga, Takao Saito, Eri Muso
{"title":"A case of nephrotic syndrome showing contemporary presence of apolipoprotein E2 homozygote glomerulopathy and membranous nephropathy-like findings modified by apolipoprotein E Toyonaka.","authors":"Hisako Hirashima,&nbsp;Toshiyuki Komiya,&nbsp;Naoya Toriu,&nbsp;Shigeo Hara,&nbsp;Akira Matsunaga,&nbsp;Takao Saito,&nbsp;Eri Muso","doi":"10.5414/CNCS109509","DOIUrl":"https://doi.org/10.5414/CNCS109509","url":null,"abstract":"<p><p>A 79-year-old man was admitted to our hospital for proteinuria due to nephrotic syndrome. Renal biopsy revealed focal sclerosis and foam cell infiltration in the glomerulus. In addition, electron microscopic findings (EM) revealed peculiar electron-dense deposits (EDDs) in both sides of the glomerular basement membrane. Although subepithelial deposits had spike formation highly resembling those seen in membranous nephropathy (MN), immunoglobulins and complements were not identified by immunofluorescence study, and microbubbles appeared in high magnification of EM different from the immune disease. The analysis of apolipoprotein (Apo) E showed an elevated concentration of plasma ApoE. The phenotype, genotype, and DNA sequence studies revealed homozygous ApoE2/2 and a novel missense mutation called ApoE Toyonaka (Ser197Cys). This case may confirm the independent responsibility of ApoE2/2 and ApoE Toyonaka for ApoE2 homozygote glomerulopathy and MN-like EDD findings, respectively.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5414/CNCS109509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36774219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Management of Denys-Drash syndrome: A case series based on an international survey. Denys-Drash综合征的管理:基于国际调查的病例系列。
Clinical Nephrology. Case Studies Pub Date : 2018-11-12 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109515
Laurence Gariépy-Assal, Rodney D Gilbert, Aleksas Žiaugra, Bethany Joy Foster
{"title":"Management of Denys-Drash syndrome: A case series based on an international survey.","authors":"Laurence Gariépy-Assal,&nbsp;Rodney D Gilbert,&nbsp;Aleksas Žiaugra,&nbsp;Bethany Joy Foster","doi":"10.5414/CNCS109515","DOIUrl":"https://doi.org/10.5414/CNCS109515","url":null,"abstract":"<p><p>Denys-Drash syndrome (DDS), a condition caused by mutations in the tumor-suppressor gene WT-1, is associated with a triad of disorders: ambiguous genitalia, nephrotic syndrome leading to end-stage renal disease (ESRD), and Wilms' tumor. Given the variable disease course, management is challenging. We aimed to describe the evolution of DDS and the range of management strategies by summarizing the clinical courses of cases collected from a questionnaire sent to the international pediatric nephrology community. 15 respondents provided information on 23 patients; 21 DDS cases were confirmed and analyzed. At DDS diagnosis, 6 patients had a Wilms' tumor (group A) and 15 had no Wilms' tumor (group B). Three group A patients had unilateral nephrectomy. Two of these still had renal function, with no second tumor, at 36 months and 16 years of age, and 1 progressed to ESRD. Three had bilateral nephrectomy before ESRD. Eight group B patients progressed to ESRD, all of whom later had all renal tissue removed. Two group B patients subsequently developed a unilateral Wilms' tumor and had bilateral nephrectomy pre-ESRD. Three had bilateral nephrectomy prior to reaching ESRD without ever having a Wilms' tumor. Two group B patients remained tumor-free with renal function at last follow-up. Two main management approaches were taken: pre-emptive nephrectomy prior to ESRD and conservative surveillance. Based on the known risks associated with ESRD in infants and young children, the variable course of DDS, and the relatively good prognosis associated with Wilms' tumor, a guiding principle of preservation of renal function is most logical. Most would advocate bilateral prophylactic nephrectomy after ESRD is reached due to the high tumor risk, which is likely heightened after transplant.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"2018-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36742329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature. 索非布韦和daclatasvir治疗HCV和HIV患者相关间质性肾炎和局灶节段性肾小球硬化的成功恢复及文献修订
Clinical Nephrology. Case Studies Pub Date : 2018-10-26 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109221
Michele Mirabella, Lucia Taramasso, Laura Ambra Nicolini, Rodolfo Russo, Claudio Viscoli, Antonio Di Biagio
{"title":"Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature.","authors":"Michele Mirabella,&nbsp;Lucia Taramasso,&nbsp;Laura Ambra Nicolini,&nbsp;Rodolfo Russo,&nbsp;Claudio Viscoli,&nbsp;Antonio Di Biagio","doi":"10.5414/CNCS109221","DOIUrl":"https://doi.org/10.5414/CNCS109221","url":null,"abstract":"<p><p>In this report, we describe the coexistence of two rare and debated complications of hepatitis C virus (HCV) infection: interstitial nephritis, with associated focal glomerulosclerosis, and autoimmune hepatitis, in a 55-year-old HIV/HCV-coinfected woman. The patient was treated for the immune-mediated manifestations with mycophenolate mofetil, which she continued for 9 years, as symptoms relapsed at every attempt to discontinue immunosuppression. The patient finally cleared HCV infection thanks to new direct-acting agents and could discontinue immunosuppressive therapy maintaining stable conditions and laboratory parameters after 24-weeks follow-up.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2018-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36645911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Disappearance of a thrombotic microangiopathy-like glomerular lesion in a patient with a placental site trophoblastic tumor after hysterectomy. 子宫切除术后胎盘部位滋养细胞瘤患者血栓性微血管病变样肾小球病变消失。
Clinical Nephrology. Case Studies Pub Date : 2018-09-20 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109440
Masato Sawamura, Atsushi Komatsuda, Mizuho Nara, Masaru Togashi, Hideki Wakui, Naoto Takahashi
{"title":"Disappearance of a thrombotic microangiopathy-like glomerular lesion in a patient with a placental site trophoblastic tumor after hysterectomy.","authors":"Masato Sawamura,&nbsp;Atsushi Komatsuda,&nbsp;Mizuho Nara,&nbsp;Masaru Togashi,&nbsp;Hideki Wakui,&nbsp;Naoto Takahashi","doi":"10.5414/CNCS109440","DOIUrl":"https://doi.org/10.5414/CNCS109440","url":null,"abstract":"<p><p>A 32-year-old woman presented with amenorrhea after a normal childbirth and subsequently developed nephrotic syndrome. Renal biopsy showed a thrombotic microangiopathy (TMA)-like glomerular lesion with deposits of immunoglobulins, complements, and fibrinogen. Increased serum levels of the beta subunit of human chorionic gonadotropin, abnormal uterine findings from imaging studies, and endometrial biopsy findings suggested gestational trophoblastic disease. She was diagnosed with a placental site trophoblastic tumor (PSTT) after hysterectomy and, following treatment, her proteinuria disappeared. Follow-up renal biopsy showed the disappearance of the TMA-like lesion. To our knowledge, this is the first case report of the pathological remission of renal disease associated with PSTT.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2018-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36552196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hypercalcemia-induced acute kidney injury in a Caucasian female due to radiographically silent systemic sarcoidosis. 高钙血症引起的急性肾损伤的白种人女性由于放射学沉默系统性结节病。
Clinical Nephrology. Case Studies Pub Date : 2018-09-04 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109513
Ramy M Hanna, Marian Kaldas, Farid Arman, Melissa Wang, Terrance Hammer, Deren Sinkowitz, Anjay Rastogi
{"title":"Hypercalcemia-induced acute kidney injury in a Caucasian female due to radiographically silent systemic sarcoidosis.","authors":"Ramy M Hanna,&nbsp;Marian Kaldas,&nbsp;Farid Arman,&nbsp;Melissa Wang,&nbsp;Terrance Hammer,&nbsp;Deren Sinkowitz,&nbsp;Anjay Rastogi","doi":"10.5414/CNCS109513","DOIUrl":"https://doi.org/10.5414/CNCS109513","url":null,"abstract":"<p><p>. Sarcoidosis is a rare autoimmune disease resulting in formation of non-necrotizing \"non-caseating\" granulomas generally in the lung. The disease classically strikes African American females in their fourth and fifth decades. The resulting hypercalcemia is a result of 1-α hydroxylase overexpression in granulomas with increased 1,25-dihydroxy vitamin D levels. This phenomenon can also be observed in mycobacterial and fungal infections that produce granulomas in infected patients. Thus, chronic infectious diseases are part of differential diagnosis of granulomatous processes. We present an elderly Caucasian female who presented with hypercalcemia with serum calcium of 11 - 14 mg/dL and an elevated ionized calcium of 1.4 - 1.5 mmol/L. Initially cholecalciferol supplements were stopped, but hypercalcemia persisted for more than 2 months. 1,25-dihydroxy vitamin D levels were markedly elevated with low normal 25-hydroxy vitamin D levels, angiotensin-converting enzyme levels were also high, and chest computed tomography (CT) imaging was negative for any lymphadenopathy (including perihilar lymphadenopathy). Malignancy and infectious workups were negative for fungal and mycobacterial infections. Positron emission tomography revealed several small lymph nodes in right upper lobe of lung, and biopsy of bone marrow and lung lymph-nodes revealed non-caseating granulomata. We present an atypical case of occult sarcoidosis presenting mainly with biochemical findings without any definitive imaging findings, making diagnosis a clinical challenge.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2018-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36483803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Successful rituximab treatment of TAFRO syndrome with pathological findings of glomerular endothelial damage. 利妥昔单抗成功治疗肾小球内皮损伤病理表现的TAFRO综合征。
Clinical Nephrology. Case Studies Pub Date : 2018-06-22 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109400
Yuhei Noda, Yosuke Saka, Akihisa Kato, Tetsushi Mimura, Tomohiko Naruse
{"title":"Successful rituximab treatment of TAFRO syndrome with pathological findings of glomerular endothelial damage.","authors":"Yuhei Noda,&nbsp;Yosuke Saka,&nbsp;Akihisa Kato,&nbsp;Tetsushi Mimura,&nbsp;Tomohiko Naruse","doi":"10.5414/CNCS109400","DOIUrl":"https://doi.org/10.5414/CNCS109400","url":null,"abstract":"<p><p>Thrombocytopenia, anasarca, fever, renal insufficiency, and organomegaly constitute TAFRO syndrome, a variant of Castleman disease. We describe a patient with TAFRO syndrome who underwent renal biopsy. A 79-year-old woman was referred to us with fever and leg edema. She also had thrombocytopenia, pleural effusion, ascites, and acute kidney injury, and was admitted to our hospital. Her response to initial therapy with corticosteroid and cyclosporine was poor. Therefore, she received 4 doses of rituximab per week, which resulted in clinical improvement, including recovery of thrombocytopenia. A kidney biopsy thereafter showed diffuse, global glomerular endothelial injury indicating thrombotic microangiopathy (TMA). These findings suggested that TMA is associated with the thrombocytopenia and renal insufficiency of TAFRO syndrome.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2018-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36314096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Malignant renal epithelioid angiomyolipoma with TFE3 gene amplification mimicking renal carcinoma. 肾上皮样血管平滑肌脂肪瘤伴TFE3基因扩增模拟肾癌。
Clinical Nephrology. Case Studies Pub Date : 2018-05-24 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109443
Haili Wang, Haiyu Zhan, Zhigang Yao, Qingwei Liu
{"title":"Malignant renal epithelioid angiomyolipoma with TFE3 gene amplification mimicking renal carcinoma.","authors":"Haili Wang,&nbsp;Haiyu Zhan,&nbsp;Zhigang Yao,&nbsp;Qingwei Liu","doi":"10.5414/CNCS109443","DOIUrl":"https://doi.org/10.5414/CNCS109443","url":null,"abstract":"<p><p>Malignant renal epithelioid angiomyolipoma (EAML) is an extremely rare disease with a poor prognosis, and currently there are no uniform criteria for its biological behavior. Here, we present a case of malignant renal EAML with TFE3 gene amplification in a 53-year-old woman. Four months after surgery, unenhanced computed tomography scans showed recurrence as well as metastasis in the abdomen and lung. The patient succumbed to rapid neoplastic progression of the disease 6 months later.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2018-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report and literature review. 利妥昔单抗治疗igg4相关疾病所致腹膜后纤维化1例报告及文献综述
Clinical Nephrology. Case Studies Pub Date : 2018-04-27 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109321
Mohammad Almeqdadi, Mohammed Al-Dulaimi, Aleksandr Perepletchikov, Kevin Tomera, Bertrand L Jaber
{"title":"Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report and literature review.","authors":"Mohammad Almeqdadi,&nbsp;Mohammed Al-Dulaimi,&nbsp;Aleksandr Perepletchikov,&nbsp;Kevin Tomera,&nbsp;Bertrand L Jaber","doi":"10.5414/CNCS109321","DOIUrl":"https://doi.org/10.5414/CNCS109321","url":null,"abstract":"<p><p>Retroperitoneal fibrosis (RPF) is a progressive fibroinflammatory disease that can be complicated by urinary obstruction. RPF can be the only manifestation of IgG4-related disease (IgG4-RD). Treatment of IgG4-related RPF is challenging and mostly consists of long-term glucocorticoids leading to significant side effects and treatment intolerance. Recent exploration of the role of rituximab as a B-cell depleting therapy in the treatment of IgG4-RD provides therapeutic potential as a well-tolerated alternative to glucocorticoids. We present a case of IgG4-related RPF for which rituximab was instituted as a steroid-sparing treatment strategy. Following 4 doses, kidney function partially recovered, and the disease went into remission. We discuss the potential merit of rituximab for the treatment of patients with IgG4-related RPF.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"4-10"},"PeriodicalIF":0.0,"publicationDate":"2018-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36174165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Comment to: Focal segmental glomerulosclerosis associated with mitochondrial disease by Lim et al. in Clin Nephrol Case Stud. 2017; 5: 20-25. 评论:局灶节段性肾小球硬化与线粒体疾病相关，Lim等人发表在《临床肾脏病病例研究》2017;5: 20 - 25。
Clinical Nephrology. Case Studies Pub Date : 2018-01-16 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109366L
Josef Finsterer, Sinda Zarrouk-Mahjoub
{"title":"Comment to: Focal segmental glomerulosclerosis associated with mitochondrial disease by Lim et al. in Clin Nephrol Case Stud. 2017; 5: 20-25.","authors":"Josef Finsterer,&nbsp;Sinda Zarrouk-Mahjoub","doi":"10.5414/CNCS109366L","DOIUrl":"https://doi.org/10.5414/CNCS109366L","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35843564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the Letter to the Editor by Finsterer and Zarrouk-Mahjoub in Clin Nephrol Case Stud. 2018; 6: 1. 对Finsterer和Zarrouk-Mahjoub给编辑的信的回应，发表在《clinnephrol Case Stud》2018;6: 1。
Clinical Nephrology. Case Studies Pub Date : 2018-01-16 eCollection Date: 2018-01-01 DOI: 10.5414/CNCS109366R
Kenneth Lim, David Steele, Andrew Fenves, Ravi Thadhani, Eliot Heher, Amel Karaa
{"title":"Response to the Letter to the Editor by Finsterer and Zarrouk-Mahjoub in Clin Nephrol Case Stud. 2018; 6: 1.","authors":"Kenneth Lim,&nbsp;David Steele,&nbsp;Andrew Fenves,&nbsp;Ravi Thadhani,&nbsp;Eliot Heher,&nbsp;Amel Karaa","doi":"10.5414/CNCS109366R","DOIUrl":"https://doi.org/10.5414/CNCS109366R","url":null,"abstract":"<p><p>Not available.</p>","PeriodicalId":10398,"journal":{"name":"Clinical Nephrology. Case Studies","volume":"6 ","pages":"2-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35843436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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