索非布韦和daclatasvir治疗HCV和HIV患者相关间质性肾炎和局灶节段性肾小球硬化的成功恢复及文献修订

Clinical Nephrology. Case Studies Pub Date : 2018-10-26 eCollection Date: 2018-01-01 DOI:10.5414/CNCS109221
Michele Mirabella, Lucia Taramasso, Laura Ambra Nicolini, Rodolfo Russo, Claudio Viscoli, Antonio Di Biagio
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引用次数: 3

摘要

在这篇报告中,我们描述了一名55岁的HIV/HCV合并感染女性的两种罕见且有争议的丙型肝炎病毒(HCV)感染并发症的共存:间质性肾炎伴局灶性肾小球硬化和自身免疫性肝炎。患者使用霉酚酸酯治疗免疫介导的症状,并持续使用了9年,因为每次尝试停止免疫抑制时症状都会复发。由于新的直接作用药物,患者最终清除了HCV感染,并在24周的随访后保持病情和实验室参数稳定,可以停止免疫抑制治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature.

Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature.

Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature.

In this report, we describe the coexistence of two rare and debated complications of hepatitis C virus (HCV) infection: interstitial nephritis, with associated focal glomerulosclerosis, and autoimmune hepatitis, in a 55-year-old HIV/HCV-coinfected woman. The patient was treated for the immune-mediated manifestations with mycophenolate mofetil, which she continued for 9 years, as symptoms relapsed at every attempt to discontinue immunosuppression. The patient finally cleared HCV infection thanks to new direct-acting agents and could discontinue immunosuppressive therapy maintaining stable conditions and laboratory parameters after 24-weeks follow-up.

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