Clinical nephrology最新文献_第5页

Preoperative dapagliflozin use and cardiac surgery-associated acute kidney injury: A single-center retrospective cohort study. 术前使用达格列净和心脏手术相关急性肾损伤：一项单中心回顾性队列研究

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-04-01 DOI: 10.5414/CN111514

Zitong Chen, Kang Liu, Xiaohua Liu, Buyun Wu, Zhimin Huang, Changying Xing, Huijuan Mao

{"title":"Preoperative dapagliflozin use and cardiac surgery-associated acute kidney injury: A single-center retrospective cohort study.","authors":"Zitong Chen, Kang Liu, Xiaohua Liu, Buyun Wu, Zhimin Huang, Changying Xing, Huijuan Mao","doi":"10.5414/CN111514","DOIUrl":"10.5414/CN111514","url":null,"abstract":"Background: No drug has been shown to be effective in preventing cardiac surgery-associated acute kidney injury (CSA-AKI). In different clinical settings, sodium-glucose transporter 2 (SGLT2) inhibitors confer renal protection and may be promising drug candidates. We examined the association between preoperative dapagliflozin use and the incidence and prognosis of CSA-AKI.Materials and methods: Data were obtained for consecutive patients undergoing cardiac surgery with cardiopulmonary bypass between December 2020 and November 2022 at a large teaching hospital in Eastern China. The exposure was preoperative dapagliflozin use, and the primary outcome was the incidence of AKI within seven days following cardiac surgery. The secondary outcomes included dialysis, death, AKI recovery, and length of hospitalization. The association between the exposures and outcomes was determined by various logistic regression models with propensity scores.Results: A total of 1,424 patients were included, of which 201 (14.1%) received dapagliflozin preoperatively, and 321 (22.5%) developed CSA-AKI. Patients with dapagliflozin use developed CSA-AKI more frequently than those without (32.3 vs. 20.9%, unadjusted odds ratio 1.81; 95% CI, 1.30 - 2.50). However, the association became non-significant in the multivariate model (adjusted odds ratio, 1.11; 95% CI, 0.73 - 1.68), in the adjusted model with inverse probability weighting (odds ratio, 1.21; 95% CI, 0.76 - 1.93), or in the propensity-score-matched model (odds ratio, 1.09, 95% CI, 0.68 - 1.73). Furthermore, there was no significant association between preoperative dapagliflozin use and secondary outcomes.Conclusion: Results from this study suggest that preoperative dapagliflozin use was not associated with a lower risk of CSA-AKI.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"259-267"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of adverse drug reactions of heparin and its derivates in the European Economic Area based on data from EudraVigilance between 2017 and 2021. 基于2017年至2021年EudraVigilance数据的欧洲经济区肝素及其衍生物药物不良反应比较

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-04-01 DOI: 10.5414/CN111448

Yan Wang, Liang-Ying Gan, Zhun Sui, Mi Wang, Li Zuo

{"title":"Comparison of adverse drug reactions of heparin and its derivates in the European Economic Area based on data from EudraVigilance between 2017 and 2021.","authors":"Yan Wang, Liang-Ying Gan, Zhun Sui, Mi Wang, Li Zuo","doi":"10.5414/CN111448","DOIUrl":"10.5414/CN111448","url":null,"abstract":"Introduction: Hemodialysis patients need long-term frequent use of parenteral anticoagulants, and the side effects need to be taken seriously. This study aimed to assess the reporting of adverse drug reactions (ADRs) following administration of unfractionated heparin (UFH), low molecular weight heparins (LMWHs), fondaparinux, and danaparoid, in relation to their usage in European Economic Area (EEA).Materials and methods: The total number of ADRs of each anticoagulant between 2017 to 2021 was collected using data from the EudraVigilance database. The number of hemorrhages, thrombocytopenia, injection-site reaction, liver injury, hypersensitivity and bone disorder were collected, respectively. Usage of these anticoagulants was estimated using sales data from the IQVIA MIDAS database. The reporting rates of ADRs were calculated and compared using χ2-test.Results: Between 2017 and 2021 in the EEA, the overall ADRs reporting rates per 10,000,000 standard units (SU) of UFH, enoxaparin, nadroparin, dalteparin, fondaparinux, and danaparoid were 12.3, 40.8, 23.6, 36.5, 91.4, and 430.0, respectively. There were significant differences among these drugs (χ2 = 7,239.26, p < 0.001). Specifically, hemorrhage and thrombocytopenia were reported at higher rates, ranging from 2.8 to 140.1, and 2.0 to 115.9 per 10,000,000 SU among different anticoagulants. Injection-site reactions and hypersensitivity came in second, between 0.2 - 29.0 and 0.1 - 53.1 per 10,000,000 SU, respectively. The reporting rates for liver injury and bone disorder were reported at low rates.Conclusion: The reporting rates of ADRs for heparin and its derivates were all very low. In comparison, the reporting rate of ADRs for danaparoid and fondaparinux was relatively high. The most commonly reported ADRs were hemorrhage, thrombocytopenia, followed by injection-site reactions and hypersensitivity.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"290-295"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unplanned dialysis initiation in patients known to renal services: A case-control study. 已知有肾脏服务的患者的计划外透析起始：一项病例对照研究。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-04-01 DOI: 10.5414/CN111455

Tony Lopez, Damien Ashby

{"title":"Unplanned dialysis initiation in patients known to renal services: A case-control study.","authors":"Tony Lopez, Damien Ashby","doi":"10.5414/CN111455","DOIUrl":"10.5414/CN111455","url":null,"abstract":"Dialysis initiation during an emergency hospital admission is associated with increased complications, more temporary access, and higher mortality. Even in patients known to nephrologists, more than one-third start dialysis in an unplanned fashion. This retrospective case-control study sought to identify features of the pre-dialysis period that are associated with unplanned dialysis initiation in patients known to nephrology services. 40 consecutive patients (median age 61, 85% male) who underwent unplanned dialysis initiation (cases) were individually matched by age and sex with patients who started dialysis in a planned fashion during a similar period (controls). Clinical and laboratory data were collected from electronic patient records and correspondence. Across the pre-dialysis year, cases had a faster estimated glomerular filtration rate (eGFR) decline, greater weight gain, missed more nephrology clinic appointments, and had more emergency hospital admissions compared to controls. In multivariable analysis, predictors of unplanned dialysis initiation were eGFR trajectory (OR 1.91 per -1 mL/min/1.73m2/month, 95% CI 1.10 - 3.30, p = 0.021), weight gain (OR 1.97 per +1%/month, 95% CI 1.33 - 2.93, p < 0.001), and clinic non-attendance (OR 1.54 per clinic, 95% CI 1.09 - 2.18, p = 0.015). The findings of this study suggest that to better identify individuals nearing dialysis who are at high risk for unplanned initiation, nephrologists need to move away from traditional markers of disease progression, such as latest eGFR and proteinuria, and instead look at trends in eGFR, trends in weight, and levels of patient engagement with pre-dialysis care.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"251-258"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic kidney disease and dysbiosis: An overview of gut microbiota and uremic toxins. 慢性肾脏疾病和生态失调：肠道微生物群和尿毒症毒素的概述。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-04-01 DOI: 10.5414/CN111393

Marcelo Rodrigues Bacci

{"title":"Chronic kidney disease and dysbiosis: An overview of gut microbiota and uremic toxins.","authors":"Marcelo Rodrigues Bacci","doi":"10.5414/CN111393","DOIUrl":"10.5414/CN111393","url":null,"abstract":"Background: Chronic kidney disease (CKD) is a highly prevalent condition with complications such as constipation, inflammation, and dietary restrictions. Gut microbiota is an ecosystem of trillions of bacteria and other microorganisms such as viruses, fungi, and other eukaryotes. This review aimed to analyze the correlation between CKD and the microbiota.Materials and methods: This is a literature review of recent articles published in the Medline database.Results: As CKD progresses, there is a change in the composition of the gut bacteria colonies, with the production of gut-derived uremic toxins. Gut-impaired permeability facilitates the bacteria fragments' translocation, increasing the stimulus for producing inflammatory mediators. Many interventions have been suggested to modulate the gut composition, and the administration of substances to interact with bacteria or decrease inflammatory status is of central interest. Probiotics are live microorganisms that interact with the local microbiota, and prebiotics are non-digested compounds that reach the colon. Their administration reduces the production of uremic toxins and inflammatory substances but fails to protect against chronic kidney disease progression.Conclusion: Curcumin decreases uremic compounds and inflammation. Physical exercise did not act as a gut microbiota modulator. Systematic reviews and metanalysis evaluating gut microbiota modulators revealed a lack of positive impact on renal deterioration but a good reduction in the production of uremic toxins.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"243-250"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of dietary vitamin E intake with current stone formation: A NHANES analysis 2017 - 2020. 膳食维生素E摄入量与当前结石形成的关系：2017 - 2020年NHANES分析

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-03-01 DOI: 10.5414/CN111499

Vikram Lyall, Tyler Bartholomew, Vernon Pais

{"title":"Association of dietary vitamin E intake with current stone formation: A NHANES analysis 2017 - 2020.","authors":"Vikram Lyall, Tyler Bartholomew, Vernon Pais","doi":"10.5414/CN111499","DOIUrl":"10.5414/CN111499","url":null,"abstract":"Introduction: Free radical-mediated oxidative renal tubular injury secondary to hyperoxaluria is a proposed mechanism in the formation of calcium oxalate stones. Vitamin E, an important physiologic antioxidant, has been shown in rat models to prevent calcium oxalate crystal deposition. Our objective was to determine if low dietary vitamin E intake was associated with a higher incidence of stones.Materials and methods: We analyzed data from the 2017 to 2020 National Health and Nutrition Examination Survey, a nationally representative sample (n = 7,707). A multivariable logistic regression model was used to assess the association between elevated dietary vitamin E intake (≥ 15 mg/day) and nephrolithiasis controlling for key demographic variables: water and nutrient intake (sodium, calcium, vitamin C), and diabetes mellitus.Results: The incidence of nephrolithiasis was 1.66% (1.38% - 1.95%). In patients consuming < 15 mg/day vitamin E, the incidence was 1.8% compared to 0.8% in patients with vitamin E intake ≥ 15 mg/day (p = 0.024). In adjusted models, participants with low vitamin E intake had a significantly higher odds of reporting stone passage (aOR = 2.83, 95% CI (1.07 - 7.5)).Conclusion: We found that low vitamin E intake is associated with a > 2.5× greater odds of stone passage. These data are consistent with animal models suggesting that vitamin E may play an important protective role in the pathogenesis of calcium oxalate stone formation. This is the first study assessing the relationship between vitamin E intake and nephrolithiasis in humans. Future investigation of vitamin E supplementation in stone formers may help further determine if vitamin E is useful in the management of calcium oxalate stones.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"193-199"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunosuppressant-resistant nephrotic syndrome and primary amenorrhea: A case report of adult Frasier syndrome and literature review. 免疫抑制剂抵抗性肾病综合征和原发性闭经：成人弗雷泽综合征病例报告和文献综述。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-03-01 DOI: 10.5414/CN111432

Caifeng Li, Liyu Lin, Tao Pu, Jie Teng, Ziyan Shen

引用次数: 0

Construction and validation of a survival prognostic model for clear cell renal cell carcinoma. 透明细胞肾细胞癌生存预后模型的构建与验证。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-03-01 DOI: 10.5414/CN111509

Chen-Li Li, Yu-Qian Jiang, Wei Pan, Yan-Li Yang

{"title":"Construction and validation of a survival prognostic model for clear cell renal cell carcinoma.","authors":"Chen-Li Li, Yu-Qian Jiang, Wei Pan, Yan-Li Yang","doi":"10.5414/CN111509","DOIUrl":"10.5414/CN111509","url":null,"abstract":"Objective: Utilizing expression data of clear cell renal cell carcinoma (ccRCC) genes from the Cancer Genome Atlas (TCGA) database, this study employs weighted gene co-expression network analysis (WGCNA) and Cox regression analysis to identify genes associated with the occurrence and development of ccRCC, thereby providing a scientific basis for its treatment.Materials and methods: Differentially expressed genes between tumor and control groups were identified by preprocessing and batch correction of ccRCC transcriptome data in the TCGA database using the Wilcoxon test. Prognostic prediction models were established through a combination of WGCNA analysis, univariate Cox regression analysis, and multivariate Cox regression analysis. The reliability of these prognostic models was evaluated by plotting Kaplan-Meier survival analysis and receiver operating characteristic (ROC) curves and by further analyzing the relationship between model gene expression levels, tumor staging, and tumor grading.Results: Post-batch correction, M2-type macrophage infiltration was pronounced in tumor tissue, and 13 out of 290 screened relevant differential genes were included in the prognostic model. The Kaplan-Meier survival curves indicated that the 3- and 5-year overall survival rates were significantly higher in the low-risk group compared with the high-risk group (83.7 vs. 69.1%; 75.7 vs. 52.6%, p = 1.169e-08). The area under the ROC curve was 0.732, signifying strong predictive power for the survival curve. In this model, the expression levels of 11 genes were positively correlated with tumor stage and pathological grade, whereas the remaining 2 genes were negatively correlated.Conclusion: This model can predict the overall survival of patients with ccRCC and has the potential to become an important therapeutic target.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"200-212"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic significance of NT-proBNP levels in patients treated with empagliflozin. 恩格列净治疗患者NT-proBNP水平的预后意义。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-03-01 DOI: 10.5414/CN111640

Beyza Algul Durak, Musa Ilker Durak, Naim Ata, Mahir Ülgü, Şuayip Birinci

{"title":"Prognostic significance of NT-proBNP levels in patients treated with empagliflozin.","authors":"Beyza Algul Durak, Musa Ilker Durak, Naim Ata, Mahir Ülgü, Şuayip Birinci","doi":"10.5414/CN111640","DOIUrl":"10.5414/CN111640","url":null,"abstract":"Background: Sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been added to the mainstay of treatment for chronic heart failure. Recent studies suggest that empagliflozin may also reverse cardiac remodeling in heart failure by reducing N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. In our study, we wanted to show the decrease in NT-proBNP levels, which is an indicator of poor prognosis in heart failure, and to see if there was a decrease in the rate of renal progression in patients with HF after empagliflozin use.Materials and methods: Patients with type 2 diabetes mellitus and heart failure using empagliflozin were selected from the system and 456 patients were found. Patients were divided into two groups: heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). The patients were divided into two groups according to their NT-proBNP levels at the beginning of the drug and on the 90th day. The laboratory data were analyzed at the time of drug initiation and at day 90.Results: There was a statistically significant difference between baseline and day 90 HbA1C and NT-proBNP levels (p < 0.001), (p < 0.001). NT-proBNP and creatinine levels at baseline and day 90 were significantly higher in patients with HFrEF than in those with HFpEF (p < 0.001). According to the multivariate analysis, patients with HFrEF were 11.42 times more likely to have an NT-proBNP change above 300 pg/mL than patients with HFpEF (OR: 11.42, p = 0.028).Conclusion: In our study, a significant reduction in NT-proBNP and HbA1C levels was observed, while renal function was preserved.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"225-231"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and safety of low-dose roxadustat in combination with recombinant human erythropoietin for treating hemodialysis patients with moderate anemia: A retrospective cohort study. 低剂量罗沙司他联合重组人促红细胞生成素治疗血液透析合并中度贫血患者的疗效和安全性：一项回顾性队列研究。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-03-01 DOI: 10.5414/CN111433

Yanfei Huang, Xinxin Jiang, Guiqin Shu, Hui Li, Jingjing Lin, Qingqing Duan, Xue Cao, Min Cheng, Zhigui Zheng

{"title":"The efficacy and safety of low-dose roxadustat in combination with recombinant human erythropoietin for treating hemodialysis patients with moderate anemia: A retrospective cohort study.","authors":"Yanfei Huang, Xinxin Jiang, Guiqin Shu, Hui Li, Jingjing Lin, Qingqing Duan, Xue Cao, Min Cheng, Zhigui Zheng","doi":"10.5414/CN111433","DOIUrl":"10.5414/CN111433","url":null,"abstract":"Background: To evaluate the safety and efficacy of low-dose roxadustat combined with low-dose recombinant human erythropoietin (rhEPO) for the treatment of renal anemia in hemodialysis patients.Materials and methods: We retrospectively reviewed the medical records of hemodialysis patients with moderate renal anemia between December 2019 and July 2023 from two medical centers. Patients were classified into 3 groups: rhEPO (150 - 300 IU/kg/week), roxadustat (1.5 - 2.5 mg/kg thrice weekly), and combination therapy (low-dose (≤ 1.5 mg/kg thrice weekly) roxadustat in addition to low-dose (≤ 150 IU/kg per week) rhEPO. After 24 weeks of treatment, the efficacy therapeutic endpoints and the safety endpoints were evaluated.Results: Overall, a total of 158 patients were included: 53 in the rhEPO group, 52 in the roxadustat group, and 53 in the combination group. The median time to achieve Hb response in the combination therapy group was 20 days, which was shorter than that in the roxadustat group (20 vs. 25.5 days, log-rank p = 0.027) and the rhEPO group (20 vs. 27 days, log-rank p = 0.004). The mean rate of increase in Hb (g/L/month) during the first month of the treatment period was significantly greater in the combination group than in the roxadustat group (15.4 ± 4.7 vs. 11.1 ± 5.7, p = 0.038) or in the rhEPO group (15.4 ± 4.7 vs. 10.5 ± 4.3, p = 0.026). The incidence and frequency of adverse events were similar among the 3 groups.Conclusion: The combination of low-dose roxadustat and rhEPO appears to have better effects in treating hemodialysis patients with moderate anemia by shortening the hemoglobin response time with minimal adverse effects.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"172-183"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of kidney disease knowledge and its determinants among patients with chronic kidney disease. 慢性肾病患者肾病知识及其决定因素的评估。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2025-03-01 DOI: 10.5414/CN111543

Sibel Gulcicek, Zeynep Atli, Ertugrul Erol, Talat Alp Ikizler, Nurhan Seyahi

{"title":"Evaluation of kidney disease knowledge and its determinants among patients with chronic kidney disease.","authors":"Sibel Gulcicek, Zeynep Atli, Ertugrul Erol, Talat Alp Ikizler, Nurhan Seyahi","doi":"10.5414/CN111543","DOIUrl":"10.5414/CN111543","url":null,"abstract":"Purpose: Patient self-care and knowledge of chronic kidney disease (CKD) play a crucial role in treatment effectiveness at slowing disease progression and reducing complications. There is need for tools that can quantitatively assess patients' knowledge of CKD. We aimed to translate the Kidney Disease Knowledge Survey (KiKS) to Turkish, validate the questionnaire among CKD patients, and identify the determinants of CKD knowledge.Materials and methods: The 28-item KiKS was translated into Turkish and administered to 271 CKD patients not on dialysis. Reliability of survey questions was assessed using Cronbach's α coefficient. Hotelling's T-squared test was used to measure effectiveness and homogeneity of the scale. Univariate and multivariate regression analyses were performed to identify the determinants of CKD knowledge.Results: The mean age of participants was 56.7 ± 13.0 years; 54.2% were male, and 68.3% had CKD stages 3 - 5. Cronbach's α value of scale for the 28-item KiKS was 0.804, confirming its reliability (p < 0.001). Multivariate linear regression analysis showed that CKD stage 3 patients were associated with lower KiKS scores compared to stage 1. Participants who were aware of their CKD diagnosis and used the internet to obtain information about kidney disease had higher scores.Conclusion: The Turkish version of KiKS is reliable and valid to assess the knowledge level of Turkish CKD patients. Advanced stages of CKD were associated with less knowledge about kidney disease in this population. Targeted educational interventions or longitudinal studies are needed to assess the impact of improved CKD knowledge on clinical outcomes.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":" ","pages":"213-224"},"PeriodicalIF":1.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0