Clinical nephrology最新文献_第5页

Peritoneal dialysis is feasible for TAFRO syndrome with acute kidney injury and refractory ascites: A case report. 腹膜透析对伴有急性肾损伤和难治性腹水的 TAFRO 综合征是可行的：病例报告。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2024-04-01 DOI: 10.5414/CN111255

Cheng Xue, Xiaohua Hu, Bo Yang, Liming Zhang, Zhiguo Mao

引用次数: 0

Corrigendum for the article Clin Nephrol. 2022; 98: 198-204. 文章 Corrigendum for the article Clin Nephrol.2022; 98: 198-204.

IF 1.1 4区医学

Clinical nephrology Pub Date : 2024-03-18 DOI: 10.5414/cn110656cor

S. Dheda, H. Min, D.A. Vesey, C. Hawley, D.W. Johnson, G. Dimeski, H. Healy, M. Fahim

引用次数: 0

Characteristics of registered research in peritoneal dialysis: Past and present. 腹膜透析注册研究的特点:过去和现在。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2024-01-01 DOI: 10.5414/CN111162

Martin L Li, Ankush Bajaj, Uttam Bhetuwal, Ankur D Shah

引用次数: 0

The reasons for comparative effectiveness clinical trials of arteriovenous fistula versus graft strategy in older adults on hemodialysis with a catheter. 动静脉瘘与移植物策略在老年人导管血液透析中比较效果的临床试验的原因。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-12-01 DOI: 10.5414/CN111227

Mariana Murea, Michael Allon

引用次数: 0

Clinical and pathological correlation between urinary exosome miR-223 and IgAN patients. 尿外泌体miR-223与IgAN患者的临床和病理相关性。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-11-01 DOI: 10.5414/CN110810

Jianling Song, Xinfang Qin, Hong Li, Guxiang Huang, Huixin Bi

{"title":"Clinical and pathological correlation between urinary exosome miR-223 and IgAN patients.","authors":"Jianling Song, Xinfang Qin, Hong Li, Guxiang Huang, Huixin Bi","doi":"10.5414/CN110810","DOIUrl":"10.5414/CN110810","url":null,"abstract":"Objective: To investigate the association between urine exosome miR-223 and clinical markers with pathological severity of IgA nephropathy (IgAN) in order to offer a new perspective for the evaluation of IgAN patients.Materials and methods: Western blotting and transmission electron microscopy were used to identify the exosomes collected and isolated from subjects' urine. qRT-PCR was then performed to determine the expression level of miR-223. Following that, the relationship between miR-223 expression, clinical markers, and the severity of pathology in IgAN patients was examined.Results: (1) Urine can be used to isolate exosomes since its marker protein was visible by Western blotting, and its size and structure were observable using transmission electron microscopy. (2) Expression levels of miR-223 in urinary exosomes were much higher in IgAN patients than in healthy subjects, and these were also positively correlated with creatinine (Cr) (rho = 0.396; p = 0.006), blood urea nitrogen (BUN) (rho = 0.371; p = 0.011), 24-hour urinary microalbumin (24hU-mALB) (rho = 0.341; p = 0.036), mesangial cell proliferation (rho = 0.359; p = 0.014), glomerular segmental sclerosis (rho = 0.417; p = 0.004), cell/fibroblast crescents (rho = 0.612; p = 0.000), glomerulosclerosis, and renal interstitial fibrosis (rho = 0.331; p = 0.025).Conclusion: In urine exosomes, miR-223 might be considered a non-invasive biomarker for the assessment of IgAN disease progression.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10158396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of canagliflozin in non-diabetic obese patients with albuminuria: A randomized, double-blind, placebo-controlled trial. 卡格列净治疗伴有蛋白尿的非糖尿病肥胖患者的疗效：一项随机、双盲、安慰剂对照试验。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-11-01 DOI: 10.5414/CN111143

Primploy Greeviroj, Pongpratch Puapatanakul, Jeerath Phannajit, Kullaya Takkavatakarn, Wonngarm Kittanamongkolchai, Patchaya Boonchaya-Anant, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong

{"title":"Effect of canagliflozin in non-diabetic obese patients with albuminuria: A randomized, double-blind, placebo-controlled trial.","authors":"Primploy Greeviroj, Pongpratch Puapatanakul, Jeerath Phannajit, Kullaya Takkavatakarn, Wonngarm Kittanamongkolchai, Patchaya Boonchaya-Anant, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong","doi":"10.5414/CN111143","DOIUrl":"10.5414/CN111143","url":null,"abstract":"Background: Sodium-glucose co-transporter 2 inhibitor (SGLT2i) has been shown to improve renal outcomes in both diabetic and non-diabetic kidney disease. However, the effect of SGLT2i on renal outcomes in patients with non-diabetic obesity is still not established.Materials and methods: In this double-blind, randomized controlled trial, we assigned non-diabetic patients with body mass index (BMI) ≥ 25 kg/m2, persistent 24-hour urine albumin-creatinine ratio (UACR) ≥ 10 mg/gCr, and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73m2, who had been treated with renin-angiotensin system blockade, to canagliflozin 100 mg daily or placebo for 24 weeks. The reduction in UACR and eGFR at 12 and 24 weeks were explored. (Thai Clinical Trials Registry 20190203003).Results: Of 247 non-diabetic obese patients screened, 32 patients met inclusion criteria and underwent randomization. The median baseline of UACR was 69.1 mg/gCr. There were no statistically significant differences in albuminuria reduction between the groups at 12 weeks and 24 weeks. The estimated GFR in the canagliflozin group decreased significantly from baseline at 12 weeks (-5.39 mL/min/1.73m2; 95% CI -9.81 to -0.97; p = 0.017) but not at 24 weeks (-1.16 mL/min/1.73m2; 95% CI -5.58 to 3.26; p = 0.66), and there was no significant change from baseline in the placebo group at both 12 and 24 weeks.Conclusion: Canagliflozin 100 mg daily was well tolerated but did not significantly reduce UACR in non-diabetic obese patients with microalbuminuria. However, a significant temporary decline in eGFR might reflect a subtle reduction in glomerular hyperfiltration.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10171654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The drivers of non-adherence to albuminuria testing guidelines and the clinical and economic impact of not identifying chronic kidney disease. 不遵守蛋白尿检测指南的驱动因素以及不确定慢性肾脏疾病的临床和经济影响。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-10-01 DOI: 10.5414/CN111106

Franziska Groehl, Antonio Garreta-Rufas, Kimberley Meredith, James Harris, Peter Rossing, F D Richard Hobbs, Christoph Wanner

{"title":"The drivers of non-adherence to albuminuria testing guidelines and the clinical and economic impact of not identifying chronic kidney disease.","authors":"Franziska Groehl, Antonio Garreta-Rufas, Kimberley Meredith, James Harris, Peter Rossing, F D Richard Hobbs, Christoph Wanner","doi":"10.5414/CN111106","DOIUrl":"10.5414/CN111106","url":null,"abstract":"Background: Regular monitoring is required to ensure that patients who have, or are at risk of, chronic kidney disease (CKD) receive appropriate management. Guidelines recommend regular testing of estimated glomerular filtration rate (GFR) and albuminuria. However, evidence suggests that albuminuria testing rates, specifically urine albumin-to-creatinine ratio (UACR), are suboptimal.Aim: To assess published evidence relating to the drivers of non-adherence to albuminuria testing guidelines and the impact of not identifying CKD across the course of progression.Materials and methods: A systematic review of five bibliographic databases was conducted, supplemented by hand searches of relevant conference abstracts.Results: One study was identified that reported drivers of non-adherence to albuminuria testing guidelines. The largest barrier was the perception that testing does not impact patient management. Thirteen studies were identified that evaluated the impact of not identifying CKD patients. All included studies analyzed the effect of not identifying worsening CKD severity leading to late referral (LR). 12/13 studies reported only on clinical impact, and 1/13 reported on clinical and economic impact. LR led to higher costs and worse outcomes than early referral, including higher rates of mortality and worsened kidney replacement therapy preparation.Conclusion: This systematic review demonstrates a gap in evidence exploring the drivers of non-adherence to albuminuria testing guidelines and the impact of not identifying patients in the early stages of CKD. Guideline-recommended testing allows timely identification, referral, and treatment for patients with, or at risk of, CKD, providing the best chance of avoiding the worsened outcomes identified in this review.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10220023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospective observational study of purse-string suturing of the anterior rectus fascia for urgent-start peritoneal dialysis. 荷包线缝合前直肌筋膜用于紧急腹膜透析的前瞻性观察研究。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-09-01 DOI: 10.5414/CN111134

Tuncay Sahutoglu, Yadigar Akturk Kus, Halenur Harman, Meral Beyaz

{"title":"Prospective observational study of purse-string suturing of the anterior rectus fascia for urgent-start peritoneal dialysis.","authors":"Tuncay Sahutoglu, Yadigar Akturk Kus, Halenur Harman, Meral Beyaz","doi":"10.5414/CN111134","DOIUrl":"https://doi.org/10.5414/CN111134","url":null,"abstract":"Introduction: To assess the efficacy and safety of a consistent percutaneous procedure for peritoneal dialysis (PD) catheter placement in initiating immediate-start PD in patients with end-stage kidney disease (ESKD).Materials and methods: In this single-center prospective observational study, we enrolled patients with ESKD who were willing to undergo long-term PD. Tenckhoff catheters were placed under local anesthesia by a nephrologist, with the inner cuffs pushed underneath the anterior rectus fascia and purse-string sutures applied. Automated PD (APD) and continuous ambulatory PD (CAPD) were started within 1 hour following catheter placement. The primary outcomes were peri-catheter leakage, technique failure, and the need for hemodialysis during admission.Results: APD was initiated in 12 patients, with a median initial dwell volume of 1,350 mL (range 1 - 2 L, 7 exchanges) and CAPD in 8 patients, with a median initial dwell volume of 1,500 mL (range 1 - 1.8 L, 4 exchanges). No cases of peri-catheter leakage, flow restriction, or hemodialysis inception occurred. There were 2 minor complications: 1 case of hemoperitoneum and 1 case of incisional bleeding, both of which were managed conservatively.Conclusion: The use of purse-string suturing of the rectus fascia may allow for the immediate start of PD within 1 hour of catheter placement, with larger dwell volumes and a low risk of complications.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10047112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary thrombotic microangiopathy following CNI and mTOR inhibitor toxicity after COVID-19 therapy with nirmatrelvir/ritonavir in a kidney transplant patient. 一名肾移植患者接受尼马特利韦/利托那韦治疗后CNI和mTOR抑制剂毒性引起的继发性血栓性微血管病变

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-09-01 DOI: 10.5414/CN111178

Johanna Reindl, Martin Busch, Gunter Wolf

引用次数: 0

An analysis of the relationship of blood pressure and its variability with residual kidney function loss in hemodialysis patients. 血透患者血压及其变异性与残余肾功能丧失的关系分析。

IF 1.1 4区医学

Clinical nephrology Pub Date : 2023-09-01 DOI: 10.5414/CN111010

Feiyan Li, Xu He, Yongchao Yang

{"title":"An analysis of the relationship of blood pressure and its variability with residual kidney function loss in hemodialysis patients.","authors":"Feiyan Li, Xu He, Yongchao Yang","doi":"10.5414/CN111010","DOIUrl":"https://doi.org/10.5414/CN111010","url":null,"abstract":"Aims: This study aims to investigate the relationship of blood pressure (BP) and systolic BP (SBP) variability with residual kidney function (RKF) loss in hemodialysis (HD) patients.Materials and methods: The demographic and clinical information and data on RKF loss events in HD patients were collected. The baseline characteristics of the patients were compared among groups according to pre- and postdialysis SBP (< 120, 120 - 139, 140 - 159, and ≥ 160 mmHg) and diastolic BP (DBP) (< 80, 80 - 89, 90 - 99, and ≥ 1 00 mmHg). Participants were divided into two groups based on the mean intradialytic and interdialytic SBP variability. Kaplan-Meier analysis and Cox regression analysis were used to evaluate the risk of RKF loss.Results: A total of 157 participants with an average HD vintage of 35.97 months were included. The group with the lowest predialysis SBP showed the longest duration of residual urine. However, Kaplan-Meier analysis and Cox regression analysis indicated that BP and SBP variability were not independent risk factors for RKF loss. Higher serum albumin levels showed protective effects against RKF loss, and diabetes mellitus (DM) and higher serum calcium were the independent risk factors for RKF loss.Conclusion: BP and SBP variability were not independent risk factors for RKF loss in HD patients. DM, serum albumin, and calcium were independent factors related to RKF loss.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0