Clinical Medicine Insights. Gastroenterology最新文献_第8页

Diagnostic Performance of Ultrafast 3-Dimensional Ultrasound on the Small Bowel: Single Center Experience 超快三维超声对小肠的诊断性能:单中心体验

Clinical Medicine Insights. Gastroenterology Pub Date : 2011-01-01 DOI: 10.4137/CGast.S8143

S. Elwagdy, M. Ramadan, M. Farag, M. Farag, S. Eladawy, Hosni A-Karim, Gamal M M Soliman, Ali Ibrahim, S. Salah, Abdel Hamid Elgargani

{"title":"Diagnostic Performance of Ultrafast 3-Dimensional Ultrasound on the Small Bowel: Single Center Experience","authors":"S. Elwagdy, M. Ramadan, M. Farag, M. Farag, S. Eladawy, Hosni A-Karim, Gamal M M Soliman, Ali Ibrahim, S. Salah, Abdel Hamid Elgargani","doi":"10.4137/CGast.S8143","DOIUrl":"https://doi.org/10.4137/CGast.S8143","url":null,"abstract":"Background Increased speed and resolution of ultrasound have made it a first-line modality for the abdominal examination. During the last 5 years trans-abdominal ultrasonography has been used increasingly, for assessment of patients with small bowel (SB) diseases. Around 350 such examinations are performed annually in the diagnostic imaging department at Azhar University Hospital. Hence, the aim is to determine if the ultrafast three-dimensional ultrasound (U3D US) is potent for optimal examination of SB diseases. Patients and Methods Tap-water intake has been used to distend the SB. All patients have been examined in supine position. The U3D US data of 198 patients with SB diseases were assessed. The proximal and distal SB image quality along with the evaluation of bowel distention, motility and lesions were reported. Results Image quality was good in all examinations. Adequate demonstration of the proximal and distal SB was obtained in all of U3D US examinations. The inclusive diagnostic accuracy of U3D US was precise in 92.3%. Proximal SB was, however, less frequently involved, particularly in patients below the age of 30 years (P = 0.050). Conclusion The diagnostic accuracy of U3D US enterography is valuable for detecting SB lesions. This modality is widely available, inexpensive and easy technique, can be used as an initial investigation in the evaluation of patients with SB disorders.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CGast.S8143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70690118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Azathioprine and Infliximab: Monotherapy or Combination Therapy in the Treatment of Crohn's Disease 硫唑嘌呤和英夫利昔单抗:单药或联合治疗克罗恩病

Clinical Medicine Insights. Gastroenterology Pub Date : 2011-01-01 DOI: 10.4137/CGast.S5256

B. Love, Lisa S. Smith, S. Sarbah, F. Fowler

引用次数: 1

Three Patients with Viral Breakthrough during Pegylated Interferon Alpha-2b and Ribavirin Therapy: A Case Series 聚乙二醇化干扰素α -2b和利巴韦林治疗期间病毒突破的3例患者:病例系列

Clinical Medicine Insights. Gastroenterology Pub Date : 2011-01-01 DOI: 10.4137/CGast.S6264

Daigo Kon, T. Goto, Kouichi Miura, Shigetoshi Ohshima, T. Shibuya, E. Kataoka, Wataru Sato, Takahiro Dohmen, Yumiko Anezaki, H. Ishii, Ikuhiro Yamada, Kentaro Kamada, H. Ohnishi

{"title":"Three Patients with Viral Breakthrough during Pegylated Interferon Alpha-2b and Ribavirin Therapy: A Case Series","authors":"Daigo Kon, T. Goto, Kouichi Miura, Shigetoshi Ohshima, T. Shibuya, E. Kataoka, Wataru Sato, Takahiro Dohmen, Yumiko Anezaki, H. Ishii, Ikuhiro Yamada, Kentaro Kamada, H. Ohnishi","doi":"10.4137/CGast.S6264","DOIUrl":"https://doi.org/10.4137/CGast.S6264","url":null,"abstract":"Introduction A viral breakthrough occurs when a patient achieves a response while on interferon (IFN) therapy and then loses the response despite continued IFN therapy. The cause of viral breakthroughs is not well understood. We encountered three cases with viral breakthrough during treatment with pegylated interferon (PEG-IFN) and ribavirin (RBV). Case presentation The three cases were all late virological responders. They did not express anti-IFN alpha-2b antibodies after PEG-IFN and RBV therapy. We analyzed amino acid substitutions of core 70, core 91, and interferon sensitivity-determining region (ISDR), which significantly influence sustained virological response (SVR). Their amino acid substitutions of core 91 were mutant in two cases. Amino acid substitutions of ISDR were wild pattern in two cases. PEG-IFN adherence was above 80% in three cases, and RBV adherence was below 80% in two cases. Conclusion During PEG-IFN and RBV therapy, we should watch for viral breakthrough in late virological responders with mutant type of amino acid substitutions of core 91, wild pattern of amino acid substitution of ISDR, and decrease of RBV adherence. Viral breakthrough is an important problem in PEG-IFN and RBV therapy for chronic hepatitis C. Therefore, it should be investigated more thoroughly in more cases.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CGast.S6264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70689756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endoscopic Sclerotherapy for Bleeding Oesophageal Varices: Experience in Gezira State, Sudan 内镜硬化疗法治疗食管静脉曲张出血:苏丹Gezira州的经验

Clinical Medicine Insights. Gastroenterology Pub Date : 2011-01-01 DOI: 10.4137/CGast.S7146

M. Mohammed

{"title":"Endoscopic Sclerotherapy for Bleeding Oesophageal Varices: Experience in Gezira State, Sudan","authors":"M. Mohammed","doi":"10.4137/CGast.S7146","DOIUrl":"https://doi.org/10.4137/CGast.S7146","url":null,"abstract":"Introduction Bleeding due to oesophageal varices is the most common cause of upper gastrointestinal tract haemorrhage in Gezira State, Central Sudan. Endoscopic injection sclerotherapy (EST) is a valuable therapeutic modality for the management of variceal bleeding. Other options for treatment such as variceal band ligation are either expensive or unavailable. Objectives A retrospective study to evaluate the outcome of (EST) in the management of bleeding oesophageal varices due to portal hypertension in Gezira State, the centre of a developing country, Sudan. Methods A total of 1073 patients, during 2001-2010, were carefully selected particularly those with bleeding oesophageal varices consequent to portal hypertension. EST was performed using a standard technique and ethanolamine oleate (5%) was utilized as sclerosing agent. Results There were 777 males (72.4%) and 296 females (27.6%) in a ratio of 2.6. The causes of portal hypertension were found to be schistosomal periportal fibrosis (PPF) in 1001 (93.3%) patients, liver cirrhosis in 60 (5.5%) mixed PPF and cirrhosis in seven (0.7%) and portal vein thrombosis in five (0.5%) patients. Full obliteration of varices required a mean of four sessions with a range of 2-6. In the present study 350 (32.6%) patients have been followed up until complete sclerosis of varices. Conclusion This study provides evidence that endoscopic injection sclerotherapy is an important component in the management of bleeding oesophageal varices caused by hypertension. It is a safe and effective procedure.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CGast.S7146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70689864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Once-Daily MMX Mesalamine in the Management of Ulcerative colitis 每日一次MMX美沙拉明治疗溃疡性结肠炎

Clinical Medicine Insights. Gastroenterology Pub Date : 2011-01-01 DOI: 10.4137/CGast.S4276

W. Blonski, A. Buchner, G. Lichtenstein

引用次数: 2

Microscopic colitis and Medication Use. 显微镜下结肠炎和药物使用。

Clinical Medicine Insights. Gastroenterology Pub Date : 2010-05-18 DOI: 10.4137/cgast.s4469

Monina F Pascua, Prashant Kedia, Mark G Weiner, John Holmes, Jonas Ellenberg, James D Lewis

{"title":"Microscopic colitis and Medication Use.","authors":"Monina F Pascua, Prashant Kedia, Mark G Weiner, John Holmes, Jonas Ellenberg, James D Lewis","doi":"10.4137/cgast.s4469","DOIUrl":"https://doi.org/10.4137/cgast.s4469","url":null,"abstract":"<p><p>BACKGROUND: The incidence of microscopic colitis (MC) is increasing, but its etiology remains unknown. Case reports and limited controlled data suggest that commonly prescribed drugs may be triggers. The aim of this study was to evaluate the prevalence of selected medication use [Proton pump inhibitors (PPIs), HMG-CoA reductase inhibitors (statins), and Selective serotonin reuptake inhibitors (SSRIs)] in patients with MC compared to 'random controls' and 'diarrhea controls.' METHODS: All patients were selected from primary care practices of a university health system during 2002 to 2007. Patients with biopsy proven lymphocytic or collagenous colitis were identified as cases. Diarrhea controls consisted of a 10:1 random sample of patients with chronic diarrhea and normal colon biopsies. Ten random controls were matched to each case on sex and index date (date of biopsy proven diagnosis). Drugs prescribed within the year prior to the index date were collected from the electronic medical record system. RESULTS: 26 cases (median age 68.9 yrs), 259 random, and 259 diarrhea controls were identified. The adjusted ORs for PPI, SSRI, and statin prescription within 12 months of diagnosis of MC between cases and diarrhea controls were 0.28 (0.07-1.07), 0.87 (0.28-2.64), 1.12 (0.34-3.71) respectively. Use of PPI and statins was less common in MC patients than in random controls (p<0.05 for both comparisons). CONCLUSIONS: While prior data suggest that PPIs, statins, and SSRIs may be etiologically related to MC, our study found no increased association with these drugs.</p>","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":"2010 3","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2010-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/cgast.s4469","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29133503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Constipation, IBs and the 5-HT4 Receptor: What Role for Prucalopride? 便秘、肠易激和5-HT4受体:普芦卡必利的作用是什么?

Clinical Medicine Insights. Gastroenterology Pub Date : 2010-01-01 DOI: 10.4137/CGast.S4136

G. Sanger, E. Quigley

引用次数: 13

Hepatitis B screening compliance and non-compliance among Chinese, Koreans, Vietnamese and Cambodians 中国人、韩国人、越南人和柬埔寨人的乙肝筛查依从性和不依从性

Clinical Medicine Insights. Gastroenterology Pub Date : 2010-01-01 DOI: 10.4137/CGast.S3732

G. Ma, Yin Tan, M. Wang, Ying Yuan, Wang G. Chae

{"title":"Hepatitis B screening compliance and non-compliance among Chinese, Koreans, Vietnamese and Cambodians","authors":"G. Ma, Yin Tan, M. Wang, Ying Yuan, Wang G. Chae","doi":"10.4137/CGast.S3732","DOIUrl":"https://doi.org/10.4137/CGast.S3732","url":null,"abstract":"Objective The purpose of this community-based study was to determine factors associated with hepatitis B virus (HBV) screening compliance and non-compliance among Chinese, Korean, Vietnamese and Cambodian adults with varying levels of English language proficiency. Methods A cross-sectional design was used consisting of a sample of 1,603 Asian adult men and women. Results Overall, 71.4% of the sample reported having never been screened and 28.6% reported being screened for HBV Demographic, acculturation, and barrier factors were differentially associated with screening rates among the subgroups. Demographic factors associated with never-screened were: lower education, younger age, being male, and no insurance for Chinese; lower education, lower income and no insurance for Cambodians; younger age and unmarried for Koreans; and no health insurance for Vietnamese; Acculturation factors associated with never-screened were: not speaking English for Chinese; not speaking English, not reading newspapers in English, and watching TV in one's native language for Cambodians; not speaking English for Koreans; while no significant factors were found for Vietnamese. All barriers were associated with never-screened for Cambodians and Chinese. Those who lacked knowledge about HBV and had language and transportation barrier were more likely to be never-screened for Koreans. There were no significant relationships between the barriers and the screening status for Vietnamese. Conclusions High incidence of HBV and liver cancer in Asian Americans mandates a more vigorous and more culturally and linguistically appropriate educational effort to increase screening and vaccination for HBV in these underserved and mostly uninsured populations.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90431869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Endoscopic Needle Knife Precut Papillotomy for Inaccessible Bile Duct following Failed Pancreatic Duct Access 内镜下针刀预切乳头状切开术治疗胰管进入失败后无法进入的胆管

Clinical Medicine Insights. Gastroenterology Pub Date : 2009-01-01 DOI: 10.4137/CGast.S1120

H. Miyatani, Y. Yoshida

{"title":"Endoscopic Needle Knife Precut Papillotomy for Inaccessible Bile Duct following Failed Pancreatic Duct Access","authors":"H. Miyatani, Y. Yoshida","doi":"10.4137/CGast.S1120","DOIUrl":"https://doi.org/10.4137/CGast.S1120","url":null,"abstract":"Aims To evaluate the safety, effectiveness, success rate and complications of needle knife precut papillotomy for inaccessible bile duct after failed pancreatic ducts access. Methods Selective common bile duct cannulation was required for 582 patients from November 2004 to May 2008. Precut sphincterotomy was performed in 28 patients (16 male, 12 female; mean age 71). When standard bile duct cannulation was unsuccessful after more than 20 minutes, the bile duct was considered inaccessible. Group A consisted of patients where pancreatic duct access was possible and transpancreatic papillary septotomy was performed (20 patients). If pancreatic duct cannulation also failed, needle knife precut method was performed and these patients belonged to group B (8 patients). The success and complication rates of the two groups were compared using the Chi-square test. Results The success rates were 85% and 87.5% respectively. Of the 28 patients in group A, 6 had mild to moderate pancreatitis and one patient had mild bleeding. The complication rates were 35% and 0% respectively and the differences were not significant. Conclusion Needle knife precut papillotomy is useful and acceptable in patients after failed pancreatic duct access.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CGast.S1120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70689243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Fulminant Hepatic Failure Caused by Diffuse Liver Metastases following Gastrointestinal Stromal Tumor Resection 胃肠道间质瘤切除术后弥漫性肝转移引起暴发性肝衰竭

Clinical Medicine Insights. Gastroenterology Pub Date : 2009-01-01 DOI: 10.4137/CGast.S3221

A. Zeina, A. Nachtigal, E. Vlodavsky, J. Naschitz

引用次数: 0