Clinical Medicine Insights. Gastroenterology最新文献

Biodegradable Stents in Resistant Peptic Oesophageal Stricture: Is It the Right Way to Go? 可生物降解支架治疗难治性消化性食管狭窄:这是正确的方法吗?

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-12-20 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218819492

Tom Richardson, Gerlin Naidoo, Namal Rupasinghe, Howard Smart, Sayantan Bhattacharya

引用次数: 1

Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation? 大肠黑素病:有益的对比效果还是有害的色素沉着?

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-12-04 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218817321

Fadi Abu Baker, Amir Mari, Dan Feldman, Muhammad Suki, Oren Gal, Yael Kopelman

{"title":"Melanosis Coli: A Helpful Contrast Effect or a Harmful Pigmentation?","authors":"Fadi Abu Baker, Amir Mari, Dan Feldman, Muhammad Suki, Oren Gal, Yael Kopelman","doi":"10.1177/1179552218817321","DOIUrl":"https://doi.org/10.1177/1179552218817321","url":null,"abstract":"Background: Melanosis coli, a brown discoloration of colonic mucosa, is considered as a benign condition mainly observed in patients under chronic anthranoid laxatives. Recent data link this condition with an increased adenoma detection rate. Moreover, its tumorigenic potential and possible association with the development of colorectal cancer remains uncertain. We conducted this study to compare the polyp detection rate and colorectal cancer diagnosis in patients with melanosis against matched control group without melanosis.Patients and methods: A retrospective single-center study. Patients diagnosed with melanosis coli on colonoscopy over a 15-year period were included. Each melanosis coli patient was matched with three controls by age, gender, setting (inpatient/outpatient), and procedure's indication. Polyp detection rate and diagnosis of colorectal cancer were recorded and compared between the groups before and after adjustment for bowel preparation.Results: A cohort of 718 patients with melanosis and 2154 controls were included. The polyp detection rates were 33.4% and 21.8% of melanosis and control groups, respectively (P < .001). Melanosis coli, however, was associated with less diagnosis of colorectal cancer than controls (0.3% vs 3.9%; P < .001). In multivariate analysis, melanosis diagnosis on endoscopy was significantly associated with higher polyp detection rate (odds ratio [OR] = 1.986, 95% confidence interval [CI]: 1.626-2.425; P value < .01).Conclusions: Melanosis coli is not associated with increased diagnosis of colorectal cancer. It is associated, however, with enhanced polyp detection likely due to chromo-endoscopy-like effect.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":" ","pages":"1179552218817321"},"PeriodicalIF":0.0,"publicationDate":"2018-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179552218817321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36847455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Understanding Therapeutic Concepts in Crohn's Disease. 理解克罗恩病的治疗概念。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-12-03 DOI: 10.1177/1179552218815169

Gilles Rg Monif

引用次数: 8

The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial. 神经肌肉电刺激对肝硬化患者肌肉和功能能力的益处:一项随机临床试验方案。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-11-26 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218811834

Carolina Luana de Mello, Thaís Martins Albanaz da Conceição, Tarcila Dal Pont, Catherine Corrêa Peruzzolo, Mariana Nunes Lúcio, Elaine Paulin

{"title":"The Benefits of Neuromuscular Electrical Stimulation in the Muscular and Functional Capacity of Patients With Liver Cirrhosis: Protocol for a Randomized Clinical Trial.","authors":"Carolina Luana de Mello, Thaís Martins Albanaz da Conceição, Tarcila Dal Pont, Catherine Corrêa Peruzzolo, Mariana Nunes Lúcio, Elaine Paulin","doi":"10.1177/1179552218811834","DOIUrl":"https://doi.org/10.1177/1179552218811834","url":null,"abstract":"Cirrhosis causes systemic and metabolic changes that culminate in various complications, such as compromised pulmonary function, ascites, hepatic encephalopathy, weight loss, and muscle weakness with significant physical function limitations. Our aim is to evaluate the effects of training with neuromuscular electrical stimulation (NMES) on the muscular and functional capacity of patients with cirrhosis classified as Child-Pugh B and C. A total of 72 patients diagnosed with cirrhosis will be recruited and randomized to perform an NMES protocol for 50 minutes, 3 times a week, for 4 weeks. The evaluations will be performed at the beginning and after 12 sessions, and patients will be submitted to a pulmonary function test, an ultrasound evaluation of the rectus femoris, an evaluation of peripheral muscle strength, a submaximal exercise capacity test associated with an evaluation of peripheral tissue oxygenation, a quality of life evaluation, and orientation about monitoring daily physical activities. The evaluators and patients will be blinded to the allocation of the groups. Training Group will be treated with the following parameters: frequency of 50 Hz, pulse width of 400 μs, rise and fall times of 2 s, and on:off 1:1; Sham Group: 5 Hz, 100 μs, on:off 1:3. The data will be analyzed using the principles of the intention to treat. This study provides health professionals with information on the benefits of this intervention. In this way, we believe that the results of this study could stimulate the use of NMES as a way of rehabilitating patients with more severe cirrhosis, with the objective of improving these patients' functional independence.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":" ","pages":"1179552218811834"},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179552218811834","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36743257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Video Aid on Quality of Bowel Preparation Among Patients Undergoing Outpatient Screening Colonoscopy. 视频辅助对门诊结肠镜筛查患者肠道准备质量的影响。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-10-08 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218803304

Sanna Fatima, Deepanshu Jain, Christopher Hibbard

{"title":"Impact of Video Aid on Quality of Bowel Preparation Among Patients Undergoing Outpatient Screening Colonoscopy.","authors":"Sanna Fatima, Deepanshu Jain, Christopher Hibbard","doi":"10.1177/1179552218803304","DOIUrl":"https://doi.org/10.1177/1179552218803304","url":null,"abstract":"Aim: To investigate the effect of video aid on quality of bowel preparation.Study: A retrospective study was done on patients undergoing outpatient screening colonoscopy. All subjects received educational video prior to colonoscopy in addition to the standard counseling. Patient charts were reviewed to collect data regarding quality of bowel preparation (adequate or inadequate). The study population was stratified into four groups according to viewing status: Group I 0% (control group), Group II <50%, Group III >50% to <75%, and Group IV watched ⩾75% of the video.Results: A total of 338 patients with an average age of 59.1 years and 60.3% females were included in the final study cohort. Of the patients in Groups I, II, III, and IV, 94.3%, 90.9%, 100%, and 91.7%, respectively, had adequate preparation (P value = .827). Adenoma detection rate (ADR) for Groups I, II, III, and IV was 28.8%, 50%, 50%, and 22.6%, respectively (P value = .305). The mean cecal intubation time was 20.7, 16.4, 16.57, and 17 minutes for Groups I, II, III, and IV, respectively (P value = .041).Conclusions: Video aid use for patients undergoing screening colonoscopy lacked a statistically significant impact on the quality of bowel preparation, ADR, and advanced adenoma detection rate when compared with standard practice.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":" ","pages":"1179552218803304"},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179552218803304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36572493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Extramedullary Plasmacytoma Presenting as a Pancreatic Mass. 胰腺髓外浆细胞瘤表现为胰腺肿块。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-09-24 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218801603

Michelle Le, Balarama Krishna Surapaneni, Vardhmaan Jain, Rakesh Vinayek, Sudhir K Dutta

引用次数: 4

Gastroduodenal Tuberculosis: A Case Series and Review of Literature. 胃十二指肠结核:病例系列及文献回顾。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-07-30 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218790566

Suhas Udgirkar, Ravindra Surude, Vinay Zanwar, Sanjay Chandnani, Qais Contractor, Pravin Rathi

引用次数: 16

Esophageal Adenocarcinoma: Opportunities for Targeted Prevention in Ohio. 食管腺癌:俄亥俄州针对性预防的机会。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-07-30 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218791170

Julie A Stephens, James L Fisher, Jessica L Krok-Schoen, Ryan D Baltic, Holly L Sobotka, Electra D Paskett

{"title":"Esophageal Adenocarcinoma: Opportunities for Targeted Prevention in Ohio.","authors":"Julie A Stephens, James L Fisher, Jessica L Krok-Schoen, Ryan D Baltic, Holly L Sobotka, Electra D Paskett","doi":"10.1177/1179552218791170","DOIUrl":"https://doi.org/10.1177/1179552218791170","url":null,"abstract":"Objective: The incidence of esophageal adenocarcinoma, one of the most lethal gastroenterological diseases, has been increasing since the 1960s. Prevention of esophageal adenocarcinoma is important because no early detection screening programs have been shown to reduce mortality. Obesity, gastroesophageal reflux disease, and tobacco smoking are risk factors for esophageal adenocarcinoma. Due to the high prevalence in Ohio of obesity (32.6%) and cigarette smoking (21.0%), this study sought to identify trends and patterns of these risk factors and esophageal adenocarcinoma in Ohio as compared with the United States.Methods: Data from the Ohio Cancer Incidence Surveillance System, Surveillance Epidemiology and End Results Program (SEER), and Behavioral Risk Factor Surveillance System were used. Incidence rates overall, by demographics and by county, as well as trends in incidence of esophageal adenocarcinoma and the percent of esophageal adenocarcinoma among esophageal cancers were examined. Trends in obesity and cigarette smoking in Ohio, and the prevalence of each by county, were reported.Results: There was an increasing trend in esophageal adenocarcinoma incidence in Ohio. Ohio's average annual esophageal adenocarcinoma incidence rate was higher than the SEER rate overall and for each sex, race, and age group in 2009 to 2013. There was also an increasing prevalence of obesity in Ohio. Although the prevalence of cigarette smoking has been stable, it was high in Ohio compared with the United States.Conclusions: Health care providers and researchers should be aware of the esophageal adenocarcinoma incidence rates and risk factor patterns and tailor interventions for areas and populations at higher risk.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":" ","pages":"1179552218791170"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179552218791170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36377014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index. 克罗恩病血浆无氨基酸谱:与克罗恩病活动指数的关系

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-07-30 eCollection Date: 2018-01-01 DOI: 10.1177/1179552218791173

Toshimi Chiba, Kazuyuki Suzuki, Takayuki Matsumoto

{"title":"Plasma-Free Amino Acid Profiles in Crohn's Disease: Relationship With the Crohn Disease Activity Index.","authors":"Toshimi Chiba, Kazuyuki Suzuki, Takayuki Matsumoto","doi":"10.1177/1179552218791173","DOIUrl":"https://doi.org/10.1177/1179552218791173","url":null,"abstract":"We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn's disease (CD) activity index (CDAI) in patients with CD.Methods: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity.Results: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA.Conclusions: In patients with CD, plasma amino acids appear to be associated with disease activity.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":" ","pages":"1179552218791173"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179552218791173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36377015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

An Evidence-Based Review of Statin Use in Patients With Nonalcoholic Fatty Liver Disease. 他汀类药物在非酒精性脂肪肝患者中应用的循证回顾。

Clinical Medicine Insights. Gastroenterology Pub Date : 2018-07-10 DOI: 10.1177/1179552218787502

Meredith A Sigler, Lee Congdon, Krystal L Edwards

{"title":"An Evidence-Based Review of Statin Use in Patients With Nonalcoholic Fatty Liver Disease.","authors":"Meredith A Sigler, Lee Congdon, Krystal L Edwards","doi":"10.1177/1179552218787502","DOIUrl":"10.1177/1179552218787502","url":null,"abstract":"Background: Nonalcoholic fatty liver disease (NAFLD) is a common complication in patients with metabolic syndrome. The role of statin therapy specifically for the treatment of NAFLD remains unknown. The aim of this review is to discuss outcomes of recent articles analyzing statin therapy in patients with NAFLD.Findings: A total of 12 trials met the inclusion criteria. Statins were not found to increase the prevalence of NAFLD once confounding variables were considered. Statins were also found to be beneficial in treating dyslipidemia and improving liver function. Histological liver outcomes in patients with NAFLD were controversial. One trial found a reduction in the incidence of hepatocellular carcinoma associated with the use of statins.Conclusions: Overall, therapy with statins appears to be safe for use in patients with NAFLD. Several trials have validated the use of statins for the treatment of dyslipidemia; however, it remains unknown as to whether statins should be used to specifically treat NAFLD.","PeriodicalId":10382,"journal":{"name":"Clinical Medicine Insights. Gastroenterology","volume":" ","pages":"1179552218787502"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179552218787502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36317716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36