Clinical Endocrinology最新文献

{"title":"Post-Bariatric Hypoglycemia After Gastric Bypass: Clinical Characteristics, Risk Factors, and Future Directions-A Response to Grover et al.","authors":"Chi-Wei Ye, Lien-Chung Wei","doi":"10.1111/cen.15229","DOIUrl":"https://doi.org/10.1111/cen.15229","url":null,"abstract":"<p><strong>Background: </strong>Post-bariatric hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB) is a complex complication, often characterized by potentially severe hypoglycemic episodes and reduced hypoglycemia awareness. Recent findings suggest that autonomic dysfunction, preoperative hypoglycemia symptoms, and early dumping syndrome may each contribute to PBH risk.</p><p><strong>Objective: </strong>To discuss critical insights from the recent study by Grover et al. regarding the clinical characteristics, prevalence, and possible contributing factors of PBH, and to propose avenues for future research, including standardized preoperative screening and targeted dietary interventions.</p><p><strong>Discussion: </strong>Current evidence underscores a high prevalence of severe (level 3) hypoglycemia episodes among PBH patients, with notable rates of autonomic dysfunction and neuropathy. Dietary strategies (e.g., fermented wheat supplements) hold promise for mitigating PBH-related complications. Emerging data further highlight the significance of preoperative hypoglycemia symptoms and dumping syndrome as early predictors of PBH risk, emphasizing the need for improved risk stratification.</p><p><strong>Conclusion: </strong>Comprehensive preoperative screening, investigation of autonomic dysfunction in glucose metabolism, and individualized dietary or pharmacological interventions may optimize PBH management. These strategies could refine patient selection, reduce hypoglycemia incidence, and improve long-term outcomes for individuals undergoing RYGB.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin and Adrenal Androgens During Adrenarche.","authors":"German Iñiguez, Esteban Barnafi, Enzo Lalli, Ana Pereira, Pedro Ferrer, Verónica Mericq","doi":"10.1111/cen.15227","DOIUrl":"https://doi.org/10.1111/cen.15227","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Premature adrenarche (PremA), is associated with increased adiposity and in girls to earlier puberty and adverse metabolic profiles. Recently LC-MS/MS studies demonstrated adrenal production of more potent androgens: 11-oxygenated C19 steroids. Defining the mechanisms that regulate adrenal 11-oxygenated C19 steroids production has been elusive. We recently showed that genetic determinants of DHEAS during adrenarche differed from those during adulthood. One highly significant variant was at the prolactin receptor which is strongly expressed in human adrenal tissue. The aim of this study is to test whether an association exists between DHEAS/11-oxygenated C19 steroids and prolactin concentrations in pre-pubertal girls.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Two hundred and forty four prepubertal girls recruited within the 'the Food and Environment Chilean Cohort,' with normal birth weight (3.37 ± 0.02 Kg) were examined at 6.7 ± 0.6 years, including anthropometry and blood sampling. DHEAS and 11-oxygenated C19 steroids were measured by LC-MS/MS. Girls were categorized according to the DHEAS concentrations in normal DHEAS (ND, &lt; 75th percentile for the population) or high DHEAS (HD, ≥ 75th percentile). This definition of adrenarche subgroups allows identification of PremA independently from other factors influencing clinical manifestations (i.e ethnicity, tissue sensitivity).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;None of the girls presented clinical evidence of pubarche. At this age mean DHEAS concentration was 16.4 (9.6, -25) μg/dL and the 75th percentile set at 25.0 μg/dL. Girls with HD had higher weight (1.3 ± 1.2 vs. 0.7 ± 1.1, p &lt; 0.001), height (0.6 ± 1.0 vs. 0 ± 0.9, p &lt; 0.001) and BMI (1.3 ± 1.2 vs. 0.9 ± 1.1, p &lt; 0.01) SDs compared to ND. The concentrations of all 11-oxygenated C19 steroids (ng/mL) were higher in girls with HD compared to girls with ND: 11KA by 16% [0.14 (0.12, 0.16) vs. 0.12 (0.10, 0.14)], 11OHA by 43% [0.07 (0.05, 0.08) vs. 0.04 (0.03, 0.05)], 11KT by 35% [0.19(0.15, 0.25) vs. 0.14 (0.11, 0.19)] and 11OHT by 30% [0.03 (0.02, 0.05) vs. 0.03 (0.01, 0.04)]. DHEAS levels correlated with each of the 11-oxygenated C19 steroids both in the raw and in fully adjusted model. Prolactin levels [6.5 (4.4, 10.7) vs. 5.7 (4.1, 9.3)] ng/mL and insulin [7.2 (5.7, 8.7) vs. 6.8 (5.3, -9.4)] μUI/mL did not differ in HD compared to ND girls. Prolactin levels were not associated with DHEAS concentrations but significantly associated with 11KA (p &lt; 0.001) even after adjustment by covariates and was close to the limit of significance in the fully adjusted model for 11OHA (p = 0.051).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our observations confirm that 11KT is the dominant bioactive androgen in children during adrenarche and PremA. Prolactin levels are directly correlated to the concentrations of the adrenal bioactive androgens. Conditions or medications that increase prolactin concentrations during childhood could have a role in","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Metabolomic Analysis of Healthy and Central Precocious Puberty Girls.","authors":"Yunhui Xia, Lei Li, Dongmei Li, Yanmei Liu, Lanxiang Hao","doi":"10.1111/cen.15226","DOIUrl":"https://doi.org/10.1111/cen.15226","url":null,"abstract":"<p><strong>Background: </strong>The incidence of precocious puberty (PP) has been on the rise in recent years. Based on different control mechanisms, childhood PP is divided into central precocious puberty (CPP) and peripheral precocious puberty (PPP). CPP accounts for 80% of all PP cases. Metabolomics is considered a link between genomics and phenotypes, providing a direct reflection of intricate biological traits. However, studies on serum metabolomic changes in CPP are very limited.</p><p><strong>Methods: </strong>In this study, non-targeted metabolomics analysis of serum from healthy controls and CPP groups was performed. Serum samples were collected from a total of 55 individuals, including 30 girls diagnosed with CPP who had not yet received treatment and did not have any other comorbidities, and 25 healthy girls serving as controls who underwent physical examinations.</p><p><strong>Results: </strong>A total of 1107 differential metabolites were identified, including 681 upregulated and 426 downregulated ones. The main pathway involved was citrate cycle (TCA cycle), primary bile acid biosynthesis, arginine biosynthesis, purine metabolism, caffeine metabolism, alanine, aspartate and glutamate metabolism, valine, leucine and isoleucine biosynthesis, beta-alanine metabolism, taurine and hypotaurine metabolism, inositol phosphate metabolism, sphingolipid metabolism, pyruvate metabolism, propanoate metabolism, butanoate metabolism, C5-branched dibasic acid metabolism, sulphur metabolism, carbon metabolism and biosynthesis of amino acids.</p><p><strong>Conclusion: </strong>A total of 14 metabolites were identified through non-targeted metabolomics combined with four major metabolic network analyses. The above metabolites form a metabolic network that may serve as a novel marker and potential combined therapeutic target for the diagnosis of CPP.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6-14 Years.","authors":"Pinar Altun Yildirim, Ersin Nazlican, Zeliha Haytoglu, İhsan Turan, Betul Kilincli, Asli Atasoy Aydin, Eda Mengen, Nebile Daglioglu","doi":"10.1111/cen.15221","DOIUrl":"https://doi.org/10.1111/cen.15221","url":null,"abstract":"<p><strong>Background: </strong>The incidence of hypothyroidism in childhood is increasing. This study aimed to investigate the potential role of exposure to bisphenol A, an environmental endocrine disruptor, and its substitutes in the development of hypothyroidism. To this end, thyroid hormone levels and urinary bisphenol concentrations were compared in newly diagnosed hypothyroid children and a healthy control group.</p><p><strong>Methods: </strong>In this case-control study, 51 newly diagnosed hypothyroid children aged 6-14 years were matched with 51 healthy controls. The association between thyroid hormone levels and urinary bisphenol levels was investigated by measuring urinary bisphenol levels in both the case and control groups.</p><p><strong>Results: </strong>There was no significant difference in age, sex or BMI percentile between the case and control groups. The groups were homogeneously distributed. When urinary bisphenol levels were examined, BPA, BPS, BPF and BPB were not detected in the control group. There was a significant difference between the groups in terms of urinary bisphenol BPS levels. The case group showed a mean total concentration of 16.5 ng/mL and a median of 5.8 ng/mL. Diagnosing hypothyroidism in the children can be considered by examining the bisphenol level. In the ROC analysis, if this level is over 1.3 and is considered positive for hypothyroidism, the sensitivity value is determined as 83.7% and the specificity value is 75%.</p><p><strong>Conclusion: </strong>This study demonstrated that at least 50% of the children in the case group had bisphenol concentrations exceeding the highest value recorded in the control group, suggesting that total BP levels could be used as a potential biomarker for hypothyroidism.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Postoperative Growth in Japanese Children with Craniopharyngioma.","authors":"Yuri Mukoyama, Shun Moriguchi, Fumihiko Takizawa, Atsushi Ogawa, Tetsushi Ogawa, Junko Ito, Susumu Yokoya, Noriaki Fukuhara, Mitsuo Yamaguchi-Okada, Hiroshi Nishioka, Shozo Yamada, Tsuyoshi Isojima","doi":"10.1111/cen.15224","DOIUrl":"https://doi.org/10.1111/cen.15224","url":null,"abstract":"<p><strong>Objective: </strong>Craniopharyngioma (CP) has mostly nonspecific symptoms, leading to delayed diagnosis. Early indicators of CP in children are needed for early diagnosis and to detect postoperative growth patterns for their optimal care. This study aimed to investigate the clinical characteristics and postoperative growth patterns in Japanese children with CP.</p><p><strong>Design: </strong>Retrospective analysis of medical records (2000-2022).</p><p><strong>Methods: </strong>Seventy-three children (median age at diagnosis = 9.3 (0.9-18) years; 44 females) from Toranomon Hospital, Tokyo, Japan, who were diagnosed with CP and undergoing trans-sphenoidal or trans-cranial surgery, or both, were followed up for at least 3 years. We assessed clinical characteristics and changes in height and body mass index (BMI) standard deviation scores (SDSs).</p><p><strong>Results: </strong>The SDSs for height and BMI were -1.7 (-4.0 to 1.3) and 0.21 (-2.3 to 2.2), respectively. Chief complaints at diagnosis were neurologic (n = 25, 34.2%), endocrine (n = 22, 30.1%), or ophthalmic (n = 22, 30.1%), while accompanying neurologic, endocrine, and ophthalmic symptoms were present in 34 (46.6%), 63 (86.3%), and 37 (50.7%) patients, respectively. One year after surgery, growth without growth hormone (GWGH) was detected in seven patients (13%), which could be categorized based on MRI-evident hypothalamic involvement (transient: n = 3, 5.6%; permanent: n = 4, 7.4%). Preoperative hydrocephalus (n = 21, 32.8%) was the only factor significantly associated with postoperative GWGH at 1 year (p = 0.037).</p><p><strong>Conclusion: </strong>Children with CP have distinctive clinical characteristics and postoperative growth patterns. Identifying symptoms using school-based auxological measurements could help in early diagnosis.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial Comparing Testosterone Enanthate and Testosterone Undecanoate as a Gender Affirming Hormonal Therapy in Trans Males.","authors":"Sankar Sinju, Subbiah Sridhar, Palaniyappan Sreenivasan, Sureshkumar Paramasivam, Geethaanjali Varadarajan, Nattanmai Krishnan Mahalakshmi, Thangavel Gnanasekharan, Vasanthiy Natarajan","doi":"10.1111/cen.15223","DOIUrl":"https://doi.org/10.1111/cen.15223","url":null,"abstract":"<p><strong>Objective: </strong>Testosterone is the only available gender affirming hormonal therapy (GAHT) for female-to-male (FtM) transsexuals, to alleviate gender dysphoria and to obtain desired masculinizing effects. The objective is to study the effect of two different formulations of testosterone- testosterone enanthate (TE) and testosterone undecanoate (TU) on various clinical, biochemical and hormonal parameters.</p><p><strong>Design: </strong>This is a prospective randomized controlled trial conducted over a period of 28 months in a Transgender multi-specialty clinic. Fifty-eight testosterone naive transgender men, randomized into two groups, 29 received TE and the remaining 29 received TU.</p><p><strong>Patients and measurements: </strong>The variables assessed were cessation of menstrual cycles, onset of facial and body hair, deepening of voice, waist-to-hip ratio, clitoromegaly, muscle strength, hematological, lipid, liver functions and gonadal hormonal profile. The changes were compared at baseline, 6 months and 1 year following TE and TU and compared between the groups.</p><p><strong>Results: </strong>Both groups had desired masculinizing effects at the end of 1 year. There was a statistically significant increase in hemoglobin, hematocrit, LDL cholesterol and testosterone levels with a simultaneous decrease in HDL and estradiol levels at 1 year in both the groups with no statistical significance between the groups, despite the lesser number of injections received by TU group than TE group (6 vs. 18).</p><p><strong>Conclusion: </strong>Both TE and TU is safe, effective and well tolerated GAHT among FtM transsexuals with no significant differences in clinical, biochemical and hormonal parameters. Testosterone undecanoate was preferred at the end of 1 year due to its long dosing intervals.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Hormones, Sex Hormone-Binding Globulin and Sleep Problems in Females With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.","authors":"Nur K Abdul Jafar, Meng Fan, Lisa J Moran, Darren R Mansfield, Christie J Bennett","doi":"10.1111/cen.15219","DOIUrl":"https://doi.org/10.1111/cen.15219","url":null,"abstract":"<p><strong>Objective: </strong>Sleep problems like obstructive sleep apnea (OSA) are common in polycystic ovary syndrome (PCOS), although the underlying mechanisms are not well understood. We aimed to determine the prevalence of sleep problems, synthesise and appraise studies analysing the associations between serum sex hormones, sex hormone-binding globulin (SHBG) and sleep problems in females with PCOS.</p><p><strong>Design: </strong>Systematic review and meta-analysis.</p><p><strong>Methods: </strong>A systematic search using MEDLINE, Embase, PsycInfo, CINAHL, Scopus, and Google Scholar was performed till 3 August 2024. Studies that examined serum sex hormones, SHBG or hyperandrogenism with sleep disorders and/or sleep disturbances in PCOS were eligible. Random effects meta-analyses of sex hormones and SHBG among females with PCOS with compared to without OSA were conducted.</p><p><strong>Results: </strong>From 4487 screened studies, 24 were included, with nine suitable for meta-analyses. Among females with PCOS, 46.0% had OSA and 56.0% had other sleep disturbances. SHBG levels were significantly lower in women with PCOS and OSA compared to those without OSA (standardised mean difference = -0.62; 95% CI = -0.82 to -0.42; I² = 0%; 179 participants; p < 0.00001), but no differences were seen in total and free testosterone, dehydroepiandrosterone sulfate, androstenedione, and oestradiol. No significant associations between serum sex hormones, SHBG or hyperandrogenism with sleep disturbances in PCOS were observed.</p><p><strong>Conclusion: </strong>SHBG, rather than hyperandrogenism, may play a more important mechanistic role for OSA in PCOS, while other sleep disturbances exhibit a less severe SHBG profile. These findings enhance comprehension of underlying pathophysiology of sleep problems in PCOS. Further validation across PCOS populations is warranted.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical Thyroid Dysfunction and Mortality in an Older, Community-Dwelling Population-Results of the PolSenior Study.","authors":"Piotr Kocełak, Aleksander J Owczarek, Małgorzata Mossakowska, Monika Puzianowska-Kuźnicka, Marek Bolanowski, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek","doi":"10.1111/cen.15220","DOIUrl":"https://doi.org/10.1111/cen.15220","url":null,"abstract":"<p><strong>Objective: </strong>There is limited data concerning the effect of untreated subclinical thyroid disorders on mortality in older adults. Therefore, this study aimed to analyze 5-year overall mortality among participants in the PolSenior study with treated and untreated subclinical thyroid dysfunction.</p><p><strong>Design and methods: </strong>The study group consisted of 407 participants with thyroid disorders (305 with hypothyroidism and 102 with hyperthyroidism) and 2776 euthyroid individuals aged 65 years and older. Overall mortality risk factors were assessed with Cox proportional hazard regression. Additionally, overall survival analyses were performed with Kaplan‒Meier estimates stratified by sex and hypo-/hyperthyroidism status.</p><p><strong>Results: </strong>In women, there was no difference in survival between the euthyroid and hypothyroid groups. Survival was significantly worse in patients with subclinical hyperthyroidism than in euthyroid and treated hyperthyroidism patients. In men, there were no differences in survival between the hyperthyroidism group and the subclinical hypothyroidism or euthyroid group. Notably, survival was better in the treated hypothyroidism group than in the euthyroid group. According to the multivariate models, subclinical hyperthyroidism appeared to be linked to a 30% reduction in survival among women (hazard ratio [HR] for mortality = 1.43; 95% CI = 0.98-2.07, p = 0.06) but not among men.</p><p><strong>Conclusions: </strong>Our study showed that women with subclinical hyperthyroidism had a higher mortality rate. At the same time, men with treated hypothyroidism had improved survival compared to those in the euthyroid group among participants aged 65 years and older during a 5-year follow-up period. Subclinical hypothyroidism did not influence the survival rates.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis on the Prevalence of Radiotherapy-Induced Hypopituitarism in Adults With Primary Non-Pituitary Brain Tumours.","authors":"Darran Mc Donald, Maria Tomkins, Liam O'Connell, David Fitzpatrick, Clare Faul, Michael W O'Reilly, Kathleen Bennett, Mark Sherlock","doi":"10.1111/cen.15216","DOIUrl":"https://doi.org/10.1111/cen.15216","url":null,"abstract":"<p><strong>Context: </strong>It is well recognised there is a high prevalence of pituitary dysfunction in childhood brain tumours survivors who are treated with radiotherapy. In contrast, the potential for survivors of brain tumours arising in adulthood to develop radiotherapy-induced hypopituitarism may be underestimated. The aim of this systematic review and meta-analysis is to determine the pooled prevalence of radiotherapy-induced hypopituitarism in survivors of primary non-pituitary brain tumours arising in adulthood.</p><p><strong>Design: </strong>A systematic literature search of five databases was performed. Two reviewers independently screened potential articles and then extracted data from accepted studies. A random effects meta-analysis was performed to assess the pooled prevalence of radiotherapy-induced hypopituitarism for each hormone axis. Forest plots were created to graphically represent these estimates with 95% confidence intervals (CI). Between study heterogeneity was quantified using the I² statistic.</p><p><strong>Results: </strong>Fourteen studies comprising a total of 580 participants were included in the review. The pooled prevalence of hypopituitarism was 48% (95% CI 36.7-59.4; I² = 81%) with significant heterogeneity between study results. The pooled prevalence of growth hormone (GH) deficiency was 35.2% (95% CI 24.2-47.0; I² = 81.4%), gonadotropin deficiency 20.9% (95% CI 14.4-28.1, I² = 63.1%), adrenocorticotrophic hormone (ACTH) deficiency 16.0% (95% CI 11.4-21.1; I² = 42.6%) and thyroid stimulating hormone (TSH) deficiency 18.2% (95% CI 12.3-24.8; I² = 63.5%). Heterogeneity among study results was further evaluated through a meta-regression.</p><p><strong>Conclusion: </strong>Radiotherapy-induced hypopituitarism is common, affecting almost half of survivors with a primary non-pituitary brain tumour arising in adulthood. Protocolised endocrine surveillance is essential in this cohort to identify and treat pituitary hormone deficits in a timely manner. These patients report decreased quality of life which may be due, in part, to undiagnosed pituitary dysfunction.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Gonadotropin Treatment of Cryptorchidism in Congenital Hypogonadotropic Hypogonadism-Age Is No Limit?\"","authors":"Yoon Hi Cho, Aniruddh Deshpande, Catherine Langusch, Geoffrey Ambler","doi":"10.1111/cen.15222","DOIUrl":"https://doi.org/10.1111/cen.15222","url":null,"abstract":"","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}