Clinical Endocrinology最新文献

{"title":"The Relationship Between Sleep, Fatigue and Quality of Life in Young Adults With Autoimmune Addison's Disease.","authors":"Sara Fletcher-Sandersjöö, Annelies van T Westeinde, Tim Spelman, Tatja Hirvikosi, Svetlana Lajic, Sophie Bensing","doi":"10.1111/cen.70028","DOIUrl":"https://doi.org/10.1111/cen.70028","url":null,"abstract":"<p><strong>Objective: </strong>Standard glucocorticoid (GC) replacement therapy in autoimmune Addison's disease (AAD) fails to replicate natural cortisol rhythms. Despite adherence, patients report persistent fatigue, reduced vitality, and impaired wellbeing, ultimately lowering health-related quality of life (HRQoL). Cortisol is essential for sleep regulation, yet the impact of cortisol imbalance on sleep and HRQoL in AAD remains poorly understood. This study investigates self-reported sleep impairments and their associations with fatigue and HRQoL in young adults with AAD.</p><p><strong>Patients and methods: </strong>Sixty-four patients with AAD and 128 healthy controls completed validated questionnaires assessing sleep (Karolinska Sleep Questionnaire), fatigue (Multidimensional Fatigue Inventory), and HRQoL (Short Form-36).</p><p><strong>Results: </strong>Patients reported significantly more non-restorative sleep (p = 0.015) than controls. While overall rates of clinically relevant sleep impairments were similar, patients more frequently experienced awakening difficulties (p = 0.011) and struggling to stay awake (p = 0.036). Patients also reported poorer physical health (p < 0.001) and greater general fatigue (p = 0.007), with female patients experiencing more mental fatigue (p = 0.013). Poor sleep and fatigue were associated with reduced HRQoL across the cohort, with patients showing a more pronounced decline in physical health in relation to these factors. Mental health scores remained similar between groups.</p><p><strong>Conclusion: </strong>Non-restorative sleep emerged as a distinct feature of AAD. While the prevalence and severity of sleep impairments were similar to controls, the association with poorer physical health was stronger in patients. Mental health remained similar despite sleep disturbances. These findings highlight the importance of addressing even modest sleep disturbances, which may worsen fatigue and reduce physical wellbeing in AAD.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis.","authors":"Berçem Ayçiçek, Mazhar Müslüm Tuna, Ismail Engin, Mustafa Şahin, Sayid Zuhur, Neşe Ersöz Gülçelik, Hüseyin Yağcı, Ersen Karakılıç, Evin Bozkur, Bekir Çakır, Elif Güneş, Süleyman Baldane, Özen Öz Gül, Gulhan Akbaba, Cevdet Duran, Faruk Kılınç, Güven Barış Cansu, Cüneyt Bilginer, Ramazan Sarı, Nurdan Gul, Ayten Oğuz, Bekir Uçan, Eren Gürkan, Murat Çalapkulu, Mehmet Güven, Arzu Or Koca, Sema Taban, Nergis Basmacı","doi":"10.1111/cen.70024","DOIUrl":"https://doi.org/10.1111/cen.70024","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size.</p><p><strong>Methods: </strong>In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols. Although in routine clinical practice these measurements are typically performed at regular intervals of 3-6 months, resulting in approximately three assessments during an 18-month follow-up period. Urinary calcium and creatinine levels were also determined, and imaging modalities (ultrasonography, sestamibi scintigraphy, and computed tomography) were employed for adenoma detection. Statistical analyses comprised repeated measures ANOVA, logistic regression, correlation analysis, and ROC analysis, performed using Jamovi software.</p><p><strong>Results: </strong>Serial evaluations revealed significant temporal changes in key biochemical parameters, including a significant decline in serum calcium and PTH levels alongside a significant increase in urinary calcium excretion. Logistic regression analysis identified higher PTH levels, higher corrected calcium, and larger adenoma size as independent predictors of adenoma localisation, while ROC analysis confirmed that PTH exhibited the highest diagnostic accuracy (AUC = 0.91, 95% CI: 0.84-0.95, p < 0.001).</p><p><strong>Conclusion: </strong>The large scale of our patient cohort reinforces the robustness of our statistical analyses and provides comprehensive insight into the dynamic nature of nPHPT. Our findings demonstrate that, even in normocalcemic patients, higher PTH levels and relatively higher calcium levels within the normal range are important indicators of parathyroid adenoma. Integrating serial biochemical measurements with targeted imaging can facilitate earlier diagnosis, potentially preventing future complications and informing more tailored management strategies.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Thyroglobulin Interpretation to Reduce Ultrasound Examinations in the Follow-Up of Differentiated Thyroid Carcinoma.","authors":"Luca Giovanella, Petra Petranović Ovčariček","doi":"10.1111/cen.70029","DOIUrl":"https://doi.org/10.1111/cen.70029","url":null,"abstract":"","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal Insufficiency During Treatment With Immune-Checkpoint Inhibitors: How to Simplify the Diagnostic Pathway?","authors":"Alice Nervo, Giovanni Gruosso, Marta Marino, Enrica Migliore, Matteo Rubiolo, Elisa Vaccaro, Emanuela Arvat","doi":"10.1111/cen.70023","DOIUrl":"https://doi.org/10.1111/cen.70023","url":null,"abstract":"<p><strong>Objective and background: </strong>Early identification of adrenal insufficiency (AI) during immune-checkpoint inhibitors (ICIs) is crucial to prevent life-threatening consequences; however, the diagnosis is challenging.</p><p><strong>Design, patients and measurement: </strong>In this prospective observational study, ICI-treated cancer patients with morning serum cortisol (SC) within the grey zone (83-414 nmol/L) were enroled. A low-dose adrenocorticotropic hormone (ACTH) stimulation test was performed to assess peak stimulated SC, preceded by re-evaluation of morning SC. The analysis aimed to refine morning SC cut-offs to minimize the diagnostic grey zone reducing the need for ACTH stimulation. To interpret the results of ACTH test, it was employed both the threshold for peak stimulated SC provided by the Endocrine Society guidelines (500 nmol/L) and an assay-specific cut-off for the Abbott platform recently proposed in literature (414 nmol/L). Moreover, the utility of salivary cortisol and cortisone upon awakening was explored.</p><p><strong>Results: </strong>In 30 ICI-treated patients, a good positive correlation between morning and peak stimulated SC was confirmed (r = 0.72, p < 0.001); peak stimulated SC ≤ 500 nmol/L and ≤ 414 nmol/L was detected in 36.7% and 20% of subjects, respectively; all cases were secondary AI. ROC curve analysis identified optimal morning SC thresholds for AI prediction and exclusion (> 196 nmol/L and ≤ 397 nmol/L in case of pathological peak stimulated SC ≤ 500 nmol/L; > 163 nmol/L and ≤ 251 nmol/L in case of pathological peak stimulated SC ≤ 414 nmol/L). Salivary cortisol and cortisone upon awakening positively correlated with peak stimulated SC (r = 0.49 and r = 0.56, respectively, p < 0.01).</p><p><strong>Conclusions: </strong>Morning SC is a reliable tool for the screening of ICI-related AI; the need for dynamic stimulation would be reduced by the application of assay-specific cut-offs. Salivary hormone analysis of cortisol and cortisone upon awakening may represent a viable alternative in selected cases.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Follicular Thyroid Neoplasia With Papillary-Like Nuclear Characteristics (NIFTP): Clinico-Pathological Analysis in a Chilean Centre.","authors":"Iván Muñoz, Marlín Solórzano, Ignacio Fuentes, José Miguel González, Joel Falcón Acevedo, Catalina Ruiz Rademacher, Joaquín Viñambres Giavio, Rodolfo Cabello Torres, Pablo Montero Miranda, Hernán González Díaz, Antonieta Solar, Francisco Cruz Olivos, Lorena Mosso Gómez, Nicole Lustig Franco, José Miguel Domínguez","doi":"10.1111/cen.70026","DOIUrl":"https://doi.org/10.1111/cen.70026","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Noninvasive follicular thyroid neoplasia with papillary-like nuclear characteristics (NIFTP) is characterised by an indolent behaviour and was defined in 2016 to avoid overtreatment in differentiated thyroid cancer (DTC).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To report the clinicopathological characteristics and outcomes of patients with NIFTP treated at a Chilean centre between 2016 and 2023.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;Observational retrospective study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Of 1103 patients with thyroid neoplasia treated with surgery, 104 (9.42%) had NIFTP. Clinicopathological variables were recorded, including ultrasound characteristics, fine-needle aspiration biopsy (FNAB) results, genetic testing when available, type of surgery, tumour size, and follow-up data.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 104 patients, 85 (81.7%) were female, age of 44 ± 14.2 years and a median tumour size of 1.7 cm (range 0.1-7.1). Eighty-six (82.7%) had available preoperative staging ultrasound: 1 (1.2%), 39 (45.3%), 38 (44.2%), and 8 (9.3%) were ACR-TIRADS 2, 3, 4, and 5, respectively. Sixteen (15%) NIFTP were incidental, which were smaller than non-incidental NIFTP (median 0.4 cm (0.1-2.2) vs. 1.9 cm (0.6-7.1), p &lt; 0.001). Of the 86 FNAB results available, 2 (2.3%), 10 (11.6%), 20 (23.3%), 24 (27.9%), and 30 (34.9%) were Bethesda I, II, III, IV, and V, respectively. Forty-three patients (41.3%) were treated with lobectomy, 58 (55.8%) with total thyroidectomy (TT), and only 3 (2.9%) with TT and lymph node dissection. In Bethesda II patients, surgery was indicated in cases of nodule growth, showing a larger tumour size than other Bethesda categories (3.0 ± 1.4 vs. 1.8 ± 1.02 cm, p = 0.015). ThyroidPrint® was performed in 12 patients with Bethesda III or IV, resulting suspicious in 11 (92%): of these, 8 (67%) underwent lobectomy. There were no significant differences between lobectomy and TT regarding sex, ACR-TIRADS, tumour size, or ThyroidPrint® results. Twelve (11.5%) were multifocal and 5 (4.8%) bilateral. Fifty-two patients (54%) were followed for ≥ 1 year using follow-up criteria and response to treatment for low-risk DTC recurrence. Thirty-four (65%) had excellent response, 15 (28.8%) indeterminate (13 (25%) by biochemical criteria and 2 (3.8%) by ultrasound), 3 (5.7%) incomplete biochemical (2 (3.8%) due to elevated Tg and 1 (1.9%) due to elevated anti-Tg antibodies), and none with incomplete structural response. There were no differences between lobectomy and TT ± lymph node dissection regarding the type of response. At the end of the follow-up, there were no deaths, and no new interventions were required due to recurrence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In this series, NIFTP showed indolent behaviour and excellent prognosis. Ultrasonographically, 90% presented as ACR-TIRADS 3 or 4, with less than 10% as ACR-TIRADS 5. Regarding FNAB, nearly half were indeterminate, one-third were Bethesda V, and none Bethesda","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical Diagnosis of Phaeochromocytoma and Paraganglioma in Children and Adolescents: A Retrospective Cohort Study.","authors":"Kristin Potthoff, Tamara Prodanov, Lara M Knigge, Angela Hübner, Stefan Bornstein, Jacques Lenders, Karel Pacak, Graeme Eisenhofer, Christina Pamporaki","doi":"10.1111/cen.70025","DOIUrl":"https://doi.org/10.1111/cen.70025","url":null,"abstract":"<p><strong>Introduction: </strong>Currently, it is unclear whether plasma free or 24-h urinary fractionated metanephrines are preferable for diagnosis of phaeochromocytoma/paraganglioma (PPGL) in children.</p><p><strong>Objectives: </strong>To investigate whether measurements of plasma free and 24-h urinary fractionated metanephrines are reliable tests for screening for PPGL in children.</p><p><strong>Methods: </strong>This retrospective study included a cohort of 138 paediatric patients (5 to 18 years), 64 with and 74 without PPGL. Data included sex, age, plasma concentrations of free metanephrines, and genetic test results. For a subset of 89 children tested for PPGL, concentrations of 24-h urinary fractionated metanephrines were also available. For patients with PPGL, data also included tumour location, size, catecholamine tumour phenotype, and presence of recurrent and/or metastatic disease.</p><p><strong>Results: </strong>Among children with PPGL, results of plasma metanephrines showed larger fold increases of normetanephrine above the upper cut-off compared to the urinary metabolites (9.5-fold vs 7.1-fold, p < 0.001). Plasma metanephrines showed a diagnostic sensitivity of 92% and specificity of 96%, whereas for urinary metanephrines sensitivity and specificity of 92% and 91% respectively. Sub-analysis of intra-individual temporal measurements of metabolites showed that subsequent increases of plasma normetanephrine may be associated with early-stage development of a noradrenergic PPGL.</p><p><strong>Conclusions: </strong>Plasma free and 24-h urinary fractionated metanephrines are both reliable screening tests for PPGL in children and adolescents. The plasma panel may be useful for early detection of noradrenergic PPGL relevant for children tested within surveillance programs due to hereditary risk of noradrenergic tumours.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Thyroid Hormone Status: Are Simultaneous TSH and FT4 Tests Necessary? Analysis of Thyroid Function Test Results Taken From the Greater Manchester Care Record 2010-2023.","authors":"Michael Stedman, Peter Taylor, Ian Halsall, David Halsall, Buchi Okosieme, Suhani Bahl, Lakdasa Premawardhana, Colin Dayan, Anthony A Fryer, Adrian Heald","doi":"10.1111/cen.70012","DOIUrl":"10.1111/cen.70012","url":null,"abstract":"","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Syndrome and Insulin Resistance Are Associated With Normal-Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome.","authors":"Jiaxing Feng, Rong Luo, Jing Cong, Qing Xia, Yang Liu, Hang Ge, Hui He, Wen Yang, Xiaoke Wu","doi":"10.1111/cen.70018","DOIUrl":"10.1111/cen.70018","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To determine whether metabolic syndrome (MS), insulin resistance (IR), myocardial enzymes, and kidney function are related to the normal-range of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and their ratio in Chinese women with polycystic ovary syndrome (PCOS).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The research, a secondary analysis of the Acupuncture and Clomiphene for Chinese Women with PCOS trial (PCOSAct), enrolled 922 participants with less than 40 U/L of AST and ALT. Linear regression and trend analyses were used to analyze the relationship between AST, ALT, AST/ALT ratio and anthropometric and metabolic characteristics. The association between AST, ALT, AST/ALT ratio and the prevalence of MS, IR was estimated by logistic regression. The diagnostic performance of AST, ALT, and AST/ALT ratio for MS and IR was determined by the receiver operating characteristics (ROC) curve.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The results showed that AST was positively associated with body mass index (BMI), waist circumference (WC), systolic/diastole blood pressure (SBP/DBP), triacylglycerol (TG), creatine kinase (CK), lactate dehydrogenase (LDH), creatinine (Cr), urea, cystatin-C (Cys-C), and prevalence of MS; negatively correlated with HDL and fasting plasma glucose (FPG). ALT was positively associated with BMI, WC, SBP, DBP, total cholesterol (TC), TG, low-density lipoprotein (LDL), fasting insulin (FINS), homeostatic model assessment values for insulin resistance (HOMA-IR), CK, LDH, urea, Cys-C and prevalence of MS, IR; negatively correlated with HDL and quantitative insulin sensitivity check index (QUICKI). AST/ALT ratio was positively associated with HDL, QUICKI, Cr, Cys-C; negatively correlated with age, BMI, WC, DBP, TC, TG, LDL, FPG, FINS, HOMA-IR, LDH and prevalence of MS and IR. Linear regression analysis showed that after adjusting for confounding factors, a positive association between AST and WC, SBP, TG, CK, LDH, Cr, urea and Cys-C; ALT and WC, TG, FINS, HOMA-IR, CK, LDH, urea, Cys-C; AST/ALT ratio and HDL, QUICKI, CK, Cr and Cys-C; a negative association between AST and HDL, FPG; ALT and HDL, QUICKI; AST/ALT ratio and TG, TC, LDL, FINS, LDH. Univariate logistic regression showed that after adjusted for confounding factors, AST (OR: 1.04; 95% CI: 1.01-1.08, p = 0.022), ALT (OR: 1.04; 95% CI: 1.01-1.07, p = 0.008), and AST/ALT ratio are related to MS (OR: 0.80; 95% CI: 0.64-0.99, p = 0.044), and AST/ALT ratio is related to IR (OR: 0.79; 95% CI: 0.67-0.93, p = 0.005). ROC curve revealed that ALT demonstrated the highest diagnostic performance for MS (AUC = 0.655, 95% CI: 0.61-0.7, cut-off value = 7.5, Sensitive = 0.60, and Specificity = 0.63), whereas AST/ALT ratio was more strongly associated with IR (AUC = 0.619, 95% CI: 0.58-0.66, cut-off value = 1.52, sensitive = 0.64, and specificity = 0.56).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In Chinese PCOS patients, normal-range elevations in ALT and AST along with a ","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sucessful Transition in Rare Endocrine Diseases: Patient Experiences in a French Reference Centre.","authors":"Karine Aouchiche, Thierry Brue, Emeline Marquant, Gilbert Simonin, Sarah Castets, Rachel Reynaud, Frederique Albarel","doi":"10.1111/cen.70016","DOIUrl":"10.1111/cen.70016","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the experiences of patients who had a joint endocrinology consultation for transition to adult care at Marseille university hospitals between 2010 and 2020, focusing on patient follow-up, satisfaction, difficulties, and expectations.</p><p><strong>Methods: </strong>A healthcare transition questionnaire was designed and administered to patients several years after transition to adult care.</p><p><strong>Results: </strong>One hundred and fifteen patients with rare endocrine disorders were included, with a mean age of 18.8 years at the transition consultation. Ninety-six percent (110/115) continued adult care after the first joint consultation, and 75% were still in follow-up when completing the questionnaire (mean follow-up, 4.5 years). Of the 81 respondents, 89% were satisfied with the transition, and 64% reported no difficulties. The most common difficulties were psychological, logistical, and medical. Fifty-three out of 74 respondents (72%) felt the transition occurred at the right time, 17 (24%) thought it was too early, and 4 (5%) felt it was too late. The main concern was the transmission of medical information between doctors. Suggestions for improvement included more joint consultations and personalized transition pathways.</p><p><strong>Conclusion: </strong>In this group of rare endocrine disease patients, a transition pathway based on a joint pediatric-adult consultation was associated with high patient satisfaction and long-term follow-up rates. Patients' suggestions and reported difficulties highlight issues to be addressed and complementary strategies to develop.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Adverse Effects of Endocrine Therapy in Early-Stage Breast Cancer: Pharmacological and Nonpharmacological Approaches.","authors":"Timothy B Winslow, Alissa Huston, Ruth O'Regan, Susan Dent","doi":"10.1111/cen.70011","DOIUrl":"10.1111/cen.70011","url":null,"abstract":"<p><strong>Objective: </strong>Over 70% of breast cancers are hormone receptor positive and endocrine therapy (i.e., aromatase inhibitors and tamoxifen) is considered standard of care. Side effects from endocrine therapy can be significant for patients leading to early treatment discontinuation. As adjuvant endocrine therapy is typically recommended for 5-10 years, proactively addressing adverse effects is important to facilitate patient compliance. This review addresses the common adverse effects of adjuvant endocrine therapy in early-stage breast cancer and approaches to management including both pharmacologic and non-pharmacologic strategies.</p><p><strong>Conclusion: </strong>There are multiple pharmacologic and non-pharmacologic management strategies available to alleviate side effects from endocrine therapy in patients with hormone receptor positive early stage breast cancer. Non-pharmacologic management strategies may be underutilized and should be considered early in the management of endocrine therapy adverse effects.</p>","PeriodicalId":10346,"journal":{"name":"Clinical Endocrinology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}