Clinical Case Studies and Reports最新文献_第5页

A case of idiopathic middle cerebral artery occlusion and perforating branch aneurysm in an unusual location 特发性大脑中动脉闭塞及异常位置穿支动脉瘤1例

Clinical Case Studies and Reports Pub Date : 2021-01-01 DOI: 10.15761/ccsr.1000172

Masatomo Maeda, Akihiro Fukuda, Kouki Shinoda, M. Tamura, M. Yamada, Hidemitsu Nakagawa

引用次数: 0

Elimination of histamine liberator (acetaldehyde) by L-cysteine in prevention of migraine attacks: Randomized controlled trial with a medical device (Acetium® Capsules) l -半胱氨酸消除组胺解离剂(乙醛)预防偏头痛发作:一种医疗器械(Acetium®胶囊)的随机对照试验

Clinical Case Studies and Reports Pub Date : 2021-01-01 DOI: 10.15761/ccsr.1000167

M. Kallela, M. Nissila, P. Keski-Santti, M. Sumelahti, Mikko Karppa, M. Ilmavirta, M. Farkkila, L. Paloheimo, M. Maki, K. Syrjanen, O. Suovaniemi

{"title":"Elimination of histamine liberator (acetaldehyde) by L-cysteine in prevention of migraine attacks: Randomized controlled trial with a medical device (Acetium® Capsules)","authors":"M. Kallela, M. Nissila, P. Keski-Santti, M. Sumelahti, Mikko Karppa, M. Ilmavirta, M. Farkkila, L. Paloheimo, M. Maki, K. Syrjanen, O. Suovaniemi","doi":"10.15761/ccsr.1000167","DOIUrl":"https://doi.org/10.15761/ccsr.1000167","url":null,"abstract":"Background & Study Design: Endorsements from migraine patients testifying that L-cysteine effectively prevented their headache attacks, prompted us to design a double-blind, randomized placebo-controlled, multi-centre trial (with 218 patients) comparing Acetium® capsules (100mg L-cysteine, inactivating acetaldehyde in the stomach) and placebo in prevention of migraine attacks during a 3-month trial period. Methods: Migraine diaries were evaluated at monthly intervals for study compliance. The primary study endpoint was reduction in the number of migraine days (NMD), assessed at 4 cut-offs: ≥50%, ≥30%, ≥25% and ≥20%. Results : Altogether, 146 patients had completed the study per protocol. Using the most stringent cut-off (≥50%) for reduction of NMD, the success rate in the Acetium® arm was 26.0% and in the placebo arm 25.4%; OR=1.027 (95%CI 0.589-1.79) (p=NS). Among the patients with a potential acetaldehyde-associated trigger (alcohol, smoking, dietary), Acetium® was up to 50% more effective than placebo in NMD reduction by various cut-offs, with the highest OR=1.569 (95%CI 0.743-3.312). Conclusions : Although Acetium® was not more effective than placebo in reducing the NMD in the global analysis, certain sub-groups might benefit from Acetium® intervention considerably more than migraine patients collectively.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91115128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated adrenal metastasis of hepatocellular carcinoma (HCC) post liver transplantation: a rare entity 肝移植后肝细胞癌(HCC)的孤立肾上腺转移:一个罕见的实体

Clinical Case Studies and Reports Pub Date : 2021-01-01 DOI: 10.15761/ccsr.1000166

Jatin Agrawal, Praveen Kumar, A. Arora, Ashish Kumar

引用次数: 0

Characteristic and management of Sars-Cov-2 pneumonia without Remdesivir in patient with chronic kidney diseases and sarcomatous endothelial carcinoma 慢性肾脏疾病和肉瘤内皮癌患者非瑞德西韦治疗Sars-Cov-2肺炎的特点和处理

Clinical Case Studies and Reports Pub Date : 2021-01-01 DOI: 10.15761/ccsr.1000162

Weimer Le, G. Cattari, A. Binelli, E. Fanales‐Belasio, Poddighe Af, F. Sensi

{"title":"Characteristic and management of Sars-Cov-2 pneumonia without Remdesivir in patient with chronic kidney diseases and sarcomatous endothelial carcinoma","authors":"Weimer Le, G. Cattari, A. Binelli, E. Fanales‐Belasio, Poddighe Af, F. Sensi","doi":"10.15761/ccsr.1000162","DOIUrl":"https://doi.org/10.15761/ccsr.1000162","url":null,"abstract":"The SARS-CoV-2 pandemic has already infected more than 98 million people worldwide and resulted in 2.1 million deaths. Though originally described as a respiratory virus, SARS-CoV-2 has now been shown to have multiorgan involvement. Chronic kidney disease (CKD) has emerged as a risk factor for adverse outcomes. The virus can cause renal involvement, and severe renal dysfunction is more common among patients with chronic comorbid conditions, especially patients with chronic kidney disease. Angiotensin-converting enzyme 2 (ACE2) has been proven to be the major receptor of SARS-CoV-2 in kidneys, suggesting that ACE2-related changes may be involved in renal injury during the infection. For patients with SARS-CoV-2 infection, renal injury by either direct infection or systemic effects, including host immune clearance and immune tolerance disorders, endothelium-mediated vasculitis, thrombus formation, glucose and lipid metabolism disorder, increased serum creatinine, variable degrees of proteinuria, hematuria, and radiographic abnormalities of the kidneys and hypoxia. Here, we report an Italian patient with Chronic kidney diseases, hypertension and sarcomatous endothelial carcinoma responding to alternative therapy with regression of pneumonia caused by Sars-Cov-2 without Remdesivir for nefrotoxicity.","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85275927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Closure of Ischemic Ventricular Septal Rupture: a case report 手术治疗缺血性室间隔破裂1例

Clinical Case Studies and Reports Pub Date : 2021-01-01 DOI: 10.15761/ccsr.1000165

Hassan Sandogji, M. Talat, Y. Mubarak

引用次数: 0

Prominent Corneal Nerves 突出的角膜神经

Clinical Case Studies and Reports Pub Date : 2021-01-01 DOI: 10.15761/ccsr.1000170

L. Yin, Ningzhi Wangyang, Jing Zhu, Chengye Tan, Chao Sun, Yong Yao

引用次数: 0

One ICD-10 diagnosis- different conflicts: Using the OPD-CA as tool for treatment planning 一个ICD-10诊断-不同的冲突:使用OPD-CA作为治疗计划的工具

Clinical Case Studies and Reports Pub Date : 2020-01-01 DOI: 10.15761/ccsr.1000150

I. Seiffge-Krenke

引用次数: 0

Tumoral calcinosis of buttock in a patient with end stage kidney disease on haemodialysis 终末期肾病血液透析患者的臀部肿瘤性钙质沉着

Clinical Case Studies and Reports Pub Date : 2020-01-01 DOI: 10.15761/ccsr.1000151

A. Hayat

{"title":"Tumoral calcinosis of buttock in a patient with end stage kidney disease on haemodialysis","authors":"A. Hayat","doi":"10.15761/ccsr.1000151","DOIUrl":"https://doi.org/10.15761/ccsr.1000151","url":null,"abstract":"Patients with End-stage Kidney Disease (ESKD) on renal replacement therapy (RRT) are at high risk of extraosseous metastatic calcifications at multiple sites, which includes widespread arterial calcification, cardiac valvular calcification, and soft tissues calcium deposits. Tumoral calcinosis (TC) and calciphylaxis are two dreaded consequences of metastatic soft tissues calcium phosphate complex deposits in patients with ESKD with very poor outcome [1]. A 71-year-old female patient with ESKD secondary to systemic sclerosis on hemodialysis (HD) for last four years, presents with progressively increasing soft tissue swellings involving, both her buttocks over last one year. The swellings were non-tender and firm in consistency. Her X- rays revealed TC in both her buttocks and upper thigh, showing marked progression since the last study done 6 months prior. Vascular calcification was also noted in the pelvis [2] (Figure 1). She is on 4 hours 3 times a week HD with dialysis clearance within the target range. Her serum calcium was 2.8 mmol/L, serum phosphate of 2 mmol/L and parathyroid hormone level of 60-90 pmol/L. She did not improve with treatment with phosphate binders; Vitamin D. There were no improvements in the swellings with further treatment with sodium thiosulfate and Cinacalcet and aggressive dialysis. Parathyroidectomy was declined","PeriodicalId":10345,"journal":{"name":"Clinical Case Studies and Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74362870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of spontaneous cerebellar hemorrhage 自发性小脑出血1例

Clinical Case Studies and Reports Pub Date : 2020-01-01 DOI: 10.15761/ccsr.1000142

Arash Lashani, R. Hage

引用次数: 0

Refractory hypotension in an anephric patient: Immediate response to renal transplantation 肾移植后难治性低血压1例

Clinical Case Studies and Reports Pub Date : 2020-01-01 DOI: 10.15761/ccsr.1000145

Tony Bose, K. Nicholls

引用次数: 2