Clinical and Translational Radiation Oncology最新文献

{"title":"Letter to the editor: Reply to Chen et al.","authors":"Wilma D. Heemsbergen,&nbsp;Kim C. de Vries,&nbsp;Luca Incrocci","doi":"10.1016/j.ctro.2025.100979","DOIUrl":"10.1016/j.ctro.2025.100979","url":null,"abstract":"<div><div>We have read the Letter to the Editor of Chen et al. with great interest, and appreciate their pursuit to expand the discussion on how patient-reported outcomes can inform toxicity risk stratification and supportive care strategies in real-world settings. We have added our vision to their raised points in order to contribute to this useful discussion.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100979"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity","authors":"Partha Patel ,&nbsp;Syed Minhaj Rahman ,&nbsp;Tara Behroozian ,&nbsp;Samuel Finkelstein ,&nbsp;Lauren Kanee ,&nbsp;Elwyn Zhang ,&nbsp;Suvam Banerjee ,&nbsp;Michele Aquilano ,&nbsp;Pierluigi Bonomo ,&nbsp;Raymond J. Chan ,&nbsp;Edward Chow ,&nbsp;Adrian Wai Chan ,&nbsp;Jennifer Yin Yee Kwan ,&nbsp;Shing Fung Lee ,&nbsp;Henry Wong ,&nbsp;Corina van den Hurk ,&nbsp;Mark Trombetta ,&nbsp;Julie Ryan Wolf ,&nbsp;on behalf of the Multinational Association of Supportive Care in Cancer MASCC Oncodermatology Study Group Radiation Dermatitis Tools Working Group","doi":"10.1016/j.ctro.2025.100977","DOIUrl":"10.1016/j.ctro.2025.100977","url":null,"abstract":"<div><div>Acute radiation dermatitis (ARD) is a common adverse effect experienced by patients undergoing radiation therapy. Effective assessment tools to accurately measure and manage ARD’s impact on patients’ quality of life and treatment outcomes is needed. The aim of this study was to evaluate the diverse tools and outcome measures used in the assessment of ARD. A systematic review of MEDLINE®, Embase, and Cochrane was conducted for records 1946-March 2024. A total of 423 studies, including 227 randomized controlled trials (RCTs), were included in the analysis. The review identified 58 distinct tools utilized in the assessment of ARD including clinician and patient-reported outcomes, quality-of-life instruments, and biophysical measures. The most frequently employed tools were the Radiation Therapy Oncology Group criteria, Common Terminology Criteria for Adverse Events, Skindex-16, Visual Analogue Scale, Dermatology Life Quality Index, European Organization for Research and Treatment of Cancer Quality of Life C30, Radiation-Induced Skin Reaction Assessment Scale, Skin Toxicity Assessment Tool, photography, reflectance spectrophotometry, and the corneometer. This investigation into ARD assessment tools reveals a broad application of instruments but is limited by a pervasive lack of consensus, preventing the endorsement of a standardized toolset. The variability in tool use necessitates further research, particularly high-quality RCTs, to establish validated and reliable measures. Future publications, including Delphi consensus-based recommendations, are anticipated to address these gaps, aiming to standardize ARD assessment methodologies.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100977"},"PeriodicalIF":2.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of dose calculation approaches and clinical dose–response in image-guided head&neck brachytherapy of the oral cavity","authors":"Sabrina Schaller ,&nbsp;Vratislav Strnad ,&nbsp;Claudia Schweizer ,&nbsp;Dorota Lubgan ,&nbsp;Ricarda Merten ,&nbsp;Rainer Fietkau ,&nbsp;Christoph Bert ,&nbsp;Andre Karius","doi":"10.1016/j.ctro.2025.100968","DOIUrl":"10.1016/j.ctro.2025.100968","url":null,"abstract":"<div><h3>Purpose</h3><div>Model-based dose calculation algorithms (MBDCAs) are increasingly applied in brachytherapy, but their considerations in dose–response analyses is still lacking. This study aimed to assess correlations between both TG-43 and MBDCA dosimetry and reports on clinical outcomes for oral cavity brachytherapy.</div></div><div><h3>Methods</h3><div>We considered 158 patients with oral cavity cancer treated in our institution between 2012 and 2021. Survival outcomes and toxicity (soft tissue necrosis, osteoradionecrosis, mucositis, xerostomia) were reported for a median follow-up of 80 months (2–152 months). All clinical, TG-43 based treatment plans were re-calculated using a MBDCA integrated into our planning system. Differences considering several target volume, tissue, and bone dose parameters were evaluated. Parameter correlations with clinical outcomes and thresholds associated with increased toxicity were investigated.</div></div><div><h3>Results</h3><div>Cumulative local recurrence, soft-tissue necrosis, osteoradionecrosis, mucositis, and xerostomia rate were 21 %, 22 %, 28 % and 79 % considering all patients. Substantial differences between MBDCA and TG-43 were observed, especially regarding high-dose areas with changes up to 19 %. A number of dose-toxicity correlations were observed, as for osteoradionecrosis (1.6 % vs. 10.3 % for bone D_2ccm ≥ 59.3 Gy), soft tissue necrosis (16 % vs. 32 % for tissue D_5ccm ≥ 87.7 Gy), and local recurrence (13 % vs. 25 % for dose non-uniformity ratio &lt; 0.29) (using the MBDCA). Target volumes ≥ 10.2–11.8ccm were associated with increased rates of soft tissue necrosis and mucositis. Dosimetric thresholds and correlations differed between TG-43 and MBDCA.</div></div><div><h3>Conclusion</h3><div>For oral cavity brachytherapy, several important dosimetric thresholds associated with increased toxicity were determined. MBDCAs for corresponding dose calculations should be advanced and used in clinical practice.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100968"},"PeriodicalIF":2.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of radiotherapy in the management of metastatic rectal cancer: A narrative review on the opportunities for non-operative management and organ preservation","authors":"Reza Ghalehtaki ,&nbsp;Parmida Sadat Pezeshki ,&nbsp;Amirali Azimi ,&nbsp;Fatemeh-sadat Tabatabaei ,&nbsp;Nina N. Sanford ,&nbsp;Krishan R. Jethwa","doi":"10.1016/j.ctro.2025.100976","DOIUrl":"10.1016/j.ctro.2025.100976","url":null,"abstract":"<div><div>About 20% of patients with rectal cancer present with metastatic rectal cancer (MRC). The 5-year relative survival for patients with MRC is about 15%. With emerging systemic therapies, including more effective chemotherapy regimens, immunotherapy, targeted therapies, and radiotherapy as a local option, more patients with advanced rectal cancer are achieving complete clinical response in the primary tumor. Consequently, non-operative management (NOM) through a “watch and wait approach” is becoming increasingly desired. Additionally, improved biomarkers, such as circulating tumor DNA (ctDNA), can improve accuracy in predicting responses to neoadjuvant chemoradiotherapy and monitoring recurrence after achieving complete clinical response. In this narrative review, we examine the current evidence on the role of radiotherapy in the management of MRC, with a focus on NOM and organ preservation strategies. Notably, although several investigations have evaluated various aspects of the NOM approach, there is still limited data regarding patient satisfaction and quality of life. The improved quality of life may be a key factor driving patient preference for NOM, and we also emphasize the data on the impact of NOM on patient’s quality of life.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100976"},"PeriodicalIF":2.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-related toxicity in head and neck cancer patients treated with proton therapy is less common than with conventional radiotherapy","authors":"Efsun Somay ,&nbsp;Erkan Topkan ,&nbsp;Ugur Selek","doi":"10.1016/j.ctro.2025.100972","DOIUrl":"10.1016/j.ctro.2025.100972","url":null,"abstract":"","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100972"},"PeriodicalIF":2.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the interpretation of post-radiotherapy urinary and bowel outcomes in prostate cancer: A clinical perspective","authors":"Shengyi Chen,&nbsp;Yuekun Fang,&nbsp;Bin Cheng","doi":"10.1016/j.ctro.2025.100973","DOIUrl":"10.1016/j.ctro.2025.100973","url":null,"abstract":"","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100973"},"PeriodicalIF":2.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Evaluation of the effect of metformin as a radiosensitiser in solid tumours: A systematic review” [Clin. Translat. Radiat. Oncol. 52 (2025) 100930]","authors":"Elísabet González del Portillo ,&nbsp;Alejandro Olivares-Hernández ,&nbsp;Luis Corral-Gudino ,&nbsp;Laura Corvo Félix ,&nbsp;Lorena Bellido Hernández ,&nbsp;Luis Posado Domínguez ,&nbsp;David León Jiménez ,&nbsp;Rogelio González Sarmiento ,&nbsp;Edel del Barco Morillo ,&nbsp;Emilio Fonseca Sánchez ,&nbsp;José Pablo Miramontes-González","doi":"10.1016/j.ctro.2025.100974","DOIUrl":"10.1016/j.ctro.2025.100974","url":null,"abstract":"","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100974"},"PeriodicalIF":2.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positioning in deep inspiration breath-hold is comparable to free breathing in paediatric patients","authors":"Daniella Elisabet Østergaard ,&nbsp;Laura Ann Rechner ,&nbsp;Anni Young Lundgaard ,&nbsp;Hanne Krogh Rose ,&nbsp;Jolanta Hansen ,&nbsp;Ivan Richter Vogelius ,&nbsp;Lisa Lyngsie Hjalgrim ,&nbsp;Marianne C Aznar ,&nbsp;Maja Vestmø Maraldo","doi":"10.1016/j.ctro.2025.100975","DOIUrl":"10.1016/j.ctro.2025.100975","url":null,"abstract":"","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100975"},"PeriodicalIF":2.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcomes between proton and photon therapy in nasopharyngeal carcinoma patients: A longitudinal cohort study","authors":"Ching-Nung Wu ,&nbsp;Yu-Ming Wang ,&nbsp;Wei-Chih Chen ,&nbsp;Yun-Hsuan Lin ,&nbsp;Shau-Hsuan Li ,&nbsp;Chung-Feng Hwang ,&nbsp;Bing-Shen Huang ,&nbsp;Chung-Ying Lin ,&nbsp;Sheng-Dean Luo","doi":"10.1016/j.ctro.2025.100971","DOIUrl":"10.1016/j.ctro.2025.100971","url":null,"abstract":"<div><h3>Background and purpose</h3><div>This study aimed to compare patient-reported outcomes (PROs) between intensity-modulated proton therapy (IMPT) and volumetric-modulated arc therapy (VMAT) in treating nasopharyngeal carcinoma (NPC).</div></div><div><h3>Materials and methods</h3><div>A prospective cohort study was conducted at a tertiary care center from 2021 to 2023. Newly diagnosed NPC patients were assessed using the modified 28-item symptom distress scale at seven time points, from baseline (T0) to one year post-radiotherapy (RT) (T6). The analysis focused on symptom changes during the acute phase (T0 to T3 [one month post-RT]) using linear mixed models. Sensitivity analyses incorporated inverse probability treatment weighting and data from non-metastatic patients adhering to survey protocols.</div></div><div><h3>Results</h3><div>IMPT recipients (n = 65) had higher education levels, marital stability, household incomes, and better performance statuses compared to VMAT recipients (n = 36). Oral-related symptoms peaked by the seventh week of RT and declined thereafter. IMPT significantly reduced “oral ulcer” (coefficient: −0.83, SE: 0.27) and “difficulty opening mouth” (coefficient: −0.44, SE: 0.18) symptoms by the seventh week but did not improve “dry mouth.” “Tinnitus” was rated as more distressing than “hearing difficulty,” with no significant differences between IMPT and VMAT for ear-related symptoms. Sensitivity analyses validated these findings.</div></div><div><h3>Conclusion</h3><div>IMPT was associated with reduced severity of specific oral-related symptoms during the acute phase of RT compared to VMAT. While these findings suggest potential benefits of IMPT, baseline differences between groups necessitate cautious interpretation and further validation through randomized studies.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100971"},"PeriodicalIF":2.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations","authors":"Rutger Jan Cornelis de Koster ,&nbsp;Jeremy Putra Gunawan ,&nbsp;Hans Peters ,&nbsp;Johan Bussink ,&nbsp;Lara Barazzuol ,&nbsp;Marc-Jan van Goethem ,&nbsp;Alexander Gerbershagen ,&nbsp;Robert Paul Coppes ,&nbsp;Stefan Both","doi":"10.1016/j.ctro.2025.100970","DOIUrl":"10.1016/j.ctro.2025.100970","url":null,"abstract":"<div><div>The tissue sparing of ultra-high dose rate irradiation has been partially observed <em>in vitro</em> while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids and spheroids, enabling the study of the effect of oxygen on radiation responses.</div></div>","PeriodicalId":10342,"journal":{"name":"Clinical and Translational Radiation Oncology","volume":"53 ","pages":"Article 100970"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}