用于质子超高剂量率类器官辐照的高性价比多样品缺氧室的开发与验证

IF 2.7 3区医学 Q3 ONCOLOGY

Clinical and Translational Radiation Oncology Pub Date : 2025-05-01 DOI:10.1016/j.ctro.2025.100970

Rutger Jan Cornelis de Koster , Jeremy Putra Gunawan , Hans Peters , Johan Bussink , Lara Barazzuol , Marc-Jan van Goethem , Alexander Gerbershagen , Robert Paul Coppes , Stefan Both

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引用次数: 0

摘要

在体外实验中，在控制氧水平的情况下，部分观察到超高剂量率辐照对组织的保护作用。在这里，我们开发了一种用于高通量辐射的缺氧系统，该系统可容纳嵌入的3D培养物，如类器官和球体，从而可以研究氧对辐射响应的影响。

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Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations

The tissue sparing of ultra-high dose rate irradiation has been partially observed in vitro while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids and spheroids, enabling the study of the effect of oxygen on radiation responses.

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