中国药理学通报 Pub Date : 2020-04-01 DOI: 10.3969/J.ISSN.1001-1978.2020.04.002

Xiaowei Fang, Q. Mei, Tian-jun Yang, Lei Zhang, Yun Yang, Yin Wang, Fei Tong, Chongyang Ye, Yu Gao, Yao Huang, Shike Geng, A. Pan

{"title":"Clinical characteristics and treatment strategies of 79 patients with COVID-19","authors":"Xiaowei Fang, Q. Mei, Tian-jun Yang, Lei Zhang, Yun Yang, Yin Wang, Fei Tong, Chongyang Ye, Yu Gao, Yao Huang, Shike Geng, A. Pan","doi":"10.3969/J.ISSN.1001-1978.2020.04.002","DOIUrl":"https://doi.org/10.3969/J.ISSN.1001-1978.2020.04.002","url":null,"abstract":"Aim To analyze the clinical characteristics of patients of corona virus disease 2019 (COVID-19), and summarize the treatment experience, aiming to provide diagnostic and treatment reference for the front-line clinicians Methods Seventy-nine patients with COVID-19 admitted to the Infectious Hospital of Anhui Provincial Hospital from January 22 to February 18, 2020 were selected as the research subjects There were 55 cases in general group and 24 cases in severe and critical group The clinical data of the two groups were collected and compared, including general conditions, clinical symptoms, signs, laboratory tests, computed tomography imaging of the lungs and complications Results The average age of 79 COVID-19 patients was 45 1 ± 16 6 years, and forty-five of them are males The severe and critical group was older than the general group Besides, there were more males and comorbidities In terms of laboratory tests, the lymphocyte (LYM) count and albumin (A L B) decreased more significantly in the severe and critical groups Moreover, the percentage of neutrophils (N E U), c-reactive protein (CRP), D-dimer, lactate dehydrogenase (L D H), troponin I (cTnl) and urea nitrogen (BUN) increased significantly Among all the patients, the types of antiviral drugs in severe and critical group were significantly more than those in general group;moreover, the glucocorticoids, gamma globulin and oxygen inhalation by nasal catheter were used more frequently in severe and critical patients By the time of February 18, one patient died of acute large area cerebral infarction, 34 patients were discharged from hospital, and the rest were still receiving treatment Conclusions The elderly patients with multiple cardiovascular diseases are more likely to get severe and critical COVID-19 They usually combine multiple organ or system abnormalities Clinicians should make timely judgment and adjust the treatment plan according to the clinical symptoms, signs and laboratory examination results","PeriodicalId":10296,"journal":{"name":"中国药理学通报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44840642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

The research progress ot nanomedicme tor lmmunomodulation therapy 纳米药物免疫调节治疗的研究进展

中国药理学通报 Pub Date : 2017-02-01 DOI: 10.3969/J.ISSN.1001-1978.2017.02.003

X. Wang, L. Tang, Jun Wang, Yang Shu, Yi Wang

引用次数: 0

Effects of chemokine MCP-1 on NMDA-mediated exciatory postsynaptic current in hippocampal slice of rats 趋化因子MCP-1对nmda介导的大鼠海马皮层兴奋性突触后电流的影响

中国药理学通报 Pub Date : 2016-07-01 DOI: 10.3969/J.ISSN.1001-1978.2016.07.013

Shan Li, Zheng-quan Hu, Yan Zhou, Huan Xiong

引用次数: 0

Research progress of relationship between DNA homologous recombination repair and breast cancer DNA同源重组修复与乳腺癌关系的研究进展

中国药理学通报 Pub Date : 2016-07-01 DOI: 10.3969/J.ISSN.1001-1978.2016.07.006

Y. Qiu, Yun Hu, Jin Zhang

引用次数: 1

Chronic intermittent hypobaric hypoxia ameliorates myocardial apoptosis through inhibiting mitochondrial pathway in rats with metabolism syndrome 慢性间歇性低压缺氧通过抑制线粒体通路改善代谢综合征大鼠心肌凋亡

中国药理学通报 Pub Date : 2015-08-01 DOI: 10.3969/J.ISSN.1001-1978.2015.08.021

F. Yuan, Yan Li, X. Teng, Jing-jing Zhou, Zan Guo, Xin Wang, Z. Zhang, Yi Zhang

引用次数: 0

Research progress of phosphodiesterases and phosphodiesterase inhibitors 磷酸二酯酶及磷酸二酯酶抑制剂的研究进展

中国药理学通报 Pub Date : 2014-02-01 DOI: 10.3969/J.ISSN.1001-1978.2014.02.031

C. Chen, Shuang‐Quan Huang

引用次数: 0

Recombination and purification of IL-23 gene and its effect on immune response to airway inflammation in asthma during pregnancy IL-23基因重组纯化及其对妊娠期哮喘气道炎症免疫应答的影响

中国药理学通报 Pub Date : 2014-01-01 DOI: 10.3969/J.ISSN.1001-1978.2014.03.019

Jia-jia Ma, N. Lu, Bi-liang Chen

{"title":"Recombination and purification of IL-23 gene and its effect on immune response to airway inflammation in asthma during pregnancy","authors":"Jia-jia Ma, N. Lu, Bi-liang Chen","doi":"10.3969/J.ISSN.1001-1978.2014.03.019","DOIUrl":"https://doi.org/10.3969/J.ISSN.1001-1978.2014.03.019","url":null,"abstract":"Aim To investigate the immune regulation of IL-23 fusion gene and the correlation between its biological function and the airway inflammation in asthma during pregnancy. Methods The eukaryotic expression plasmid,which was constructed to express the IL-23p40 + p19 double subunit,was used to transform E.coilBL21 bacteria,and the expression products,which were induced by IPTG,were purified and detected by SDS-PAGE and Western blot. The transfection,mediated by recombinant protein,was identified by fluorescence microscopy and plasmid's Western blot,while DNA binding activity of nuclear proteins was measured by gel electrophoresis. To evaluate the impact of foreign protein in vivo,mouse serum inflammatory cytokines levels and inflammation injury in lung tissue were measured by ELISA method and HE staining. The CD4+T cell subset's proportion of mononuclear cells in peripheral blood was verified by flow cytometry. Results The results showed that soluble exogenous recombinant protein,which was obtained successfully,had the ability of trans-membrane transport and could effectively mediate EGFP into the target cells. Its stable expression and transcriptional activity were higher than those of simple plasmid's effect. The specific binding between GST/pCEP4-IL-23 and plasmid DNA formed macromolecular complexes,which could decrease the mobility of gel. The combined effect with LPS significantly increased the IL-17A levels in serum(P 0. 05) and the inflammation reaction in lung tissue of sensitized mice. Mean while,it also reduced the IFN-γ,Foxp3 level in serum,promoted the activation of IL-4 and IL-17A,and then increased the ratio of Th2/Th1and Th17/Treg(P 0. 05). Conclusions The recombinant IL-23 protein is pathogenic,and it adjusts the inflammation of asthma in pregnancy. The immune imbalance of CD4+T subsets affects the immune tolerance of pregnant body and the development of asthma during pregnancy.","PeriodicalId":10296,"journal":{"name":"中国药理学通报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70068325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal effects of milbemycins on multidrug resistance in MCF-7/adr cells 米贝霉素对MCF-7/adr细胞多药耐药的逆转作用

中国药理学通报 Pub Date : 2013-10-01 DOI: 10.3969/J.ISSN.1001-1978.2013.10.019

Aili Gao, Hongsheng Liang, Zhao Wang, Shuai Liu, Qing Wang, Ning Zhao

引用次数: 0

Eukaryotic expression and functional activities of human soluble TNFR1-IgG membrane extracellular region(Fc) fusion protein using recombinant adenovirus 重组腺病毒对人可溶性TNFR1-IgG膜胞外区融合蛋白的真核表达及功能活性研究

中国药理学通报 Pub Date : 2013-08-01 DOI: 10.3969/J.ISSN.1001-1978.2013.08.014

Jia-jia Ma, N. Lu, Bi-liang Chen

引用次数: 0

Serum metabonomic study on liuwei dihuang pills in the treatment of hyperthyroidism 六味地黄丸治疗甲亢的血清代谢组学研究

中国药理学通报 Pub Date : 2013-05-01 DOI: 10.3969/J.ISSN.1001-1978.2013.05.010

Bin Wang, Lan Shen, W. Cong, Yunyun Zhu, Qiang Wang, Yi Feng

{"title":"Serum metabonomic study on liuwei dihuang pills in the treatment of hyperthyroidism","authors":"Bin Wang, Lan Shen, W. Cong, Yunyun Zhu, Qiang Wang, Yi Feng","doi":"10.3969/J.ISSN.1001-1978.2013.05.010","DOIUrl":"https://doi.org/10.3969/J.ISSN.1001-1978.2013.05.010","url":null,"abstract":"Aim: To explore the underlying mechanism of hyperthyroidism induced by subcutaneous injection of L-levothyroxine sodium and and intervention effects of Liuwei Dihuang pills on sprague dawley rats via serum metabolomics. Methods: After rats were injected with L-levothyroxine sodium at a dosage of 35 μg·(100 g)-1 every day for 1 week,and then Liuwei dihuang pills(LDPs) were treated at a dose of 4.7 g·kg-1 for 3 consecutive weeks.The serum samples for rats were obtained after the treatment of LDPS and the metabolic profiles of serum were obtained with ultra performance liquid chromatography coupled with time-of-flight mass spectrometry(UPLC-QTOF-MS). Results: The levels of oxaloacetic acid,Dihydroxyacetone phosphate(DHAP),ethyl glucuronide,triglyceride,lysophospholipids and cholesterol were significantly increased in the model group as compared to the normal rats.Moreover,these levels could be regulated to be close to normal after the treatment of LDPS. Conclusions: There is severe disturbance in the tricarboxylic acid cycle as well as sugar and lipid metabolism for hyperthyroidism rats.LDPS can exhibite obvious effects on the treatment of hyperthyroidism.Serum metabonomics analysis reveals the changes of metabolites traits during the treatment of LDPS,thus providing a supplementary evaluation method of LDPS in the treatment of hyperthyroidism.","PeriodicalId":10296,"journal":{"name":"中国药理学通报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70068246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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