Research progress of phosphodiesterases and phosphodiesterase inhibitors

Q4 Pharmacology, Toxicology and Pharmaceutics

中国药理学通报 Pub Date : 2014-02-01 DOI:10.3969/J.ISSN.1001-1978.2014.02.031

C. Chen, Shuang‐Quan Huang

引用次数: 0

Abstract

Intracellular levels of ubiquitous transduction signal cyclic adenosine 3',5'-monophosphate( cAMP) and cyclic guanosine 3',5'-monophosphate( cGMP) are partly determined by the hydrolysis by phosphodiesterases( PDEs). So far,the superfamily of PDE is composed of at least 11 isoforms and each family is characterized with unique cellular distribution,expression,regulation mode and inhibitor sensitivity,and PDEs are considered to be involved in a variety of pathological processes, such as inflammation,asthma,depression,and erectile dysfunction,etc. Currently,these characteristics draw PDEs more and more attention as great targets for drugs. In this review,the basic biochemical properties,cellular regulation,expression pattern,physiological functions and inhibitors of different PDE isoforms will be briefly discussed.

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磷酸二酯酶及磷酸二酯酶抑制剂的研究进展

细胞内普遍存在的转导信号环腺苷3′，5′-单磷酸(cAMP)和环鸟苷3′，5′-单磷酸(cGMP)的水平部分由磷酸二酯酶(PDEs)的水解决定。迄今为止，PDE超家族至少由11个亚型组成，每个家族都具有独特的细胞分布、表达、调控模式和抑制剂敏感性，PDE被认为参与多种病理过程，如炎症、哮喘、抑郁、勃起功能障碍等。目前，PDEs作为药物的重要靶点越来越受到人们的关注。本文就不同PDE亚型的基本生化特性、细胞调控、表达模式、生理功能及抑制因子等方面进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国药理学通报 Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

0.80

自引率

0.00%

发文量

11201

期刊介绍： Chinese Pharmacological Bulletin (CPB) is an academic monthly magazine sponsored by the Chinese Association for Science and Technology, the Chinese Pharmacological Society, and Anhui Medical University. Publicly issued domestically and internationally, CN:34:1086/R,ISSN:1001-1978。 The inclusion status of Chinese Pharmaceutical Bulletin (CPB): 1. This journal has been identified as a core medical journal by the China Science Citation Database (CSCD) of the Document Information Center of the Chinese Academy of Sciences (since 1993, there are 909 journals in the core library); 2. Selected as a pharmaceutical core journal by the editor in chief of Peking University Library's "Overview of Chinese Core Journals" (Peking University Core), 1st to 8th editions (1243 scientific and technological journals, including 232 medical and health journals); 3. Designated by the Institute of Science and Technology Information of the Ministry of Science and Technology of China as a source journal for Chinese scientific and technological paper statistics (China Science and Technology Core Journal); 4. Other: Domestic: Chinese Academic Journal Abstracts, Chinese Basic Medical Abstracts, Chinese Pharmaceutical Abstracts, Chinese Biological Abstracts, Chinese Academic Journals (CD version), Wanfang Database, VIP Database, etc; International: Chemical Abstract (USA), Corrective Bulletin on Science and Technology, CBST (Japan), Biological Abstract (USA), Biochemical Abstract (USA), EMBASE/Excerpta Medica (Netherlands), Index Copernicus (Poland), Kunst and Wissen (Germany), WPRIM (World Health Organization Western Pacific Regional Medical Index), Scopus (Netherlands, 2019 CiteScore 0.9), A&I (Netherlands), Centre for Agriculture and Biosciences international (CAB international, UK), Biosis Previews (USA), etc.