Clinical and Translational Gastroenterology最新文献

{"title":"Effects of Ricinoleic Acid (Castor Oil) on Gut Permeability in Healthy Participants: Provocative Test for Treatments Aimed at Restoring Barrier Function.","authors":"David Yi Yang, Camille Lupianez-Merly, Kara Jencks, Saam Dilmaghani, Irene Busciglio, Deborah Eckert, Michael Ryks, Roy Dyer, Brady A Vizenor, Yuxi Zhao, Anna Sapone, Michelle G Rooks, Jeremy D Gale, Michael Camilleri","doi":"10.14309/ctg.0000000000000865","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000865","url":null,"abstract":"<p><strong>Introduction: </strong>Altered intestinal permeability (IP) is implicated in multiple gastrointestinal and systemic disease conditions; an experimental model of perturbed IP in healthy subjects is needed. Traditional approaches to perturbing IP include use of nonsteroidal anti-inflammatory drugs (NSAIDs).</p><p><strong>Methods: </strong>We conducted a single-center, randomized, placebo-controlled pilot study of dose-related effects of CO (and its ingredient ricinoleic acid [RA]) at 750, 1500, or 3000 mg daily doses on IP. Permeability was assessed using validated 13C-mannitol and lactulose urine excretion at 0-2h, 8-24h, 0-24h after oral administration.</p><p><strong>Results: </strong>Permeability analysis across all groups demonstrated significant difference among the groups for 0-2h 13C-mannitol, 0-24h 13C-mannitol, and borderline significant difference for 2-8h 13C-mannitol (p=0.060) and 0-24h lactulose (p=0.056). Direct comparison of 3000 mg CO vs. placebo (t-test) demonstrated higher excretion of 13C-mannitol and lactulose at 0-2h, and 0-24h, and lactulose at 2-8h.</p><p><strong>Conclusion: </strong>CO may perturb small intestinal and colonic permeability in healthy adults.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating etiological insights with machine learning for precision diagnosis of obstructive jaundice: findings from a high-volume center.","authors":"Ningyuan Wen, Yaoqun Wang, Xianze Xiong, Jianrong Xu, Shaofeng Wang, Yuan Tian, Di Zeng, Xingyu Pu, Geng Liu, Bei Li, Jiong Lu, Nansheng Cheng","doi":"10.14309/ctg.0000000000000849","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000849","url":null,"abstract":"<p><strong>Introduction: </strong>Large-scale cohort studies exploring the etiology of obstructive jaundice (OJ) are scarce, with current serum-based diagnostic markers offering suboptimal performance. This study leverages the largest retrospective cohort of OJ patients to date to investigate its disease spectrum and to develop a novel diagnostic system.</p><p><strong>Methods: </strong>This study involves two retrospective observational cohorts. The biliary surgery cohort (BS cohort, n=349) served for initial data exploration and external validation of ML models. The large general cohort (LG cohort, n=5726) enabled an in-depth analysis of etiologies and the determination of relevant diagnostic indicators, in addition to supporting ML model development. Interpretable ML techniques were employed to derive insights from the models.</p><p><strong>Results: </strong>The LG cohort highlighted a diverse disease spectrum of OJ, including cholangiocarcinoma (10.39% distal, 10.01% perihilar, 5.59% intrahepatic), pancreatic adenocarcinoma (19.11%), and common bile duct stones (18.27%) as leading causes. Traditional serum markers such as CA 19-9 and CEA lacked standalone diagnostic accuracy. Two ML-based models (collectively termed the MOLT model) were developed: a classifier to differentiate benign from malignant causes (AUROC=0.862) and a multi-class model to further stratify malignant and benign diseases (ACC=0.777). Interpretable ML tools provided clarity on critical features, offering actionable insights and enhancing transparency in the decision-making process.</p><p><strong>Discussion: </strong>This study elucidates the etiological spectrum of OJ, meanwhile providing a practical and interpretable ML-based diagnostic tool. By leveraging large-scale clinical data, our model provides a rapid and reliable primary assessment for patients with OJ, enabling clinicians to identify potential etiologies and guide further diagnostic workup.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Enteric Microbiome in Early Onset Colorectal Cancer: A Comprehensive Review of its role as a Biomarker of Disease.","authors":"Jesús M Luévano, Julia Liu, Thaddeus Stappenbeck","doi":"10.14309/ctg.0000000000000864","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000864","url":null,"abstract":"<p><strong>Abstract: </strong>Early onset colorectal cancer (EoCRC), a distinct entity from late onset colorectal cancer (LoCRC), continues to increase in incidence. Known risk factors for LoCRC have been explored to explain this trend, but do not account for it completely. The gastrointestinal microbiome has been associated with LoCRC and additional risk factors of disease, however it is only now being investigated in the context of EoCRC. A better understanding of the microbiome's function in EoCRC could elucidate its role in the increasing incidence of EoCRC. This article reviews the state of literature related to studies specifically isolating microbiome related changes in EoCRC compared to LoCRC and age matched controls. Several studies reviewed in this article highlight the varied results of overall diversity and specific bacteria that are influenced by EoCRC, and the utility of these unique changes to predict for EoCRC. Although the microbiome can be useful in understanding EoCRC, to better predict for disease the microbiome must be studied in more diverse populations, and with deeper, more functional characterization in a manner that allows for transference of findings amongst future studies. These studies indicate that the enteric microbiome holds significant potential as a biomarker for disease but has yet to fully meet an understanding necessary for direct clinical utilization.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of pancreatic cancer in cystic fibrosis and cystic fibrosis transmembrane conductance regulator (CFTR) germline variants: A retrospective cohort study.","authors":"Nikita Patel, Qiaoling Chen, Tiffany Q Luong, Bechien Wu","doi":"10.14309/ctg.0000000000000857","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000857","url":null,"abstract":"<p><strong>Purpose: </strong>Screening guidelines for pancreatic cancer (PC) based on genetic risk do not include patients with CF or CFTR gene variants. The objective of this study was to determine risk of PC in patients with CF or CFTR pathogenic/likely pathogenic (PLPV) gene variants.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of CF/CFTR PLPV patients in an integrated healthcare system from 2008-2023. Index date was the initial encounter within the health system, with censoring at loss of membership, death, or study completion. PC incidence rate (IR) was based on person-time at risk. Age- and sex-adjusted standardized incidence rate ratio (SIR) for PC was calculated for CF/CFTR compared to the non-CFTR reference population. We further stratified PC risk by age and family history of PC.</p><p><strong>Results: </strong>12,682 patients with CF/CFTR were included with a median follow-up of 8.3 years (IQR 4.3-13.1). The cohort was 88% female, had median age at index of 25.8 (IQR 19.1-31.1) years, and was majority White and Hispanic. 8 total PC events occurred in the CF/CFTR group (IR 7.3 per 100,000 person-years). The adjusted SIR for PC was 2.3 (95% CL 1.2-4.7) for CF/CFTR variant patients. There was effect modification by age, with SIR (age≥50 years) of 2.87 (95% CL 1.37-6.01). Among CF/CFTR patients with family history of PC, 1 PC case was observed with SIR (age≥50 years) of 13.</p><p><strong>Conclusion: </strong>Patients with CF or CFTR gene variants had an almost 3-fold higher adjusted risk of PC than the general population after age 50 years. The risk may be further increased with a family history of PC.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile acid diarrhea is associated with an increased risk of type 2 diabetes and cardiovascular disease: a nationwide cohort study.","authors":"Anne-Marie Ellegaard, Matilde Winther-Jensen, Line L Kårhus, Filip K Knop, Martin L Kårhus","doi":"10.14309/ctg.0000000000000863","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000863","url":null,"abstract":"<p><strong>Introduction: </strong>Bile acid diarrhea (BAD) is a socially debilitating disease characterized by diarrhea, fecal urgency, and fecal incontinence. It is caused by excessive amounts of bile acids in the colon and is estimated to affect up to 1% of the population. Among other actions, bile acids regulate systemic glucose and lipid metabolism, and BAD has been associated with a dysmetabolic prediabetic-like state. Here, we investigate the association between BAD and type 2 diabetes (T2D) and cardiovascular disease (CVD), respectively.</p><p><strong>Methods: </strong>By using nationwide Danish health registries, individuals with BAD were identified by referral to the diagnostic 75selenium-homotaurocholic acid test followed by redemption of a prescription of a bile acid sequestrant within 365 days or a BAD diagnosis code (n=5,954). A reference population of age and sex-matched individuals was included for comparison (n=59,540).</p><p><strong>Results: </strong>More individuals with BAD than controls developed T2D (8.8% vs. 5.2%) and experienced CVD (22.7% vs. 18.0%) after index date (i.e., BAD diagnosis or matching, respectively). Sensitivity analyses revealed earlier onset of T2D and CVD in the BAD population compared with matches but no difference between sexes. The cause-specific hazards for T2D and CVD were 1.79 and 1.34, respectively, in the BAD population compared with matches. All-cause mortality-but not CVD-related mortality-was increased among individuals with BAD compared with matches.</p><p><strong>Discussion: </strong>BAD is associated with increased risk and earlier onset of T2D and CVD, respectively, as well as disturbed glucose and lipid metabolism, indicating BAD as a high-risk condition requiring intensified monitoring and relevant preventive interventions.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of 30-day unplanned readmission in necrotizing pancreatitis - A 12 year experience from a tertiary care center.","authors":"Gaurav Suryawanshi, Meghan Ghai, Nauroze Faizi, Stuart K Amateau, Nabeel Azeem, Shawn Mallery, Martin L Freeman, Guru Trikudanathan","doi":"10.14309/ctg.0000000000000848","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000848","url":null,"abstract":"<p><strong>Background and aim: </strong>Hospital readmission rate is a key hospital metric and represents a substantial burden to patients and the health care system. Necrotizing pancreatitis (NP) patients are at high risk for unplanned readmission. The aim of this study was to determine the incidence and predictors of 30-day unplanned readmission following index hospitalization for NP.</p><p><strong>Methods: </strong>Adult NP patients who were managed at a single tertiary referral center between 2009-2022 were identified from a prospective database and categorized into 2 groups based on 30-day unplanned readmission following index hospitalization. Patients with no follow up, who died during index admission or within 30 days of discharge were excluded. Baseline data on admission including demographic, clinical, interventional, imaging, and discharge characteristics were compared. Multivariable analysis was completed to identify independent predictors of 30-day readmission.</p><p><strong>Results: </strong>Among 505 patients with NP, [males - 347 (69%), median age- 50 years (IQR 37-63)] 191 (37.8%) had at least one unplanned readmission. The most common causes of readmission were abdominal pain (40%) and sepsis (27%). On multivariable analysis, independent predictors for early readmission were necrosis collection size ≥ 6 cm [aOR 1.91 (1.11-3.30), P<0.03], stay at outside hospital ≥ 14 days prior to transfer to tertiary center [aOR 2.89 (1.27-6.60), P<0.01], and need for percutaneous feeding tube at time of discharge [aOR 2.06 (1.01-4.21), P<0.05].</p><p><strong>Conclusion: </strong>Readmission following NP is common and associated with greater mortality at 6 months. Expedited transfer to tertiary center for timely intervention, assiduous follow up of other high-risk patients (large collections and those who need enteral nutrition) could help avoid readmissions and optimize outcomes.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of treatment adjustment on the endoscopic prognosis of postoperative anastomotic lesions in patients with Crohn's disease.","authors":"Linlin Yin, Chenliang Ding, Yi Li, Lei Cao, Hongfei Tu, Yue Zhu, Luxuan Tan, Bin Zhang, Jianfeng Gong","doi":"10.14309/ctg.0000000000000859","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000859","url":null,"abstract":"<p><strong>Background: </strong>Anastomotic ulcers are common after ileocolonic resection in patients with Crohn's disease (CD). However, the endoscopic prognosis of isolated anastomotic lesions after treatment adjustment remains unclear.</p><p><strong>Methods: </strong>We retrospectively included CD patients with anastomotic lesions who were referred to our center for ileocolonoscopy between 2020 and 2024. We conducted an initial evaluation of the impact of treatment adjustment on the endoscopic prognosis of anastomotic lesions. Additionally, we analyzed the association between different adjustment strategies and endoscopic outcome.</p><p><strong>Results: </strong>In total, 199 eligible CD patients with anastomotic lesions were included in our study. Treatment adjustment promoted mucosal healing (multivariable Cox HR: 2.376, 1.400-4.032, p=0.001) and endoscopic improvement (multivariable Cox HR: 2.373, 1.596-3.530, p<0.001). We also found that the endoscopic ulcer improvement of biologics to biologics switching was superior to that of non-treatment adjustment (Cox HR: 2.055, 1.212-3.482, p=0.007). Cox regression analyses further confirmed that non-biologics to biologics switching was associated with better endoscopic mucosal healing(Cox HR: 2.751, 1.494-5.063, p=0.001) and ulcer improvement(Cox HR: 2.154, 1.322-3.509, p=0.002). Regarding patients with insufficient trough levels of biologics, biologic optimization significantly improved endoscopic mucosal healing (Cox HR: 2.854, 1.345-6.053, p=0.006) and endoscopic ulcer improvement (Cox HR: 2.344, 1.288-4.265, p=0.005).</p><p><strong>Conclusions: </strong>Treatment adjustment contributed to the improvement of endoscopic prognosis in anastomotic lesions patients. Different adjustment strategies (biologics to biologics switching, non-biologics to biologics switching, biologic optimization) similarly resulted in better endoscopic outcome.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Suggestions for Improving Study Design and Incorporating Virological Markers in HBV Functional Cure Research.","authors":"Chaoting Yang, Huaguo Shao, Jinsong Huang","doi":"10.14309/ctg.0000000000000847","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000847","url":null,"abstract":"","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Tumor Regression Grading on the Prognosis of Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer: A Systematic Review and Meta-Analysis.","authors":"Ruchen Wu, Shuying Lin, Junze Chen, Gang Wang, Lulu Han","doi":"10.14309/ctg.0000000000000860","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000860","url":null,"abstract":"<p><strong>Background: </strong>Tumor regression grade (TRG) following neoadjuvant chemotherapy is recognized as a significant and favorable prognostic indicator in various cancer types. However, this relationship remains less defined and has not been systematically investigated in local advanced gastric cancer (LAGC). To address this gap, we conducted a meta-analysis aimed at assessing the prognostic influence of tumor regression after preoperative therapy on disease-free survival (DFS) and overall survival (OS) among patients with LAGC.</p><p><strong>Methods: </strong>A systematic search was conducted across the following databases: PubMed, Web of Science, Embase, Cochrane, WF, CNKI, SinoMed, and VIP. The primary outcomes included DFS and OS, estimated using hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). Subsequently, either the fixed-effects model or the random-effects model was employed to compute HR and 95% CI based on the results of heterogeneity analysis.</p><p><strong>Results: </strong>A total of 11 studies, comprising 2,733 patients, were included in the final analysis. The results indicated that a lower TRG was associated with prolonged DFS (HR = 0.53, 95% CI: 0.32-0.88) and prolonged OS (HR = 0.59, 95% CI: 0.39-0.87) in patients with LAGC who received neoadjuvant chemotherapy. Sensitivity analysis demonstrated that no single study significantly influenced the results for both DFS and OS. Publication bias was identified in the meta-analysis for OS, whereas no publication bias was detected in the meta-analysis for DFS.</p><p><strong>Conclusion: </strong>A lower TRG score is associated with improved DFS and OS in patients with LAGC receiving neoadjuvant chemotherapy.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downregulated expression of serum exosome-derived miR-375-3p alleviates interface hepatitis and promotes fibrosis regression in patients with chronic hepatitis B.","authors":"Ran Xu, Sihao Wang, Quanwei He, Wei Han, Shujuan Gong, Liping Yan, Jiagan Huang, Xiaoyan Zhan, Zhaofang Bai, Jiangtao Liu, Yan Chen, Yongping Yang","doi":"10.14309/ctg.0000000000000850","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000850","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic liver inflammation leads to fibrosis, cirrhosis and hepatocellular carcinoma. Serum alanine aminotransferase is the most widely used indicator of liver inflammatory injury, but it does not accurately reflect the extent of chronic liver inflammation. The role of exosomes in chronic liver inflammation and fibrosis has gained significant interest. This study aimed to investigate the association between serum exosome-derived miRNAs and chronic liver inflammation injury in chronic hepatitis B (CHB) patients with significant fibrosis, and to evaluate their potential clinical value.</p><p><strong>Methods: </strong>Using serum samples collected from healthy adults and patients with paired histologic CHB and significant fibrosis. Transcriptome analysis was conducted to identify dysregulated exosome-derived miRNAs associated with chronic liver inflammation. These were validated by lipopolysaccharide/ D-galactosamine-induced acute liver injury in mice and CCl4-induced cirrhosis in rat models, and 80 CHB patients with paired histologic after a 72-week treatment.</p><p><strong>Results: </strong>Exosome-derived miR-375-3p was positively associated with interface hepatitis, as determined by transcriptomic screening. Its upregulation was associated with severe interface hepatitis in the mouse and rat models. In the validation cohort, a high proportion of patients in the high-expression group demonstrated severe interface hepatitis (85%, p=0.022), while the low-expression group showed a higher proportion of interface hepatitis improvement (80%, p=0.002) and regression of fibrosis (70%, p<0.001).</p><p><strong>Discussion: </strong>The expression level of serum exosome-derived miR-375-3p was positively associated with interface hepatitis and is independently associated with the prognosis of interface hepatitis and fibrosis in patients with CHB and significant fibrosis.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}