Clinical and Translational Gastroenterology最新文献

{"title":"Patients With Inflammatory Bowel Disease Are At Increased Risk Of Respiratory Syncytial Virus Infections post-SARS-CoV2 Infection: A Propensity-Matched Cohort Analysis.","authors":"Saqr Alsakarneh, Oscar Ramirez Ramirez, Mary S Hayney, Jana G Hashash, Francis A Farraye, Freddy Caldera","doi":"10.14309/ctg.0000000000000840","DOIUrl":"10.14309/ctg.0000000000000840","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with inflammatory bowel disease (IBD) are at an increased risk of infections. Before the COVID-19 pandemic, respiratory syncytial virus (RSV) followed predictable seasonal patterns, which have been recently disrupted. This study aimed to investigate whether SARS-CoV2 infection is associated with an increased risk of RSV infection in patients with IBD compared to those without a history of SARS-CoV-2.</p><p><strong>Methods: </strong>This retrospective cohort study used the TriNetX database to identify patients aged ≥18 years with IBD and SARS-CoV2 (IBD-SARS-CoV2 cohort) during the 2022 and 2023 RSV seasons. A 1:1 propensity score matching was used to compare patients with IBD but no history of SARS-CoV2 (IBD non-SARS-CoV2 cohort).</p><p><strong>Results: </strong>In the 2022 IBD-SARS-CoV2 cohort (mean age: 53.7 ± 17.6; 59% female; 77% white), the RSV infection risk was 0.47%, higher than 0.19% in the matched IBD non-SARS-CoV2 cohort (aOR: 2.4; 95% CI: 1.5-3.6). The risk was highest 30-60 days post-SARS-CoV2 infection (aOR: 2.9; 95% CI: 1.7-4.9), particularly in those aged ≥60 years (aOR: 2.5; 95% CI: 1.3-4.5). The use of systemic corticosteroids (aOR: 2.3; 95% CI: 1.1-4.6) or immune-modifying therapies (aOR: 3.9; 95% CI: 2-7.1) was associated with higher RSV risk. Similar trends were observed during the 2023 RSV season, with no significant differences in RSV-related hospitalizations.</p><p><strong>Discussion: </strong>Adults with IBD have a higher risk of RSV following SARS-CoV2 infection, particularly those receiving steroids or immune therapies. SARS-CoV2 may have contributed to the recent RSV surge in this population, warranting further research.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of bile microbiota in patients with obstructive jaundice associated with biliary tract diseases.","authors":"Junxiong Wang, Qi Liu, Shangjia Jin, Boxing Yang, Chong Wang, Yuan Tan, Weimin Feng, Jingjin Tao, He Wang, Yongjun Wang, Shuo Yang, Liyan Cui","doi":"10.14309/ctg.0000000000000841","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000841","url":null,"abstract":"<p><strong>Background: </strong>Cholangiocarcinoma (CHOL), a malignant tumor of the biliary system, is particularly concerning due to its high malignancy and poor prognosis, often leading to obstructive jaundice. The advent of metagenomic sequencing(mNGS) technology has expanded diagnostic capabilities, including the identification of microbes within tumors and their potential role in cancer progression.</p><p><strong>Objective: </strong>This study aims to explore the bacterial composition in bile from patients with obstructive jaundice of different etiologies and to investigate the association between bile microbiota and biochemical analytes, as well as their potential as biomarkers for diagnosis of obstructive jaundice diseases.</p><p><strong>Methods: </strong>Bile samples from patients with obstructive jaundice admitted to Beijing Friendship Hospital were collected and subjected to 16S rRNA and metagenomic sequencing. The study included patients diagnosed with benign biliary stricture, gallstone, and cholangiocarcinoma. Clinical data and bile chemical components were analyzed. The potential functional roles of the identified microbiota were predicted using bioinformatics tools.</p><p><strong>Results: </strong>The study enrolled 13 patients with benign biliary stricture, 19 with gallstones, and 10 with cholangiocarcinoma. Significant differences in bile chemical components and microbial diversity were observed among the groups. The bile microbiota was dominated by distinct phyla and genera across the groups, with Proteobacteria and Fusobacteriota enriched in benign biliary stricture, Firmicutes and Desulfobacterota in cholangiocarcinoma, and Synergistota in gallstone patients. Functional analysis revealed differences in gene functions related to metabolism and other biological processes. A correlation between bile microbiota and biochemical markers was established, and the combination of differential microbiota showed potential as a diagnostic marker for obstructive jaundice of different etiologies.</p><p><strong>Conclusion: </strong>Bile microbiota varies significantly among patients with obstructive jaundice of different etiologies. The identified microbial signatures and their functional roles could serve as novel diagnostic markers and provide insights into the pathogenesis of biliary diseases.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence as a surrogate for inspection time to assess completeness in Esophagogastroduodenoscopy: a prospective, randomized, non-inferiority study.","authors":"Xia Tan, Liwen Yao, Zehua Dong, Yanxia Li, Yuanjie Yu, Xin Gao, Kai Zhu, Wenhao Su, Haisen Yin, Wen Wang, Chaijie Luo, Jialing Li, Hang You, Huiyan Hu, Wei Zhou, Honggang Yu","doi":"10.14309/ctg.0000000000000839","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000839","url":null,"abstract":"<p><strong>Introduction: </strong>The completeness of esophagogastroduodenoscopy (EGD) is a prerequisite for detecting lesions. This study aims to explore whether the quality of complete examinations assisted by artificial intelligence (AI) would be comparable to those conducted within the guideline-recommended inspection time.</p><p><strong>Methods: </strong>Patients referred for diagnostic, screening, or surveillance EGD were enrolled at Renmin Hospital of Wuhan University. Patients were randomly assigned to two groups in a 1:1 ratio. In the AI-assisted group, endoscopists completed observation of the entire upper gastrointestinal (UGI) tract with AI assistance. In the control group, endoscopists were instructed to spend no less than 7 minutes (min) on each procedure. The primary outcome was the detection rate of neoplastic lesions. Non-inferiority was confirmed when the lower bound of the 95% confidence interval (CI) was greater than the margin of -1.5%.</p><p><strong>Results: </strong>1,723 patients were prospectively enrolled between July 3, 2023, and April 7, 2024. 796 and 763 patients in the AI-assisted and control groups were included in the final analysis, respectively. The detection rates of neoplastic lesions in the AI-assisted and control group were 3.14% and 2.36%, respectively, resulting in an absolute proportion difference of 0.78% (95%CI, -0.58%-2.14%; OR 1.342 [95%CI, 0.726-2.480]). The median inspection time was reduced by 1.5 min in the AI-assisted group (6.18[2.87] vs 7.70[1.90], P < 0.001).</p><p><strong>Conclusions: </strong>Inspection time of complete EGD can be significantly shortened by AI without compromising its quality. These findings provide crucial evidence to support that AI-assisted procedural completeness serves as an objective and effective quality indicator for EGD.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucin 5AC as a biomarker for sessile serrated lesions: results from a systematic review and meta-analysis.","authors":"Kevin Liu, Moniyka Sachar, Violeta Popov, Ziheng Pei, Giulio Quarta","doi":"10.14309/ctg.0000000000000831","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000831","url":null,"abstract":"<p><strong>Abstract: </strong>Sessile serrated lesions (SSLs) are a class of colon polyps challenging to detect through current screening methods but highly associated with colon cancer. To improve detection, we sought a biomarker sensitive for SSLs. Recent endoscopic and histopathologic studies suggest that SSLs are associated with alterations in intestinal mucin expression, but the frequency with which this occurs is not known. We performed a meta-analysis of available pathologic studies comparing mucin expression on SSLs to normal colonic mucosa, tubular adenomas (TAs), villous adenomas (VAs), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). We searched Medline, Pubmed, and Embase and found 440 publications in this topic, and 18 total studies met inclusion. We found that MUC5AC expression was more common in SSLs compared to normal colonic mucosa (OR=82.9, p<0.01), TAs (OR=11, p<0.01), and TSAs (OR=3.6, p=0.04). We found no difference in MUC5AC expression between SSLs versus HPs (OR=2.1, p=0.09) and no difference in MUC5AC expression between left colon and right colon HPs, with an OR=1.8, p=0.23. We found that MUC5AC expression was found commonly on VAs, SSLs, and TSAs while the frequency on colon cancers declined. MUC5AC is also upregulated in inflammatory bowel disease and in response to intestinal infections. MUC5AC expression highlights the potential of mucins as useful biomarkers, though not specific to SSLs. Further research into the clinical utility of MUC5AC as a pathologic or fecal biomarker could enhance SSL detection.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Providers' Perspectives on Anoreceptive Intercourse in Sexual and Gender Minorities with Ileal Pouch Anal Anastomosis.","authors":"Darine Daher, Kira L Newman, Rachel Canning, Sherief Shawki, Jana Al Hashash, Sunanda Kane, Daniela Guerrero Vinsard, Victor Chedid","doi":"10.14309/ctg.0000000000000838","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000838","url":null,"abstract":"<p><strong>Introduction: </strong>Evidence-based recommendations for sexual practices regarding anal receptive intercourse (ARI) do not exist in patients with inflammatory bowel diseases (IBD) undergoing restorative proctocolectomy with ileal-pouch anal anastomosis (IPAA). This study surveys providers on perspectives and attitudes related to sexual practices post-IPAA.</p><p><strong>Methods: </strong>We developed a 23-item survey and distributed it to providers caring for patients with IBD.</p><p><strong>Results: </strong>95% of providers think that it is important to discuss sexual orientation or practices before IPAA, but only 27% routinely discuss this. 50% did not feel comfortable and 74% did not feel confident discussing ARI recommendations with patients who underwent or will undergo IPAA.</p><p><strong>Conclusion: </strong>Future interventions should aim to standardize recommendations regarding feasibility and timeline to safe ARI after IPAA.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram prediction for gastric cancer development.","authors":"Joo Hyun Lim, Areum Han, Soo-Jeong Cho, Seokyung Hahn, Sang Gyun Kim","doi":"10.14309/ctg.0000000000000833","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000833","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori (Hp) and gastric atrophy represent significant risk factors for gastric cancer. Nevertheless, to date no nomogram has been developed to predict gastric cancer based on the specific combination of risk factors, present in individual cases.</p><p><strong>Methods: </strong>A retrospective-cohort study was conducted using health-screening data collected between 2003 and 2018. Subjects with positive results for anti-Hp antibody were enrolled. Individuals were classified into 4 groups: low-B (low titer without atrophy), high-B (high titer without atrophy), high-C (high titer with atrophy), and low-C (low titer with atrophy). Nomogram prediction models were developed for overall gastric cancers as well as intestinal and diffuse cancers, with each type considered a competing event, by employing both Cox proportional and sub-distribution hazard models. Prediction performance was evaluated using concordance index (c-index) and the area under the curve (AUC) through 10-fold cross-validation.</p><p><strong>Results: </strong>During a median follow-up period of 5.7 years, 231 new gastric cancer cases developed among the total cohort of 28,311 subjects, including 159 intestinal type, 68 diffuse type, and 4 cases of unknown type. Multivariable analyses indicated that age, body mass index, family history, smoking, and classification into the high-C or low-C group were significant predictors of gastric cancer. The nomograms for intestinal type, diffuse type, and total gastric cancer demonstrated AUC values of 0.82, 0.62, and 0.75, respectively and c-indices of 0.85, 0.54, and 0.76, respectively.</p><p><strong>Conclusions: </strong>The nomograms for gastric cancer prediction would be useful in identifying high risk individuals, particularly for intestinal type. This would facilitate the implementation of personalized eradication and intensive screening strategies to target those at higher risk for gastric cancer.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary SBP Prophylaxis is associated with a higher rate of non-SBP infections in Two US-based National Cirrhosis Cohorts.","authors":"Scott Silvey, Nilang Patel, Jacqueline G O'Leary, Sofia S Jakab, Heather Patton, Shari Rogal, John D Markley, Ramsey Cheung, Arpan Patel, Timothy R Morgan, Jasmohan S Bajaj","doi":"10.14309/ctg.0000000000000837","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000837","url":null,"abstract":"<p><strong>Introduction: </strong>Antibiotic overuse and subsequent antibiotic resistance lead to worse infection outcomes in cirrhosis. Secondary spontaneous bacterial peritonitis prophylaxis (SecSBBPr) is associated with higher SBP recurrence but impact on non-SBP infections is unclear.</p><p><strong>Methods: </strong>We studied patients with cirrhosis and SBP who were given SecSBPPr or not between 2009-2019 in two complementary national cohorts [Veterans affairs corporate data warehouse (VA-CDW) and non-VA TriNetX]. Development of total non-SBP infections and specifically urinary tract infections (UTI), bacteremia, pneumonia, and C.difficile using validated codes over 2 years was compared between those on SecSBPPr versus not. Multi-variable regression for non-SBP infections was performed.</p><p><strong>Results: </strong>VA-CDW: Of 4673 Veterans with index SBP, 2539 (54.3%) were started on SecSBPPr. 1406 (30.1%) developed non-SBP infections (13.5% UTI, 12.4% pneumonia, 8.5% bacteremia and 6.8% C.difficile). On multi-variable regression, SecSBPPr was significantly associated with any non-SBP infection (OR 1.26, 95% CI:1.10-1.44, p<0.0001) and UTI (OR 1.21, 95% CI:1.01-1.45, p=0.036). TriNetX: Of 6708 patients with index SBP, 3261 (48.6%) were started on SecSBPPr. 1932 (28.8%) patients developed non-SBP infections (13.4% UTI, 12.9% pneumonia, 8.6% bacteremia and 5.9% C.difficile). On multi-variable regression, SecSBPPr was significantly associated with any non-SBP infection (OR 1.33, 95% CI:1.12-1.59, p<0.0001), UTI (OR 1.35, 95% CI:1.07-1.71, p=0.010), pneumonia (OR 1.35, 95% CI:1.06-1.72, p=0.017), and bacteremia (OR 1.47, 95% CI:1.10-1.97, p=0.009).</p><p><strong>Conclusions: </strong>In two diverse US-based national cohorts of patients with cirrhosis and SBP, use of secondary SBP prophylaxis was associated with a higher risk of non-SBP infections, especially urinary tract infections.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased Subcutaneous Adipose Tissue Correlates with Higher Portal Hypertension And Poor Survival in Patients with Cirrhosis: A Retrospective Binary-center Study.","authors":"Siwei Yang, Xiuwan Ren, Xiaoqing Guo, Jianan Yu, Lizhen Niu, Yao Niu, Linpeng Zhang, Long Jin","doi":"10.14309/ctg.0000000000000836","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000836","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the impact of hepatic venous portal gradient (HVPG) on BC values and the prognostic value of BC value in cirrhotic patients.</p><p><strong>Methods: </strong>A total of 173 cirrhotic patients with HVPG and Computed Tomography scan were screened retrospectively from a binary-center database. Seven BC values, including skeletal muscle index (SMI), subcutaneous adipose tissue index (SATI), deep SATI (dSATI), superficial SATI (sSATI), visceral adipose tissue index (VATI), and ratio of VATI and SATI (VSR) along with skeletal muscle radiodensity (SMRD), were analyzed. The correlation analyses and multiple linear regression were used to assess the impact of HVPG on BC values. The cumulative survival rate was assessed and risk factors of survival were identified by competing risk analysis using Fine-Gray model.</p><p><strong>Results: </strong>Among 173 patients with a mean age 53.7±10.5 years, there were 111(64.2%) males and 62(35.8%) females. In male patients, SATI, dSATI and sSATI inversely correlated with HVPG, respectively (SATI: rho=-0.227; dSATI: rho=-0.229; sSATI: rho=-0.219; all P<0.05), especially in patients aged≤60 years or with compensated cirrhosis; Male patients with clinically significant portal hypertension (CSPH) had a lower SATI, dSATI, sSATI and SMRD than those without CSPH. After adjusted multiple linear models, male sex, Child-Pugh class B or C and elevated HVPG contributed to decreased SATI. Multiple competing survival analysis showed a lower SATI (male:<38 cm2/m2; female:<23 cm2/m2) and Child-Pugh B or C predict mortality.</p><p><strong>Discussion: </strong>Decreased SATI, dSATI and sSATI were more closely associated with increased HVPG. A lower SATI and Child-Pugh B or C predicted mortality.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN IMAGE-BASED MODEL FOR ASSISTING IN DIAGNOSING MALIGNANT ESOPHAGEAL LESIONS DURING LUGOL'S CHROMOENDOSCOPIC EXAMINATION.","authors":"Mengfei Liu, Zifan Qi, Ren Zhou, Chuanhai Guo, Anxiang Liu, Haijun Yang, Fenglei Li, Liping Duan, Lin Shen, Qi Wu, Zhen Liu, Yaqi Pan, Fangfang Liu, Ying Liu, Huanyu Chen, Zhe Hu, Hong Cai, Zhonghu He, Yang Ke","doi":"10.14309/ctg.0000000000000835","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000835","url":null,"abstract":"<p><strong>Introduction: </strong>Image-based diagnostic tools that aid endoscopists to biopsy putative esophageal malignant lesions are essential for ensuring the standardization and quality of Lugol's chromoendoscopy. But there's no such model available yet.</p><p><strong>Methods: </strong>We developed a diagnostic model using endoscopic Lugol-unstained lesions (LULs) features and baseline data from 1099 individuals enrolled from a large-scale population-based ESCC screening cohort. 603 participants from a clinical outpatient cohort were included as the external validation set. High-grade intraepithelial neoplasia and above (HGINA) lesions identified at baseline or within 1 year after screening were defined as outcome. The final model was determined using logistic regression analysis by the Akaike Information Criterion.</p><p><strong>Results: </strong>The optimal diagnostic model contained the size, irregularity, sharp border of LUL, age and body mass index of the participant, with the area under the curve of 0.83 (95% CI: 0.78-0.87) in the development set, 0.81 (95% CI: 0.77-0.86) in the internal validation set, and 0.87 (95% CI: 0.84-0.90) in the external set. This model stratified individuals with LULs into low-, moderate-, and high-risk groups based on tertiles of predicted probabilities. The high-risk group accounted for < 40% participants but enriched 80.8% and 82.7% of HGINA cases in the development and external validation sets, respectively, achieving detection ratios 16.2 and 11.0 times higher than the low-risk group.</p><p><strong>Discussion: </strong>Our model can help maintain consistency and accuracy in detecting esophageal malignancy through Lugol's chromoendoscopy, particularly in primary healthcare units in high-risk rural areas.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic identification of visceroptosis in hypermobile Ehlers-Danlos syndrome patients with functional gastrointestinal symptoms compared to healthy subjects.","authors":"Yin Chan, Bianca W Chang, Amrit K Kaboj, Yaniv Raphael, Richard Sukov, Ali Rezaie","doi":"10.14309/ctg.0000000000000834","DOIUrl":"https://doi.org/10.14309/ctg.0000000000000834","url":null,"abstract":"<p><strong>Introduction: </strong>Visceroptosis is a potential cause of gastrointestinal symptoms in hypermobile Ehlers-Danlos syndrome (hEDS).</p><p><strong>Methods: </strong>We systematically examined the prolapse of abdominal organs below their natural supine position (visceroptosis) during upright small bowel barium study in healthy and hEDS subjects with irritable bowel syndrome.</p><p><strong>Results: </strong>Comparison of age- and sex-matched healthy (n=20) and hEDS (n=10) subjects did not show any significant difference in dynamic movement of the viscera. Subgroup analysis did not demonstrate any correlation between the degree of prolapse, clinical symptoms, and hypermobility clinical (Beighton) scores. The interobserver reliability for 3 out the 4 anatomical landmarks showed 'moderate' or 'good' correlation based on their interclass correlation coefficients.</p><p><strong>Discussion: </strong>hEDS patients do not appear to have a significantly increased incidence of visceroptosis.</p>","PeriodicalId":10278,"journal":{"name":"Clinical and Translational Gastroenterology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}