Functional Lumen Imaging Probe (FLIP) Predictors of Esophageal Clearance in Symptomatic Post-Fundoplication Patients: Opening Diameter Has Greater Value Than Distensibility Index.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-09-19 DOI:10.14309/ctg.0000000000000922

Ryan Flanagan, Edward Hurtte, Mayssan Muftah, Brent Hiramoto, Jennifer X Cai, C Prakash Gyawali, Walter W Chan

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引用次数: 0

Abstract

Background: Clinically relevant esophagogastric junction metrics on functional lumen imaging probe (FLIP) in post-fundoplication patients remain unclear.

Methods: 63 symptomatic post-fundoplication patients underwent FLIP, barium esophagram, and high-resolution manometry. Logistic regressions and receiver-operating characteristic curves for distensibility index (DI) at 60 mL and maximal diameter were generated to predict impaired clearance.

Results: Maximal diameter (OR:0.77, CI:0.62-0.96,p=0.02, AUROC=0.73), but not DI, independently predicted impaired clearance. Diameter >16.5 mm achieved >90% sensitivity for normal clearance; DI <2.0 mm2/mmHg and diameter <8 mm were >90% specific for impaired clearance.

Conclusions: Maximal diameter on post-fundoplication FLIP predicts impaired clearance and discriminates better than DI.

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功能性管腔成像探针（FLIP）预测有症状的底叠后患者食管清除率：开口直径比扩张指数更有价值。

背景：功能性管腔成像探针（FLIP）在胃底折叠后患者中的临床相关食管胃连接指标尚不清楚。方法：63例有症状的底叠术后患者行FLIP、食管钡剂造影和高分辨率测压术。在60 mL和最大直径时，生成了扩张指数（DI）的Logistic回归和受体-操作特征曲线，以预测清除率受损。结果：最大直径（OR:0.77, CI:0.62-0.96,p=0.02， AUROC=0.73）独立预测清除率受损，而非DI。直径>16.5 mm达到>正常间隙90%的灵敏度；DI 90%特异性清除受损。结论：最大直径对复底后FLIP的预测效果优于DI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.