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Clinical and Molecular Hepatology最新文献

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Global Strategies and Actions to Eliminate HBV infection. 消除乙肝病毒感染的全球战略和行动。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-28 DOI: 10.3350/cmh.2025.0492
Chih-Lin Lin, Jia-Horng Kao
{"title":"Global Strategies and Actions to Eliminate HBV infection.","authors":"Chih-Lin Lin, Jia-Horng Kao","doi":"10.3350/cmh.2025.0492","DOIUrl":"https://doi.org/10.3350/cmh.2025.0492","url":null,"abstract":"<p><p>Through the implementation of hepatitis B vaccination and effective antiviral treatment over the past four decades, the HBsAg seroprevalence of the vaccinated generation dramatically decline. The incidence of HBV-related HCC also decreases. However, the elimination of HBV is still a challenge to achieve. Novel HBV biomarkers, including quantitative HBsAg, HBcrAg and HBV RNA are promising in predicting clinical phases, risks of disease progression and HBV functional cure. Current antiviral therapies, nucleoside/nucleotide (NA) and pegylated alpha-interferon, effectively decrease HCC incidence in CHB patients and minimize the recurrence of HCC in patients receiving curative therapy. Novel agents under development to achieve HBV cure include direct-acting antivirals that target various stages of the HBV lifecycle and host targeting agents that enhance HBV-specific immunity. The action plans for eliminating hepatitis B in the future are universal HBV screening, early and simplified treatment as well as precision lifelong management for CHB patients. This narrative review will summarize and discuss global strategies and initiatives aimed at eliminating HBV infection.</p>","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HCC Surveillance After Curative Treatment: A New Frontier for Abbreviated MRI Editorial on: "Non-contrast MRI for Detection of Late Recurrent Hepatocellular Carcinoma After Curative Treatment: Comparison to CT". HCC治疗后的监测：缩写MRI的新前沿：“非对比MRI检测晚期复发性肝细胞癌治疗后：与CT的比较”。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-28 DOI: 10.3350/cmh.2025.0786
Hyungjin Rhee, Jin-Young Choi
{"title":"HCC Surveillance After Curative Treatment: A New Frontier for Abbreviated MRI Editorial on: \"Non-contrast MRI for Detection of Late Recurrent Hepatocellular Carcinoma After Curative Treatment: Comparison to CT\".","authors":"Hyungjin Rhee, Jin-Young Choi","doi":"10.3350/cmh.2025.0786","DOIUrl":"https://doi.org/10.3350/cmh.2025.0786","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence to editorial on "Factors associated with hepatitis B mother-to-child transmission in a national prevention program": Redefining MTCT prevention strategies toward HBV elimination. 与“国家预防规划中乙型肝炎母婴传播相关因素”社论的对应：重新定义消除乙型肝炎病毒的母婴传播预防战略。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-28 DOI: 10.3350/cmh.2025.0805
Moran Ki, Jong-Hyun Kim
{"title":"Correspondence to editorial on \"Factors associated with hepatitis B mother-to-child transmission in a national prevention program\": Redefining MTCT prevention strategies toward HBV elimination.","authors":"Moran Ki, Jong-Hyun Kim","doi":"10.3350/cmh.2025.0805","DOIUrl":"https://doi.org/10.3350/cmh.2025.0805","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes. 信：GLP-1RA对MASLD结果影响的方法学问题。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-21 DOI: 10.3350/cmh.2025.0620
Xingyu Yao
{"title":"Letter: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes.","authors":"Xingyu Yao","doi":"10.3350/cmh.2025.0620","DOIUrl":"https://doi.org/10.3350/cmh.2025.0620","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter "Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunction-associated steatotic liver disease". 在代谢功能障碍相关的脂肪变性肝病中，氨基酸在肝脏糖异生和脂肪生成调节中的作用。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-21 DOI: 10.3350/cmh.2025.0731
Xinyi Cai, Lu Zhang, Tuo Li
{"title":"Letter \"Role of amino acids in the regulation of hepatic gluconeogenesis and lipogenesis in metabolic dysfunction-associated steatotic liver disease\".","authors":"Xinyi Cai, Lu Zhang, Tuo Li","doi":"10.3350/cmh.2025.0731","DOIUrl":"https://doi.org/10.3350/cmh.2025.0731","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting the Role of Non-Contrast MRI in Recurrent HCC: Bridging Diagnostic Performance and Real-World Applicability. 重新审视非对比MRI在复发性HCC中的作用：桥接诊断性能和现实应用。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-21 DOI: 10.3350/cmh.2025.0683
Lu Sun, Xin Zhang
{"title":"Revisiting the Role of Non-Contrast MRI in Recurrent HCC: Bridging Diagnostic Performance and Real-World Applicability.","authors":"Lu Sun, Xin Zhang","doi":"10.3350/cmh.2025.0683","DOIUrl":"https://doi.org/10.3350/cmh.2025.0683","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence to "Critical Flaws in the Molecular Classification of HCC Based on Metabolic Zonation". 对应于“基于代谢分区的HCC分子分类的关键缺陷”。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-14 DOI: 10.3350/cmh.2025.0760
Tomoko Aoki, Naoshi Nishida, Masatoshi Kudo
{"title":"Correspondence to \"Critical Flaws in the Molecular Classification of HCC Based on Metabolic Zonation\".","authors":"Tomoko Aoki, Naoshi Nishida, Masatoshi Kudo","doi":"10.3350/cmh.2025.0760","DOIUrl":"https://doi.org/10.3350/cmh.2025.0760","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor on" Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial. ". 致编辑的信“HK-660S在原发性硬化性胆管炎患者中的安全性和有效性：一项随机双盲2a期试验。"．
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-14 DOI: 10.3350/cmh.2025.0699
Bitao Jiang, Song Zhang, Lingling Bao
{"title":"Letter to the editor on\" Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial. \".","authors":"Bitao Jiang, Song Zhang, Lingling Bao","doi":"10.3350/cmh.2025.0699","DOIUrl":"https://doi.org/10.3350/cmh.2025.0699","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Editorial on Ciociola et al., "Downregulation of the MARC1 p.A165 Risk Allele Reduces Hepatocyte Lipid Content by Increasing Beta-Oxidation". 对Ciociola等人社论“下调MARC1 p.A165风险等位基因通过增加β -氧化降低肝细胞脂质含量”的回应。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-14 DOI: 10.3350/cmh.2025.0765
Ester Ciociola, Tanmoy Dutta, Rosellina M Mancina, Stefano Romeo
{"title":"Response to Editorial on Ciociola et al., \"Downregulation of the MARC1 p.A165 Risk Allele Reduces Hepatocyte Lipid Content by Increasing Beta-Oxidation\".","authors":"Ester Ciociola, Tanmoy Dutta, Rosellina M Mancina, Stefano Romeo","doi":"10.3350/cmh.2025.0765","DOIUrl":"https://doi.org/10.3350/cmh.2025.0765","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical implications of residual changes following HCV clearance. HCV清除后残留变化的临床意义。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-07-14 DOI: 10.3350/cmh.2025.0728
So-Young Kim, Eui-Cheol Shin
{"title":"Clinical implications of residual changes following HCV clearance.","authors":"So-Young Kim, Eui-Cheol Shin","doi":"10.3350/cmh.2025.0728","DOIUrl":"https://doi.org/10.3350/cmh.2025.0728","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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