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Reply to correspondence on "Factors associated with hepatitis B mother-to-child transmission in a national prevention program". 答复关于“国家预防规划中乙型肝炎母婴传播相关因素”的函件。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-19 DOI: 10.3350/cmh.2025.0871
Eunho Choi, Ji Hoon Kim, Young-Sun Lee
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引用次数: 0
Reply to correspondence on: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes. 回复关于GLP-1RA对MASLD结果影响的方法学问题的信函。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-19 DOI: 10.3350/cmh.2025.0892
Xingyu Yao
{"title":"Reply to correspondence on: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes.","authors":"Xingyu Yao","doi":"10.3350/cmh.2025.0892","DOIUrl":"10.3350/cmh.2025.0892","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter "GLP-1 RA and Reduced Liver and Non-Liver Complications in Adults with T2D and MASLD: A Target Trial Emulation Study". 信“GLP-1 RA与T2D和MASLD成人肝脏和非肝脏并发症减少：一项目标试验模拟研究”。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-19 DOI: 10.3350/cmh.2025.0676
Chunyan Wang, Xu Han, Yinyan Li
{"title":"Letter \"GLP-1 RA and Reduced Liver and Non-Liver Complications in Adults with T2D and MASLD: A Target Trial Emulation Study\".","authors":"Chunyan Wang, Xu Han, Yinyan Li","doi":"10.3350/cmh.2025.0676","DOIUrl":"10.3350/cmh.2025.0676","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes. 答复：GLP-1RA对MASLD结果影响的方法学问题。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-19 DOI: 10.3350/cmh.2025.0884
Xianhua Mao, Mindie H Nguyen
{"title":"Reply: Methodological Concerns Regarding GLP-1RA Effects on MASLD Outcomes.","authors":"Xianhua Mao, Mindie H Nguyen","doi":"10.3350/cmh.2025.0884","DOIUrl":"10.3350/cmh.2025.0884","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond Diagnostic Accuracy: Economic and Clinical Considerations for NC-MRI in Late HCC Recurrence Surveillance. 超越诊断准确性：NC-MRI在HCC晚期复发监测中的经济和临床考虑。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-19 DOI: 10.3350/cmh.2025.0769
Qi-Feng Chen, Sui-Xing Zhong, Ming Zhao
{"title":"Beyond Diagnostic Accuracy: Economic and Clinical Considerations for NC-MRI in Late HCC Recurrence Surveillance.","authors":"Qi-Feng Chen, Sui-Xing Zhong, Ming Zhao","doi":"10.3350/cmh.2025.0769","DOIUrl":"10.3350/cmh.2025.0769","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "High Steatosis-Associated Fibrosis Estimator Scores Predict Hepatocellular Carcinoma in Viral and Non-Viral Hepatitis and Metabolic Dysfunction-Associated Steatotic Liver Disease". 对“高脂肪变性相关纤维化估计评分预测病毒性和非病毒性肝炎及代谢功能障碍相关脂肪变性肝病的肝细胞癌”的评论。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-08 DOI: 10.3350/cmh.2025.0875
Prajnasini Satapathy, Rachana Mehta, Ranjana Sah
{"title":"Comment on \"High Steatosis-Associated Fibrosis Estimator Scores Predict Hepatocellular Carcinoma in Viral and Non-Viral Hepatitis and Metabolic Dysfunction-Associated Steatotic Liver Disease\".","authors":"Prajnasini Satapathy, Rachana Mehta, Ranjana Sah","doi":"10.3350/cmh.2025.0875","DOIUrl":"https://doi.org/10.3350/cmh.2025.0875","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocytic ASB3 deficiency alleviates MASLD by decreasing ubiquitin-mediated CPT1A. 肝细胞ASB3缺乏通过降低泛素介导的CPT1A来缓解MASLD。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-08 DOI: 10.3350/cmh.2024.1041
Yuli Lin, Wulei Hou, Mengxiao Ge, Zhihao Wu, Linlin Huang, Haoye Liu, Wenli Zhang, Xiyu Deng, Lanxin Wang, Ming Guan, Chunhua Song, Zuoyun Wang, Dongqin Yang
{"title":"Hepatocytic ASB3 deficiency alleviates MASLD by decreasing ubiquitin-mediated CPT1A.","authors":"Yuli Lin, Wulei Hou, Mengxiao Ge, Zhihao Wu, Linlin Huang, Haoye Liu, Wenli Zhang, Xiyu Deng, Lanxin Wang, Ming Guan, Chunhua Song, Zuoyun Wang, Dongqin Yang","doi":"10.3350/cmh.2024.1041","DOIUrl":"https://doi.org/10.3350/cmh.2024.1041","url":null,"abstract":"<p><strong>Background: </strong>Excessive lipid accumulation in hepatocytes is a critical cause of metabolic dysfunction-associated steatotic liver disease (MASLD) progression. Ankyrin repeat and SOCS box protein 3 (ASB3) is an E3 ubiquitin ligase that mediates diverse disease processes; however, the direct substrates of ASB3 in lipid metabolism and its role in MASLD remain unexplored.</p><p><strong>Methods: </strong>We generated ASB3 knockout mice fed a high-fat diet (HFD) to induce MASLD. Oxygen consumption and fatty acid oxidation (FAO) were used to assess lipid metabolism. LC‒MS/MS and IP were used to verify the ASB3 target protein. Correlation analysis was conducted on the cohort of MASLD patients versus the control group.</p><p><strong>Results: </strong>Loss of the ASB3 E3 ubiquitin ligase in hepatocytes strengthens mitochondrial FAO, thereby influencing energy consumption to decrease triglyceride storage and lipid accumulation. Quantitative lysine ubiquitination proteomics revealed that ASB3 directly mediated the ubiquitin levels at two sites (K180 and K639) in carnitine palmitoyl transferase 1A (CPT1A), a rate-limiting enzyme of FAO, to induce CPT1A degradation. Moreover, both constitutive and hepatocyte-specific ASB3 knockout enhance FAO and delay lipid accumulation, liver steatosis, and MASLD progression in a CPT1A-dependent manner. Hepatic ASB3 deficiency also delays fibrosis in MASLD. Analysis of public databases and liver tissue samples from MASLD patients revealed that ASB3 was highly expressed in MASLD patients and was negatively correlated with CPT1A.</p><p><strong>Conclusions: </strong>Our study reveals the key roles of ASB3 in the development of MASLD and suggests a novel therapeutic potential for MASLD.</p>","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Call for Preemptive Treatment of Cytomegalovirus in Patients with Cirrhosis and Acute Decompensation Hong等人关于肝硬化急性代偿失代偿患者巨细胞病毒再激活的社论。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-06 DOI: 10.3350/cmh.2025.0840
Norihiro Imai
{"title":"Call for Preemptive Treatment of Cytomegalovirus in Patients with Cirrhosis and Acute Decompensation","authors":"Norihiro Imai","doi":"10.3350/cmh.2025.0840","DOIUrl":"10.3350/cmh.2025.0840","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic dysfunction-associated steatotic liver disease(MASLD): On track to become the dominant etiology of hepatocellular carcinoma. 代谢功能障碍相关脂肪变性肝病（MALSD）：有望成为肝细胞癌的主要病因。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-06 DOI: 10.3350/cmh.2025.0853
Jian Xu, Wei Zhang, Guo Wu, Jingdong Li
{"title":"Metabolic dysfunction-associated steatotic liver disease(MASLD): On track to become the dominant etiology of hepatocellular carcinoma.","authors":"Jian Xu, Wei Zhang, Guo Wu, Jingdong Li","doi":"10.3350/cmh.2025.0853","DOIUrl":"10.3350/cmh.2025.0853","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early oxidative protein modifications and gut damage/leakiness contribute to drug-induced acute liver failure. 早期氧化蛋白修饰和肠道损伤/渗漏有助于药物性急性肝衰竭。
IF 16.9 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-08-04 DOI: 10.3350/cmh.2025.0748
Wiramon Rungratanawanich, Ying Qu, Andrew Holmes, Neil Kaplowitz, Byoung-Joon Song
{"title":"Early oxidative protein modifications and gut damage/leakiness contribute to drug-induced acute liver failure.","authors":"Wiramon Rungratanawanich, Ying Qu, Andrew Holmes, Neil Kaplowitz, Byoung-Joon Song","doi":"10.3350/cmh.2025.0748","DOIUrl":"https://doi.org/10.3350/cmh.2025.0748","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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