Clinical and Molecular Hepatology最新文献

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Reply to correspondence on "Circulating cell-free mitochondrial DNA for diagnosing hepatocellular carcinoma and assessing prognosis". 复函“循环无细胞线粒体DNA用于肝癌诊断及预后评估”。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-16 DOI: 10.3350/cmh.2025.0035
Hyuk Soo Eun
{"title":"Reply to correspondence on \"Circulating cell-free mitochondrial DNA for diagnosing hepatocellular carcinoma and assessing prognosis\".","authors":"Hyuk Soo Eun","doi":"10.3350/cmh.2025.0035","DOIUrl":"https://doi.org/10.3350/cmh.2025.0035","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revealing the Importance of a Multidisciplinary Approach to Reducing the Global Burden of SLD Through the COVID-19 Pandemic: Editorial on "Current Burden of Steatotic Liver Disease and Fibrosis among Adults in the United States, 2017-2023". 揭示通过COVID-19大流行减少全球SLD负担的多学科方法的重要性:《2017-2023年美国成年人脂肪变性肝病和纤维化的当前负担》社论
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-16 DOI: 10.3350/cmh.2025.0019
Jeayeon Park, Su Jong Yu
{"title":"Revealing the Importance of a Multidisciplinary Approach to Reducing the Global Burden of SLD Through the COVID-19 Pandemic: Editorial on \"Current Burden of Steatotic Liver Disease and Fibrosis among Adults in the United States, 2017-2023\".","authors":"Jeayeon Park, Su Jong Yu","doi":"10.3350/cmh.2025.0019","DOIUrl":"https://doi.org/10.3350/cmh.2025.0019","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the role of GOLM1-OPN-ABCG5 axis in MASH: Editorial on "GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers". 揭示GOLM1- opn - abcg5轴在MASH中的作用:关于“GOLM1通过abcg5介导的胆固醇外排在MASH肝脏中促进胆固醇胆石形成”的社论。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-16 DOI: 10.3350/cmh.2025.0036
Yoon-Su Ha, Won Kim, Seung-Jin Kim
{"title":"Unraveling the role of GOLM1-OPN-ABCG5 axis in MASH: Editorial on \"GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers\".","authors":"Yoon-Su Ha, Won Kim, Seung-Jin Kim","doi":"10.3350/cmh.2025.0036","DOIUrl":"https://doi.org/10.3350/cmh.2025.0036","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting TM4SF1 to overcome immunotherapy resistance in hepatocellular carcinoma. 靶向TM4SF1克服肝细胞癌免疫治疗耐药。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-16 DOI: 10.3350/cmh.2025.0031
Valerie Chew
{"title":"Targeting TM4SF1 to overcome immunotherapy resistance in hepatocellular carcinoma.","authors":"Valerie Chew","doi":"10.3350/cmh.2025.0031","DOIUrl":"https://doi.org/10.3350/cmh.2025.0031","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence to Editorial on "Bariatric Surgery Reduces Long-Term Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Cirrhosis". 与社论“减肥手术降低代谢功能障碍相关脂肪变性肝病和肝硬化患者的长期死亡率”对应。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-09 DOI: 10.3350/cmh.2025.0001
Nicholas A Rouillard, Linda Henry, Mindie H Nguyen
{"title":"Correspondence to Editorial on \"Bariatric Surgery Reduces Long-Term Mortality in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Cirrhosis\".","authors":"Nicholas A Rouillard, Linda Henry, Mindie H Nguyen","doi":"10.3350/cmh.2025.0001","DOIUrl":"https://doi.org/10.3350/cmh.2025.0001","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Epidemiology of Alcohol-Related Liver Disease, Liver Cancer, and Alcohol Use Disorder, 2000-2021. 2000-2021年全球酒精相关肝病、肝癌和酒精使用障碍流行病学研究
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-09 DOI: 10.3350/cmh.2024.0835
Pojsakorn Danpanichkul, Luis Antonio Díaz, Kanokphong Suparan, Primrose Tothanarungroj, Supapitch Sirimangklanurak, Thanida Auttapracha, Hanna L Blaney, Banthoon Sukphutanan, Yanfang Pang, Siwanart Kongarin, Francisco Idalsoaga, Eduardo Fuentes-López, Lorenzo Leggio, Mazen Noureddin, Trenton M White, Alexandre Louvet, Philippe Mathurin, Rohit Loomba, Patrick S Kamath, Jürgen Rehm, Jeffrey V Lazarus, Karn Wijarnpreecha, Juan Pablo Arab
{"title":"Global Epidemiology of Alcohol-Related Liver Disease, Liver Cancer, and Alcohol Use Disorder, 2000-2021.","authors":"Pojsakorn Danpanichkul, Luis Antonio Díaz, Kanokphong Suparan, Primrose Tothanarungroj, Supapitch Sirimangklanurak, Thanida Auttapracha, Hanna L Blaney, Banthoon Sukphutanan, Yanfang Pang, Siwanart Kongarin, Francisco Idalsoaga, Eduardo Fuentes-López, Lorenzo Leggio, Mazen Noureddin, Trenton M White, Alexandre Louvet, Philippe Mathurin, Rohit Loomba, Patrick S Kamath, Jürgen Rehm, Jeffrey V Lazarus, Karn Wijarnpreecha, Juan Pablo Arab","doi":"10.3350/cmh.2024.0835","DOIUrl":"https://doi.org/10.3350/cmh.2024.0835","url":null,"abstract":"<p><strong>Background/aims: </strong>Alcohol represents a leading burden of disease worldwide, including alcohol use disorder (AUD) and alcohol-related liver disease (ALD). We aim to assess the global burden of AUD, ALD, and alcohol-attributable primary liver cancer between 2000-2021.</p><p><strong>Methods: </strong>We registered the global and regional trends of AUD, ALD, and alcohol-related liver cancer using data from the Global Burden of Disease 2021 Study, the largest and most up-to-date global epidemiology database. We estimated the annual percent change (APC) and its 95% confidence interval (CI) to assess changes in age-standardized rates over time.</p><p><strong>Results: </strong>In 2021, there were 111.12 million cases of AUD, 3.02 million cases of ALD, and 132,030 cases of alcohol-attributable primary liver cancer. Between 2000 and 2021, there was a 14.66% increase in AUD, a 38.68% increase in ALD, and a 94.12% increase in alcohol-attributable primary liver cancer prevalence. While the age-standardized prevalence rate for liver cancer from alcohol increased (APC: 0.59%, 95% confidence interval [CI] 0.52 to 0.67%) over these years, it decreased for ALD (APC: -0.71%, 95% CI -0.75 to -0.67%) and AUD (APC: -0.90%, 95% CI -0.94 to -0.86%). There was significant variation by region, socioeconomic development level, and sex. During the last years (2019-2021), the prevalence, incidence, and death of ALD increased to a greater extent in females.</p><p><strong>Conclusions: </strong>Given the high burden of AUD, ALD, and alcohol-attributable primary liver cancer, urgent measures are needed to prevent them at both global and national levels.</p>","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tacrolimus Levels and Variability in CKD and ESRD Risk Post-Liver Transplant. 他克莫司在肝移植后CKD和ESRD风险中的水平和变异性。
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-09 DOI: 10.3350/cmh.2024.1159
Rui Shi, Minghua Wang
{"title":"Tacrolimus Levels and Variability in CKD and ESRD Risk Post-Liver Transplant.","authors":"Rui Shi, Minghua Wang","doi":"10.3350/cmh.2024.1159","DOIUrl":"https://doi.org/10.3350/cmh.2024.1159","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C. 直接作用抗病毒治疗后代谢功能障碍对纤维化消退的不良影响:一项针对慢性丙型肝炎的多中心研究
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-09 DOI: 10.3350/cmh.2024.0904
Tom Ryu, Young Chang, Soung Won Jeong, Jeong-Ju Yoo, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Hong Soo Kim, Seung Up Kim, Jae Young Jang
{"title":"Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C.","authors":"Tom Ryu, Young Chang, Soung Won Jeong, Jeong-Ju Yoo, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Hong Soo Kim, Seung Up Kim, Jae Young Jang","doi":"10.3350/cmh.2024.0904","DOIUrl":"https://doi.org/10.3350/cmh.2024.0904","url":null,"abstract":"<p><strong>Background/aims: </strong>Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus (HCV). This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic hepatitis C (CHC).</p><p><strong>Methods: </strong>This multicenter, retrospective study included 8,819 patients diagnosed with CHC who were treated with DAAs and achieved a sustained virological response (SVR) between January 2014 and December 2022. Fibrosis regression was defined as a 20% reduction in noninvasive surrogates for liver fibrosis, such as liver stiffness (LS) measured by vibration-controlled transient elastography (VCTE) and the fibrosis-4 (FIB-4) score. Hypercholesterolemia (h-TC) were defined as >200 mg/dL.</p><p><strong>Results: </strong>The median age of the study population was 59.6 years, with a predominance of male patients (n = 4,713, 57.3%). Genotypes 1, 2, and others were confirmed in 3,872 (46.2%), 3,487 (41.6%), and 1,024 (12.2%) patients, respectively. Diabetes mellitus (DM) was present in 1,442 (17.2%) patients and the median LS was 7.50 kPa (interquartile range, 5.30-12.50). Multivariate analysis revealed that the presence of DM and pre-DAA h-TC were independently associated with a decreased probability of fibrosis regression by VCTE Additionally, pre-DAA h-TC was independently associated with a decreased probability of fibrosis regression by the FIB-4.</p><p><strong>Conclusions: </strong>Metabolic dysfunction has an unfavorable influence on fibrosis regression in patients with CHC who achieve SVR after DAA treatment.</p>","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity. 男性对年轻HBV相关HCC中TERT改变和HBV整合的偏好:性别差异的影响
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2025-01-02 DOI: 10.3350/cmh.2024.0545
Jin Seoub Kim, Hye Seon Kim, Kwon Yong Tak, Ji Won Han, Heechul Nam, Pil Soo Sung, Sung Won Lee, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang
{"title":"Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity.","authors":"Jin Seoub Kim, Hye Seon Kim, Kwon Yong Tak, Ji Won Han, Heechul Nam, Pil Soo Sung, Sung Won Lee, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang","doi":"10.3350/cmh.2024.0545","DOIUrl":"https://doi.org/10.3350/cmh.2024.0545","url":null,"abstract":"<p><strong>Background/aims: </strong>Hepatocellular carcinoma (HCC) exhibits significant sex disparities in incidence, yet its molecular mechanisms remain unclear. We explored the role of telomerase reverse transcriptase (TERT) genetic alterations and hepatitis B virus (HBV) integration, both known major contributors to HCC, in sex-specific risk for HBV-related HCC.</p><p><strong>Methods: </strong>We examined 310 HBV-related HCC tissues to investigate sex-specific TERT promoter (TERT-pro) mutations and HBV integration profiles, stratified by sex and age, and validated with single-cell RNA sequencing (scRNA-seq) data.</p><p><strong>Results: </strong>Tumors predominantly exhibited TERT-pro mutations (26.0% vs. 0%) and HBV-TERT integration (37.0% vs. 3.0%) compared to non-tumorous tissues. While TERT-pro mutations increased with age in both sexes, younger males (≤60 years) showed marked predominance compared to younger females. Males had significantly more HBV integrations at younger ages, while females initially had fewer integrations that gradually increased with age. Younger males' integrations showed significantly greater enrichment in the TERT locus compared to younger females, alongside a preference for promoters, PreS/S regions, and CpG islands. Overall, TERT genetic alterations were significantly sex-differential in younger individuals (75.3% in males vs. 23.1% in females) but not in older individuals (76.9% vs. 83.3%, respectively). These alterations were associated with increased TERT expression. The skewed TERT abnormalities in younger males were further corroborated by independent scRNA-seq data.</p><p><strong>Conclusions: </strong>Our findings highlight the critical role of TERT alterations and HBV integration patterns in the male predominance of HCC incidence among younger HBV carriers, offering insights for future exploration to optimize sex-specific patient care and HCC surveillance strategies.</p>","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Burden of MASLD, MetALD, and Hepatic Fibrosis among US Adults with Prediabetes and Diabetes, 2017-2023. 2017-2023年美国成人糖尿病前期和糖尿病患者的MASLD、MetALD和肝纤维化负担
IF 14 1区 医学
Clinical and Molecular Hepatology Pub Date : 2024-12-30 DOI: 10.3350/cmh.2024.1150
Donghee Kim, Rohit Loomba, Aijaz Ahmed
{"title":"Current Burden of MASLD, MetALD, and Hepatic Fibrosis among US Adults with Prediabetes and Diabetes, 2017-2023.","authors":"Donghee Kim, Rohit Loomba, Aijaz Ahmed","doi":"10.3350/cmh.2024.1150","DOIUrl":"https://doi.org/10.3350/cmh.2024.1150","url":null,"abstract":"","PeriodicalId":10275,"journal":{"name":"Clinical and Molecular Hepatology","volume":" ","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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