Clinical and Vaccine Immunology最新文献

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Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans 先前存在的免疫力,而不是虚弱的表型,预测流感疫苗接种后的老年退伍军人滴度
Clinical and Vaccine Immunology Pub Date : 2017-01-18 DOI: 10.1128/CVI.00498-16
P. van Epps, T. Tumpey, Melissa B. Pearce, H. Golding, P. Higgins, T. Hornick, C. Burant, B. Wilson, R. Banks, S. Gravenstein, D. Canaday
{"title":"Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans","authors":"P. van Epps, T. Tumpey, Melissa B. Pearce, H. Golding, P. Higgins, T. Hornick, C. Burant, B. Wilson, R. Banks, S. Gravenstein, D. Canaday","doi":"10.1128/CVI.00498-16","DOIUrl":"https://doi.org/10.1128/CVI.00498-16","url":null,"abstract":"ABSTRACT Both preexisting immunity to influenza and age have been shown to be correlates of influenza vaccine responses. Frailty, an indicator of functional impairment in older adults, was also shown in one study to predict lower influenza vaccine responses among nonveterans. In the current study, we aimed to determine the associations between frailty, preexisting immunity, and immune responses to influenza vaccine among older veterans. We studied 117 subjects (age range, 62 to 95 years [median age, 81 years]), divided into three cohorts based on the Fried frailty test, i.e., nonfrail (NF) (n = 23 [median age, 68 years]), prefrail (n = 50 [median age, 80 years]), and frail (n = 44 [median age, 82 years]), during the 2010-2011 and 2011-2012 influenza seasons. Subjects received the seasonal trivalent inactivated influenza vaccine, and baseline and postvaccination samples were obtained. Anti-influenza humoral immunity, as measured by hemagglutination inhibition (HI) and microneutralization assays, was measured for influenza B, A(H1N1)pdm09, and A(H3N2) viruses. Postvaccination titers were not different between frail and NF subjects overall in this older subset of veterans. However, preexisting HI titers were strongly correlated with postvaccination titers among all functional status groups. When microneutralization titers were compared, the association between preexisting immunity and vaccine responses varied by frailty status, with the strongest correlation being observed for the NF group. In conclusion, preexisting immunity rather than frailty appeared to predict postvaccination titers in this older veteran cohort.","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89831256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
The Predominant CD4+ Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma 女性沙眼衣原体感染诱导的主要CD4+ Th1细胞因子是肿瘤坏死因子α而不是干扰素γ
Clinical and Vaccine Immunology Pub Date : 2017-01-18 DOI: 10.1128/CVI.00010-17
S. Jordan, Kanupriya Gupta, Brian M O Ogendi, Rakesh K Bakshi, R. Kapil, C. G. Press, S. Sabbaj, Jeannette Y Lee, W. Geisler
{"title":"The Predominant CD4+ Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma","authors":"S. Jordan, Kanupriya Gupta, Brian M O Ogendi, Rakesh K Bakshi, R. Kapil, C. G. Press, S. Sabbaj, Jeannette Y Lee, W. Geisler","doi":"10.1128/CVI.00010-17","DOIUrl":"https://doi.org/10.1128/CVI.00010-17","url":null,"abstract":"ABSTRACT Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and can cause significant reproductive morbidity in women. There is insufficient knowledge of C. trachomatis-specific immune responses in humans, which could be important in guiding vaccine development efforts. In contrast, murine models have clearly demonstrated the essential role of T helper type 1 (Th1) cells, especially interferon gamma (IFN-γ)-producing CD4+ T cells, in protective immunity to chlamydia. To determine the frequency and magnitude of Th1 cytokine responses elicited to C. trachomatis infection in humans, we stimulated peripheral blood mononuclear cells from 90 chlamydia-infected women with C. trachomatis elementary bodies, Pgp3, and major outer membrane protein and measured IFN-γ-, tumor necrosis factor alpha (TNF-α)-, and interleukin-2 (IL-2)-producing CD4+ and CD8+ T-cell responses using intracellular cytokine staining. The majority of chlamydia-infected women elicited CD4+ TNF-α responses, with frequency and magnitude varying significantly depending on the C. trachomatis antigen used. CD4+ IFN-γ and IL-2 responses occurred infrequently, as did production of any of the three cytokines by CD8+ T cells. About one-third of TNF-α-producing CD4+ T cells coproduced IFN-γ or IL-2. In summary, the predominant Th1 cytokine response elicited to C. trachomatis infection in women was a CD4+ TNF-α response, not CD4+ IFN-γ, and a subset of the CD4+ TNF-α-positive cells produced a second Th1 cytokine.","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"458 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86917072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine. 接种减毒结核分枝杆菌或牛分枝杆菌卡介苗的婴幼儿猕猴的训练免疫与持续免疫激活之间的平衡以及感染猿免疫缺陷病毒的风险。
Clinical and Vaccine Immunology Pub Date : 2017-01-05 Print Date: 2017-01-01 DOI: 10.1128/CVI.00360-16
Kara Jensen, Myra Grace Dela Pena-Ponce, Michael Piatak, Rebecca Shoemaker, Kelli Oswald, William R Jacobs, Glenn Fennelly, Carissa Lucero, Katie R Mollan, Michael G Hudgens, Angela Amedee, Pamela A Kozlowski, Jacob D Estes, Jeffrey D Lifson, Koen K A Van Rompay, Michelle Larsen, Kristina De Paris
{"title":"Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine.","authors":"Kara Jensen, Myra Grace Dela Pena-Ponce, Michael Piatak, Rebecca Shoemaker, Kelli Oswald, William R Jacobs, Glenn Fennelly, Carissa Lucero, Katie R Mollan, Michael G Hudgens, Angela Amedee, Pamela A Kozlowski, Jacob D Estes, Jeffrey D Lifson, Koen K A Van Rompay, Michelle Larsen, Kristina De Paris","doi":"10.1128/CVI.00360-16","DOIUrl":"10.1128/CVI.00360-16","url":null,"abstract":"<p><p>Our goal is to develop a pediatric combination vaccine to protect the vulnerable infant population against human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) infections. The vaccine consists of an auxotroph Mycobacterium tuberculosis strain that coexpresses HIV antigens. Utilizing an infant rhesus macaque model, we have previously shown that this attenuated M. tuberculosis (AMtb)-simian immunodeficiency virus (SIV) vaccine is immunogenic, and although the vaccine did not prevent oral SIV infection, a subset of vaccinated animals was able to partially control virus replication. However, unexpectedly, vaccinated infants required fewer SIV exposures to become infected compared to naive controls. Considering that the current TB vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG), can induce potent innate immune responses and confer pathogen-unspecific trained immunity, we hypothesized that an imbalance between enhanced myeloid cell function and immune activation might have influenced the outcome of oral SIV challenge in AMtb-SIV-vaccinated infants. To address this question, we used archived samples from unchallenged animals from our previous AMtb-SIV vaccine studies and vaccinated additional infant macaques with BCG or AMtb only. Our results show that vaccinated infants, regardless of vaccine strain or regimen, had enhanced myeloid cell responses. However, CD4<sup>+</sup> T cells were concurrently activated, and the persistence of these activated target cells in oral and/or gastrointestinal tissues may have facilitated oral SIV infection. Immune activation was more pronounced in BCG-vaccinated infant macaques than in AMtb-vaccinated infant macaques, indicating a role for vaccine attenuation. These findings underline the importance of understanding the interplay of vaccine-induced immunity and immune activation and its effect on HIV acquisition risk and outcome in infants.</p>","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216431/pdf/e00360-16.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9857031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multivalent and Multipathogen Viral Vector Vaccines. 多价和多病原体病毒载体疫苗。
Clinical and Vaccine Immunology Pub Date : 2017-01-05 Print Date: 2017-01-01 DOI: 10.1128/CVI.00298-16
Katharina B Lauer, Ray Borrow, Thomas J Blanchard
{"title":"Multivalent and Multipathogen Viral Vector Vaccines.","authors":"Katharina B Lauer, Ray Borrow, Thomas J Blanchard","doi":"10.1128/CVI.00298-16","DOIUrl":"10.1128/CVI.00298-16","url":null,"abstract":"<p><p>The presentation and delivery of antigens are crucial for inducing immunity and, desirably, lifelong protection. Recombinant viral vectors-proven safe and successful in veterinary vaccine applications-are ideal shuttles to deliver foreign proteins to induce an immune response with protective antibody levels by mimicking natural infection. Some examples of viral vectors are adenoviruses, measles virus, or poxviruses. The required attributes to qualify as a vaccine vector are as follows: stable insertion of coding sequences into the genome, induction of a protective immune response, a proven safety record, and the potential for large-scale production. The need to develop new vaccines for infectious diseases, increase vaccine accessibility, reduce health costs, and simplify overloaded immunization schedules has driven the idea to combine antigens from the same or various pathogens. To protect effectively, some vaccines require multiple antigens of one pathogen or different pathogen serotypes/serogroups in combination (multivalent or polyvalent vaccines). Future multivalent vaccine candidates are likely to be required for complex diseases like malaria and HIV. Other novel strategies propose an antigen combination of different pathogens to protect against several diseases at once (multidisease or multipathogen vaccines).</p>","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216423/pdf/e00298-16.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34317401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Articles of Significant Interest Selected from This Issue by the Editors 由本刊编辑从本刊精选的重要文章
Clinical and Vaccine Immunology Pub Date : 2017-01-01 DOI: 10.1128/CVI.00535-16
{"title":"Articles of Significant Interest Selected from This Issue by the Editors","authors":"","doi":"10.1128/CVI.00535-16","DOIUrl":"https://doi.org/10.1128/CVI.00535-16","url":null,"abstract":"considerable interest in farming cyanobacteria for the production of commercial goods (e.g., biofuels), but scaled cultivation of these microbes is stymied by economic barriers to processing large liquid volumes containing small, tough cells. In a study by Jordan et al. (e00053-17), division machinery of cyanobacteria was tunably controlled to disentangle processes of growth from cell division. The authors show that cyanobacteria can be triggered to increase in size by (cid:2) 3 orders of magnitude, creating cells more amenable to harvest and lysis. As such, they show that genetic approaches can be used to engineer cyanobacteria that are more compatible with bioprocessing equipment, rather than vice versa. They found that was a key predictor of anti- B. dendrobatidis bacterial richness and prevalence. indicate that harbor diverse antifungal bacteria that vary across the and likely serve a protective","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73900248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in Interpretation of Diagnostic Test Results in a Mumps Outbreak in a Highly Vaccinated Population 在高度接种人群中流行性腮腺炎暴发诊断测试结果解释的挑战
Clinical and Vaccine Immunology Pub Date : 2016-12-21 DOI: 10.1128/CVI.00542-16
L. Trotz-Williams, N. Mercer, K. Paphitis, J. Walters, D. Wallace, E. Kristjanson, J. Gubbay, T. Mazzulli
{"title":"Challenges in Interpretation of Diagnostic Test Results in a Mumps Outbreak in a Highly Vaccinated Population","authors":"L. Trotz-Williams, N. Mercer, K. Paphitis, J. Walters, D. Wallace, E. Kristjanson, J. Gubbay, T. Mazzulli","doi":"10.1128/CVI.00542-16","DOIUrl":"https://doi.org/10.1128/CVI.00542-16","url":null,"abstract":"ABSTRACT In spite of a greatly reduced incidence rate due to vaccination, mumps outbreaks continue to occur in several areas of the world, sometimes in vaccinated populations. This article describes an outbreak in a highly vaccinated population in southwestern Ontario, Canada, and the challenges encountered in interpreting the results of diagnostic tests used in the outbreak. During the outbreak, patients were interviewed and classified according to the outbreak case definition, and specimens were collected for diagnostic testing according to Ontario guidelines. Twenty-seven individuals were classified as confirmed cases (n = 19) or suspect cases (n = 8) according to the case definition, only 9 of which were laboratory-confirmed cases: 7 confirmed by reverse transcriptase PCR (RT-PCR) and 2 by IgM serology. All 19 confirmed cases represented patients who were associated with secondary schools in the local area and had been vaccinated against mumps with one (n = 2) or two (n = 17) doses of the measles-mumps-rubella (MMR) vaccine. This is the first published report of an outbreak of mumps in Ontario in which all confirmed cases had been vaccinated against the disease. It highlights the limitations of and difficulties in interpreting current mumps diagnostic tests when used in vaccinated individuals.","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74163748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Serological Analysis of Tuberculosis in Goats by Use of the Enferplex Caprine TB Multiplex Test 应用山羊结核菌复合试验对山羊结核菌进行血清学分析
Clinical and Vaccine Immunology Pub Date : 2016-12-14 DOI: 10.1128/CVI.00518-16
Amanda O’Brien, Clare Whelan, J. Clarke, A. Hayton, N. Watt, G. Harkiss
{"title":"Serological Analysis of Tuberculosis in Goats by Use of the Enferplex Caprine TB Multiplex Test","authors":"Amanda O’Brien, Clare Whelan, J. Clarke, A. Hayton, N. Watt, G. Harkiss","doi":"10.1128/CVI.00518-16","DOIUrl":"https://doi.org/10.1128/CVI.00518-16","url":null,"abstract":"ABSTRACT Tuberculosis in goats is usually diagnosed clinically, at postmortem, or by a positive skin test. However, none of these approaches detects all infected animals. Serology offers an additional tool to identify infected animals missed by current tests. We describe the use of the Enferplex Caprine TB serology test to aid the management of a large dairy goat herd undergoing a tuberculosis breakdown. Initial skin and serology testing showed that IgG antibodies were present in both serum and milk from 100% of skin test-positive animals and in serum and milk from 77.8 and 95.4% of skin test-negative animals, respectively. A good correlation was observed between serum and milk antibody levels. The herd had been vaccinated against Mycobacterium avium subsp. paratuberculosis, but no direct serological cross-reactions were found. Subsequent skin testing revealed 13.7% positive animals, 64.9% of which were antibody positive, while 42.1% of skin test-negative animals were seropositive. Antibody responses remained high 1 month later (57.1% positive), and the herd was slaughtered. Postmortem analysis of 20 skin test-negative goats revealed visible lesions in 6 animals, all of which had antibodies to six Mycobacterium bovis antigens. The results provide indirect evidence that serology testing with serum or milk could be a useful tool in the diagnosis and management of tuberculosis in goats.","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88650358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study. 一种用于健康成人的抗福氏志贺氏菌2a候选生物偶联疫苗的安全性和免疫原性:一项单盲、随机I期研究
Clinical and Vaccine Immunology Pub Date : 2016-12-05 Print Date: 2016-12-01 DOI: 10.1128/CVI.00224-16
Mark S Riddle, Robert W Kaminski, Claudio Di Paolo, Chad K Porter, Ramiro L Gutierrez, Kristen A Clarkson, Hailey E Weerts, Christopher Duplessis, Amy Castellano, Cristina Alaimo, Kristopher Paolino, Robert Gormley, Veronica Gambillara Fonck
{"title":"Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study.","authors":"Mark S Riddle, Robert W Kaminski, Claudio Di Paolo, Chad K Porter, Ramiro L Gutierrez, Kristen A Clarkson, Hailey E Weerts, Christopher Duplessis, Amy Castellano, Cristina Alaimo, Kristopher Paolino, Robert Gormley, Veronica Gambillara Fonck","doi":"10.1128/CVI.00224-16","DOIUrl":"10.1128/CVI.00224-16","url":null,"abstract":"<p><p>Several candidate vaccines against Shigella spp. are in development, but the lack of a clear correlate of protection from challenge with the induction of adequate immune responses among the youngest age groups in the developing world has hampered Shigella vaccine development over the past several decades. Bioconjugation technology, exploited here for an Shigella flexneri 2a candidate vaccine, offers a novel and potentially cost-effective way to develop and produce vaccines against a major pathogen of global health importance. Flexyn2a, a novel S. flexneri 2a bioconjugate vaccine made of the polysaccharide component of the S. flexneri 2a O-antigen, conjugated to the exotoxin protein A of Pseudomonas aeruginosa (EPA), was evaluated for safety and immunogenicity among healthy adults in a single-blind, phase I study with a staggered randomization approach. Thirty subjects (12 receiving 10 μg Flexyn2a, 12 receiving Flexyn2a with aluminum adjuvant, and 6 receiving placebo) were administered two injections 4 weeks apart and were followed for 168 days. Flexyn2a was well-tolerated, independently of the adjuvant and number of injections. The Flexyn2a vaccine elicited statistically significant S. flexneri 2a lipopolysaccharide (LPS)-specific humoral responses at all time points postimmunization in all groups that received the vaccine. Elicited serum antibodies were functional, as evidenced by bactericidal activity against S. flexneri 2a. The bioconjugate candidate vaccine Flexyn2a has a satisfactory safety profile and elicited a robust humoral response to S. flexneri 2a LPS with or without inclusion of an adjuvant. Moreover, the bioconjugate also induced functional antibodies, showing the technology's features in producing a promising candidate vaccine. (This study has been registered at ClinicalTrials.gov under registration no. NCT02388009.).</p>","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"23 12","pages":"908-917"},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1128/CVI.00224-16","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34406417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 103
Acknowledgment of Ad Hoc Reviewers 特别审稿人致谢
Clinical and Vaccine Immunology Pub Date : 2016-12-01 DOI: 10.1128/cvi.00474-16
M. Pasetti
{"title":"Acknowledgment of Ad Hoc Reviewers","authors":"M. Pasetti","doi":"10.1128/cvi.00474-16","DOIUrl":"https://doi.org/10.1128/cvi.00474-16","url":null,"abstract":"","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"15 1","pages":"901 - 902"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89427976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Articles of Significant Interest Selected from This Issue by the Editors 由本刊编辑从本刊精选的重要文章
Clinical and Vaccine Immunology Pub Date : 2016-12-01 DOI: 10.1128/cvi.00495-16
{"title":"Articles of Significant Interest Selected from This Issue by the Editors","authors":"","doi":"10.1128/cvi.00495-16","DOIUrl":"https://doi.org/10.1128/cvi.00495-16","url":null,"abstract":"","PeriodicalId":10271,"journal":{"name":"Clinical and Vaccine Immunology","volume":"27 1","pages":"903 - 903"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88344414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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