Chronicles of Young Scientists最新文献

{"title":"Application of UV spectrophotometric method to study stress degradation behavior of cefprozil","authors":"Kiran Jadhav, Dinesh Dhamecha, G. Asnani, Vrushali S Bhalekar, S. Lahoti","doi":"10.4103/2229-5186.115557","DOIUrl":"https://doi.org/10.4103/2229-5186.115557","url":null,"abstract":"Background: Cefprozil is a bactericidal drug that is used in the treatment of susceptible infections including upper and lower respiratory tract infections and skin and soft tissue infections. Materials and Methods: The objective of this research work was to develop and validate new, simple ultraviolet (UV) spectrophotometric method of Cefprozil in bulk and pharmaceutical dosage form and its application to study its stress degradation behavior. Results: The absorbance maxima peak was found at 280 nm, and linearity was observed in the concentration range of 2-10 μg/ml. The method was validated and found to be precise. Accuracy (percent recovery) for Cefprozil was found to be 99.117±1.005. Conclusion: A new method for estimation of Cefprozil by UV spectrophometry was developed and validated and Cefprozil was found to undergo degradation in all stress conditions.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82630221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Argon green-Nd: YAG dual laser posterior hyaloidotomy: An innovative approach toward treatment of premacular hemorrhage","authors":"Ashish Sharma, J. Sheth","doi":"10.4103/2229-5186.115559","DOIUrl":"https://doi.org/10.4103/2229-5186.115559","url":null,"abstract":"Background: Neodymium: YAG (Nd: YAG) laser and argon laser has been used to treat premacular hemorrhage either alone or rarely in combination. Materials and Methods: We describe a new technique of treating premacular hemorrhage by performing hyaloidotomy using a combination of argon green-Nd: YAG laser. We utilized subthreshold energy levels of Nd: YAG laser of 2.0 mJ as compared to the normal recommendation of 3.6-50 mJ. Results and Conclusions: This technique is easy, effective, and safe to manage premacular hemorrhage. The principle behind this combined laser treatment was to make the internal limiting membrane (ILM) taut by initial exposure to argon green laser, which allowed us to employ the subthreshold energy levels of Nd: YAG laser. We would like to assess the role of this combined treatment modality in comparison to other modalities, including solitary laser therapy in the management of premacular hemorrhage by performing a prospective, randomized long-term study.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75559212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality and sleep associated problems in female pharmacy students","authors":"Vivek Jain, Renu Tomar, J. Jha, Ashuthosh Pareek, Y. Ratan, N. Paliwal","doi":"10.4103/2229-5186.115553","DOIUrl":"https://doi.org/10.4103/2229-5186.115553","url":null,"abstract":"Background: Sleep is an essential element for adolescent mental and physical growth and development, but today's young adolescents are deprived of this. Earlier studies in Europe and America showed pitiable sleep quality of young college students, which affect their academic growth. However, as per our literature search there is a lack of such studies in Indian context especially, within pharmacy education. Objective: The present study was designed to investigate the interrelation between the demographic characteristics, life-style, and academic progress with sleep quality and sleep problems along with daytime and nighttime habits in young female pharmacy students of India. Materials and Methods: Questionnaire on sleep and daytime habits (QS and DH) was prepared. Our sample survey consists of 226 female pharmacy students of Banasthali University. QS and DH of multiple choice type, covered demographic characteristic (3 questions) sleep and daytime habits (25 questions), life-style and academic progress (3 questions), and one question of course curriculum. Parameters were co-related by point scale method using the SPSS 16.0 software. Results: Data derived and analyze from survey illustrated that quality of sleep was as: Excellent - 20.4%, good - 38.5%, satisfactory - 35.8%, poor - 4%, and very poor - 1.3% of participants. Living condition ( ρ =0.168, P =0.011), academic progress ( ρ =0.151, P=0.023), leisure activity ( ρ =0.133, P ρ =0.160, P=0.016) were significantly correlated with sleep quality. In addition, daytime sleepiness caused a significant problem for students and created a number of sleep disorders. Nevertheless, Sleep quality was not associated with age, body mass index, and coffee in the late evening. Conclusion: Study reported that sleep associated problems were common complaints in female pharmacy students.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75444113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burn wound: Pathophysiology and its management by herbal plants","authors":"D. Kaushik, Shiwani Kamboj, P. Kaushik, Shivkant Sharma, A. Rana","doi":"10.4103/2229-5186.115537","DOIUrl":"https://doi.org/10.4103/2229-5186.115537","url":null,"abstract":"In human body, wound healing is a normal biological phenomenon. Burns may be acute or chronic depending upon the source and its time of exposure. Burn wounds may be superficial, partial or full thickness wounds. When skin comes in contact with higher temperature, protein denaturation takes place due to which the plasma membrane integrity is lost. When skin is burned, a number of inflammatory mediators and releasing agents such as histamine, nitric oxide, oxygen free radicals, eicosanoid products, tumor necrosis factors, and interleukins etc., are released at the site. For wound healing mechanism, the keratinocytes has to move from uninjured site to the burned area. For deeper burns this process takes a long time. By some unknown mechanisms, burn wounds may convert from one form to another form. So burn wound depth must be accurately measured before starting the treatment to prevent the complications. Burns can be induced in experimental animals by using different models. Many treatments such as herbal drugs, topical agents, gene therapy, volume therapy, and rehabilitation can be employed. This review article mainly deals with the theoretical and practical aspects of burn wound healing. Some burn wound healing plants with their chemical constituents, plant part used, uses and animal models are described here.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74010098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunocosmeceuticals: An emerging trend in repairing human hair damage","authors":"K. Selvan, Sentila Rajan, T. Suganya, G. Parameshwari, Michael Antonysamy","doi":"10.4103/2229-5186.115531","DOIUrl":"https://doi.org/10.4103/2229-5186.115531","url":null,"abstract":"Hair is one of the most important portions for beauty care and in recent years grooming and cosmetic treatment of hair has drastically risen. Substantially, it may deteriorate and weaken the hair by modification of keratin protein. This makes the hair dry, brittle and split vend occurs due to loss of hair strength and the damage further increases with cosmetic treatments. The various poor ingredients are being used for repairing which have extremely poor compatibility with hair. Now the hair care products can be introduced with an active ingredient comprising a yolk derived anti-hair antibody immunoglobin obtained from egg of chickens immunized with damaged hair as antigen. This immuno-cosmeceuticals can repair the hair damage and imparts flexibility and smoothness to the hair. These effects are not lost by the ordinary shampooing. This article focuses on the characteristic of human hair, its damaging processes and the effects of immuno-cosmeceuticals for repairing the hair damage.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78468498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and determination of metabolite of verapamil hydrochloride by reversed-phase high performance liquid chromatography","authors":"P. Pathade, N. Bhatia, H. More, M. Bhatia, K. Ingale","doi":"10.4103/2229-5186.115558","DOIUrl":"https://doi.org/10.4103/2229-5186.115558","url":null,"abstract":"Aims: A suitable reversed-phase high performance liquid chromatography (RP-HPLC) method for detection and determination of laboratory synthesized metabolite norverapamil (NVER) present in the pharmaceutical formulations is the prime purpose of this study. The present study deals with synthesis, characterization, and development of simple, selective, rapid, and sensitive RP-HPLC method for simultaneous determination of verapamil (VER) and its synthetic metabolite NVER. Materials and Methods: A HIQ sil ODS C-18 column having 250 mm × 4.6 mm i.d. in isocratic mode with a mobile phase consisting methanol: Water (70:30 v/v, pH adjusted to 7.4 with dilute orthophosphoric acid (OPA) and triethylamine used as an organic modifier to avoid tailing effect). The flow rate was 1.0 ml/min and effluents were monitored at 222 nm. Results: The retention time of synthesized metabolite NVER and its parent drug VER were found to be 3.44 and 5.67 min, respectively. Valsartan (VAL) was used as the internal standard. The limit of detection were found to be 0.30 μg/ml for VER and 1.21μg/ml for NVER from physical mixture, and limit of quantitation 1.06 μg/ml for VER and 4.14 μg/ml for NVER. Conclusions: The method can be used for quantitation of synthesized metabolite NVER, in presence of the parent drug VER which could be useful in detection and determination of some impurities, such as NVER, described in European Pharmacopeia and others which can be toxic and often present in the pharma ceutical formulations.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90843382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a reversed-phase HPLC method for simultaneous estimation of clotrimazole and beclomethasone dipropionate in lotion and cream dosage form","authors":"Komal Dhudashia, Amit V. Patel, C. Patel","doi":"10.4103/2229-5186.115548","DOIUrl":"https://doi.org/10.4103/2229-5186.115548","url":null,"abstract":"Background: The combination of Clotrimazole and Beclomethasone dipropionate is used as anti-fungal and anti-inflammatory for external use in the form of cream and lotion. Aim: A simple, specific, economic, precise, and accurate reversed-phase high performance liquid chromatographic method development for the simultaneous estimation of clotrimazole (CT) and beclomethasone dipropionate (BD) in lotion and cream formulations. Materials and Methods: The chromatographic separation was achieved on a Kromasil C18 (150 mm × 4.6 mm, 5 μm) analytical column. A mixture of acetonitrile-water (70:30, v/v) was used as the mobile phase, at a flow rate of 1 ml/min and detector wavelength at 254 nm. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation, and system suitability test as per ICH guideline. Results: The retention time of CT and BD was found to be 5.4 and 4 min, respectively. The linear dynamic ranges were from 2-16 μg/ml and 80-640 μg/ml for BD and CT, respectively. Limit of detection and quantification for BD were 0.039 and 0.12 μg/ml, for CT 1.24 and 3.77 μg/ml, respectively. Conclusions: The developed method was validated and found to be simple, specific, accurate and precise and can be used for routine quality control analysis of titled drugs in combination in lotion and cream formulation.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91055011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of the effect of taping on scapular stability and upper limb function in recovering hemiplegics with scapular weakness","authors":"Dhwanit S. Shah, Divakar Balusamy, M. Verma, Giri Jui","doi":"10.4103/2229-5186.115551","DOIUrl":"https://doi.org/10.4103/2229-5186.115551","url":null,"abstract":"Background: Hemiplegia is the commonest form of paralysis, involving arm, leg and sometimes the face on one side of the body. Shoulder girdle in chronic hemiplegic suffers from two sorts of problems (a) spasticity of elevators and retractors, which pull the scapula into a fixed elevated and retracted position. (b) weakness of the opposite group of scapular muscles, i.e., depressors and protectors. This leads to instability of the scapulothoracic joint resulting in impaired functional use of the upper limb, taping is a method of maintaining orientation of the scapula by means of proprioceptive biofeedback to the patient. Aim of this study is to check the effect of taping on scapular stability and upper limb function in recovering hemiplegics. Objectives of the Study: (1) To study the effect of taping on functional performance of the hemiplegic upper extremity. (2) To compare the effect of taping combined with physiotherapeutic exercises v/s physiotherapeutic exercises alone on functional independence of the hemiplegic upper extremity. Subjects: All the 37 chronic hemiplegic patients with scapular weakness were taken and divided into two groups: Group A (Experimental group) and Group B (Control group). Materials and Methods: All the 37 chronic hemiplegic patients were evaluated by Fugl Meyer Physical Performance Assessment Scale for hemiplegic upper extremity before starting the treatment. Group A patients received scapular taping combined with physiotherapeutic exercises and Group B patients received only physiotherapeutic exercises for the period of 2 weeks. After 2 weeks both Group A and B patients were re-evaluated on Fugl Meyer Physical Performance Assessment Scale for hemiplegic upper extremity. Results: There was a significant improvement between the pre- and post-treatment scores of Group A patients on the Fugl Meyer Physical Performance Assessment Scale of hemiplegic upper extremity, whereas Group B patients score on the same scale was insignificant. Conclusion: Scapular taping has improved to be effective in improving stability of the scapula and also in improving functioning motor performance in hemiplegic upper extremities in recovering hemiplegic patients along with traditional physiotherapeutic exercises.","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83207174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital melanocytic nevus of chin","authors":"D. Chauhan, Y. Guruprasad","doi":"10.4103/2229-5186.115560","DOIUrl":"https://doi.org/10.4103/2229-5186.115560","url":null,"abstract":"","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the gene definition now and what is next","authors":"Ashok K. Singh","doi":"10.4103/2229-5186.108811","DOIUrl":"https://doi.org/10.4103/2229-5186.108811","url":null,"abstract":"","PeriodicalId":10187,"journal":{"name":"Chronicles of Young Scientists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79420036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}