Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics最新文献_第2页

Gingipain Causes Tau Tangle Formation in Alzheimer’s Disease Brains via Regulation of TREM-1 牙龈痛通过调节TREM-1导致阿尔茨海默病大脑中Tau缠结的形成

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011250000003443

Yiyi Zhu

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From Removal to Recovery: An Evaluation of Antibiotics Removal Techniques from Wastewater 从去除到回收:废水中抗生素去除技术的评价

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011379100003443

Xilai Ma

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Zeolitic Imidazolate Framework-67 Functionalized Chitosan Aerogel for Efficient Removal of Dye 沸石咪唑酸框架-67功能化壳聚糖气凝胶高效脱除染料

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011507900003443

Xiang Li, Hong Shao, Q. Ma, Wensheng Yu, Xiang-ting Dong

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Selection of Aflatoxin B1 Mimic Epitope Peptides by Phage Display 利用噬菌体展示筛选黄曲霉毒素B1模拟表位肽

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011508600003443

Ke Wu, Xiao-feng Qiu, Renrong Liu

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Exploring Wild Plant Conservation from the Perspective of Reproductive Biology: A Case Study of Rhododendron Excellens 从生殖生物学角度探讨野生植物保护——以卓越杜鹃花为例

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011192600003443

B. Cai, Chang‐Qiu Liu, Shixun Huang

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Bioengineering of G47Δ HSV-1 Combined with Stem Cell Delivery as an Alternative Virotherapy against Colon Cancer G47Δ HSV-1联合干细胞递送作为结肠癌替代病毒疗法的生物工程研究

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011377800003443

Ke Chen, Qingqing Huang, Mengzhuo Liu, Ellah Thomas, Kr Wang, Zihan Zhang

{"title":"Bioengineering of G47Δ HSV-1 Combined with Stem Cell Delivery as an Alternative Virotherapy against Colon Cancer","authors":"Ke Chen, Qingqing Huang, Mengzhuo Liu, Ellah Thomas, Kr Wang, Zihan Zhang","doi":"10.5220/0011377800003443","DOIUrl":"https://doi.org/10.5220/0011377800003443","url":null,"abstract":"Oncolytic virus (OV) therapy is a recently developed strategy in cancer treatment, especially towards patients who are unresponsive to conventional therapies. Numerous viruses have been identified efficiently lysing tumor cells both in vitro and in vivo and eliciting anti-tumor immunity, including but not limited to Herpes Simplex Virus (HSV), adenovirus, and Newcastle Disease Virus (NDV). However, there are some caveats with present OV therapies. The delivery of the virus to the human body and its replication before immune response are essential to the effectiveness of the therapy. Therefore, to maximize the efficacy of existing OV therapies, we propose a hypothetical herpes simplex virus (HSV)-based OV which combines several engineered traits to tackle colon cancer. The re-designed virus conceivably limits HSV neutralization by preexisting antibodies. It is also conceivable that the engineered oncolytic virus can secrete chimeric molecules that specifically bind to colon cancer cells. Also, we aim to activate neoantigen-specific T cell responses through the synergy of PD-L1 inhibition, GM-CSF activation, and viral immunogenic oncolysis. We hypothesize that a combination of OV therapies with the usage of mesenchymal stem cells (MSCs) as carriers could enhance the overall efficacy in tumor cell targeting and systemic immune response stimulation. MSC delivery is likely to aid in the migration of the engineered OV to tumor sites. In summary, the modifications of HSV enable more effective injection of oncolytic viruses and more accurate binding with tumors, improving therapeutic outcomes of existing HSV-based immunotherapies.","PeriodicalId":101862,"journal":{"name":"Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129856430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Corona Discharge on the Germination Characteristics of Wild Pea Seeds in High Altitude Alpine Meadow 电晕放电对高寒草甸野生豌豆种子萌发特性的影响

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011193800003443

F. Jin, Jinqiang Shi, Shangang Ma, Jiuxiang Xie, Ning Xin

引用次数: 0

Impacts of Global Warming on the Snow Leopard 全球变暖对雪豹的影响

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011198000003443

Xiaotong Feng, Jiaxuan Li, Hanwei Liu, Jiahui Zhang

{"title":"Impacts of Global Warming on the Snow Leopard","authors":"Xiaotong Feng, Jiaxuan Li, Hanwei Liu, Jiahui Zhang","doi":"10.5220/0011198000003443","DOIUrl":"https://doi.org/10.5220/0011198000003443","url":null,"abstract":": The distribution of the snow leopard is around 12 countries where the elevation is between 3, 000-4, 500 meters with arid and semi-arid shrubland, grasslands, or steppes. As a top predator, the snow leopard plays an important role in controlling the prey population and promoting biodiversity. However, global warming caused by human activities is destroying the living environment of the snow leopard. In order to protect snow leopards effectively, this study investigates the impacts of global warming on the living situation of the snow leopard from four aspects. Primarily, glacial melting is discussed, where the retreating speed of many glaciers in snow leopard's habitat and their prey is reduced. Subsequently, treeline shift effects are analysed, where climate change results in treeline shift, and the forest ascending into alpine shrub and grassland which are snow leopard's preferred habitats. In addition, extreme weather events are also evaluated, where global warming brings the high frequency of extreme weather, decreasing the survival rate of the main prey of the snow leopard. Eventually, the impacts of wetlands are demonstrated, where destruction of wetlands due to global warming threatens the livestock the main prey and increases the competition between humans and snow leopards. These results show the urgency of protecting the snow leopard.","PeriodicalId":101862,"journal":{"name":"Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130419406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the Impact of Alkylbenzene Sulfonate Surfactants in Use in Oilfields on Native Biodiversity of Mining Areas and Response to Environmental Remediation of Native Biodiversity 油田使用烷基苯磺酸盐表面活性剂对矿区原生生物多样性的影响及对原生生物多样性环境修复的响应研究

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011211200003443

Zhen He, Ziqian Xu, Min Zhao, Yan Li, Ning Liu

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Biomarker Study of Cholangiocarcinoma 胆管癌的生物标志物研究

Proceedings of the 11th International Conference on Biomedical Engineering and Bioinformatics Pub Date : 1900-01-01 DOI: 10.5220/0011201800003443

Qinyi Cai

引用次数: 0