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Clinical & Experimental Allergy最新文献

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Treatment with a platelet‐activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock 在致死性过敏性休克的啮齿动物模型中，血小板活化因子受体拮抗剂治疗可改善血流动力学并降低肾上腺素需求
Clinical & Experimental Allergy Pub Date : 2019-11-22 DOI: 10.1111/cea.13540
C. Tacquard, W. Oulehri, O. Collange, L. H. Garvey, S. Nicoll, N. Tuzin, B. Gény, P. Mertes
{"title":"Treatment with a platelet‐activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock","authors":"C. Tacquard, W. Oulehri, O. Collange, L. H. Garvey, S. Nicoll, N. Tuzin, B. Gény, P. Mertes","doi":"10.1111/cea.13540","DOIUrl":"https://doi.org/10.1111/cea.13540","url":null,"abstract":"In some cases, anaphylactic shock (AS) is still lethal, despite rapid use of epinephrine. High doses of epinephrine are associated with severe complications. Platelet‐activating factor (PAF) is secreted in massive amounts during AS, and a high plasma level is correlated with increased AS severity.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"33 1","pages":"383 - 390"},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77276009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho‐associated protein kinase signalling 免疫球蛋白G的嗜酸性细胞溶解与微管形成和rho相关蛋白激酶信号的抑制有关
Clinical & Experimental Allergy Pub Date : 2019-11-21 DOI: 10.1111/cea.13538
S. Esnault, J. Leet, M. Johansson, Karina T. Barretto, P. Fichtinger, F. J. Fogerty, K. Bernau, S. Mathur, D. Mosher, N. Sandbo, N. Jarjour
{"title":"Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho‐associated protein kinase signalling","authors":"S. Esnault, J. Leet, M. Johansson, Karina T. Barretto, P. Fichtinger, F. J. Fogerty, K. Bernau, S. Mathur, D. Mosher, N. Sandbo, N. Jarjour","doi":"10.1111/cea.13538","DOIUrl":"https://doi.org/10.1111/cea.13538","url":null,"abstract":"The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Cell‐free eosinophil granules are found in tissues in eosinophilic diseases, including asthma. This suggests that eosinophils have lysed and released cellular content, likely harming tissues.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"13 1","pages":"198 - 212"},"PeriodicalIF":0.0,"publicationDate":"2019-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81732091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Key role of the epithelium in chronic upper airways diseases 上皮在慢性上呼吸道疾病中的关键作用
Clinical & Experimental Allergy Pub Date : 2019-11-20 DOI: 10.1111/cea.13539
S. Gohy, C. Hupin, M. Ladjemi, V. Hox, C. Pilette
{"title":"Key role of the epithelium in chronic upper airways diseases","authors":"S. Gohy, C. Hupin, M. Ladjemi, V. Hox, C. Pilette","doi":"10.1111/cea.13539","DOIUrl":"https://doi.org/10.1111/cea.13539","url":null,"abstract":"The respiratory epithelium of the upper airways is a first‐line defence against inhaled irritants, pathogens and allergens. It ensures a physical barrier provided by apical junctions and mucociliary clearance to avoid excessive activation of the immune system. The epithelium also forms a chemical and immunological barrier, extensively equipped to protect the airways against external aggressions before the adaptive immune system is required. Under normal circumstances, the epithelium is capable of recovering rapidly after damage. This manuscript reviews these main properties of the upper airway epithelium as well as its reported impairments in chronic inflammatory diseases. The knowledge on normal epithelial functions and their dysregulation in upper airway diseases should help to design new epithelial‐targeted treatments.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"54 1","pages":"135 - 146"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84976318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Prevalence of allergic sensitization to storage mites in Northern Europe 北欧贮存螨过敏致敏的流行
Clinical & Experimental Allergy Pub Date : 2019-11-19 DOI: 10.1111/cea.13536
Nils O. Jõgi, Robin Kleppe Olsen, C. Svanes, D. Gíslason, T. Gislason, V. Schlünssen, T. Sigsgaard, Fredrik Sundbom, T. Storaas, R. Bertelsen
{"title":"Prevalence of allergic sensitization to storage mites in Northern Europe","authors":"Nils O. Jõgi, Robin Kleppe Olsen, C. Svanes, D. Gíslason, T. Gislason, V. Schlünssen, T. Sigsgaard, Fredrik Sundbom, T. Storaas, R. Bertelsen","doi":"10.1111/cea.13536","DOIUrl":"https://doi.org/10.1111/cea.13536","url":null,"abstract":"Allergic sensitization to storage mites has mostly been related to occupational exposures like farming, grain/cattle handling, whereas for non‐occupational settings, storage mite sensitization has been attributed to cross‐reactivity with house dust mite (HDM) allergens.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"188 1","pages":"372 - 382"},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79403543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Pubertal BMI change and adult‐onset asthma in men: Population‐based cohort study in Sweden 男性青春期BMI变化与成年发作哮喘:瑞典人群队列研究
Clinical & Experimental Allergy Pub Date : 2019-11-15 DOI: 10.1111/cea.13534
B. Nwaru, C. Ohlsson, Maria Bygdell, Jari Martikainen, J. Kindblom
{"title":"Pubertal BMI change and adult‐onset asthma in men: Population‐based cohort study in Sweden","authors":"B. Nwaru, C. Ohlsson, Maria Bygdell, Jari Martikainen, J. Kindblom","doi":"10.1111/cea.13534","DOIUrl":"https://doi.org/10.1111/cea.13534","url":null,"abstract":"The role of pubertal BMI change in adult‐onset concomitant asthma and allergic rhinitis is unknown.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"45 1","pages":"51 - 60"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89141404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Switch‐over from Pharmalgen to Alutard Bee and Wasp venom in the UK 在英国，从Pharmalgen换成Alutard蜜蜂和黄蜂毒液
Clinical & Experimental Allergy Pub Date : 2019-11-12 DOI: 10.1111/cea.13529
S. Nasser, A. Whyte, S. Durham, M. Krishna
{"title":"Switch‐over from Pharmalgen to Alutard Bee and Wasp venom in the UK","authors":"S. Nasser, A. Whyte, S. Durham, M. Krishna","doi":"10.1111/cea.13529","DOIUrl":"https://doi.org/10.1111/cea.13529","url":null,"abstract":"Hymenoptera venom immunotherapy (VIT) extracts can be non-purified aqueous, purified aqueous, or purified aluminium hydroxide adsorbed (\"depot\") preparations. All of these are efficacious, but the choice of preparation will influence the updosing protocol and dose interval. Pharmalgen Bee Venom and Wasp Venom (ALK) are partially-purified aqueous products, and until now have been the only licensed products available in the UK.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83785162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Chimeric specific antigen epitope‐carrying dendritic cells induce interleukin‐17(+) regulatory T cells to suppress food allergy 携带嵌合特异性抗原表位的树突状细胞诱导白细胞介素- 17(+)调节性T细胞抑制食物过敏
Clinical & Experimental Allergy Pub Date : 2019-11-12 DOI: 10.1111/cea.13528
Ling-Zhi Xu, Rui-Di Xie, Hai Xie, J. Ju, Xiao-yan Fu, Da-lin Di, Mei-Yu Peng, Wei Gao, Yuan-Yi Zhang, Dian Yu, Jiang-Qi Liu, Gui Yang, Zhiqiang Liu, Zhi-Gang Liu, Ping-Chang Yang
{"title":"Chimeric specific antigen epitope‐carrying dendritic cells induce interleukin‐17(+) regulatory T cells to suppress food allergy","authors":"Ling-Zhi Xu, Rui-Di Xie, Hai Xie, J. Ju, Xiao-yan Fu, Da-lin Di, Mei-Yu Peng, Wei Gao, Yuan-Yi Zhang, Dian Yu, Jiang-Qi Liu, Gui Yang, Zhiqiang Liu, Zhi-Gang Liu, Ping-Chang Yang","doi":"10.1111/cea.13528","DOIUrl":"https://doi.org/10.1111/cea.13528","url":null,"abstract":"The on‐purpose‐modulated dendritic cells (DCs) have shown charming effects on restoring immune regulatory functions in subjects with immune diseases.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"33 1","pages":"231 - 243"},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84244045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Efficacy of air cleaners in asthmatics allergic to cat in ALYATEC® environmental exposure chamber 空气净化器对ALYATEC®环境暴露室内猫过敏哮喘患者的疗效
Clinical & Experimental Allergy Pub Date : 2019-11-06 DOI: 10.1111/cea.13511
A. Gherasim, Audrey Jacob, Florian Schoettel, N. Domis, F. Blay
{"title":"Efficacy of air cleaners in asthmatics allergic to cat in ALYATEC® environmental exposure chamber","authors":"A. Gherasim, Audrey Jacob, Florian Schoettel, N. Domis, F. Blay","doi":"10.1111/cea.13511","DOIUrl":"https://doi.org/10.1111/cea.13511","url":null,"abstract":"Air cleaners have been promoted for respiratory allergic disease prevention, but there is no clear clinical proof of their efficacy in allergic asthma.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"134 1","pages":"160 - 169"},"PeriodicalIF":0.0,"publicationDate":"2019-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77357080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Forthcoming Meetings 即将到来的会议
Clinical & Experimental Allergy Pub Date : 2019-11-01 DOI: 10.1111/cea.13521
{"title":"Forthcoming Meetings","authors":"","doi":"10.1111/cea.13521","DOIUrl":"https://doi.org/10.1111/cea.13521","url":null,"abstract":"","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88707386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhaled corticosteroid use during pregnancy among women with asthma: A systematic review and meta‐analysis 哮喘妇女妊娠期间吸入皮质类固醇的使用:一项系统回顾和荟萃分析
Clinical & Experimental Allergy Pub Date : 2019-11-01 DOI: 10.1111/cea.13474
Annelies L. Robijn, M. Jensen, Karen McLaughlin, P. Gibson, V. Murphy
{"title":"Inhaled corticosteroid use during pregnancy among women with asthma: A systematic review and meta‐analysis","authors":"Annelies L. Robijn, M. Jensen, Karen McLaughlin, P. Gibson, V. Murphy","doi":"10.1111/cea.13474","DOIUrl":"https://doi.org/10.1111/cea.13474","url":null,"abstract":"Studies demonstrate the prescription rate for inhaled corticosteroids (ICS) decreases in early pregnancy, possibly increasing exacerbation risk. This could be related to non‐adherence to prescribed asthma medication or medication cessation by the patient or doctor. ICS use during pregnancy has not previously been summarized in a systematic review.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"19 1","pages":"1403 - 1417"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81287142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
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