Rustika Rustika, Suzy Indharty, Hasnida Hasnida, Desvi Y Mukhtar, Nora V Nasution, Elman Boy, Ristrini Ristrini, Joko Irianto, Jane K Propiona, Iin Nurlinawati, Wahyu P Nugraheni, Mohammad R Akbar, Asep Kusnali
{"title":"Comorbidity status and stress levels during the 2024 Hajj season: A Logistic regression analysis of Hajj pilgrims in North Sumatra.","authors":"Rustika Rustika, Suzy Indharty, Hasnida Hasnida, Desvi Y Mukhtar, Nora V Nasution, Elman Boy, Ristrini Ristrini, Joko Irianto, Jane K Propiona, Iin Nurlinawati, Wahyu P Nugraheni, Mohammad R Akbar, Asep Kusnali","doi":"10.4103/jfcm.jfcm_145_26","DOIUrl":"10.4103/jfcm.jfcm_145_26","url":null,"abstract":"<p><strong>Background: </strong>The Hajj pilgrimage demands optimal physical and psychological readiness because of various factors, such as the physical health conditions that could influence the stress experienced during the pilgrimage. This study's aim was to analyze the association between comorbidity status and stress levels in Hajj pilgrims.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted among 5362 prospective Hajj pilgrims from North Sumatra Province for the 2024 Hajj season. Stress levels were measured using the Perceived Stress Scale-10 and categorized as mild stress or moderate-to-severe stress. Data on comorbidity and respondent characteristics were collected using a structured questionnaire. Bivariate analysis was performed using the Chi-square test, while multivariate analysis employed binary logistic regression.</p><p><strong>Results: </strong>The prevalence of moderate-to-severe stress was higher in pilgrims with comorbidities. Multivariate analysis revealed that having one comorbidity (odds ratio (OR) =1.29; 95% confidence interval (CI): 1.06-1.56) and two or more comorbidities (OR = 1.33; 95% CI: 1.04-1.71) was significantly associated with increased risk of stress. Of specific comorbidities, digestive disorders showed a trend toward increased stress risk (OR = 1.23; 95% CI: 0.97-1.56; <i>P</i> < 0.1). Ages 40-59 years and ≥60 years, as well as higher education, were associated with increased stress risk, while being married and engagement in moderate physical activity showed protective effect.</p><p><strong>Conclusion: </strong>Comorbidity status, in terms of both the number and type of comorbidities, is independently associated with increased stress risk in Hajj pilgrims. Health promotion programs should integrate a biopsychosocial approach paying particular attention to pilgrims with comorbid conditions.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 3","pages":"180-187"},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dalia Yahia M El Kheir, Mohammed A Al-Ibrahim, Mohammed I Alhaddad, Hussam J Alsafwani, Mohammed N Alkhater, Mohammed H Alameer, Mohammed H Almousa
{"title":"Author's reply.","authors":"Dalia Yahia M El Kheir, Mohammed A Al-Ibrahim, Mohammed I Alhaddad, Hussam J Alsafwani, Mohammed N Alkhater, Mohammed H Alameer, Mohammed H Almousa","doi":"10.4103/jfcm.jfcm_217_26","DOIUrl":"https://doi.org/10.4103/jfcm.jfcm_217_26","url":null,"abstract":"","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 3","pages":"229"},"PeriodicalIF":0.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148633455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danya M Gari, Hadi A Aljarrash, Mohammed H Alkhamis, Mohammed R Alqasim, Hussain A Alyousef, Mohammed A Aldahan, Shareef H Alayuob, Hossin R Almahozi, Ahmed A Alsaud, Hassan N Alzaher, Marwa M Shafey
{"title":"Understanding knowledge and practices of nutritional supplements in the Eastern Province of Saudi Arabia.","authors":"Danya M Gari, Hadi A Aljarrash, Mohammed H Alkhamis, Mohammed R Alqasim, Hussain A Alyousef, Mohammed A Aldahan, Shareef H Alayuob, Hossin R Almahozi, Ahmed A Alsaud, Hassan N Alzaher, Marwa M Shafey","doi":"10.4103/jfcm.jfcm_349_25","DOIUrl":"10.4103/jfcm.jfcm_349_25","url":null,"abstract":"<p><strong>Background: </strong>The use of nutritional supplements (NSs) has increased worldwide and is usually driven by improved health, athletic performance, and esthetics. However, motivations, practices, and health impacts differ across populations. The aim of this research was to assess knowledge, attitudes, and practices of NSs, especially those with public health implications, such as folic acid and iodine.</p><p><strong>Materials and methods: </strong>A descriptive cross-sectional study was conducted among Saudi adults in the Eastern Province. Using convenient sampling, online questionnaire solicited data on demographics, health status, knowledge, attitudes, and practices regarding NSs. Initial data analysis included descriptive statistics; knowledge scores between groups were compared using Mann-Whitney U test or Kruskal-Wallis test.</p><p><strong>Results: </strong>A total of 483 Saudi adults completed the questionnaire; 55.3% were male and 43.9% were aged 18 to <36 years. Knowledge about iodine and Vitamin B12 was highest but was moderate for folic acid and Vitamin C. Knowledge of folic acid/iodine and Vitamin C varied significantly by age, sex, education, employment, and smoking status (<i>P</i> < 0.05). Most respondents (69.8%) had a favorable attitude toward supplements. About half of the participants reported using nutritional supplements, but only 20.4% used supplements regularly, mainly Vitamin D and multivitamins. Most commonly reported barriers included costs and the fear of side effects.</p><p><strong>Conclusion: </strong>Respondents had good knowledge and positive attitudes toward NSs, but usage was low. Knowledge gaps included folic acid fortification and awareness of Vitamin C deficiency. This highlights the need for targeted educational campaigns.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"100-108"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes B Ginting, Tri Suci, Chrismis N Ginting, Kristiawan Indriyanto
{"title":"Trend and predictive modeling of hypertension risk using multiyear community health surveillance data: Evidence from 2019 to 2021.","authors":"Johannes B Ginting, Tri Suci, Chrismis N Ginting, Kristiawan Indriyanto","doi":"10.4103/jfcm.jfcm_26_26","DOIUrl":"10.4103/jfcm.jfcm_26_26","url":null,"abstract":"<p><strong>Background: </strong>Hypertension remains a major global health burden, often undetected until complications occur. In Indonesia, evidence integrating multiyear surveillance data with machine learning (ML) to predict population-level risk remains limited. The objective of the study was to examine temporal trends in hypertension risk and develop predictive models at the population level.</p><p><strong>Materials and methods: </strong>This observational study utilized community health surveillance data on 196,951 adults (2019-2021). Blood pressure was classified using World Health Organization/Joint National Committee 7 criteria, with prehypertension and hypertension combined as abnormal (<i>y</i> = 1). Predictors included sociodemographic characteristics, anthropometric measurements, various health behaviors, and comorbidities. Missing values were imputed using K-Nearest Neighbors. Logistic Regression, Random Forest, Gradient Boosting, eXtreme Gradient Boosting (XGBoost), and Support Vector Machine models were developed using an 80:20 split, 10-fold cross-validation, and hyperparameter tuning. Model interpretability was assessed using SHapley Additive exPlanations (SHAP).</p><p><strong>Results: </strong>Abnormal blood pressure prevalence increased from 74.4% (2019) to 79.7% (2020) and 80.2% (2021). XGBoost demonstrated superior performance, achieving 78.3% accuracy and an area under the curve of 0.736, outperforming other models. SHAP analysis identified age, waist circumference, body mass index, and male sex as the strongest predictors of the risk of hypertension.</p><p><strong>Conclusion: </strong>Hypertension risk in Indonesia rose from 2019 to 2021. Interpretable ML models, particularly XGBoost, show potential for population-level risk stratification and early detection in community and primary healthcare settings.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"137-144"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akhmad Azmiardi, Ratih P Febrinasari, Bhisma Murti
{"title":"Effectiveness of family and peer support intervention on glycemic control, self-management, and quality of life in type 2 diabetes in rural Indonesia: A randomized controlled trial.","authors":"Akhmad Azmiardi, Ratih P Febrinasari, Bhisma Murti","doi":"10.4103/jfcm.jfcm_357_25","DOIUrl":"10.4103/jfcm.jfcm_357_25","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a major global health burden, with many patients failing to achieve optimal glycemic targets. Family and peer support are recognized as important determinants of effective diabetes self-management. However, there is little evidence of the combined impact. Therefore, this study aimed to evaluate the effectiveness of a structured family and peer support intervention, delivered alongside standard diabetes care, to improve glycemic control.</p><p><strong>Materials and methods: </strong>A randomized controlled trial was conducted on 120 patients with T2DM, allocated into two equal intervention and control groups. The intervention consisted of eight weekly group-based educational sessions followed by four structured weekly telephone follow-ups, during which emphasis was placed on family and peer support in diabetes education, self-management, and problem-solving strategies. The primary outcome was glycemic control measured with Glycated hemoglobin (HbA1c), while the secondary outcomes included self-management, knowledge, and diabetes-related quality of life (DQoL). Data were analyzed using SPSS. Chi-square test and independent t-test were used to compare baseline data between groups. Mann Whitney U test or t-test, as appropriate, assessed the changes from baseline to 12 weeks.</p><p><strong>Results: </strong>A total of 110 subjects completed 12 week follow-up. Majority (75%) were females, and were aged 46-65 years (>70.0%). At the 3-month follow-up, the intervention group demonstrated significantly greater reductions in HbA1c compared to the control (6.7% ± 0.8% vs. 7.2% ± 0.8%, <i>P</i> = 0.002). Significant improvements were also observed in self-management scores (56.1 ± 2.7 vs. 46.1 ± 3.4, <i>P</i> < 0.001), DQoL (46.3 ± 7.9 vs. 37.1 ± 8.4, <i>P</i> < 0.001), and knowledge of diabetes (4.31 ± 0.61 vs. 3.91 ± 0.72, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Family and peer support intervention significantly improved glycemic control, self-management behaviors, diabetes knowledge, and the quality of life of patients with T2DM. Therefore, healthcare providers should consider making family members and peers an essential part of the diabetes management routine.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"84-91"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faisal A Abuabat, Leen T Alowaidah, Raghad M Assiri, Asmaa Y Alshangiti, Hind Y Alshangiti, Norah A Almudawi
{"title":"Thyroid function in pregnant Saudi women: A cross-sectional study at a tertiary hospital.","authors":"Faisal A Abuabat, Leen T Alowaidah, Raghad M Assiri, Asmaa Y Alshangiti, Hind Y Alshangiti, Norah A Almudawi","doi":"10.4103/jfcm.jfcm_318_25","DOIUrl":"10.4103/jfcm.jfcm_318_25","url":null,"abstract":"<p><strong>Background: </strong>Thyroid dysfunction during pregnancy can have significant implications for both maternal and fetal health. The physiological changes of pregnancy, including increased thyroxine-binding globulin and human chorionic gonadotropin-mediated thyroid-stimulating hormone (TSH) suppression, alter thyroid hormone concentrations and highlight the need for population-specific reference ranges. This study aimed to characterize trimester-specific thyroid function patterns and hypothyroidism in Saudi pregnant women.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted among Saudi women who delivered singleton live births during January1 and December31, 2023 at a tertiary care hospital in Riyadh, Saudi Arabia. A random sample of 329 women meeting the inclusion criteria was selected from a total of 2259 women who delivered during the study period. Data regarding patient demographic characteristics, thyroid disease history, TSH levels, thyroid peroxidase antibody (TPO-Ab) status, and the use of levothyroxine was abstracted from hospital's electronic health record system using a structured data collection sheet. Data were analyzed using SPSS; Categorical variables were summarized as frequencies and percentages, whereas mean and standard deviation was calculated for continuous variables. Categorical variables were summarized as frequencies and percentages. Thyroid function parameters were compared across clinical groups using ANOVA or Kruskal-Wallis test, as appropriate.</p><p><strong>Results: </strong>Thyroid dysfunction was identified in 27.4% of the 329 Saudi pregnant women; 21.6% of these were subclinical, and 5.8% were overt hypothyroidism. Median TSH concentrations were 2.03, 2.46, and 2.26 mIU/L across the first, second, and third trimesters, respectively. The mean TSH levels differed significantly across thyroid function groups in all trimesters (<i>P</i><0.01). TPO-Ab positivity was uncommon (5.2%), and levothyroxine was used by 31.0%.</p><p><strong>Conclusion: </strong>A notable proportion of Saudi pregnant women exhibited thyroid dysfunction, underscoring the importance of locally derived trimester-specific TSH data. These findings provide useful baseline information that could guide future multicenter or prospective studies and support the refinement of thyroid screening practices in Saudi Arabia.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"124-130"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tety Rachmawati, Stefanus Supriyanto, Dede A Musadad, Asep Kusnali, Yunita Fitrianti, Wahyu P Nugraheni, Sri Handayani, Syarifah Nuraini, Haerawati Idris, Diyan E Effendi
{"title":"Determinants of adequate antenatal care for underage mothers in Indonesia: Urban-rural inequities.","authors":"Tety Rachmawati, Stefanus Supriyanto, Dede A Musadad, Asep Kusnali, Yunita Fitrianti, Wahyu P Nugraheni, Sri Handayani, Syarifah Nuraini, Haerawati Idris, Diyan E Effendi","doi":"10.4103/jfcm.jfcm_331_25","DOIUrl":"10.4103/jfcm.jfcm_331_25","url":null,"abstract":"<p><strong>Introduction: </strong>Child marriage and adolescent pregnancy are significant public health concerns in Indonesia associated with increased obstetric and perinatal risks. Adequate antenatal care (ANC) is essential to mitigate these risks. The objective of this study was to identify the predictors of adequate ANC utilization by underage mothers in Indonesia, with specific focus on rural-urban disparities.</p><p><strong>Materials and methods: </strong>This cross-sectional study utilized the secondary data from the 2023 Indonesian Health Survey. The sample comprised 2927 underage mothers (<20 years) consisting of 1873 rural and 1054 urban residents, who had at least one pregnancy. Adequate ANC was defined in accordance with the Indonesian Ministry of Health guidelines as at least six visits throughout the stages of pregnancy. Data were analyzed using SPSS; descriptive statistics were used to describe the study variables. Chi-square test assessed the associations between ANC utilization and various independent variables. Logistic regression analysis determined the factors associated with adequate ANC, adjusting for potential confounders; separate models were developed for urban and rural subsamples.</p><p><strong>Results: </strong>Only 33.0% of underage mothers received adequate ANC and only 6.5% received all 10 essential ANC components. Higher educational attainment, health insurance ownership, and better economic status were significantly associated with likelihood of adequate ANC, particularly in rural areas. Urban residence was marginally associated with higher ANC adequacy (odds ratio = 1.19). Underage mothers with separated marital status were less likely to have adequate ANC utilization, particularly in the urban settings. Knowledge of the danger signs in pregnancy was not significantly associated with ANC adequacy.</p><p><strong>Conclusion: </strong>Adequate and comprehensive utilization of ANC by underage mothers in Indonesia remains low, with persistent urban-rural inequalities. There should be targeted, adolescent-friendly interventions that focus on education, insurance coverage, and socioeconomic support, especially for rural and disadvantaged adolescents.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"92-99"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed M Alsultan, Solaiman M Alhawas, Ruba M Alzahrani, Nada M Alhawashi, Khalid A Alamer, Abdulrahman A Alsuhibani, Amani M AlQarni
{"title":"Inappropriate medication use and associated factors in geriatric patients with hypertension and diabetes.","authors":"Mohammed M Alsultan, Solaiman M Alhawas, Ruba M Alzahrani, Nada M Alhawashi, Khalid A Alamer, Abdulrahman A Alsuhibani, Amani M AlQarni","doi":"10.4103/jfcm.jfcm_359_25","DOIUrl":"10.4103/jfcm.jfcm_359_25","url":null,"abstract":"<p><strong>Background: </strong>The potentially inappropriate medications (PIMs) are a list of drugs that should be avoided or used with caution in geriatric patients. Therefore, the aim of this study was to explore the prevalence of PIMs use and potential risk factors in geriatric patients with diabetes mellitus (DM) and hypertension (HTN).</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted between June 1, 2023, and October 31, 2024. Data were obtained from the outpatient clinics of elderly people aged 65 years and older. The 2023 updated Beers Criteria, developed by the American Geriatrics Society, was used to determine the use of PIMs among persons aged ≥65 years. The prevalence of PIMs was based on ≥1 PIM prescription divided by the total number of patients. Data analyzed using SPSS; Chi-square test, independent samples t-test, and logistic regression analysis were performed.</p><p><strong>Results: </strong>The entire sample included 198 patients with DM and HTN; 58.6% of the study participants showed PIM use. The most frequently prescribed classes of PIMs that should be avoided were gastrointestinal agents (<i>n</i> = 136). The multivariable logistic regression showed a considerably higher risk of PIMs in females (adjusted odds ratio [AOR] = 2.59, 95% confidence interval [CI]: 1.20-5.60), people with genitourinary diseases (AOR = 3.88, 95% CI: 1.53-9.87), and polypharmacy (AOR = 1.09, 95% CI: 1.05-1.13). The most frequently used PIM that should be avoided was proton-pump inhibitors (97.8%). In contrast, the PIM that should be used with caution was dapagliflozin (99.0%).</p><p><strong>Conclusions: </strong>The prevalence of PIMs was high in geriatric patients with DM and HTN. In addition, the predictors that could significantly affect the PIMs were female gender, comorbid genitourinary disease, and polypharmacy. Thus, the results of this study could help healthcare providers improve safe prescribing for geriatric patients diagnosed with DM and HTN.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioannis Zerefos, Anant Joshi, Fadia Namous, Eduardo Espiridion
{"title":"Comparative risk of depressive disorder in patients with diabetic neuropathy treated with gabapentin versus duloxetine: Retrospective cohort study.","authors":"Ioannis Zerefos, Anant Joshi, Fadia Namous, Eduardo Espiridion","doi":"10.4103/jfcm.jfcm_361_25","DOIUrl":"10.4103/jfcm.jfcm_361_25","url":null,"abstract":"<p><strong>Background: </strong>Depressive disorders (DD) are highly prevalent in patients with diabetic neuropathy (DN), yet a little is known about how commonly used neuropathic agents, duloxetine and gabapentin, differentially influence psychiatric outcomes in this population.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort analysis using the TriNetX electronic health record network containing patient data from more than 69 healthcare organizations, version v5.0, between January 2000 and December 2025. After propensity score matching, patients treated for diabetic neuropathy were grouped into balanced cohorts of 18,674 gabapentin-treated patients and 16,223 duloxetine-treated patients. The primary outcome was new-onset DD within 5 years following initiation of treatment. Risk estimates and survival analyses compared cohorts.</p><p><strong>Results: </strong>Patients treated with duloxetine had a significantly higher 5-year risk of developing DD than those treated with gabapentin (16.3% vs. 14.8%; risk ratio 1.099, 95% confidence interval [CI]: 1.046-1.154). Kaplan-Meier analysis demonstrated a lower survival probability free from DD in the duloxetine group (83.7% vs. 85.2%), with a hazard ratio of 1.318 (95% CI 1.250-1.391, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>In this propensity score-matched real-world cohort, duloxetine was associated with a significantly higher, albeit small absolute risk of incident DD compared with gabapentin. These findings suggest a correlational association with the use of duloxetine and psychiatric risk in this specific patient population. This highlights possible consideration of psychiatric outcomes when treatments are selected for DN and also supports the need for future prospective studies to confirm causality and further evaluate the psychiatric effects of therapies for neuropathic pain.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"117-123"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evi R N Hidayati, Verial Attamimy, Ininnawa Tenriawaru, Yuri S Susani, Choirunnisa Y Akhir, Irvi A Zatirah
{"title":"The association between group exercise and the quality of life of community-dwelling older adults in Indonesia.","authors":"Evi R N Hidayati, Verial Attamimy, Ininnawa Tenriawaru, Yuri S Susani, Choirunnisa Y Akhir, Irvi A Zatirah","doi":"10.4103/jfcm.jfcm_364_25","DOIUrl":"10.4103/jfcm.jfcm_364_25","url":null,"abstract":"<p><strong>Background: </strong>Indonesia has the fourth-largest older adult population with minimal physical activity levels globally. Physical inactivity reduces physical fitness and increases the risk of sarcopenia, osteoporosis, and social isolation, whereas group exercise promotes physical activity and develops social relationships among older adults. This study assessed whether participation in group exercise sessions is associated with the quality of life of community-dwelling older adults.</p><p><strong>Materials and methods: </strong>This cross-sectional study was carried out among older adults participating in community-based group exercise programs in Indonesia from January to December 2024. One hundred twenty-one persons were selected using convenience sampling technique. Physical activity was assessed through interviews. Physical fitness was evaluated using the modified 30-s sit-to-stand test and the 4-m gait speed (4MGS), whereas EuroQol 5-Dimension (EQ-5D) questionnaire was used to measure quality of life.</p><p><strong>Results: </strong>Majority (80%) were aged 60-74 years, were females (72%); 60% were categorized as having moderate physical activity levels with a mean metabolic equivalent value of 4.08 ± 0.67. A mild correlation was observed between physical activity level and mobility (<i>r</i> = 0.181, <i>P</i> = 0.047), while a significant moderate correlation was found with physical fitness (<i>r</i> = 0.202, <i>P</i> = 0.026). Quality of life was generally good (mean EQ-5D index 0.89 ± 0.15). Older adults with higher physical fitness levels demonstrated significantly better scores (0.92 ± 0.11).</p><p><strong>Conclusion: </strong>Participation in group exercise sessions was associated with better quality of life in older adults and was linked to higher physical activity levels, improved physical fitness, mobility, and peer socialization.</p>","PeriodicalId":101441,"journal":{"name":"Journal of family & community medicine","volume":"33 2","pages":"109-116"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}