Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)最新文献_第5页

[Association of IL13 rs1800925 and rs1881457 variants with severe asthma in a population from Western Mexico]. [IL13 rs1800925和rs1881457变异与墨西哥西部人群中严重哮喘的关联]。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-09-30 DOI: 10.29262/ram.v72i3.1493

Ingrid Berenice Montoya-Delgado, Bricia Melissa Gutierrez-Zepeda, Antonio Quintero-Ramos, Itzel Vianey Ochoa-García, Margarita Ortega-Cisneros, Alicia Del Toro-Arreola, Adrian Daneri-Navarro

{"title":"[Association of IL13 rs1800925 and rs1881457 variants with severe asthma in a population from Western Mexico].","authors":"Ingrid Berenice Montoya-Delgado, Bricia Melissa Gutierrez-Zepeda, Antonio Quintero-Ramos, Itzel Vianey Ochoa-García, Margarita Ortega-Cisneros, Alicia Del Toro-Arreola, Adrian Daneri-Navarro","doi":"10.29262/ram.v72i3.1493","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1493","url":null,"abstract":"Background: Asthma is a chronic inflammatory disease with variable airflow obstruction. Severe asthma (310% of cases) requires high-dose corticosteroids, increasing the risk of exacerbations. The IL13 rs1800925 and rs1881457 variants, involved in the regulation of inflammation, have been associated with asthma severity in various populations, but their impact in Mexico has not been studied.Objective: To evaluate the association of the IL13 rs1800925 and rs1881457 variants in patients with severe asthma.Methods: One hundred patients with severe asthma and 150 healthy controls were analyzed. DNA was extracted and quantified for genotyping using allelic discrimination. Lung function, IgE levels, hospitalizations, symptoms, medications, and allergen exposure were assessed. Haplotypes and linkage disequilibrium (LD) were calculated.Results: There were no significant differences in allele/genotype frequencies between groups. A strong LD was observed between rs1800925 and rs1881457 (D=0.83, r2=0.77, p<0.05). 77% had an eosinophilic Th2 endotype, 70% had aeroallergen allergy, and 54% had insufficient disease control. Women used more reliever medication and had more nighttime symptoms (p<0.05).Conclusion: The variants exhibit a strong LD but do not show a significant association with AG in this population. The high prevalence of the eosinophilic Th2 endotype and sensitization to aeroallergens reinforce the role of allergic inflammation in the disease. Furthermore, sex differences suggest a greater incidence in women, which could influence the clinical management of AG. Larger studies are needed to confirm these findings.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Chronic spontaneous urticaria with overlapping type I/IIb endotypes in a patient with Graves disease]. [Graves病患者慢性自发性荨麻疹伴I/IIb型重叠]。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-09-30 DOI: 10.29262/ram.v72i3.1513

Karla Daniela Martínez-Lee, Beatriz Altagracia Contreras-Tejada, Antonio Albarran-Godinez, Yoselin Itzel Sanchez-Perez, Andrea Velasco-Medina, Guillermo Velázquez-Samano, Circe Karime Ruiz-Palafox

{"title":"[Chronic spontaneous urticaria with overlapping type I/IIb endotypes in a patient with Graves disease].","authors":"Karla Daniela Martínez-Lee, Beatriz Altagracia Contreras-Tejada, Antonio Albarran-Godinez, Yoselin Itzel Sanchez-Perez, Andrea Velasco-Medina, Guillermo Velázquez-Samano, Circe Karime Ruiz-Palafox","doi":"10.29262/ram.v72i3.1513","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1513","url":null,"abstract":"Background: Urticaria is defined as the presence of hives, angioedema, or both. 1028% of patients have autoimmune diseases. Twenty percent have antithyroid antibodies, and only 510% present with symptoms. Two main endotypes are currently recognized: type I (anti-allergic) with IgE anti-TPO autoantibodies, and type IIb (autoimmune) with IgG antibodies and IgE anti-FcER1. However, 51% of patients have a I/IIb overlap.Case report: Clinical presentation: A 46-year-old female with a history of untreated hyperthyroidism presented with generalized pruritic hives with facial angioedema, with more than 50 hives per day, lasting <24 hours, which disappeared without leaving a residual macule, with pruritus of 10/10, interfering with sleep and quality of life, and no triggering factor. Laboratory tests: Eo 5.3% (260), IgE T 471, TSH 0.005, FT4 1.65, C3 138, C4 30, Anti-TPO 219, anti-TG 332. Positive autologous serum test. Evolution: Treatment with levocetirizine 10 mg every 12 hours was started; after 2 months, symptoms decreased.Conclusion: There are no specific statistics on the combined prevalence of hyperthyroidism and chronic urticaria worldwide. In this case, the patient presents elevated IgE, autoimmune disease, and positive autologous serum, leading to a diagnosis of type I/IIb overlap. Currently, there is no classification system for urticaria types that can be applied to any clinical setting, which impacts the patients therapeutic and prognostic decisions.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effects of air pollution on health following on environmental contingencies in Mexico City]. [墨西哥城空气污染对健康的影响：环境突发事件]。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-09-30 DOI: 10.29262/ram.v72i3.1463

Alejandro Hernández-Solís, Alejandro Hernández-de la Torriente, León Alfonso Balderas-Salazar, Galileo Navarro-Oropeza, Andrea Hernández-de la Torriente, Camila Ramírez-Padilla, Kevin Hazael Arizmendi-Venegas, Guillermo Velázquez-Samano

{"title":"[Effects of air pollution on health following on environmental contingencies in Mexico City].","authors":"Alejandro Hernández-Solís, Alejandro Hernández-de la Torriente, León Alfonso Balderas-Salazar, Galileo Navarro-Oropeza, Andrea Hernández-de la Torriente, Camila Ramírez-Padilla, Kevin Hazael Arizmendi-Venegas, Guillermo Velázquez-Samano","doi":"10.29262/ram.v72i3.1463","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1463","url":null,"abstract":"Objective: To analyze the effects of air pollution on the health of a vulnerable population in the Mexico City after the nine environmental contingencies presented in the year 2024.Methods: A cross-sectional, descriptive study was conducted among outdoor workers (street vendors). Risk factors and respiratory symptoms were documented, and respiratory function tests were performed.Results: A total of 300 patients were enrolled. The most frequent clinical symptoms were increased expectoration (52%), recurrent respiratory infections (44.3%), headache (39.6%), cough (35%), laryngeal irritation (34%), nasal itching (30%), dyspnea (26%), vertigo (22%), conjunctivitis (20.6%), and chest pain (19.6%). Spirometry results showed: 61.3% with a restrictive pattern, 14.3% with an obstructive pattern, 13.3% with a mixed pattern, and 11% with no abnormalities. Forty-four percent of this group experienced exacerbations of diseases such as asthma and chronic obstructive pulmonary disease.Conclusions: Air pollution constitutes a serious public health problem, especially for low-income people, who live and work in areas with high levels of pollution, as evidenced in our study. Further epidemiological studies are essential to evaluate the impact of ozone and other pollutants on vulnerable groups, to implement more effective preventive measures.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prevalence of sensitization to dog and cat epithelia in preschool patients from urban areas of Cuenca, Ecuador]. [厄瓜多尔昆卡城市学龄前患者对狗和猫上皮的敏感程度]。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1456

María Cristina Neira-Moscoso, Juan Marcelo Rojas-Sánchez, Claudia Rodas-Espinoza, Diana Morillo, Susana Andrade, Cristina Ochoa, María José Molina, Mayra Parra, Angélica Ochoa

{"title":"[Prevalence of sensitization to dog and cat epithelia in preschool patients from urban areas of Cuenca, Ecuador].","authors":"María Cristina Neira-Moscoso, Juan Marcelo Rojas-Sánchez, Claudia Rodas-Espinoza, Diana Morillo, Susana Andrade, Cristina Ochoa, María José Molina, Mayra Parra, Angélica Ochoa","doi":"10.29262/ram.v72i2.1456","DOIUrl":"https://doi.org/10.29262/ram.v72i2.1456","url":null,"abstract":"Objective: To establish the prevalence of sensitization to dog and cat epithelium in a pediatric population aged 3 to 6 years.Methods: A descriptive, cross-sectional prevalence study was conducted as part of the study \"Prevalence and risk factors for asthma, rhinitis, eczema, and atopy among preschool children in an Andean city.\" The study population consisted of children from the city of Cuenca, Ecuador, who were administered the culturally validated ISAAC survey and underwent inhalant skin testing.Results: A total of 600 children were enrolled, with a prevalence of atopy of 33.45% (n = 179), sensitization to dog epithelium of 1.76% (n = 10), and sensitization to cat epithelium of 2.12% (n = 12), representing 5.59% and 6.70% of the atopic population, respectively.Conclusion: The prevalence of sensitization to cat and dog epithelium in children under 6 years of age is lower than expected in the clinical setting. Future studies should assess the sample size in relation to the prevalence of sensitization to cat and dog epithelium.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 2","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Wheat-dependent exercise-induced anaphylaxis: The diagnostic utility of Omega-5 Gliadin in two clinical cases from Lima, Peru]. [小麦依赖运动诱发的过敏反应：在秘鲁利马的两个临床病例中，Omega-5麦胶蛋白的诊断效用]。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1455

Liz Veramendi-Espinoza, César Galván, Rafael Durán

引用次数: 0

Eosinophilic esophagitis with refractory response in a pediatric patient: A case report. 顽固性嗜酸性食管炎1例儿科患者：1例报告。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1444

Isamar De Agrela-Mendes, Margarita Tomás-Perez

引用次数: 0

[Low pseudoallergen and histamine diet: a therapeutic approach in patients with chronic spontaneous urticaria.] [低假过敏原和组胺饮食：慢性自发性荨麻疹患者的治疗方法]

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1452

Edwin Daniel Maldonado-Domínguez, Víctor Fernando Muñoz-Estrada, Jaime Picazo-Luna

{"title":"[Low pseudoallergen and histamine diet: a therapeutic approach in patients with chronic spontaneous urticaria.]","authors":"Edwin Daniel Maldonado-Domínguez, Víctor Fernando Muñoz-Estrada, Jaime Picazo-Luna","doi":"10.29262/ram.v72i2.1452","DOIUrl":"https://doi.org/10.29262/ram.v72i2.1452","url":null,"abstract":"Background: This article analyzes the effects of a histamine- and pseudoallergen-restricted diet as an additional strategy in the treatment of chronic spontaneous urticaria (CSU). A comprehensive review of the literature was conducted using PubMed and Google Scholar, employing both MeSH and non-MeSH terms related to urticaria, histamine, and diet. The review included 78 selected articles published between 2014 and 2024. CSU is a persistent disease in which a considerable number of patients do not respond optimally to standard treatments. Up to one-third of these patients may benefit from reducing the intake of pseudoallergens and histamine-rich foods. Bioactive amines present in various foods tend to exacerbate CSU symptoms by promoting the release of histamine and other inflammatory mediators. The restriction of dietary histamine and the enhancement of diamine oxidase (DAO) enzyme function appear to alleviate symptoms, although variability in reported histamine levels across studies complicates the development of standardized guidelines. It is concluded that a low-histamine and pseudoallergen diet is a promising option for reducing symptoms in patients with chronic spontaneous urticaria (CSU), particularly those who do not achieve adequate control with antihistamines. Evaluating the effectiveness of this diet over a period of three to four weeks is recommended to observe potential benefits. Nevertheless, additional studies and further standardization are necessary to define safe histamine levels in foods and improve therapeutic recommendations.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 2","pages":"119-130"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Adverse drug reaction in a patient with autoimmune disease: Case report]. 自身免疫性疾病患者药物不良反应1例报告

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1446

María Camila Castanier-Dávila, Paúl Leonardo Wilches-Coronel

引用次数: 0

New cosmetics patch test series: A proposal. 新化妆品斑贴试验系列：建议。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1437

Paulo Eduardo Silva Belluco, Marjorie Uber, Franciane de Paula da Silva, Júllia Eduarda Feijó Belluco, Kerstin Taniguchi Abagge, Rosana Zabulon Feijó Belluco, José Carlos Mori

{"title":"New cosmetics patch test series: A proposal.","authors":"Paulo Eduardo Silva Belluco, Marjorie Uber, Franciane de Paula da Silva, Júllia Eduarda Feijó Belluco, Kerstin Taniguchi Abagge, Rosana Zabulon Feijó Belluco, José Carlos Mori","doi":"10.29262/ram.v72i2.1437","DOIUrl":"https://doi.org/10.29262/ram.v72i2.1437","url":null,"abstract":"Background: Contact dermatitis to cosmetic products is a common condition. It is likely the most frequent reason for performing patch tests because many substances used in cosmetics are potent allergens. Cosmetic contact dermatitis most frequently affects the face. Patch test series need to be continuously revised to identify outdated and emerging allergens. The aim of this study is to propose a reformulation of the patch test series for cosmetics. The list of European Surveillance System on Contact Allergies was initially used to select the allergens. Publications in PubMed from the last 10 years were sought, showing the frequency of positive reactions to cosmetic allergens that were tested as part of a baseline series or cosmetics series. Subsequently, large international databases evaluating retail products were consulted to verify if these substances were present in cosmetics, because the relevance would be their presence in commercially sold cosmetics. It was adopted a threshold of 0.3% positive patch test reactions for including a substance in cosmetics series. It was deleted those present in the baseline series (Associação Brasileira de Alergia e Imunologia), fragrances, and allergens limited to hair products. It is believed that choosing too few allergens may result in the non-identification of relevant allergens and treatable cases. On the other hand, testing a series with many allergens is time-consuming and more costly. Therefore, it seems appropriate to create cosmetics series with 20 elements.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 2","pages":"107-118"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molecular mimicry between the major allergen of the centipede (Scolopendra subspinipes) Sco M 5 and proteins from allergenic sources. In silico analysis.] 蜈蚣（Scolopendra subspinipes）主要过敏原Sco m5与过敏原蛋白之间的分子模拟。计算机分析。

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Pub Date : 2025-06-30 DOI: 10.29262/ram.v72i2.1460

Andrés Sánchez, Giovanny Diaz, José Dussan, Marlon Múnera, Jorge Mario Sánchez-Caraballo

{"title":"[Molecular mimicry between the major allergen of the centipede (Scolopendra subspinipes) Sco M 5 and proteins from allergenic sources. In silico analysis.]","authors":"Andrés Sánchez, Giovanny Diaz, José Dussan, Marlon Múnera, Jorge Mario Sánchez-Caraballo","doi":"10.29262/ram.v72i2.1460","DOIUrl":"https://doi.org/10.29262/ram.v72i2.1460","url":null,"abstract":"Objective: To evaluate, through in silico analysis, the cross-reactivity between Sco m 5 and arthropod proteins and to identify potential IgE-binding epitopes.Methods: The homology between Sco m 5 and 15 arthropod allergens (Vespula, Polistes, Polybia, Solenopsis, Brachyponera, Phoneutria, and Dermatophagoides) was assessed using the ALLERMATCH server for pairwise alignments and PRALINE for multiple alignments. Phylogenetic trees were constructed using Molecular Evo-lutionary Genetics Analysis (MEGA). Epitope prediction was performed with the Ellipro server. Protein visualization was carried out through PyMOL.Results: The multiple alignment showed 50% identity, and the pairwise alignments between Sco m 5 and arthropod proteins revealed diverse homology. Two linear epitopes and one conformational epitope were identified in Sco m 5, which were highly conserved in the studied arthropod proteins, such as bees, wasps, and ants.Conclusion: The high homology between Sco m 5 and allergens from other arthropods supports the potential for cross-reactivity. The identification of potential epitopes in conserved regions reinforces this idea and could serve as important targets for therapeutic interventions in allergies triggered by arthropod venoms, especially Scolopendra spp. Further in vitro and in vivo studies are needed to confirm these findings.","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 2","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0