Korean journal of ophthalmology : KJO最新文献

{"title":"Managing Pseudophakic Corneal Edema: Structural Changes and Preliminary Observations on Coenzyme Q10 Use.","authors":"Umay Güvenç, Züleyha Yalnız Akkaya, Ayşe Burcu","doi":"10.3341/kjo.2025.0027","DOIUrl":"https://doi.org/10.3341/kjo.2025.0027","url":null,"abstract":"<p><strong>Purpose: </strong>Pseudophakic corneal edema (PCE) remains a significant postoperative challenge despite advancements in cataract surgery, often delaying visual recovery and affecting refractive outcomes. This study investigates the relationship between keratometric and pachymetric changes during PCE resolution, evaluates factors influencing this process, and examines the efficacy of Coenzyme Q10 (CoQ10) as an adjunct therapy.</p><p><strong>Methods: </strong>A retrospective study was conducted on 88 patients aged 50 and above who developed PCE after uneventful phacoemulsification. Corneal assessments were performed using Pentacam HR, focusing on keratometric and pachymetric changes. Patients were monitored weekly until PCE resolution, defined as a return of central corneal thickness within ±30 microns of preoperative values. Patients received standard postoperative treatment, with a subset also receiving CoQ10 as an adjunct therapy.</p><p><strong>Results: </strong>Postoperative visual acuity(VA) improved significantly (p < 0.001). Despite pachymetric normalization, persistent keratometric changes were observed, particularly a steepening of posterior curvature (p<0.001) and increased anterior asphericity (p = 0.047). CoQ10-treated patients exhibited faster edema resolution (p = 0.019), greater reduction in corneal thickness (p = 0.003), and improved transparency. Higher cumulative dissipated energy (CDE) correlated with increased edema severity (r = 0.419, p<0.001) and higher CDE was linked to slower recovery times. Diabetic patients had a prolonged recovery period compared to non-diabetics (p = 0.018), though pachymetric recovery rates were similar.. The Pachymetric Progression Index (PPI) was unreliable in edematous corneas.</p><p><strong>Conclusions: </strong>While VA and pachymetry improved in all patients, persistent topographic changes suggest incomplete structural normalization. Preliminary findings indicate that adjunctive CoQ10 use may support more efficient corneal edema resolution, as evidenced by faster recovery and favorable structural changes. Further prospective studies are warranted to confirm these observations.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Visual Disturbance Due to Posterior Ischemic Optic Neuropathy in Eosinophilic Granulomatosis with Polyangiitis: A Case Report.","authors":"Sang Hyuk Yim, Daniel Sungchul Choi, Kang Hyun Kim, Chan Yun Kim, Wungrak Choi","doi":"10.3341/kjo.2025.0038","DOIUrl":"https://doi.org/10.3341/kjo.2025.0038","url":null,"abstract":"","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Flexible Electrode for Electrical Stimulation of Rabbit Extraocular Muscle.","authors":"Hee Kyung Yang, Lee-Woon Jang, Dong Hyun Kim, Jung-Hyun Lee, Jungsuk Kim, Gheeyoung Choe, Jeong-Min Hwang","doi":"10.3341/kjo.2025.0067","DOIUrl":"https://doi.org/10.3341/kjo.2025.0067","url":null,"abstract":"<p><strong>Background/objective: </strong>To develop a flexible electrode for electrical stimulation of extraocular muscle and to evaluate the safety of applying direct electrical stimulation to muscle and its potential effects on ocular tissue in rabbits.</p><p><strong>Methods: </strong>A flexible electrode was fabricated using a conventional photolithography process. This electrode comprised a 300nm-thick platinum layer embedded within a 30μm-thick polyimide cable. In an in vivo study, five rabbits underwent electrical stimulation of the right superior and inferior rectus muscles. Stimulation consisted of 12 pulses (1 pulse/second, 2.0 mA, 0.1 ms duration) applied for five minutes to the right superior rectus muscle, followed by five minutes to the right inferior rectus muscle. This regimen was performed three times a week for four weeks. Subsequent histological examination was conducted on the conjunctiva, extraocular muscles, sclera, and retina.</p><p><strong>Results: </strong>Direct electrical stimulation of extraocular muscle using a flexible electrode could successfully elicit eye movement in rabbits. Histologic examination demonstrated no evidence of detrimental effects of the electrical stimulation.</p><p><strong>Conclusions: </strong>Direct electrical stimulation of extraocular muscle using a flexible electrode could safely elicit eye movement without any ocular damage in rabbits.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoexfoliative Deposits on an Implantable Collamer Lens.","authors":"Young Hoon Hwang","doi":"10.3341/kjo.2025.0013","DOIUrl":"https://doi.org/10.3341/kjo.2025.0013","url":null,"abstract":"","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Sutureless Amnion Membrane Transplantation for Corneal Epithelialization in Delayed Corneal Healing: A Systematic Review.","authors":"Michelle Eva Rebeca Natalia, Made Susiyanti","doi":"10.3341/kjo.2025.0004","DOIUrl":"https://doi.org/10.3341/kjo.2025.0004","url":null,"abstract":"<p><strong>Purpose: </strong>To review the current evidence on the efficacy and safety of sutureless amniotic membrane (AM) transplantation for promoting corneal epithelialization in delayed corneal healing disorders.</p><p><strong>Methods: </strong>A comprehensive search was conducted for studies published from January 2003 to December 2023. The inclusion criteria were studies that focused on delayed corneal healing (including persistent epithelial defect, dry eye disease, corneal ulcer, chemical injury, recalcitrant keratitis, or others), observed corneal re-epithelialization as the outcome, with the used of sutureless amniotic membrane graft. Studies that were reporting sutureless AM combined with cyanoacrylate or fibrin glue were excluded.</p><p><strong>Results: </strong>A total of 14 studies met the inclusion and exclusion criteria. The most common technique for sutureless AM on the cornea was self-retained cryopreserved AM transplantation. The result of sutureless AM transplantation in various delayed corneal healing disorders showed complete corneal epithelialization occurred in most patients (64.4%) which ranged from 3 to 43 days. There was a low rate of adverse events (pain 2.9%, displaced AM or lost ring 1.7%) and complications (sterile infiltrate 1.8%, corneal perforation 0.6%, ring trauma 0.4%, and central corneal scarring 0.2%).</p><p><strong>Conclusion: </strong>Sutureless AM transplantation promotes complete corneal epithelialization. It is easier for multiple application, more comfortable, and has a lower risk of suture-related complications. Overall, sutureless AM transplantation is effective and safe for a variety of corneal delayed healing disorders.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neopterin levels and immune response in autoimmune uveitis in an experiment.","authors":"Nadiia Kuryltsiv","doi":"10.3341/kjo.2024.0118","DOIUrl":"https://doi.org/10.3341/kjo.2024.0118","url":null,"abstract":"<p><strong>Purpose: </strong>To study and compare the immune response and neopterin levels in the blood in experimental autoimmune uveitis (EAU).</p><p><strong>Methods: </strong>A model of EAU was created in 30 Chinchilla rabbits. Intravenous and intravitreal injections of normal horse serum were administered for this purpose. Clinical examinations and blood tests were conducted on days 3, 7, 10, 14, and 21. The blood investigation included the determination of neopterin (NP) level, counts of white blood cells (WBC), lymphocytes (Lymphs), CD3+, CD4+, CD8+ and CD16+.</p><p><strong>Results: </strong>The peak in WBC count was observed on Days 7 and 10 (6.4 ± 0.4 g/l, 6.0 ± 0.3 g/l), Lymphs- on Day 3 (68.3±2.4 %, 3,0±0.2 g/l), CD3+ - on Day 7 (64.9±3.1%, 2232.5±91.2 cells/µL), CD4+ and CD16+ - on Day 10 (21.8±1.8%, 691.2±37.1 cells/µL). All these values did not return to the initial ones. There was a gradual decrease in the CD8+ count from Day 3 (12.5±1.1%, 142.8±9.1 cells/µL) with a subsequent gradual return towards normal levels by Day 21. NP level was incresed on Day 3 (5.2 ± 0.7 nmol/l), was sustained on Day 7 (5.2 ± 0.8 nmol/l) and started to decrease from Day 10 (4.25 ± 1.7 nmol/l) to 2.3 ± 0.5 nmol/l on Day 21. Also the highest correlation was observed for r (clinical manifestations/NP) = 0.80 (95% CI: 0.72-0.86), which was significantly stronger (p < 0.05) than the correlations with other immune response markers.</p><p><strong>Conclusion: </strong>During the modeling of EAU, there is an active immune response and a rapid reaction of NP on inflammation. NP is a significantly more sensitive marker of intraocular inflammation than the immune response. It can serve as a predictor of the onset and development of EAU.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Skeletal Muscle Mass and Ocular Perfusion Pressure in Glaucoma.","authors":"Jisoo Kang, Ji Hong Kim, Yu Jeong Kim, Han Woong Lim, Jooyoung Yoon, Won June Lee","doi":"10.3341/kjo.2025.0018","DOIUrl":"https://doi.org/10.3341/kjo.2025.0018","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the relationship between body composition and glaucoma by analyzing the associations between anthropometric and ocular parameters.</p><p><strong>Methods: </strong>A total of 494 eyes from 247 patients were reviewed from a general health examination database at a tertiary hospital. Anthropometric parameters were assessed using a multi-frequency bioelectrical impedance device. Mean ocular perfusion pressure (MOPP) was calculated based on systolic and diastolic blood pressures and intraocular pressure (IOP). Retinal thickness and other ocular parameters were analyzed for their association with body composition.</p><p><strong>Results: </strong>A total of 221 eyes from 221 patients, including 104 with glaucoma, were enrolled in the final analysis. The prevalence of sarcopenia was significantly higher in patients with glaucomatous damage than in those without (P= 0.025). Higher IOP showed significant associations with lower MOPP (P<0.001), higher body mass index (BMI, P= 0.001), and higher waist-to-hip ratio (P= 0.001). Retinal thickness was not significantly associated with body composition parameters, including BMI and appendicular lean mass/(height)2 (ALM/ht2). Higher MOPP was significantly correlated with lower IOP (P<0.001), higher BMI (P<0.001), higher waist-to-hip ratio (P<0.001), and higher ALM/ht2 (P= 0.009).</p><p><strong>Conclusions: </strong>Skeletal muscle mass and BMI were significantly associated with MOPP. Since low MOPP is a known risk factor for glaucoma, its association with skeletal muscle mass may indicate a relationship between systemic muscle health, ocular blood perfusion, and glaucomatous damage. Further large-scale studies are needed to validate these associations between skeletal muscle mass and glaucoma and explore their clinical implications.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 50 Hz Filters on Pattern Electroretinogram.","authors":"Dong Hee Ha, Ungsoo Samuel Kim","doi":"10.3341/kjo.2024.0105","DOIUrl":"https://doi.org/10.3341/kjo.2024.0105","url":null,"abstract":"<p><strong>Purpose: </strong>Pattern electroretinogram (PERG) is used to evaluate the function of retinal ganglion cells. However, the amplitude of PERG is quite small, thus making the examination challenging to perform. Waveform noise may be minimized by applying various filters. We aimed to investigate the effect of 50-Hz filters on PERG test results.</p><p><strong>Methods: </strong>This is the retrospective observational study. PERG tests were performed using the RETI-scan system (Roland Consult, Germany) according to the International Society for Clinical Electrophysiology of Vision (ISCEV) guidelines. Three types of 50-Hz filters (soft, middle, and hard) were applied. The differences in parameters (N35 peak time, P50 peak time, N95 peak time, P50 amplitude, N95 amplitude, and N95/P50 ratio) were analyzed. Based on the provided normal range, the changes from normal to abnormal range or vice versa were investigated.</p><p><strong>Results: </strong>A total of 24 waveforms were analyzed. After filtering, the P50 and N95 amplitudes showed significant reduction of 8-15% (P50 amplitude: without filter, 5.1 ± 2.7 μV; 50-Hz soft filter, 4.6 ± 2.3 μV; 50-Hz middle filter, 4.3 ± 2.1 μV; 50-Hz hard filter, 4.3 ± 2.1 μV. N95 amplitude: without filter, 7.2 ± 4.2 μV; 50-Hz soft filter, 6.6 ± 3.8 μV; 50-Hz middle filter, 6.3 ± 3.6 μV, 50-Hz hard filter, 6.1 ± 3.6 μV). This pattern was more prominent in normal subjects. All latencies except the N35 peak time exhibited no differences between the tests. The N95/P50 ratio was decreased after 50-Hz middle and hard filtering. Considering the normative data, switching between normal and abnormal results was rare.</p><p><strong>Conclusions: </strong>Although peak time was not significantly affected, amplitude was significantly reduced after using 50-Hz filters. Thus, 50-Hz filters can smoothen the waveform. Nevertheless, caution must be exercised while taking readings.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Tonometry Methods in Keratoconic Eyes Following Intracorneal Ring Segments Implantation: A Comparative Study.","authors":"Siamak Zarei-Ghanavati, Seyed Mehdi Tabatabaei, Samaneh Gholamhoseinpour-Omran, Hamed Hosseinikhah-Manshadi, Saeed Banan, Mehdi Aminizade, Kosar Esmaili, Ebrahim Azaripour","doi":"10.3341/kjo.2025.0016","DOIUrl":"https://doi.org/10.3341/kjo.2025.0016","url":null,"abstract":"<p><strong>Purpose: </strong>To compare intraocular pressure (IOP) readings from corneas with intrastromal corneal ring segments (ICRS) using various methods, including Goldmann applanation tonometry (GAT), Tonopen, corneal-compensated IOP (IOPcc) from ORA, and biomechanically corrected IOP (IOPb) from Corvis ST.</p><p><strong>Methods: </strong>This cross-sectional observational study included participants who had undergone ICRS implantation with KeraRing (Mediphacos, Belo Horizonte, Brazil) at least 3 months before the study. The mean IOP recorded by different instruments was compared using ANOVA. Agreement among the methods was assessed with Bland-Altman plots.</p><p><strong>Results: </strong>A total of 54 eyes from 27 participants were enrolled. The mean IOP measured by Tonopen was significantly lower in the center compared to the peripheral quadrants (p < 0.001). IOP measured by GAT was significantly lower than that measured by Tonopen (13.02 ± 2.31 mmHg vs. 14.50 ± 2.91 mmHg, p = 0.02). There were no significant differences between the IOP measurements provided by Tonopen, ORA, and Corvis ST. The IOPcc from ORA and IOPb from Corvis ST had the highest correlation, with a weak intraclass correlation coefficient (ICC) of 0.38.</p><p><strong>Conclusions: </strong>IOP measurements using Tonopen were significantly lower in the central 5 mm zone compared to other quadrants. GAT measurements were significantly lower than those from Tonopen. Different measurement tools did not show a strong correlation. Corvis ST (IOPb) tended to present lower readings at higher IOP levels in eyes with ICRS.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management practice for hordeolum and chalazion: a survey of KSOPRS members.","authors":"Hyun Jin Shin, Jin Sook Yoon, Hokyung Choung, Helen Lew","doi":"10.3341/kjo.2025.0024","DOIUrl":"https://doi.org/10.3341/kjo.2025.0024","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the current management pattern for hordeolum and chalazion among members of the Korean Society of Ophthalmic Plastic and Reconstructive Surgery (KSOPRS).</p><p><strong>Methods: </strong>An anonymous web-based survey was emailed to 260 current members of the KSOPRS. The survey comprised five sections: (1) differential diagnosis, (2) treatment strategies for hordeolum, (3) treatment strategies for chalazion, (4) postsurgical care, and (5) pediatric-specific approaches.</p><p><strong>Results: </strong>Eighty KSOPRS members participated in this study (30.8% response rate). Redness, swelling, and pain were the most-important factors for differentiating hordeolum from chalazion. For hordeolum, topical antibiotics are preferred by 73.8% of respondents, with 83.7% considering them effective. Most (77.6%) pursue nonsurgical treatment for 5-14 days before considering incision and curettage. For chalazion, treatment practices are split between conservative management and invasive methods. Intralesional steroid injections are recommended by 68.8% of respondents, with a preference for diluted triamcinolone acetonide. Relative to hordeolum, chalazion treatment involves less-frequent antibiotic use, with only 26.3% of respondents always recommending antibiotic ointments. Tissue biopsy is considered for abnormal changes in the surrounding tissues (90%) and frequent recurrence (57.5%). The practices differ between pediatric and adult cases among 47.5% of respondents, with 81.4% extending conservative management and delaying surgical interventions in pediatric cases. Anesthesia preferences for pediatric cases varied, with 50% favoring local anesthesia, 23.8% opting for monitored anesthesia care, and 16.2% choosing general anesthesia.</p><p><strong>Conclusions: </strong>This survey of the management of hordeolum and chalazion by KSOPRS members has revealed several interesting common practices that are considered valuable by current practitioners.</p>","PeriodicalId":101356,"journal":{"name":"Korean journal of ophthalmology : KJO","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}